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Jian Shen, Weizhi Wang, Jindao Wu, Bing Feng, Wen Chen, Meng Wang, Jincao Tang, Fuqiang Wang, Feng Cheng, Liyong Pu, Qiyun Tang, Xuehao Wang, Xiangcheng Li
BACKGROUND: Cholangiocarcinoma (CC) is an intractable cancer, arising from biliary epithelial cells, which has a poor prognosis and is increasing in incidence. Early diagnosis of CC is essential as surgical resection remains the only effective therapy. The purpose of this study was to identify improved biomarkers to facilitate early diagnosis and prognostication in CC. METHODS: A comparative expression profile of human bile samples from patients with cholangitis and CC was constructed using a classic 2D/MS/MS strategy and the expression of selected proteins was confirmed by Western blotting...
2012: PloS One
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