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Fariba Bayat, Ramin Baghaei, Morteza Safi, Zahra Ansari Aval, Isa Khaheshi, Mohammadreza Naderian
We present a 33-year-old man with atypical chest pain and with no significant past medical history. The patient was finally diagnosed as a case of huge fistula from the left main coronary artery to the right atrium, a very rare condition with challenging diagnostic and therapeutic approaches. The majority of cases of coronary artery fistula are small, asymptomatic and clinically undetectable; they frequently do not cause any complications and can spontaneously resolve. However, larger fistulas are frequently three times the size of a typical caliber of a coronary artery and may or may not cause symptoms or complications...
March 8, 2019: Future Cardiology
David Cibula, Richard Pötter, François Planchamp, Elisabeth Avall-Lundqvist, Daniela Fischerova, Christine Haie Meder, Christhardt Köhler, Fabio Landoni, Sigurd Lax, Jacob Christian Lindegaard, Umesh Mahantshetty, Patrice Mathevet, W Glenn McCluggage, Mary McCormack, Raj Naik, Remi Nout, Sandro Pignata, Jordi Ponce, Denis Querleu, Francesco Raspagliesi, Alexandros Rodolakis, Karl Tamussino, Pauline Wimberger, Maria Rosaria Raspollini
BACKGROUND: Despite significant advances in the screening, detection, and treatment of preinvasive cervical lesions, invasive cervical cancer is the fifth most common cancer in European women. There are large disparities in Europe and worldwide in the incidence, management, and mortality of cervical cancer. OBJECTIVE: The European Society of Gynaecological Oncology (ESGO), the European Society for Radiotherapy and Oncology (ESTRO), and the European Society of Pathology (ESP) jointly develop clinically relevant and evidence-based guidelines in order to improve the quality of care for women with cervical cancer across Europe and worldwide...
May 2018: International Journal of Gynecological Cancer
Azadeh Kamel Ghalibaf, Elham Nazari, Mahdi Gholian-Aval, Mahmood Tara
OBJECTIVES: To explore the scope of the published literature on computer-tailoring, considering both the development and the evaluation aspects, with the aim of identifying and categorising main approaches and detecting research gaps, tendencies and trends. SETTING: Original researches from any country and healthcare setting. PARTICIPANTS: Patients or health consumers with any health condition regardless of their specific characteristics. METHOD: A systematic scoping review was undertaken based on the York's five-stage framework outlined by Arksey and O'Malley...
January 9, 2019: BMJ Open
L Fekri Aval, M Ghoranneviss, G Behzadi Pour
In this study, the three structures of the symmetric paper supercapacitors based on the carbon nanotubes (CNTs), graphite nanoparticles (GNPs) and graphene electrodes have been fabricated. In the supercapacitors was used of polyvinyl alcohol (PVA)/phosphoric acid (H3 PO4 ) as a gel electrolyte and the BaTiO3 film as a separator film. The carbon nanomaterials, gel electrolyte surface, and electrode films were characterized by scanning electron microscopy (SEM) and transmission electron microscope (TEM). The specific capacitance of the symmetric paper supercapacitors using charge-discharge technique and C-V curves at the voltage scan rates 20 mV/s and 150 mV/s have been investigated...
November 2018: Heliyon
Ma Assumpta Recasens, Eva Xicola-Coromina, Josep-Maria Manresa, Pierre Antoine Ullmo, Bjarne Bruun Jensen, Rosa Franco, Anna Suarez, Anna Nadal, Maria Vila, Isabel Recasens, M José Pérez, Conxa Castell, Esteve Llargués
BACKGROUND & AIMS: The prevalence of obesity and overweight among children is increasing, representing a new and pressing societal problem. Excess weight in childhood is an independent risk factor for adult obesity. Although school-based interventions are generally considered effective in the short term, few studies analyze their longterm impact. The aim of study was to assess if the effect of the intervention on body mass Index (BMI) immediately after the intervention remained eight years later (AVall Study)...
January 24, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Raheleh Ganjali, Zhila Taherzadeh, Mahin Ghorban Sabbagh, Fatemeh Nazemiyan, Fereshteh Mamdouhi, Hamed Tabesh, Shapour Badiee Aval, Reza Golmakani, Sayyed Mostafa Mostafavi, Saeid Eslami
INTRODUCTION: Adherence to a complex and ongoing set of therapeutic recommendations significantly determines short and long-term outcomes after kidney transplantation (KT). Interactive voice response system (IVRS) is a novel phone-based platform which is potentially useful to deliver health behavior interventions. OBJECTIVE: The aims of the study is to describe the development of a theory-driven and educational IVRS investigate the effect of an IVRS on the self-management outcomes in KT recipients as compared with the control group...
February 2019: Medicine (Baltimore)
Toktam Alirezaei, Zahra Ansari Aval
A 58-year-old man who presented with syncope, dyspnea, and hemodynamic compromise was found to have large free-floating right atrial thrombuses on echocardiogram. Decision was made to transfer the patient for emergent atriotomy. Cardiothoracic surgeons declared the patient as inoperable and recommended to use a lytic agent. Alteplase was administered with subsequent near-complete resolution of symptoms and near-normalization of echocardio-graphic parameters. The post-thrombolytic course was complicated by saddle pulmonary emboli requiring embolectomy...
2019: International Medical Case Reports Journal
Sahar Salehi, Elisabeth Åvall-Lundqvist, Yvonne Brandberg, Hemming Johansson, Chikako Suzuki, Henrik Falconer
BACKGROUND AND OBJECTIVES: In the Robot Assisted Surgery for High Risk Endometrial Cancer (RASHEC) trial, patients with high-risk endometrial cancer were randomly assigned to robot-assisted laparoscopic surgery (RALS) or laparotomy for pelvic and infrarenal para-aortic lymph node dissection. We here report on self-reported lower limb lymphedema (LLL), lymphocyst formation, ascites, and long-term serious adverse events 12 months after surgery. PATIENTS AND METHODS: Patients were enrolled between 2013 and 2016, and 96 patients were included in the per protocol analysis, evenly distributed between RALS and laparotomy...
January 2019: International Journal of Gynecological Cancer
Ebba Bagge, Ulrica Beiron, Susanne Malander, Per Rosenberg, Elisabeth Åvall-Lundqvist
AIM OF THE STUDY: Endocrine treatment (ET) is an alternative as salvage therapy in epithelial ovarian cancer (EOC) but the usage in routine care is unknown. We evaluated the treatment patterns and outcome of patients receiving ET for EOC in the Southeast medical region in Sweden. METHOD: Patients were identified through the population-based Southeast Quality Registry for gynaecological cancer. Inclusion criteria were: age ≥18 years, histologically verified EOC diagnosed 2000-2013, ET for ≥4 weeks...
January 11, 2019: Acta Oncologica
Anoush Azarfar, Yalda Ravanshad, Hassan Mehrad-Majd, Mohammad Esmaeeli, Shapour Badiei Aval, Maryam Emadzadeh, Maryam Salehi, Ali Moradi, Mohadese Golsorkhi, Mahmood Reza Khazaei
Kidney transplantation is usually followed by immunosuppressive therapy to prevent early rejection and prolong graft survival. The calcineurin inhibitors (CNIs) represent the most commonly used agents. However, available evidence suggests the poor outcome over the long term, maybe be due to the potential nephrotoxicity associated with CNIs. Several randomized trials have compared tacrolimus (TAC) with cyclosporine, to find the optimal agent for renal transplantation; however, studies have shown conflicting results...
November 2018: Saudi Journal of Kidney Diseases and Transplantation
Maryam Akbarzadeh, Maryam Majidinia, Sedigheh Fekri Aval, Soltanali Mahbub, Nosratollah Zarghami
Background: Ovarian cancer is one of the most important gynecological malignancies, causing significant mortality. Recently, there has been extensive attention to the involvement of signaling cascades in its initiation/progression. In this study, we focused on the possible role of Notch signal transduction in proliferation and metalloproteinase 2 and 9 function in human ovarian cancer OVCAR-3 cells. Methods: MTT proliferation assays were used to evaluate effects of a DAPT inhibitor on cell proliferation. For measurement of Hes-1 mRNA levels, quantitative reverse transcription polymerase chain reaction (qRT-PCR) was applied following 48 h incubation with the inhibitor...
December 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Behnaz Taheri, Masoud Soleimani, Sedigheh Fekri Aval, Elaheh Esmaeili, Zahra Bazi, Nosratollah Zarghami
In recent years, induced pluripotent stem cells (iPSCs) have been considered as a promising approach in the field of regenerative medicine. iPSCs can be generated from patients' somatic cells and possess the potential to differentiate, under proper conditions, into any cell type. However, the clinical application of iPS cells is restricted because of their tumorigenic potential. Recent studies have indicated that stem cells exert their therapeutic benefit via a paracrine mechanism, and extracellular vesicles have been demonstrated that play a critical role in this paracrine mechanism...
November 27, 2018: Journal of Cellular Physiology
F Heitz, P Harter, E Åvall-Lundqvist, A Reuss, P Pautier, G Cormio, N Colombo, A Reinthaller, I Vergote, A Poveda, P B Ottevanger, L C Hanker, A Leminen, J Alexandre, U Canzler, J Sehouli, J Herrstedt, B Fiane, M Merger, A du Bois
OBJECTIVE: Surgical assessment of residual tumor provides the strongest prognostic information in advanced ovarian cancer (AOC), with the best outcome observed after complete resection. Postoperative radiological assessment before initiation of chemotherapy can supplement the information obtained by surgical assessment; however, it may also reveal conflicting findings. METHODS: Patients with AOC enrolled in the AGO-OVAR 12 trial underwent baseline imaging before the first chemotherapy cycle...
November 19, 2018: Gynecologic Oncology
Simone Beretta, Anna Coppo, Elisa Bianchi, Clara Zanchi, Davide Carone, Andrea Stabile, Giada Padovano, Endrit Sulmina, Alice Grassi, Graziella Bogliun, Giuseppe Foti, Carlo Ferrarese, Antonio Pesenti, Ettore Beghi, Leonello Avalli
OBJECTIVE: To investigate neurologic outcome of patients with cardiac arrest with refractory status epilepticus (RSE) treated with a standardized aggressive protocol with antiepileptic drugs and anesthetics compared to patients with other EEG patterns. METHODS: In the prospective cohort study, 166 consecutive patients with cardiac arrest in coma were stratified according to 4 independent EEG patterns (benign, RSE, generalized periodic discharges [GPDs], malignant nonepileptiform) and multimodal prognostic indicators...
December 4, 2018: Neurology
Karin Åvall, Per-Olof Berggren, Lisa Juntti-Berggren
Serum levels of the pro-inflammatory apolipoprotein CIII (apoCIII) are increased in type-1 diabetic (T1D) patients and when β-cells are exposed to apoCIII they undergo apoptosis, which can be prevented by an antibody against apoCIII. We have previously investigated the BB rat, an animal model that develops a human-like T1D at the age of around 60 days, and found that apoCIII was also increased in sera from pre-diabetic rats and this promoted β-cell death. Lowering apoCIII with an oligonucleotide antisense during a phase of the pre-diabetic period prolonged the time to onset of T1D...
September 2018: Laboratory Animal Research
Sahar Salehi, Yvonne Brandberg, Elisabeth Åvall-Lundqvist, Chikako Suzuki, Hemming Johansson, Berit Legerstam, Henrik Falconer
PURPOSE: The health-related quality of life (HRQoL) outcomes after comprehensive surgical staging including infrarenal paraaortic lymphadenectomy in women with high-risk endometrial cancer (EC) are unknown. Our aim was to investigate the long-term HRQoL between robot-assisted laparoscopic surgery (RALS) and laparotomy (LT). PATIENTS AND METHODS: A total of 120 women with high-risk stage I-II EC were randomised to RALS or LT for hysterectomy, bilateral salpingoophorectomy, pelvic and infrarenal paraaortic lymphadenectomy in the previously reported Robot-Assisted Surgery for High-Risk Endometrial Cancer trial...
October 5, 2018: Acta Oncologica
Farzane Ordoni Aval, Shaghayegh Askarian Amiri, Abbas Azadmehr, Morteza Oladnabi, Payam Saadat, Hadi Ebrahimi, Behzad Baradaran, Behzad Mansoori, Fereshteh Pourabdolhossein, Pedram Torabian, Mahmoud Hajiahmadi
Objective: Glioblastoma (GBM) is the most malignant and aggressive type of glioma, associated with a high rate of mortality. The transforming growth factor-β receptor II (TGFβ RII) is involved in glioma initiation and progression. On the other hand, TGFβ RII silencing is critical to the inhibition of GBM. Therefore, we aimed to determine the effects of specific TGFβ RII siRNA on the survival of U-373MG cells. Methods: TGFβ RII siRNA was transfected, and qRT-PCR was performed to examine TGFβ RII mRNA expression...
September 26, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
Mojtaba Aghaeepoor, Ali Akbarzadeh, Sako Mirzaie, Asieh Hadian, Sanaz Jamshidi Aval, Ehsan Dehnavi
Type II l‑asparaginase (l‑ASNase) is an FDA approved enzyme drug with extensive applications for treatment of certain blood cancers. However, the therapeutic efficiency of this enzyme is hampered by its undesirable glutaminase activity. Given the pivotal role of this enzyme against cancer, designing engineered mutants with diminished glutaminase activity would be of great therapeutic interest. To this end, N248S mutation was selected as the potential mutation with beneficial effects. Various in silico analyses including MD simulation, molecular docking and QMMM studies were performed to assess the effects of N248S mutation on the activity of the enzyme...
December 2018: International Journal of Biological Macromolecules
Maryam Hassanzadeh-Bashtian, Talat Khadivzadeh, Shapour Badiee-Aval, Habibollah Esmaily
Background: Women, who are in a critical situation like infertility, are more prone to depression, anxiety, and low self-esteem than other people. The aim of this study was to explore the deep experience of anxiety in infertile women who received acupressure during in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Materials and Methods: This qualitative, conventional content analysis study was performed on 14 infertile female participants in the Milad IVF Center in Mashhad, Iran, from September 2015 to August 2016...
September 2018: Iranian Journal of Nursing and Midwifery Research
Fatemeh Memari, Zeinab Joneidi, Behnaz Taheri, Sedigheh Fekri Aval, Amir Roointan, Nosratollah Zarghami
Epigenetic variations can play remarkable roles in different normal and abnormal situations. Such variations have been shown to have a direct role in the pathogenesis of various diseases either through inhibition of tumor suppressor genes or increasing the expression of oncogenes. Enzymes involving in epigenetic machinery are the main actors in tuning the epigenetic-based controls on gene expressions. Aberrant expression of these enzymes can trigger a big chaos in the cellular gene expression networks and finally lead to cancer progression...
October 2018: Biomedicine & Pharmacotherapy
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