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Curcumin delivery by nano

Lakshminarasimhan Harini, Sweta Srivastava, George Peter Gnanakumar, Bose Karthikeyan, Cecil Ross, Vaithilingam Krishnakumar, Velu Rajesh Kannan, Krishnan Sundar, Thandavarayan Kathiresan
Curcumin delivery to cancer cells is challenging due to its hydrophobic nature, low bio distribution and low availability. Many nano vehicles suffer from low stability and toxicity, and hence the prerequisite of a non-toxic nano vehicle with effective drug delivery is still being delved. The present study investigates the delivery efficiency of curcumin with non-spherical mesoporous silica nanoparticles (MSNAs). Their mechanism of drug delivery and signalling proteins activated to induce apoptosis was further explored in MCF-7 cells...
February 5, 2019: Oncotarget
Mina Karimpour, Mohammad Ali Hosseinpour Feizi, Majid Mahdavi, Barbara Krammer, Thomas Verwanger, Farhood Najafi, Esmaeil Babaei
BACKGROUND: Curcumin, the polyphenolic constituent of turmeric, has been recognized as an effective anticancer agent in the treatment of breast cancer. However, the poor bioavailability of curcumin triggers finding of new approaches for elevating its therapeutic efficiency. PURPOSE: We aimed to use gemini surfactant nanocarriers for curcumin in order to overcome its limitations. STUDY DESIGN: We investigated the in vitro characterization of gemini surfactant-curcumin (Gemini-Cur) and examined its antiproliferative & apoptotic activities on breast cancer cell lines...
November 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Vinod S Ipar, Anisha Dsouza, Padma V Devarajan
Curcumin is a promising therapeutic agent that exhibits manifold therapeutic activities. However, it is challenging to study curcumin as it exhibits poor aqueous solubility and low permeability and it is a substrate for P-glycoprotein (P-gp). It is readily metabolized in the body, but many active metabolites of curcumin have been identified that could also be exploited for therapy. Strategies for the oral bioenhancement of curcumin to leverage the potential of curcumin as a therapeutic molecule are discussed here in light of these challenges...
February 15, 2019: European Journal of Drug Metabolism and Pharmacokinetics
G Roopa, Roopa Karki, C Jayanthi, S Mukunthan, K S Akshay Kumar, Hanumanthachar K Joshi, Goli Divakar
Curcumin loaded alginate - polysorbate 80 nanoparticles prepared by ionotropic gelation method, successfully entrapped curcumin, exhibiting higher encapsulation efficiency nearing - 95%. Nano particles Produced were in the size range 105-383 nm and the Zeta potential found to be in the range of 150-200 mV. Formulations exhibited very low dissolution in Simulated Gastric fluid (SGF) & Simulated Intestinal fluid (SIF), but major portion got released in SCF which is attributed to the digestibility of alginate in Simulated Colonic fluid (SCF) under the influence of colonic micro flora which is not present in stomach or small intestine...
January 22, 2019: Pharmaceutical Nanotechnology
Yuzhen Hou, Hui Wang, Fan Zhang, Fengyuan Sun, Meng Xin, Mengshuang Li, Jun Li, Xianggen Wu
Purpose: Rebaudioside A (RA) has nanocarrier characteristics that allow it to self-assemble into micelles in aqueous solutions. The purpose of this study was to determine if a self-nanomicellizing solid dispersion based on RA could be utilized as an oral nano-drug delivery system. Materials and methods: Curcumin (Cur) served as a model hydrophobic drug, and a Cur-loaded self-nanomicellizing solid dispersion based on RA (RA-Cur) was formulated. The properties of RA-Cur in the solid state and in aqueous solution were characterized...
2019: International Journal of Nanomedicine
Manu Sharma, Shipra Sharma, Jyoti Wadhwa
This study was focussed on development of curcumin loaded solid binary lipid nanoparticles (C-SBLNs) to ameliorate stability, uptake and therapeutic potential of curcumin during inflammatory bowel disease (IBD). C-SBLNs with nano-size range (210.56 ± 41.22 nm) and high entrapment efficiency (83.12 ± 6.57%) were prepared by solvent emulsification evaporation method using binary lipids i.e. stearic acid and tristearin after optimizing various formulation and process variables. Physicochemical characterization of C-SBLNs by ATR-FTIR confirmed drug entrapment whereas thermal and pXRD study corroborated loss of crystallinity of drug into C-SBLNs...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
Ngoc The Nguyen, Ngoc Nhat Thanh Nguyen, Ngo The Nhan Tran, Phung Ngan Le, Thi Bich Tram Nguyen, Ngoc Hoa Nguyen, Long Giang Bach, Vu Nguyen Doan, Ha Le Bao Tran, Van Thu Le, Ngoc Quyen Tran
Nanogel-based systems loaded with single anticancer drugs display miscellaneous effectiveness in tumor remission, gradually circumventing mutation and resistance in chemotherapy. Hence, the existence of dual-drug delivered nano-sized systems has been contemporaneous with drug development and preceded the conventional-dose chemotherapy. Among outstanding synergistic drug nanoplatforms, thermosensitive copolymer heparin-Pluronic F127 (Hep-F127) co-delivering cisplatin (CDDP) and curcumins (Cur) (Hep-F127/CDDP/Cur) has emerged as a notable candidate for temperature-responsive drug delivery...
December 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Saurabh Srivastava, Shadab Mohammad, Shalini Gupta, Abbas Ali Mahdi, Rakesh Kumar Dixit, Vibha Singh, Fahad Mansoor Samadi
Introduction: Cancer of oral cavity is the uncontrolled expansion of damaged cell within the mouth cavity. 5-fluorouracil (5-FU) chemotherapy was focused to kill the cancer cell, but it would affect the surrounding normal cells during oral cancer treatment. This study included the evaluation of chemoprotective effects of curcumin (CU), as an herbal remedy, on 5-FU-induced-cytotoxicity toward oral cancer treatment, loaded within a nanocarrier system. CU was combined with 5-FU chemotherapy as a combinational drug-delivery system to evaluate synergistic effects...
July 2018: National Journal of Maxillofacial Surgery
Neil Hammond
Retraction of 'The next generation cell-penetrating peptide and carbon dot conjugated nano-liposome for transdermal delivery of curcumin' by Santanu Patra et al., Biomater. Sci., 2016, 4, 418-429.
December 3, 2018: Biomaterials Science
Xinlong Huo, Yongqiang Zhang, Xinchun Jin, Yongang Li, Li Zhang
The main factors of Alzheimer's disease (AD) are the cerebral accumulation and the formation of extracellular amyloid plaques. The Aβ peptides are highly able to accumulative and produce fibrils that are placed to form these plaques in the AD. The biological action and drug delivery properties of curcumin (Cur) nanoformulation in the Alzheimer's disease therapeutics can be developed by the altering surface of the Poly-lactide-co-glycolide (PLGA) polymer and encapsulation of selenium nanoparticles (Se NPs)...
November 15, 2018: Journal of Photochemistry and Photobiology. B, Biology
Hui-Yun Zhang, Cong-Yong Sun, Michael Adu-Frimpong, Jiang-Nan Yu, Xi-Ming Xu
The anti-tumor efficacy of curcumin can be markedly improved by nano-drug self-delivery systems with high drug loading capacity and smart stimulus-triggered drug release in tumor cells. Herein, a type of novel, glutathione (GSH)-responsive, PEGylated prodrug nano-micelles (PPNMs) was prepared by self-assembly of curcumin-s-s-vitamin E/mPEG2k-DSPE mixture. The PPNMs (entrapment efficiency: 96.7%) was acceptably stable in water with a mean particle size of 29.84 nm. Compared with curcumin-loaded mPEG2k-DSPE nano-micelles (CUR-NMs), PPNMs showed a higher drug loading (1...
November 22, 2018: International Journal of Pharmaceutics
Lijun You, Xiaocui Liu, Zhexiang Fang, Qianhui Xu, Qiqing Zhang
A new folic acid (FA)-conjugated poly (lactic-co-glycolicacid) (PLGA)-polyethylene glycol (PEG) nano-noisome was prepared. The noisome was employed as a drug delivery system to load curcumin (Cur) as a model drug and fluorescent probe for cervical cancer therapy and cell imaging. The Fe3 O4 @PLGA-PEG@FA noisomes were prepared through facile emulsion solvent evaporation and conjugation chemistry method, possessing the properties of high rapid magnetic separation and targeting character. X-ray photoelectron spectroscopy (XRD), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), thermogravimetric analysis (TGA), and vibrating sample magnetometer (VSM) were adopted to characterize the chemical structure and properties of these niosomes...
January 1, 2019: Materials Science & Engineering. C, Materials for Biological Applications
N Sanoj Rejinold, Jisang Yoo, Sangyong Jon, Yeu-Chun Kim
Curcumin (CRC) has been widely used as a therapeutic agent for various drug delivery applications. In this work, we focused on the applicability of CRC as a nanodrug delivery agent for doxorubicin hydrochloride (DOX) (commercially known as Adriamycin) coated with poly(ethylene glycol) (PEG) as an effective therapeutic strategy against multidrug-resistant cancer cells. The developed PEG-coated CRC/DOX nanoparticles (NPs) (PEG-CRC/DOX NPs) were well localized within the resistant cancer cells inducing apoptosis confirmed by flow cytometry and DNA fragmentation assays...
August 29, 2018: ACS Applied Materials & Interfaces
Vandita Kakkar, Indu Pal Kaur, Amrit Pal Kaur, Komal Saini, Kamalinder K Singh
Tetrahydrocurcumin (THC) also referred to as 'white curcumin', is a stable colorless hydrogenated product of curcumin with superior antioxidant and anti-inflammatory properties. The present study is an attempt to elevate the topical bioavailability of THC, post-incorporation into a nano-carrier system with its final dosage as a hydrogel. Lipid nanoparticles of THC (THC-SLNs) prepared by microemulsification technique were ellipsoidal in shape (revealed in transmission electron microscopy) with a mean particle size of 96...
October 2018: Drug Development and Industrial Pharmacy
Mozhgan Aghajanzadeh, Mostafa Zamani, Hamid Rashidzadeh, Kobra Rostamizadeh, Ali Sharafi, Hossein Danafar
In this project, a core-shell polymersome based on miktoarm star-copolymer:methoxy poly-ethylene glycol-lysine-(poly-caprolactone)2 was synthesized by a new method as controlled targeted drug delivery systems for codelivery of the chemotherapeutic methotrexate (MTX) and curcumin (CUR). Some properties of these nanocarriers (NCs), such as surface morphology, structure, surface charge, stability, and biocompatibility, were evaluated by proton nuclear magnetic resonance, dynamic scanning colorimetry, Fourier-transform infrared spectroscopy, dynamic light scattering, atomic force microscopy, critical aggregation concentration, hemolysis test, MTT assay, and lethal dose 50 (LD50)...
June 16, 2018: Journal of Biomedical Materials Research. Part A
Mukta Agrawal, Swarnlata Saraf, Shailendra Saraf, Sophia G Antimisiaris, Mahavir Bhupal Chougule, Sunday A Shoyele, Amit Alexander
According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the year 2017 itself, the cost of AD treatment in the USA has been reported to rise to $259 billion. This statistic shows the severity of the disease in the USA which is very much similar across the globe. On the other hand, the treatment remains limited to a few conventional oral medications (approved by FDA). These are mainly acting superficially from mild to the moderate AD...
July 10, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Sare Hosseini, Jamshidkhan Chamani, Hamidreza Rahimi, Navid Azmoodeh, Faezeh Ghasemi, Porya Hassan Abadi
Background: The incidence of esophageal squamous cell carcinoma (ESCC) is increasing, causing catastrophic health burdens on communities. Curcumin has shown promise as a therapeutic agent in the treatment of colon, colorectal, pancreatic, and esophageal cancers but it has very poor bioavailability. The application of nano-carriers as drug delivery systems increases curcumin's bioavailability. Cyclin D1 is overexpressed in ESCC and curcumin may change its expression. Methods: In this study, the effect of SinaCurcumin®, a novel nano-micelle product containing 80 mg curcumin, on the growth of KYSE-30 cells and expression of cyclin D1, was investigated...
April 2018: Reports of Biochemistry & Molecular Biology
Himanshu Bhatt, Sri Vishnu Kiran Rompicharla, Neeraja Komanduri, Aashma Shah, Sateja Paradkar, Balaram Ghosh, Swati Biswas
BACKGROUND: Solid lipid nanoparticles (SLNs) represent an affordable, easily scalable, stable and biocompatible drug delivery system with a high drug to lipid ratio which also improves solubility of poorly soluble drugs. OBJECTIVE: SLNs were developed by using glyceryl monostearate as the single lipid in presence of surfactant Poloxamer 188 and evaluated the efficiency of the SLNs to load the therapeutic cargo, curcumin (CUR). METHOD: The nano-formulation was optimized by Quality by Design approach to understand the effect of various process parameters on various quality attributes, including drug loadability, particle size and polydispersity...
May 3, 2018: Current Drug Delivery
Fatemeh Tavakoli, Rana Jahanban-Esfahlan, Khaled Seidi, Masoumeh Jabbari, Ramezan Behzadi, Younes Pilehvar-Soltanahmadi, Nosratollah Zarghami
Due to the high rate of drug resistance among malignant melanoma cases, it seems necessary to introduce an efficient pharmaceutical approach to melanoma treatment. For this purpose, Curcumin (Cur) and Chrysin (Chr), two natural anti-cancers, were co-encapsulated in PLGA-PEG nanoparticles (NPs), characterized by DLS, FTIR and FE-SEM and investigated for their effects on MMPs, TIMPs and TERT genes expression in C57B16 mice bearing B16F10 melanoma tumours. The results showed that the expression of MMP-9, MMP-2 and TERT genes were significantly decreased in all treated groups compared to the control...
April 1, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Pramod Kushwaha, Abhishek Yadav, M Samim, S J S Flora
Chelation therapy is the mainstream treatment for heavy metal poisoning. Apart from this, therapy using antioxidant/herbal extracts are the other strategies now commonly being tried for the treatment. We have previously reported individual beneficial efficacy of nanoparticle mediated administration of an antioxidant like 'curcumin' and an arsenic chelator 'monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA)' for the treatment of arsenic toxicity compared to bulk drugs. The present paper investigates our hypothesis that a combination drug delivery therapy employing two nanosystems, a chelator and a strong antioxidant, may produce more pronounced therapeutic effects compared to individual effects in the treatment of arsenic toxicity...
April 25, 2018: Chemico-biological Interactions
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