Piotr Zareba, Richard Flavin, Masis Isikbay, Jennifer R Rider, Travis A Gerke, Stephen Finn, Andreas Pettersson, Francesca Giunchi, Robert H Unger, Alex M Tinianow, Swen-Olof Andersson, Ove Andrén, Katja Fall, Michelangelo Fiorentino, Lorelei A Mucci
Background: Prostate cancer has a propensity to invade and grow along nerves, a phenomenon called perineural invasion (PNI). Recent studies suggest that the presence of PNI in prostate cancer has been associated with cancer aggressiveness. Methods: We investigated the association between PNI and lethal prostate cancer in untreated and treated prostate cancer cohorts: the Swedish Watchful Waiting Cohort of 615 men who underwent watchful waiting, and the U.S. Health Professionals Follow-Up Study of 849 men treated with radical prostatectomy...
May 2017: Cancer Epidemiology, Biomarkers & Prevention