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Christopher J Staples, Giancarlo Barone, Katie N Myers, Anil Ganesh, Ian Gibbs-Seymour, Abhijit A Patil, Ryan D Beveridge, Caroline Daye, Richard Beniston, Sarah Maslen, Ivan Ahel, J Mark Skehel, Spencer J Collis
Through an RNAi-based screen for previously uncharacterized regulators of genome stability, we have identified the human protein C5orf45 as an important factor in preventing the accumulation of DNA damage in human cells. Here, we functionally characterize C5orf45 as a binding partner of the MRE11-RAD50-NBS1 (MRN) damage-sensing complex. Hence, we rename C5orf45 as MRNIP for MRN-interacting protein (MRNIP). We find that MRNIP is rapidly recruited to sites of DNA damage. Cells depleted of MRNIP display impaired chromatin loading of the MRN complex, resulting in reduced DNA end resection and defective ATM-mediated DNA damage signaling, a reduced ability to repair DNA breaks, and radiation sensitivity...
September 6, 2016: Cell Reports
Navid Saleh, Hye-Jin Kim, Tanapon Phenrat, Krzysztof Matyjaszewski, Robert D Tilton, Gregory V Lowry
The surfaces of nanoscale zerovalent iron (NZVI) used for groundwater remediation must be modified to be mobile in the subsurface for emplacement. Adsorbed polymers and surfactants can electrostatically, sterically, or electrosterically stabilize nanoparticle suspensions in water, but their efficacy will depend on groundwater ionic strength and cation type as well as physical and chemical heterogeneities of the aquifer material. Here, the effect of ionic strength and cation type on the mobility of bare, polymer-, and surfactant-modified NZVI is evaluated in water-saturated sand columns at low particle concentrations where filtration theory is applicable...
May 1, 2008: Environmental Science & Technology
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