Wenjing Su, Anna V Mastova, Maya A Ul'yanova, Polina A Kononova, Olga Yu Selyutina, Veronika I Evseenko, Elizaveta S Meteleva, Alexander V Dushkin, Weike Su, Nikolay E Polyakov
Crocin is a unique water-soluble carotenoid found in crocus and gardenia flowers. Crocin has been shown to have a variety of pharmacological activities, such as antioxidant, anti-cancer, memory improvement, antidepressant, anti-ischemia, blood pressure lowering and aphrodisiac, gene protection and detoxification activities. Due to their amphiphilicity, crocin molecules form concentration-dependent self-associates (micelles) in a water solution. In the present study, using various NMR techniques (T2 relaxation and selective gradient NOESY), we have demonstrated that crocin forms mixed micelles with water-soluble drug delivery system glycyrrhizin and linoleic acid molecules...
March 11, 2024: International Journal of Molecular Sciences