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https://read.qxmd.com/read/30901608/higher-lactate-and-purine-metabolite-levels-in-erythrocyte-rich-fresh-venous-thrombus-potential-markers-for-early-deep-vein-thrombosis
#1
Kazunari Maekawa, Chihiro Sugita, Atsushi Yamashita, Sayaka Moriguchi-Goto, Eiji Furukoji, Tatefumi Sakae, Toshihiro Gi, Toshinori Hirai, Yujiro Asada
BACKGROUND: Thrombolytic therapy is effective in fresh deep vein thrombosis (DVT) although the benefit may fall below the risk of bleeding in non-fresh thrombosis. Markers reflecting fresh DVT have not been established. The present study aims to identify metabolites reflecting fresh venous thrombus and their role in thrombus formation. METHODS: Metabolites of rabbit venous blood and jugular venous thrombus 4 h after thrombus induction were analysed using electrophoresis-time of flight mass spectrometry...
March 14, 2019: Thrombosis Research
https://read.qxmd.com/read/30901569/case-report-intraoperative-thrombosis-cardiac-arrest-in-extended-right-hepatectomy-involving-use-of-local-haemostatic-agent-in-intraoperative-cell-salvage-ics-and-administration-of-recombinant-activated-factor-vii-rfviia
#2
Lee S Kyang, Andrew Howard, Nayef A Alzahrani, David L Morris
INTRODUCTION: In modern surgical era, local haemostatic agents and blood components such as recombinant activated factor VII (rFVIIa) have expanded surgeons' armamentarium in controlling "surgical" and "nonsurgical bleeding". We report a case of intraoperative thrombosis and cardiac arrest involving use of local haemostatic agent in intraoperative cell salvage and rFVIIa administration in extended right hepatectomy. PRESENTATION OF CASE: A 46-year-old lady underwent extended right hepatectomy using cardiopulmonary bypass (CPB) and autotransfusion with ICS for metastatic gastrointestinal stromal tumour...
March 6, 2019: International Journal of Surgery Case Reports
https://read.qxmd.com/read/30901474/early-complement-and-fibrinolytic-activation-in-a-rat-model-of-blast-induced-multi-organ-damage
#3
Zhangsheng Yang, Olawale A Aderemi, Qingwei Zhao, Peter R Edsall, Milomir O Simovic, Brian J Lund, Mark D Espinoza, Amber M Woodson, Yansong Li, Leopoldo C Cancio
OBJECTIVE: Blast injury is associated with multi-organ failure (MOF), causing significant morbidity and mortality in trauma patients. However, the pathogenesis of blast-induced MOF still remains obscure. In this study, we evaluate the pathophysiological changes related to blast-induced MOF in a clinically relevant rat model of blast injury. METHODS: A moderate blast overpressure was applied to induce injury in anesthetized rats. Pathological changes were evaluated by H&E staining...
March 1, 2019: Military Medicine
https://read.qxmd.com/read/30901382/rapid-communication-tlr4-expressed-but-with-reduced-functionality-on-equine-b-lymphocytes
#4
Alayna N Hay, Ashley Potter, Leah Kasmark, Jing Zhu, Caroline M Leeth
Varying susceptibility exists among mammalian species to the development of potentially fatal endotoxemia due to gram-negative bacteria molecular component, lipopolysaccharide (LPS). Toll-like receptor 4 (TLR4) is responsible for LPS-associated immune response and is expressed on numerous immune cells including B lymphocytes. TLR4 is expressed in a functional form on mouse B lymphocytes, a species much less susceptible to endotoxemia compared with humans who are highly sensitive to endotoxin. Humans possess B lymphocytes that are not responsive to LPS...
February 19, 2019: Journal of Animal Science
https://read.qxmd.com/read/30901284/four-dimensional-flow-mri-principles-and-cardiovascular-applications
#5
Arshid Azarine, Philippe Garçon, Audrey Stansal, Nadia Canepa, Giorgios Angelopoulos, Stephane Silvera, Daniel Sidi, Véronique Marteau, Marc Zins
In-plane phase-contrast (PC) imaging is now a routine component of MRI of regional blood flow in the heart and great vessels. In-plane PC MRI provides a volumetric, isotropic, time-resolved cine sequence that enables three-directional velocity encoding, a technique known as four-dimensional (4D) flow MRI. Recent advances in 4D flow MRI have shortened imaging times, while progress in big-data processing has improved dataset pre- and postprocessing, thereby increasing the feasibility of 4D flow MRI in clinical practice...
March 22, 2019: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://read.qxmd.com/read/30900769/attenuated-total-reflection-fourier-transform-infrared-atr-ftir-spectroscopy-to-diagnose-osteoarthritis-in-equine-serum
#6
M Paraskevaidi, P D Hook, C L M Morais, J R Anderson, R White, P L Martin-Hirsch, M J Peffers, F L Martin
BACKGROUND: Reliable and validated biomarkers for osteoarthritis (OA) are currently lacking. OBJECTIVE: To develop an accurate and minimally invasive method to assess OA-affected horses and provide potential spectral markers indicative of disease. STUDY DESIGN: Observational, cross-sectional study. METHODS: Our cohort consisted of 15 horses with OA and 48 without clinical signs of the disease, which were used as controls...
March 22, 2019: Equine Veterinary Journal
https://read.qxmd.com/read/30900620/the-effect-of-metabolic-syndrome-on-prostate-cancer-final-pathology
#7
Selahattin Caliskan, Selçuk Kaba, Emrah Özsoy, Muzaffer Oğuz Keleş, Orhan Koca, Mehmet Akyüz, Muhammet Ihsan Karaman
Aim of Study: Metabolic syndrome (MetS) is an abnormality that increases the risk of cardiovascular disease and diabetes. In the recent years, studies showed that MetS is associated with increased risk of incidence, aggressiveness, and mortality of prostate cancer (PCa). We examined the influence of MetS at final pathology in Turkish patients with PCa. Materials and Methods: MetS was defined according to the American Heart Association, National Heart, Lung, Blood Institute, and International Diabetes Federation and requires any three of five components...
March 2019: Journal of Cancer Research and Therapeutics
https://read.qxmd.com/read/30898951/blocking-a-rash-diagnosis-a-rare-case-of-infective-endocarditis
#8
Brittne Halford, Mariah Barstow Piazza, Haley Berka, Caitlin Taylor
We report a case of a previously healthy, afebrile patient who presented with subacute bilateral lower extremity rash and complete heart block, which was later found to be secondary to infective endocarditis. His transoesophageal echocardiogram detected multiple vegetations and blood cultures were positive for Granulicatella adiacens , a nutritionally variant streptococcus that is a normal component of oral flora and thought to be responsible for approximately 5% of all cases of streptococcal endocarditis. Due to concerns for renal failure, the patient was treated with an unconventional regimen of ampicillin and ceftriaxone...
March 20, 2019: BMJ Case Reports
https://read.qxmd.com/read/30898472/indigofera-oblongifolia-protects-against-trypanosomiasis-induced-spleen-injury
#9
Mohamed A Dkhil, Taghreed A Hafiz, Felwa A Thagfan, Esam M Al-Shaebi, Murad A Mubaraki, Mona Khalil, Rewaida Abdel-Gaber, Saleh Al-Quraishy
BACKGROUND: Trypanosomiasis is a neglected tropical disease, transmitted by blood-sucking insects and can affect humans and animals, depending on the species of Trypanosoma parasite. Trypanosoma has acquired resistance to the majority of drugs used; hence, alternative medicines are required. Indigofera oblongifolia leaf extract (IOE) has been shown to treat blood stage malaria. Here, IOE was used to demonstrate its effect on Trypanosoma evansi-infected mice. METHODS: Analysis of IOE by gas chromatography-mass spectrometry showed the presence of many active components like flavonoids and phenolics...
March 18, 2019: Journal of Infection and Public Health
https://read.qxmd.com/read/30898141/increased-trypanosoma-spp-richness-and-prevalence-of-haemoparasite-co-infection-following-translocation
#10
Amy S Northover, Stephanie S Godfrey, Sarah Keatley, Alan J Lymbery, Adrian F Wayne, Crystal Cooper, Louise Pallant, Keith Morris, R C Andrew Thompson
BACKGROUND: Understanding how fauna translocation and antiparasitic drug treatment impact parasite community structure within a host is vital for optimising translocation outcomes. Trypanosoma spp. and piroplasms (Babesia and Theileria spp.) are known to infect Australian marsupials, including the woylie (Bettongia penicillata). However relatively little is known about these haemoparasites, or how they respond to management practices such as translocation. We monitored haemoparasites infecting woylies for up to 12 months during two fauna translocations to supplement existing woylie populations in three different sites (Dryandra, Walcott and Warrup East) within south-western Australia between 2014 and 2016, with the aim of investigating (i) how haemoparasite prevalence, Trypanosoma spp...
March 21, 2019: Parasites & Vectors
https://read.qxmd.com/read/30898074/cultivation-of-the-causative-agent-of-human-neoehrlichiosis-from-clinical-isolates-identifies-vascular-endothelium-as-a-target-of-infection
#11
Linda Wass, Anna Grankvist, Lesley Bell-Sakyi, Malin Bergström, Erik Ulfhammer, Christine Lingblom, Christine Wennerås
Candidatus (Ca.) Neoehrlichia mikurensis is the cause of neoehrlichiosis, an emerging tick-borne infectious disease characterized by fever and vascular events. The bacterium belongs to the Anaplasmataceae, a family of obligate intracellular pathogens, but has not previously been cultivated, and it is uncertain which cell types it infects. The goals of this study were to cultivate Ca. N. mikurensis in cell lines and to identify possible target cells for human infection. Blood components derived from infected patients were inoculated into cell lines of both tick and human origin...
2019: Emerging Microbes & Infections
https://read.qxmd.com/read/30897453/poor-sleep-quality-and-lipid-profile-in-a-rural-cohort-the-baependi-heart-study
#12
Glaucylara Reis Geovanini, Geraldo Lorenzi-Filho, Lilian K de Paula, Camila Maciel Oliveira, Rafael de Oliveira Alvim, Felipe Beijamini, André Brooking Negrão, Malcolm von Schantz, Kristen L Knutson, José Eduardo Krieger, Alexandre Costa Pereira
AIM: To test the association between cardiometabolic risk factors and subjective sleep quality assessed by the Pittsburgh sleep quality index (PSQI), independent of obstructive sleep apnea (OSA) and sleep duration. METHODS: A total of 573 participants from the Baependi Heart Study, a rural cohort from Brazil, completed sleep questionnaires and underwent polygraphy for OSA evaluation. Multivariable linear regression analysis tested the association between cardiovascular risk factors (outcome variables) and sleep quality measured by PSQI, adjusting for OSA and other potential confounders (age, sex, race, salary/wage, education, marital status, alcohol intake, obesity, smoking, hypertension, and sleep duration)...
January 30, 2019: Sleep Medicine
https://read.qxmd.com/read/30897169/lipid-classes-in-adipose-tissues-and-liver-differ-between-shetland-ponies-and-warmblood-horses
#13
Stephanie Adolph, Carola Schedlbauer, Dominique Blaue, Axel Schöniger, Claudia Gittel, Walter Brehm, Herbert Fuhrmann, Ingrid Vervuert
Fatty acids, as key components of cellular membranes and complex lipids, may play a central role in endocrine signalling and the function of adipose tissue and liver. Thus, the lipid fatty acid composition may play a role in health status in the equine. This study aimed to investigate the fatty acid composition of different tissues and liver lipid classes by comparing Warmblood horses and Shetland ponies under defined conditions. We hypothesized that ponies show different lipid patterns than horses in adipose tissue, liver and plasma...
2019: PloS One
https://read.qxmd.com/read/30896804/identification-of-red-blood-cell-membrane-defects-in-a-patient-with-hereditary-spherocytosis-using-next%C3%A2-generation-sequencing-technology-and-matrix%C3%A2-assisted-laser-desorption-ionization-time%C3%A2-of%C3%A2-flight-mass-spectrometry
#14
Leyla Türker Şener, Melih Aktan, Gürcan Albeniz, Aziz Şener, Duran Üstek, Işıl Albeniz
Hereditary spherocytosis (HS) is characterized by the morphological transformation of erythrocytes into a spherical shape due to a hereditary defect in cell membrane proteins (ghosts) associated with disruption of erythrocyte skeletal structures. Contrary to the literature, pores were detected in the erythrocytes of a patient with HS. The aim of the present study was to determine the affected proteins and genes that were responsible for the pores. Ghost isolation was performed to determine the proteins responsible for the pores observed on the erythrocytes of the patient...
March 14, 2019: Molecular Medicine Reports
https://read.qxmd.com/read/30896346/human-mast-cell-development-from-hematopoietic-stem-cells-in-a-connective-tissue-equivalent-model
#15
Tahereh Derakhshan, Rudra Bhowmick, James H Meinkoth, Jerry Ritchey, Heather Gappa-Fahlenkamp
Mast cells (MCs) play critical roles in the pathogenesis of IgE- and non-IgE-mediated immune responses, as well as host defense against parasites, bacteria, and viruses. Due to the effect of the extracellular matrix components on the tissue morphogenesis and cell behavior, utilizing a tissue model that mimics MC microenvironmental conditions <i>in vivo</i> has greater relevance for <i>in vitro</i> studies. For this work, MCs were developed within a connective tissue-equivalent model and cell function was examined in response to an allergen...
March 21, 2019: Tissue Engineering. Part A
https://read.qxmd.com/read/30895107/frequencies-of-abnormal-humoral-and-cellular-immune-component-levels-in-peripheral-blood-of-patients-with-recurrent-aphthous-ulceration
#16
Huan-Huan Ruan, Guo-Yang Li, Ning Duan, Hong-Liu Jiang, Yi-Fu Fu, Yue-Feng Song, Qian Zhou, Xiang Wang, Wen-Mei Wang
Background/purpose: Recurrent aphthous ulceration (RAU) has an incidence of approximately 20% in general population. However, its exact cause remains unknown. Increasing evidence suggests that immunologic mechanisms may play crucial roles in the etiology of this disease. Materials and methods: The peripheral blood samples were obtained from 85 patients with RAU during acute phase and 87 healthy controls. The serum levels of IgG, IgA, IgM, C3 and C4 were measured by immunoturbidimetry...
June 2018: Journal of Dental Sciences
https://read.qxmd.com/read/30894854/differential-elimination-of-anti-thymocyte-globulin-of-fresenius-and-genzyme-impacts-t-cell-reconstitution-after-hematopoietic-stem-cell-transplantation
#17
Lisa V E Oostenbrink, Cornelia M Jol-van der Zijde, Katrine Kielsen, Anja M Jansen-Hoogendijk, Marianne Ifversen, Klaus G Müller, Arjan C Lankester, Astrid G S van Halteren, Robbert G M Bredius, Marco W Schilham, Maarten J D van Tol
Anti-thymocyte globulin (ATG) is a lymphocyte depleting agent applied in hematopoietic stem cell transplantation (HSCT) to prevent rejection and Graft-vs.-Host Disease (GvHD). In this study, we compared two rabbit ATG products, ATG-Genzyme (ATG-GENZ), and ATG-Fresenius (ATG-FRES), with respect to dosing, clearance of the active lymphocyte binding component, post-HSCT immune reconstitution and clinical outcome. Fifty-eigth pediatric acute leukemia patients ( n = 42 ATG-GENZ, n = 16 ATG-FRES), who received a non-depleted bone marrow or peripheral blood stem cell graft from an unrelated donor were included...
2019: Frontiers in Immunology
https://read.qxmd.com/read/30894322/sustained-release-of-exendin-4-from-tannic-acid-fe-iii-nanoparticles-prolongs-blood-glycemic-control-in-a-mouse-model-of-type-ii-diabetes
#18
Zhiyu He, Yizong Hu, Zaizhi Gui, Yang Zhou, Tianqi Nie, Jinchang Zhu, Zhijia Liu, Kuntao Chen, Lixin Liu, Kam W Leong, Peng Cao, Yongming Chen, Hai-Quan Mao
Exendin-4 has been clinically adopted as an effective drug for treating type 2 diabetes (T2D), but its short circulation half-life in the blood requires two injections per day to maintain effective glycemic control. This significantly limits its clinical application. In this study, we developed a tannic acid/exendin-4/Fe3+ ternary nanoparticle system to provide sustained release of exendin-4 in vivo. The formation of these nanoparticles relies on TA/exendin-4 complexation and stabilization through TA-Fe3+ coordination, where the rapid reaction kinetics can benefit from efficient mixing of all three components...
March 17, 2019: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://read.qxmd.com/read/30894185/evaluation-of-a-push-pull-system-consisting-of-transfluthrin-treated-eave-ribbons-and-odour-baited-traps-for-control-of-indoor-and-outdoor-biting-malaria-vectors
#19
Arnold S Mmbando, Elis P A Batista, Masoud Kilalangongono, Marceline F Finda, Emmanuel P Mwanga, Emmanuel W Kaindoa, Khamis Kifungo, Rukiyah M Njalambaha, Halfan S Ngowo, Alvaro E Eiras, Fredros O Okumu
BACKGROUND: Push-pull strategies have been proposed as options to complement primary malaria prevention tools, indoor residual spraying (IRS) and long-lasting insecticide-treated nets (LLINs), by targeting particularly early-night biting and outdoor-biting mosquitoes. This study evaluated different configurations of a push-pull system consisting of spatial repellents [transfluthrin-treated eave ribbons (0.25 g/m2 ai)] and odour-baited traps (CO2 -baited BG-Malaria traps), against indoor-biting and outdoor-biting malaria vectors inside large semi-field systems...
March 20, 2019: Malaria Journal
https://read.qxmd.com/read/30894084/measuring-real-time-blood-viscosity-with-a-ventricular-assist-device
#20
Wataru Hijikata, Takuro Maruyama, Yuki Suzumori, Tadahiko Shinshi
Ventricular assist devices assist in blood circulation and form a crucial component of artificial hearts. While it is important to measure parameters such as the flow rate, pressure head and viscosity of the blood, implanting additional devices to do such measurements is inadvisable. To this end, we demonstrate the adaptation of a ventricular assist device for the purpose of measuring blood viscosity. Such an approach eliminates the need for additional dedicated viscometers in artificial hearts. In the proposed method, the blood viscosity is measured by applying radial vibrational excitation to the impeller in a ventricular assist device using its magnetic levitation system...
March 20, 2019: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
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