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Niall W Duncan, Jianfeng Zhang, Georg Northoff, Xuchu Weng
BACKGROUND: A combination of magnetic resonance spectroscopy (MRS) and functional (f)MRI is a promising method for studying brain activity. Negative results have, however, produced uncertainty as to the validity of the approach. Using a MEGA-PRESS sequence adapted to suppress the macromolecule signal (GABA-) has been suggested as a key methodological improvement, but there is some doubt as to the relationship between such estimates and those from the standard sequence (GABA+), making interpretation difficult...
March 14, 2019: Journal of Magnetic Resonance Imaging: JMRI
Fredrik Eika, Torbjørn Nag, Bjørn Magne Jåtun, Heidi Ytredal
No abstract text is available yet for this article.
March 12, 2019: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Magne Børset
No abstract text is available yet for this article.
March 12, 2019: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Su-Zhen Dong, Ming Zhu, Dorothy Bulas
MRI is used widely in infants and young children. However, in these young cases deep sedation or general anesthesia is often required to minimize motion artifacts during MRI examinations. Although the benefits of MR typically outweigh the potential risks of sedation when delivered by an experienced team, there are increasing concerns regarding the affect of sedation on young children. There continues to be a push to develop various strategies that can minimize the need for sedation. The present review summarizes several technical and clinical approaches that can help decrease the need for sedation in the pediatric patient...
March 14, 2019: Journal of Magnetic Resonance Imaging: JMRI
Matthew S Davitz, Oded Gonen, Assaf Tal, James S Babb, Yvonne W Lui, Ivan I Kirov
BACKGROUND: 3D brain proton MR spectroscopic imaging (1 H MRSI) facilitates simultaneous metabolic profiling of multiple loci, at higher, sub-1 cm3 , spatial resolution than single-voxel 1 H MRS with the ability to separate tissue-type partial volume contribution(s). PURPOSE: To determine if: 1) white matter (WM) damage in mild traumatic brain injury (mTBI) is homogeneously diffuse, or if specific regions are more affected; 2) partial-volume-corrected, structure-specific 1 H MRSI voxel averaging is sensitive to regional WM metabolic abnormalities...
March 13, 2019: Journal of Magnetic Resonance Imaging: JMRI
Magne Refsnes, Tonje Skuland, Edel Lilleaas, Johan Øvrevik, Marit Låg
Reactive oxygen species (ROS) is regarded as a critical denominator in nanoparticle toxicology and inflammation. Previously, we have shown that silica nanoparticles sized 50 nm (Si50) induce release of CXCL8 and IL-6 from BEAS-2B cells, via mechanisms involving NFκB, p38 MAPkinase, and TGF-α-activated EGF-receptor. In the present study, the role of ROS-mediated mechanisms in the concentration-dependent Si50-induction of CXCL8 and IL-6 responses was examined. Si50 (200 μg/ml) induced a time-dependent ROS formation, and a postponed increase in expression of heme oxygenase (HO-1) mRNA and protein...
March 12, 2019: Basic & Clinical Pharmacology & Toxicology
Jin Liu, Jie Sun, Niranjan Balu, Marina S Ferguson, Jinnan Wang, William S Kerwin, Daniel S Hippe, Amy Wang, Thomas S Hatsukami, Chun Yuan
BACKGROUND: Presence of intraplaque hemorrhage (IPH) is a known risk factor for stroke and plaque progression. Accurate and reproducible measurement of IPH volume are required for further risk stratification. PURPOSE: To develop a semiautomatic method to measure carotid IPH volume. STUDY TYPE: Retrospective. POPULATION: Patients scheduled for carotid endarterectomy and patients with 16-79% asymptomatic carotid stenosis by ultrasound...
March 12, 2019: Journal of Magnetic Resonance Imaging: JMRI
Efrosini Papadaki, Eleftherios Kavroulakis, Georgios Kalaitzakis, Dimitra Karageorgou, Dimitrios Makrakis, Thomas G Maris, Panagiotis G Simos
BACKGROUND: According to the retrogenesis hypothesis, the rate of age-related changes in white matter (WM) myelin content varies between early myelinating (parietal, occipital) and late myelinating (prefrontal, lateral-posterior temporal) areas. The multiecho spin echo (MESE), PD-to-T2 -weighted sequence provides an index of myelin content (myelin water fraction [MWF]) derived from measurements of myelin water (via the short T2 component [10-50 msec]) and intra- and extracellular water (via the long T2 component [>50-200 msec])...
March 12, 2019: Journal of Magnetic Resonance Imaging: JMRI
Yong-Lan He, Yuan Li, Cheng-Yu Lin, Ya-Fei Qi, Xiaoqi Wang, Hai-Long Zhou, Jun-Jun Yang, Yang Xiang, Hua-Dan Xue, Zheng-Yu Jin
BACKGROUND: Amide proton transfer-weighted (APTw) imaging has shown great potential in the diagnosis of cancer, but has yet not been well studied in cervical cancer. PURPOSE: To evaluate the image quality and clinical feasibility of APTw MRI for cervical cancer. STUDY TYPE: Prospective. POPULATION: In all, 75 patients with cervical lesions and 49 healthy volunteers. FIELD STRENGTH/SEQUENCE: 3.0 T, 3D turbo spin echo (TSE) APTw sequence...
March 12, 2019: Journal of Magnetic Resonance Imaging: JMRI
Yingzhen N Zhang, Kathryn J Fowler, Arinc Ozturk, Chetan K Potu, Ashley L Louie, Vivian Montes, Walter C Henderson, Kang Wang, Michael P Andre, Anthony E Samir, Claude B Sirlin
Liver fibrosis is a histological hallmark of most chronic liver diseases, which can progress to cirrhosis and liver failure, and predisposes to hepatocellular carcinoma. Accurate diagnosis of liver fibrosis is necessary for prognosis, risk stratification, and treatment decision-making. Liver biopsy, the reference standard for assessing liver fibrosis, is invasive, costly, and impractical for surveillance and treatment response monitoring. Elastography offers a noninvasive, objective, and quantitative alternative to liver biopsy...
March 12, 2019: Journal of Magnetic Resonance Imaging: JMRI
Frank Riemer, Damien McHugh, Fulvio Zaccagna, Daniel Lewis, Mary A McLean, Martin J Graves, Fiona J Gilbert, Geoff J M Parker, Ferdia A Gallagher
BACKGROUND: Sodium MRI (23 Na-MRI)-derived biomarkers such as total sodium concentration (TSC) have the potential to provide information on tumor cellularity and the changes in tumor microstructure that occur following therapy. PURPOSE: To evaluate the repeatability and reproducibility of TSC measurements in the brains of healthy volunteers, providing evidence for the technical validation of 23 Na-MRI-derived biomarkers. STUDY TYPE: Prospective multicenter study...
March 12, 2019: Journal of Magnetic Resonance Imaging: JMRI
Teodora Chitiboi, Matthew Muckley, Bari Dane, Chenchan Huang, Li Feng, Hersh Chandarana
BACKGROUND: Quantifying the biomechanical properties of pancreatic tumors could potentially help with assessment of tumor aggressiveness, prognosis, and prediction of therapy response. PURPOSE: To quantify respiratory-induced deformation in the pancreas and pancreatic lesions using XD-GRASP (eXtra-Dimensional Golden-angle RAdial Sparse Parallel), MRI. STUDY TYPE: Retrospective study where patients undergoing clinically indicated abdominal MRI which included free-breathing radial T1 -weighted (T1 W) imaging were studied...
March 10, 2019: Journal of Magnetic Resonance Imaging: JMRI
Lu Lu, Qian Li, Lianqing Zhang, Shi Tang, Xubo Yang, Longqian Liu, John A Sweeney, Qiyong Gong, Xiaoqi Huang
BACKGROUND: The neural mechanism of amblyopia and its impact on the adult brain remain unclear. This hinders effective treatment for adults with this disease. PURPOSE: To investigate neuroanatomical differences in cortical morphometry between amblyopic adults and healthy controls, and to explore the structural covariance of abnormal morphometric changes. STUDY TYPE: Prospective. POPULATION: Twenty-one amblyopic adults and 34 healthy controls...
March 10, 2019: Journal of Magnetic Resonance Imaging: JMRI
Elisabeth Daguenet, Omar Jmour, Alexis Vallard, Jean-Baptiste Guy, Jean-Philippe Jacquin, Benoîte Méry, Nicolas Magné
Endocrine treatment represents the cornerstone of endocrine-sensitive pre-menopausal early breast cancer. The estrogen blockade plays a leading role in the therapeutic management with surgery, radiotherapy and selective antiestrogen treatment. For several years, selective estrogen receptor modulators, such as tamoxifen, have revolutionized medical care of hormone receptors-positive breast cancer and have conquered the therapeutic arsenal while becoming the gold standard of treatment. Other combinations associating the ovarian function suppression using LHRH agonists with tamoxifen or aromatase inhibitors have been recently investigated, leading to mitigated opinions regarding the clinical benefit of these associations...
March 7, 2019: Bulletin du Cancer
Martin Magnéli, Maria Unbeck, Cecilia Rogmark, Ola Rolfson, Ami Hommel, Bodil Samuelsson, Kristina Schildmeijer, Desirée Sjöstrand, Max Gordon, Olof Sköldenberg
OBJECTIVES: Preventing adverse events (AEs) after orthopaedic surgery is a field with great room for improvement. A Swedish instrument for measuring AEs after hip arthroplasty based on administrative data from the national patient register is used by both the Swedish Hip Arthroplasty Register and the Swedish Association of Local Authorities and Regions. It has never been validated and its accuracy is unknown. The aim of this study was to validate the instrument's ability to detect AEs, and to calculate the incidence of AEs following primary hip arthroplasties...
March 7, 2019: BMJ Open
Ruimei Chai, He Ma, Mingjie Xu, Dooman Arefan, Xiaoyu Cui, Yi Liu, Lina Zhang, Shandong Wu, Ke Xu
BACKGROUND: The axillary lymph node status is critical for breast cancer staging and individualized treatment planning. PURPOSE: To assess the effect of determining axillary lymph node (ALN) metastasis by breast MRI-derived radiomic signatures, and compare the discriminating abilities of different MR sequences. STUDY TYPE: Retrospective. POPULATION: In all, 120 breast cancer patients, 59 with ALN metastasis and 61 without metastasis, all confirmed by pathology...
March 7, 2019: Journal of Magnetic Resonance Imaging: JMRI
Reza Fardanesh, Maria Adele Marino, Daly Avendano, Doris Leithner, Katja Pinker, Sunitha B Thakur
Proton magnetic resonance spectroscopy (MRS) is a promising noninvasive diagnostic technique for investigation of breast cancer metabolism. Spectroscopic imaging data may be obtained following contrast-enhanced MRI by applying the point-resolved spectroscopy sequence (PRESS) or the stimulated echo acquisition mode (STEAM) sequence from the MR voxel encompassing the breast lesion. Total choline signal (tCho) measured in vivo using either a qualitative or quantitative approach has been used as a diagnostic test in the workup of malignant breast lesions...
March 7, 2019: Journal of Magnetic Resonance Imaging: JMRI
Chih-Yang Hsu, Yimei Li, Yuanyuan Han, Lucas Elijovich, Noah D Sabin, Tarek Abuelem, Radmehr Torabi, Austin Faught, Chia-Ho Hua, Paul Klimo, Thomas Merchant, John T Lucas
BACKGROUND: Cerebral vessel diameter changes objectively and automatically derived from longitudinal magnetic resonance angiography (MRA) facilitate quantification of vessel changes and further modeling. PURPOSE: To characterize longitudinal changes in intracranial vessel diameter using time-of-flight (TOF) MRA. STUDY TYPE: Retrospective longitudinal study. SUBJECT POPULATION: IN all, 112 pediatric patients, aged 9.96 ± 4...
March 7, 2019: Journal of Magnetic Resonance Imaging: JMRI
Ignacio O Romero, Usha Sinha
BACKGROUND: Magnetization transfer saturation (MTsat ) derives a semiquantitative index of magnetization transfer in faster acquisition times than quantitative magnetization transfer; the potential of MTsat for muscle imaging has not yet been explored. PURPOSE: To evaluate the potential of MTsat to identify regional and sex differences in calf muscle. STUDY TYPE: Prospective cohort study. PHANTOM/SUBJECTS: Vials with different agar and nickel nitrate concentrations providing a range of macromolecular fraction and T1 ...
March 6, 2019: Journal of Magnetic Resonance Imaging: JMRI
Lamia Ait Ali, Giovanni D Aquaro, Giuseppe Peritore, Fabrizio Ricci, Daniele De Marchi, Michele Emdin, Claudio Passino, Pierluigi Festa
BACKGROUND: Management of adults with repaired congenital heart disease (CHD) is still challenging. Heart failure secondary to residual anatomical sequels or arrhythmic events is not rare in this population. MRI has emerged as an accurate tool to quantify pulmonary transit time (PTT) of intravenous contrast agents and pulmonary blood volume (PBV). PURPOSE: To determine the relationship between PTT, and conventional indexes of ventricular dysfunction and heart failure in a cohort of adults with CHD and to assess its association with adverse outcomes...
March 5, 2019: Journal of Magnetic Resonance Imaging: JMRI
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