keyword
https://read.qxmd.com/read/38547061/the-%C3%AE-2-adrenergic-receptor-associates-with-cxcr4-multimers-in-human-cancer-cells
#1
JOURNAL ARTICLE
Junyi Liang, Mohamed Seghiri, Pradeep Kumar Singh, Hyeon Gyu Seo, Ji Yeong Lee, Yoonjung Jo, Yong Bhum Song, Chulo Park, Piotr Zalicki, Jae-Yeon Jeong, Won-Ki Huh, Niña G Caculitan, Adam W Smith
While the existence and functional role of class C G-protein-coupled receptors (GPCR) dimers is well established, there is still a lack of consensus regarding class A and B GPCR multimerization. This lack of consensus is largely due to the inherent challenges of demonstrating the presence of multimeric receptor complexes in a physiologically relevant cellular context. The C-X-C motif chemokine receptor 4 (CXCR4) is a class A GPCR that is a promising target of anticancer therapy. Here, we investigated the potential of CXCR4 to form multimeric complexes with other GPCRs and characterized the relative size of the complexes in a live-cell environment...
April 2, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38547014/operando-nuclear-magnetic-resonance-nmr-studies-of-a-trickle-bed-reactor-using-d-t2-correlations
#2
JOURNAL ARTICLE
Amy Sparks, Lynn Gladden, Colin Brennan, Mick Mantle
Catalytic conversions in fine-chemical and pharmaceutical production are increasingly performed in trickle-bed rectors. Optimisation of these processes is usually based on end of pipe measurement made at specific residence times. This process is both time-consuming and the data sometimes challenging to interpret. In the present work, operando nuclear magnetic resonance (NMR) techniques both at the scale of the whole bed (global) and spatially resolved within the bed (local) are used to gain new insights into the catalytic conversion process under reaction conditions...
March 27, 2024: Chimia
https://read.qxmd.com/read/38546625/speeded-classification-of-visual-events-is-sensitive-to-crossmodal-intensity-correspondence
#3
JOURNAL ARTICLE
Robert Carl Gunnar Johansson, Paul Kelber, Rolf Ulrich
Crossmodal correspondences refer to systematic associations between stimulus attributes encountered in different sensory modalities. These correspondences can be probed in the speeded classification task where they tend to produce congruency effects. This study aimed to replicate and extend previous work conducted by Marks (1987, Experiment 3, Journal of Experimental Psychology: Human Perception and Performance , Vol. 13, No. 3, 384-394) which demonstrated a crossmodal correspondence between auditory and visual intensity attributes...
March 28, 2024: Journal of Experimental Psychology. Human Perception and Performance
https://read.qxmd.com/read/38546393/hypoxia-in-tomato-solanum-lycopersicum-fruit-during-ripening-biophysical-elucidation-by-a-3d-reaction-diffusion-model
#4
JOURNAL ARTICLE
Hui Xiao, Pieter Verboven, Shuai Tong, Ole Pedersen, Bart Nicolaï
Respiration provides energy, substrates and precursors to support physiological changes of the fruit during climacteric ripening. A key substrate of respiration is oxygen that needs to be supplied to the fruit in a passive way by gas transfer from the environment. Oxygen gradients may develop within the fruit due to its bulky size and the dense fruit tissues, potentially creating hypoxia that may have a role in the spatial development of ripening. This study presents a three-dimensional reaction-diffusion model using tomato (Solanum lycopersicum) fruit as a test subject, combining the multiscale fruit geometry generated from magnetic resonance imaging and micro-computed tomography with varying respiration kinetics and contrasting boundary resistances obtained through independent experiments...
March 28, 2024: Plant Physiology
https://read.qxmd.com/read/38545949/determining-3d-structure-from-molecular-formula-and-isotopologue-rotational-spectra-in-natural-abundance-with-reflection-equivariant-diffusion
#5
JOURNAL ARTICLE
Austin H Cheng, Alston Lo, Santiago Miret, Brooks H Pate, Alán Aspuru-Guzik
Structure determination is necessary to identify unknown organic molecules, such as those in natural products, forensic samples, the interstellar medium, and laboratory syntheses. Rotational spectroscopy enables structure determination by providing accurate 3D information about small organic molecules via their moments of inertia. Using these moments, Kraitchman analysis determines isotopic substitution coordinates, which are the unsigned |x|, |y|, |z| coordinates of all atoms with natural isotopic abundance, including carbon, nitrogen, and oxygen...
March 28, 2024: Journal of Chemical Physics
https://read.qxmd.com/read/38545291/first-principles-evaluation-of-transition-metal-dichalcogenide-graphene-pairs-functionalized-with-oxygen-containing-groups-for-sodium-ion-battery-anodes
#6
JOURNAL ARTICLE
Wonmyung Choi, Sung Jun Hong, Hoejeong Jeong, Byungchan Han
Composites of reduced graphene oxides (rGOs) with transition metal dichalcogenides have garnered considerable attention as promising anode materials for sodium-ion batteries (SIBs) because of their superior theoretical capacity and long-term stability compared with pure graphene. However, the underlying mechanism of how the oxygen functional groups improve the functionality of rGO remains unclear. In this study, we investigated the roles of functional groups in rGO-based heterogeneous bilayers using first-principles density functional theory calculations...
March 26, 2024: Nanoscale advances
https://read.qxmd.com/read/38544833/meta-analysis-of-dynamic-contrast-enhancement-and-diffusion-weighted-mri-for-differentiation-of-benign-from-malignant-non-mass-enhancement-breast-lesions
#7
Jing Zhang, Longchao Li, Li Zhang, Xia Zhe, Min Tang, Xiaoyan Lei, Xiaoling Zhang
PURPOSE: The objective of this study was to conduct a meta-analysis comparing the diagnostic efficacy of models based on diffusion-weighted imaging (DWI)-MRI, dynamic contrast enhancement (DCE)-MRI, and combination models (DCE and DWI) in distinguishing benign from malignant non-mass enhancement (NME) breast lesions. MATERIALS AND METHODS: PubMed, Embase, and Cochrane Library were searched, from inception to January 30, 2023, for studies that used DCE or DWI-MRI for the prediction of NME breast cancer patients...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38544684/diffusion-kinetics-and-perfusion-times-in-tissue-models-obtained-by-bioorthogonal-raman-%C3%AE-spectroscopy
#8
JOURNAL ARTICLE
Saskia Altmaier, Ina Meiser, Frank Stracke, Heiko Zimmermann
The penetration kinetics of small-molecule compounds like nutrients, drugs, and cryoprotective agents into artificial cell aggregates are of pivotal relevance in many applications, from stem cell differentiation and drug screening through to cryopreservation. Depending on compound and tissue properties as well as aggregate size and shape, the penetration behavior can differ vastly. Here, we introduce bioorthogonal Raman microspectroscopy as a contactless technique to investigate the penetration of various compounds into spheroids, organoids, and other tissue models in terms of diffusion coefficients and perfusion times...
June 12, 2024: Biophys Rep (N Y)
https://read.qxmd.com/read/38544307/numerical-study-of-doxorubicin-transdermal-delivery-for-breast-cancer-treatment-using-microneedles
#9
JOURNAL ARTICLE
Houda Barhoumi, Marie Carole Kouassi, Achraf Kallel
The lack of in vivo studies on the delivery of doxorubicin within human skin, especially the absence of data on the doxorubicin diffusion coefficient, has made understanding its transdermal delivery kinetics challenging. In this study, as a first step, governing equations and finite element methods were employed to reproduce Franz diffusion cell experiment in human cadaver skin. The application of this experiment representative model with a fitting method resulted in approximate values for the diffusivity of doxorubicin across various skin layers...
March 27, 2024: International Journal for Numerical Methods in Biomedical Engineering
https://read.qxmd.com/read/38544252/research-on-the-flow-characteristics-and-reaction-mechanisms-of-lateral-flow-immunoassay-under-non-uniform-flow
#10
JOURNAL ARTICLE
Xuyan Zhao, Yuan Zhang, Qunfeng Niu, Li Wang, Chenglong Xing, Qiao Wang, Hui Bao
Lateral flow immunoassay (LFIA) is extensively utilized for point-of-care testing due to its ease of operation, cost-effectiveness, and swift results. This study investigates the flow dynamics and reaction mechanisms in LFIA by developing a three-dimensional model using the Richards equation and porous media transport, and employing numerical simulations through the finite element method. The study delves into the transport and diffusion behaviors of each reaction component in both sandwich LFIA and competitive LFIA under non-uniform flow conditions...
March 20, 2024: Sensors
https://read.qxmd.com/read/38544214/image-processing-techniques-for-improving-quality-of-3d-profile-in-digital-holographic-microscopy-using-deep-learning-algorithm
#11
JOURNAL ARTICLE
Hyun-Woo Kim, Myungjin Cho, Min-Chul Lee
Digital Holographic Microscopy (DHM) is a 3D imaging technology widely applied in biology, microelectronics, and medical research. However, the noise generated during the 3D imaging process can affect the accuracy of medical diagnoses. To solve this problem, we proposed several frequency domain filtering algorithms. However, the filtering algorithms we proposed have a limitation in that they can only be applied when the distance between the direct current (DC) spectrum and sidebands are sufficiently far. To address these limitations, among the proposed filtering algorithms, the HiVA algorithm and deep learning algorithm, which effectively filter by distinguishing between noise and detailed information of the object, are used to enable filtering regardless of the distance between the DC spectrum and sidebands...
March 19, 2024: Sensors
https://read.qxmd.com/read/38544170/pixrevive-latent-feature-diffusion-model-for-compressed-video-quality-enhancement
#12
JOURNAL ARTICLE
Weiran Wang, Minge Jing, Yibo Fan, Wei Weng
In recent years, the rapid prevalence of high-definition video in Internet of Things (IoT) systems has been directly facilitated by advances in imaging sensor technology. To adapt to limited uplink bandwidth, most media platforms opt to compress videos to bitrate streams for transmission. However, this compression often leads to significant texture loss and artifacts, which severely degrade the Quality of Experience (QoE). We propose a latent feature diffusion model (LFDM) for compressed video quality enhancement, which comprises a compact edge latent feature prior network (ELPN) and a conditional noise prediction network (CNPN)...
March 16, 2024: Sensors
https://read.qxmd.com/read/38544086/validation-of-a-3d-local-scale-adaptive-solar-radiation-model-by-using-pyranometer-measurements-and-a-high-resolution-digital-elevation-model
#13
JOURNAL ARTICLE
Eduardo Rodríguez, Judit García-Ferrero, María Sánchez-Aparicio, José M Iglesias, Albert Oliver-Serra, M Jesús Santos, Paula Andrés-Anaya, J Manuel Cascón, Gustavo Montero García, Alejandro Medina, Susana Lagüela, M Isabel Asensio, Rafael Montenegro Armas
The result of the multidisciplinary collaboration of researchers from different areas of knowledge to validate a solar radiation model is presented. The MAPsol is a 3D local-scale adaptive solar radiation model that allows us to estimate direct, diffuse, and reflected irradiance for clear sky conditions. The model includes the adaptation of the mesh to complex orography and albedo, and considers the shadows cast by the terrain and buildings. The surface mesh generation is based on surface refinement, smoothing and parameterization techniques and allows the generation of high-quality adapted meshes with a reasonable number of elements...
March 12, 2024: Sensors
https://read.qxmd.com/read/38543323/mannose-decorated-solid-lipid-nanoparticles-for-alveolar-macrophage-targeted-delivery-of-rifampicin
#14
JOURNAL ARTICLE
Hriday Bera, Caizhu Zhao, Xidong Tian, Dongmei Cun, Mingshi Yang
Alveolar macrophages play a vital role in a variety of lung diseases, including tuberculosis. Thus, alveolar macrophage targeted anti-tubercular drug delivery through nanocarriers could improve its therapeutic response against tuberculosis. The current study aimed at exploring the efficacy of glyceryl monostearate (GMS)-based solid-lipid nanoparticles (SLNs) and their mannose functionalized forms on the alveolar macrophage targeting ability of an anti-tubercular model drug, rifampicin (Rif). Rif-loaded SLNs were accomplished by the solvent diffusion method...
March 20, 2024: Pharmaceutics
https://read.qxmd.com/read/38543253/3d-printed-chitosan-based-scaffolds-with-scutellariae-baicalensis-extract-for-dental-applications
#15
JOURNAL ARTICLE
Magdalena Paczkowska-Walendowska, Ioanna Koumentakou, Maria Lazaridou, Dimitrios Bikiaris, Andrzej Miklaszewski, Tomasz Plech, Judyta Cielecka-Piontek
The plant material Scutellariae baicalensis radix , which is rich in flavones (baicalin), possesses antibacterial, antifungal, antioxidant, and anti-inflammatory properties. This work aimed to develop a 3D-printed chitosan-based hydrogel rich in Scutellariae baicalensis extract as an innovative approach for the personalized treatment of periodontal diseases. Chitosan-based hydrogels were prepared, and the printability of the prepared hydrogels was determined. The hydrogel with 2.5% w / v of high molecular-weight chitosan (CS), 2% w / v gelatin (Gel), and 10% w / w of extract (Ex) presented the best printability, producing smooth and uniform scaffolds...
March 4, 2024: Pharmaceutics
https://read.qxmd.com/read/38543238/the-formulation-and-characterization-of-wound-dressing-releasing-s-nitrosoglutathione-from-polyvinyl-alcohol-borax-reinforced-carboxymethyl-chitosan-self-healing-hydrogel
#16
JOURNAL ARTICLE
Juliana Palungan, Widya Luthfiyah, Apon Zaenal Mustopa, Maritsa Nurfatwa, Latifah Rahman, Risfah Yulianty, Nasrul Wathoni, Jin-Wook Yoo, Nurhasni Hasan
Self-healing hydrogels often lack mechanical properties, limiting their wound-dressing applications. This study introduced S-Nitrosoglutathione (GSNO) to self-healing hydrogel-based wound dressings. Self-healing hydrogel mechanical properties were improved via polymer blends. Applying this hydrogel to the wound site allows it to self-heal and reattach after mechanical damage. This work evaluated polyvinyl alcohol (PVA)-based self-healing hydrogels with borax as a crosslinking agent and carboxymethyl chitosan as a mechanical property enhancer...
February 29, 2024: Pharmaceutics
https://read.qxmd.com/read/38543166/-cassia-alata-l-a-study-of-antifungal-activity-against-malassezia-furfur-identification-of-major-compounds-and-molecular-docking-to-lanosterol-14-alpha-demethylase
#17
JOURNAL ARTICLE
Nyi Mekar Saptarini, Resmi Mustarichie, Silviana Hasanuddin, Mary Jho-Anne Tolentino Corpuz
Empirically, in Indonesia, the leaves of Cassia alata L. (candle bush or ketepeng cina) have been used as a topical antifungal agent. Malassezia furfur is a natural microorganism found in the human body. It is among the factors contributing to conditions such as pityriasis versicolor, a common, benign, superficial fungal infection of the skin that is closely associated with seborrheic dermatitis and dandruff. This study aimed to explore C. alata leaves, starting from determining antifungal activity against M...
March 16, 2024: Pharmaceuticals
https://read.qxmd.com/read/38542901/experimental-and-computational-methods-to-assess-central-nervous-system-penetration-of-small-molecules
#18
REVIEW
Mayuri Gupta, Jun Feng, Govinda Bhisetti
In CNS drug discovery, the estimation of brain exposure to lead compounds is critical for their optimization. Compounds need to cross the blood-brain barrier (BBB) to reach the pharmacological targets in the CNS. The BBB is a complex system involving passive and active mechanisms of transport and efflux transporters such as P-glycoproteins (P-gp) and breast cancer resistance protein (BCRP), which play an essential role in CNS penetration of small molecules. Several in vivo, in vitro, and in silico methods are available to estimate human brain penetration...
March 13, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542321/topical-neuropeptide-y-for-ischemic-skin-wounds
#19
JOURNAL ARTICLE
Tais Stangerup, Lise Mette Rahbek Gjerdrum, Michael Bzorek, Line Andersen, Anne-Marie Heegaard, Lars N Jorgensen, Magnus S Ågren
Our objective was to investigate the effects of topically applied neuropeptide Y (NPY) on ischemic wounds. Initially, the animal model for ischemic wound healing was validated using 16 male Sprague Dawley albino rats. In the intervention study, an additional 28 rats were divided into three groups: NPY (0.025%), the positive control insulin-like growth factor-I (IGF-I, 0.0025%), and the hydrogel carrier alone (control). The hydrogel was selected due to its capacity to prolong NPY release ( p < 0.001), as demonstrated in a Franz diffusion cell...
March 15, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542168/nmr-study-of-water-soluble-carotenoid-crocin-formation-of-mixed-micelles-interaction-with-lipid-membrane-and-antioxidant-activity
#20
JOURNAL ARTICLE
Wenjing Su, Anna V Mastova, Maya A Ul'yanova, Polina A Kononova, Olga Yu Selyutina, Veronika I Evseenko, Elizaveta S Meteleva, Alexander V Dushkin, Weike Su, Nikolay E Polyakov
Crocin is a unique water-soluble carotenoid found in crocus and gardenia flowers. Crocin has been shown to have a variety of pharmacological activities, such as antioxidant, anti-cancer, memory improvement, antidepressant, anti-ischemia, blood pressure lowering and aphrodisiac, gene protection and detoxification activities. Due to their amphiphilicity, crocin molecules form concentration-dependent self-associates (micelles) in a water solution. In the present study, using various NMR techniques (T2 relaxation and selective gradient NOESY), we have demonstrated that crocin forms mixed micelles with water-soluble drug delivery system glycyrrhizin and linoleic acid molecules...
March 11, 2024: International Journal of Molecular Sciences
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