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Topical Interferon

Ji Yeon Noh, Jung U Shin, Ji Hye Kim, Seo Hyeong Kim, Bo-Mi Kim, Young Hwan Kim, Semin Park, Tae-Gyun Kim, Kyong-Oh Shin, Kyungho Park, Kwang Hoon Lee
Adipokines modulate immune responses and lipid metabolism in allergic disease; however, little is known about its role in the skin barrier and atopic dermatitis (AD). We identified zinc-alpha-2 glycoprotein (ZAG), an adipokine that regulates lipid mobilization, as a biomarker for AD. ZAG levels were consistently decreased in sera, T cells, and skin in human AD patients compared with healthy controls. ZAG was primarily detected in the stratum corneum along with filaggrin (FLG) and loricrin (LOR). Knockdown of ZAG with shRNA resulted in decreased FLG and increased thymic stromal lymphopoietin (TSLP)...
February 6, 2019: Journal of Investigative Dermatology
O V Kalyuzhin, Zh B Ponezheva, A N Kupchenko, A N Shuvalov, T S Guseva, O V Parshina, V V Malinovskaya, V G Akimkin
AIM: The aim of the study was to evaluate the clinical and interferon-modulating efficacy of a combination of rectal and topical dosage forms of IFN-α2b with antioxidants in the treatment of acute respiratory infections (ARIs) in comparison with other variants of antiviral therapy. MATERIALS AND METHODS: A total of 90 servicemen aged 19.2±0.9 years with uncomplicated forms of ARI were hospitalized not later than 48 hours after the onset of the disease. Patients were randomized into 3 groups of 30 people each...
November 22, 2018: Terapevticheskiĭ Arkhiv
Anna Niezgoda, Andrzej Winnicki, Tomasz Kosmalski, Bogna Kowaliszyn, Jerzy Krysiński, Rafał Czajkowski
BACKGROUND: Vitiligo is a chronic skin disorder presenting with depigmentation, the pathogenesis of which is complex but the autoimmune theory is now preferred. Multiple immunologic processes, including stimulation of the T-helper (Th)1 response, formation of autoreactive melanocyte-specific CD8+ T lymphocytes, a decrease in the blood concentration of T regulatory (Treg) cells, and an increase in interleukin (IL)-17 and interferon (IFN) concentration, have been shown to contribute to vitiligo progression and maintenance...
January 25, 2019: Trials
Sung Woo Cho, Yu Lian Zhang, Young Kyung Ko, Jae Min Shin, Jun Ho Lee, Chae Seo Rhee, Dong Young Kim
PURPOSE: Vitamin D is a potent immunomodulator. However, its role in the pathogenesis of allergic rhinitis is unclear. METHODS: The aim of this study was to evaluate the antiallergic effect of intranasally applied vitamin D in an allergic rhinitis mouse model. BALB/c mice were intraperitoneally sensitized with ovalbumin (OVA) and alum before they were intranasally challenged with OVA. Then, they were intranasally administered 1, 25-dihydroxyvitamin D3 (0.02 μg) or solvent...
March 2019: Allergy, Asthma & Immunology Research
Abraham Fikru Mechesso, Seung-Jin Lee, Na-Hye Park, Jin-Yoon Kim, Zi-Eum Im, Joo-Won Suh, Seung-Chun Park
BACKGROUND: A combination of parts of Cornus officinalis, Rosa multiflora, Lespedeza bicolor, Platycladus orientalis, and Castanea crenata is commonly used for alleviating inflammatory skin disorders. Therefore, this study was carried out to evaluate the in vitro and in vivo preventive effects of a novel herbal formula made from the five plants (C2RLP) against atopic dermatitis in BALB/C mice. METHODS: Mice were allocated into five groups (n = 8) including, control (Normal, petrolatum, and betamethasone treated) and treatment groups (treated with 2...
January 18, 2019: BMC Complementary and Alternative Medicine
Xiangzhe Li, Boram Kang, Youngsub Eom, Hyung Keun Lee, Hyo Myung Kim, Jong Suk Song
Purpose: Exposure to airborne particulate matter can induce ocular surface damage and inflammation. We evaluated the effects of a topical mucin secretagogue on the mitigation of ocular surface damage induced by exposure to airborne carbon black (CB). Methods: Sprague-Dawley rats were exposed to ambient CB for 2 hours twice daily for 5 days. Corneal staining score and tear lactic dehydrogenase (LDH) activity were measured to evaluate ocular surface damage. Serum immunoglobulin (Ig) G and IgE levels and the sizes of cervical lymph nodes were also measured...
January 2, 2019: Investigative Ophthalmology & Visual Science
Pia R Mendoza, Caroline M Craven, Matthew H Ip, Matthew W Wilson, Minas T Coroneo, Hans E Grossniklaus
Aim: To describe 4 cases of conjunctival squamous cell carcinoma (SCC) with corneal stromal invasion. Methods: Retrospective, clinicopathologic case series. Results: All patients had prior resections of presumed pterygia. The degree of corneal involvement dictated the extent of surgical management. One eye with localized invasion was treated with lamellar keratoplasty and plaque brachytherapy. Another case with widespread invasion warranted penetrating keratoplasty and eventual enucleation...
June 2018: Ocular Oncology and Pathology
Tolga Kocatürk, Erol Erkan, İbrahim Meteoğlu, Mehmet Ekici, Aslıhan Karul Büyüköztürk, İrfan Yavaşoğlu, Harun Çakmak, Volkan Dayanır, Muharrem Balkaya
Objectives: To comparatively evaluate the effects of thymoquinone (TQ), the biologically active main component of volatile oil derived from Nigella sativa seeds, in an experimental dry eye model. Materials and Methods: A total of 36 BALB/c mice 10 weeks of age were used in the study. The mice were divided into 6 groups of 6 mice. Two groups were negative and positive controls, and the other 4 groups were treated with balanced salt solution, fluorometholone (FML), TQ, or vehicle (Tween80)...
December 27, 2018: Turkish Journal of Ophthalmology
Peng Huang, Mei Liu, Feng Zang, Yinan Yao, Ming Yue, Jie Wang, Haozhi Fan, Lingyun Zhuo, Jingjing Wu, Xueshan Xia, Yue Feng, Rongbin Yu
It has been proven that hepatitis C virus (HCV) eradication after interferon-based treatment can reduce the risk of hepatocarcinogenesis. However, there were some arguments about whether the treatment of direct-acting antivirals (DAAs) boosts the development of hepatocellular carcinoma (HCC). We systematically review this crucial topic by combining all the relevant articles to calculate the pooled HCC density after DAA treatment. Studies reporting the recurrence or occurrence in chronic hepatitis C patients who received DAA regimen were selected from three retrieval library screening...
December 31, 2018: Carcinogenesis
Claudio Gasperini, Luca Prosperini, Mar Tintoré, Maria Pia Sormani, Massimo Filippi, Jordi Rio, Jacqueline Palace, Maria A Rocca, Olga Ciccarelli, Frederik Barkhof, Jaume Sastre-Garriga, Hugo Vrenken, Jette L Frederiksen, Tarek A Yousry, Christian Enzinger, Alex Rovira, Ludwig Kappos, Carlo Pozzilli, Xavier Montalban, Nicola De Stefano
Over the last few decades, the improved diagnostic criteria, the wide use of MRI, and the growing availability of effective pharmacologic treatments have led to substantial advances in the management of multiple sclerosis (MS). The importance of early diagnosis and treatment is now well-established, but there is still no consensus on how to define and monitor response to MS treatments. In particular, the clinical relevance of the detection of minimal MRI activity is controversial and recommendations on how to define and monitor treatment response are warranted...
January 22, 2019: Neurology
Li Yang, Shaofei Ji, Liping Wang, Yi Zhang
BACKGROUND: Mucosal melanoma of the head and neck is a rare malignant tumor associated with a poor prognosis. Surgery, chemotherapy, radiotherapy, and biotherapy are common strategies for treating mucosal melanoma of the head and neck. Episcleritis is an idiopathic, immune-mediated disease, and is classified into two types: simple episcleritis and nodular episcleritis. CASE PRESENTATION: In this case report we describe ocular changes involving simple episcleritis in a 65-year-old Chinese man with mucosal melanoma of the head and neck after treatment with interferon alfa-2b and radiotherapy...
December 23, 2018: Journal of Medical Case Reports
Fatma N Hamed, Andrew J G McDonagh, Sarah Almaghrabi, Youssef Bakri, Andrew G Messenger, Rachid Tazi-Ahnini
BACKGROUND: Alopecia areata (AA) is associated with Interferon- γ (IFN-γ) mediated T-lymphocyte dysfunction and increased circulating Interleukine-17 (IL-17) levels. Epigallocatechin-3-gallate (EGCG) specifically inhibits IFN-γ pathways and unlike Janus Kinase 1 and 2 (JAK1/JAK2) inhibitors (tofacitinib, ruxolitinib), EGCG is safer, more cost-effective, and is a topically active agent. Our objective is to test the mode of action of EGCG in vitro and ex vivo using HaCat, Jurkat cell lines, and peripheral blood mononuclear cells (PBMCs) of AA patients and healthy controls (HCs), respectively...
December 15, 2018: International Journal of Environmental Research and Public Health
Alessio Gerussi, Laura Cristoferi, Marco Carbone, Rosanna Asselta, Pietro Invernizzi
Primary biliary cholangitis (PBC) is an autoimmune liver disease with a striking female preponderance. The mechanisms behind this predominance are still to be elucidated, although multiple theories have been postulated and investigated. Among the proposed involved factors, sex hormones have been the first to be studied, but unfortunately data have been inconclusive or conflicting. Similarly, fetal microchimerism has received a huge attention in the past, but data in PBC have been unsatisfactory especially if compared to other autoimmune diseases like systemic lupus erythematosus...
December 2018: Journal of Autoimmunity
Scott C Brimley, Faysal A Yafi, Jacob Greenberg, Wayne J G Hellstrom, Hoang Minh Tue Nguyen, Georgios Hatzichristodoulou
INTRODUCTION: Peyronie's disease (PD) is a fibrotic disorder that leads to plaque formation in ∼3-9% of adult men. Connective tissue buildup results in plaque formation, penile curvature and shortening, and in some cases, pain. In the active phase of PD, penile pain is a common symptom, often accompanied by progression in curvature. Treatment options for PD include oral drugs, topical cream, intralesional injections, traction, and shock wave therapy. This article reviews the different treatment options for active-phase PD...
November 29, 2018: Sexual Medicine Reviews
Nandini Venkateswaran, Carolina Mercado, Anat Galor, Carol L Karp
PURPOSE: To compare the efficacy of topical 5-fluorouracil 1% (5FU) and interferon alfa-2b 1 MIU/mL (IFN) eye drops as primary treatment modalities for ocular surface squamous neoplasia (OSSN). DESIGN: Retrospective, comparative, interventional case series. METHODS: Fifty-four patients who received 5FU and 48 patients who received IFN as primary therapy for OSSN were included. Primary outcome measures were the frequency of clinical resolution and time to OSSN recurrence by treatment modality...
November 21, 2018: American Journal of Ophthalmology
Michael Spinosa, Gang Su, Morgan D Salmon, Guanyi Lu, J Michael Cullen, Anna Z Fashandi, Robert B Hawkins, William Montgomery, Akshaya K Meher, Michael S Conte, Ashish K Sharma, Gorav Ailawadi, Gilbert R Upchurch
OBJECTIVE: Resolvins have been shown to attenuate inflammation, whereas NETosis, the process of neutrophils releasing neutrophil extracellular traps (NETs), produces increased inflammation. It is hypothesized that treatment of animals with resolvin D1 (RvD1) would reduce abdominal aortic aneurysm (AAA) formation by inhibiting NETosis. METHODS: Wild-type 8- to 12-week-old C57BL/6 male mice (n = 47) and apolipoprotein E-deficient (ApoE-/- ) mice (n = 20) were used in two models to demonstrate the effects of RvD1 on AAA growth...
December 2018: Journal of Vascular Surgery
Peiyu Li, Ji Wang, Miao Cao, Qiwen Deng, Shibo Jiang, Mei X Wu, Lu Lu
Skin contains a large number of antigen presenting cells, making intradermal (ID) injection one of the most effective ways for vaccine administration. However, although current adjuvants may cause severe local reactions and inflammations in the skin, no adjuvant has been approved for ID vaccination so far. Here, we report that topical application of all- trans retinoic acid (ATRA), a vitamin A derivative produced in the human body, augmented cutaneous influenza vaccination. The adjuvant effects were evaluated in a murine vaccination/challenge model by using A/California/07/2009 pandemic vaccine (09V) or a seasonal influenza vaccine (SIV)...
2018: Frontiers in Microbiology
L Rodríguez-Cabrera, P García-Regil, A Velasco-Levy, J C Serna-Ojeda
A series of paediatric patients is presented in whom topical interferon alpha-2b was used as a co-adjuvant treatment for conjunctival papilloma. This condition is frequently associated with human papillomavirus infection. There is little information on the pediatric population with the use of interferon for the treatment of these lesions. In this case series, adjuvant treatment with topical interferon alpha-2b in paediatric patients showed no recurrence and good tolerance.
November 10, 2018: Archivos de la Sociedad Española de Oftalmología
Yun-Mi Kang, Kyou-Young Lee, Hyo-Jin An
Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by complex symptoms. To treat AD without adverse effects, alternative therapeutic agents are required. The tubers of Helianthus tuberosus L. (Jerusalem artichoke) have been used in folk remedies for diabetes and rheumatism. However, its effect on AD development remains unknown. Therefore, this study examined the inhibitory effect of H. tuberosus (HT) on AD skin symptoms using an NC/Nga mouse model and HaCaT keratinocytes. The effect of HT and associated molecular mechanisms were evaluated in Dermatophagoides farina body (Dfb)-induced AD mice and tumor necrosis factor (TNF)-α/interferon (IFN)-γ-stimulated HaCaT keratinocytes by ELISA, western blot, and histological analysis...
November 3, 2018: Nutrients
Svante Twetman, Anne Marie Lynge Pedersen, Tulay Yucel-Lindberg
OBJECTIVE: The use of beneficial bacteria may stimulate wound healing. We performed a randomized, placebo-controlled double-blind cross-over study comprising ten healthy volunteers. The aim was to investigate the impact of topical and systemic applications of probiotic lactobacilli (Lactobacillus reuteri) on the healing of standardized wounds (punch biopsies) in the oral mucosa. The expression of selected matrix metalloproteinases (MMP'S) and interferons (IFN's) was analyzed with multiplex immunoassays in the wound exudate during the first healing week (day 2, 5 and 8)...
October 25, 2018: BMC Research Notes
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