J O Gasho, K Silos, C V Guthier, S C Zhang, M Burnison, A J Mirhadi, J K Jang, S L Shiao, M Kamrava, J Steers, E McKenzie, B Tamarappoo, D Ouyang, A C Kwan, A Nikolova, R H Mak, K M Atkins
PURPOSE/OBJECTIVE(S): Coronary artery calcium (CAC) is associated with increased risk of major adverse cardiac events (MACE). Accelerated CAC progression has been observed in patients with breast cancer after radiotherapy (RT) and there is a relationship between left anterior descending (LAD) coronary artery RT dose and the risk of coronary events. However, there is lack of consensus on LAD dose constraints for breast RT and limited data on the extent and impact of CAC progression. Our objective was to evaluate the association of LAD dose exposure and CAC progression with the risk of MACE in patients with breast cancer following RT...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics