keyword
https://read.qxmd.com/read/38530533/an-experimental-phototherapy-device-for-studying-the-effects-of-blue-light-on-patients-with-raynaud-s-phenomenon
#21
JOURNAL ARTICLE
Brett Levac, James Kerber, Emily Wagner, Jerry A Molitor, Steven S Saliterman
Raynaud's phenomenon (RP) is a condition that causes decreased blood flow to areas perfused by small blood vessels (e.g., fingers, toes). In severe cases, ulceration, gangrene, and loss of fingers may occur. Most treatments focus on inducing vasorelaxation in affected areas by the way of pharmaceuticals. Recently, animal studies have shown that vasorelaxation can be induced by non-coherent blue light (wavelength ~ 430-460 nm) through the actions of melanopsin, a photoreceptive opsin protein encoded by the OPN4 gene...
March 26, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38530093/effects-of-phytoncide-fragrance-on-resting-state-brain-activity-in-mild-cognitive-impairment-a-randomized-double-blind-controlled-study
#22
JOURNAL ARTICLE
Jiheon Kim, Seungchan Park, Hansol Kim, Daeyoung Roh, Do Hoon Kim
Introduction: The therapeutic potential of phytoncide fragrances may be optimal for patients with mild cognitive impairment (MCI) that display complex symptomatology. This study aimed to explore the clinical value of phytoncide by evaluating its electrophysiological effects in patients with MCI. Materials and Methods: This was a double-blind, randomized controlled trial. A total of 24 community-dwelling patients were randomly assigned to either a phytoncide or no-odor group. Participants wore a dental mask, for 30 min at rest that had either the fragrance stimulus or water added to it...
March 26, 2024: J Integr Complement Med
https://read.qxmd.com/read/38529853/a-randomized-placebo-controlled-double-blinded-study-comparing-oral-and-subcutaneous-administration-of-mistletoe-extract-for-the-treatment-of-equine-sarcoid-disease
#23
JOURNAL ARTICLE
Anke Beermann, Ophélie Clottu, Marcus Reif, Ulrike Biegel, Lucia Unger, Christoph Koch
BACKGROUND: Equine sarcoids (ES) are the most common cutaneous tumors in equids. Systemic treatment options are sparse. Subcutaneous (SC) injections of Viscum album extract (VAE) demonstrate efficacy as a systemic treatment directed against ES. OBJECTIVES/AIM: To critically assess the therapeutic efficacy of orally administered VAE. ANIMALS: Forty-five ES-affected, privately owned, 3-12 year-old horses. METHODS: A 3-armed randomized placebo-controlled, double-blinded study was conducted in a double-dummy design...
March 26, 2024: Journal of Veterinary Internal Medicine
https://read.qxmd.com/read/38529710/sq-sublingual-immunotherapy-tablets-for-children-with-allergic-rhinitis-a-review-of-phase-three-trials
#24
REVIEW
Péter Csonka, Eckard Hamelmann, Mirjana Turkalj, Graham Roberts, Douglas P Mack
AIM: To provide paediatricians with a summary of efficacy and safety of SQ sublingual immunotherapy (SLIT) tablets from phase three, randomised, double-blind, placebo-controlled trials in children and adolescents with allergic rhinitis or rhinoconjunctivitis, with and without asthma. METHODS: PubMed searches were conducted and unpublished data were included if necessary. RESULTS: Of the 93 publications, 12 were identified reporting 10 trials...
March 26, 2024: Acta Paediatrica
https://read.qxmd.com/read/38528704/the-impowr-network-divided-or-single-exposure-study-dose-protocol-a-randomized-controlled-comparison-of-once-versus-split-dosing-of-methadone-for-the-treatment-of-comorbid-chronic-pain-and-opioid-use-disorder
#25
JOURNAL ARTICLE
Greer McKendrick, Will Davis, Michael Sklar, Nicole Brown, Emma Pattillo, Patrick H Finan, Denis Antoine, Vickie Walters, Kelly E Dunn
BACKGROUND: The Divided or Single Exposure (DOSE) trial is a double-blind, placebo-controlled examination of once versus split dosing of methadone for comorbid pain and opioid use disorder (OUD) among persons receiving methadone for OUD treatment. METHODS: This multisite trial consists of a 12-week active intervention phase and 6-month follow-up period. Persons receiving methadone who endorse clinically-significant chronic pain are randomized into once-daily dosing or split dosing that is managed remotely via an electronic pillbox...
March 25, 2024: Subst Use Addctn J
https://read.qxmd.com/read/38528476/long-term-treatment-with-lasmiditan-in-patients-with-migraine-post-hoc-analysis-of-treatment-patterns-and-outcomes-from-the-open-label-extension-of-the-centurion-randomized-trial
#26
RANDOMIZED CONTROLLED TRIAL
Mika Komori, Akichika Ozeki, Yuka Tanji, Eriko Kamiki, John H Krege, Lily Qian Li, Shiho Suzuki, Mamoru Shibata, Takao Takeshima
BACKGROUND: The objective of this analysis was to gain new insights into the patient characteristics and other factors associated with lasmiditan usage and clinical outcomes under conditions resembling the real-world setting. METHODS: This was a post hoc analysis of data from the 12-month, open-label extension (OLE) of the phase 3, double-blind, randomized, controlled CENTURION trial, which examined the efficacy and safety of lasmiditan as acute treatment across four migraine attacks...
March 25, 2024: Journal of Headache and Pain
https://read.qxmd.com/read/38528113/a-randomized-controlled-study-to-assess-the-effect-of-mosapride-citrate-on-intestinal-recovery-following-gastrectomy
#27
RANDOMIZED CONTROLLED TRIAL
Shiyeol Jun, Seyeol Oh, Ji Eun Jung, In Gyu Kwon, Sung Hoon Noh
The enhanced recovery after surgery (ERAS) protocol, including prokinetic medications, is commonly used to prevent postoperative ileus. Prospective studies evaluating the effectiveness of mosapride citrate, a prokinetic 5-hydroxytryptamine 4 receptor agonist, in patients undergoing gastrectomy within the ERAS framework are lacking. This double-blind randomized trial included patients who were scheduled for laparoscopic or robotic gastrectomy for gastric cancer. Participants were randomly assigned to either a control (placebo) or experimental (mosapride citrate) group, with drugs administered on postoperative days 1-5...
March 25, 2024: Scientific Reports
https://read.qxmd.com/read/38527849/adjunctive-pascolizumab-in-rifampicin-susceptible-pulmonary-tuberculosis-proof-of-concept-partially-randomised-double-blind-placebo-controlled-dose-escalation-trial
#28
JOURNAL ARTICLE
Nicholas I Paton, Meera Gurumurthy, Qingshu Lu, Francesca Leek, Philip Kwan, Hiromi W L Koh, James Molton, Lalaine Mortera, Sullian Naval, Zamzurina Abu Bakar, Yong-Kek Pang, Lionel Lum, Tow Keang Lim, Gail B Cross, Ganesh Lekurwale, Hyungwon Choi, Veonice Au, John Connolly, Martin Hibberd, Justin A Green
BACKGROUND: Interleukin-4 (IL-4), increased in tuberculosis infection, may impair bacterial killing. Blocking IL-4 confers benefit in animal models. We evaluated safety and efficacy of pascolizumab (humanised anti-IL-4 monoclonal antibody) as adjunctive tuberculosis treatment. METHODS: Participants with rifampicin-susceptible pulmonary tuberculosis received a single intravenous infusion of pascolizumab or placebo; and standard 6-month tuberculosis treatment. Pascolizumab dose increased in successive cohorts: [1] non-randomised 0...
March 25, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38526612/a-muscarinic-receptor-antagonist-reverses-multiple-indices-of-diabetic-peripheral-neuropathy-preclinical-and-clinical-studies-using-oxybutynin
#29
RANDOMIZED CONTROLLED TRIAL
Carolina M Casselini, Henri K Parson, Katie E Frizzi, Alex Marquez, Darrell R Smith, Lucie Guernsey, Rakesh Nemmani, Alireza Tayarani, Corinne G Jolivalt, Jessica Weaver, Paul Fernyhough, Aaron I Vinik, Nigel A Calcutt
Preclinical studies indicate that diverse muscarinic receptor antagonists, acting via the M1 sub-type, promote neuritogenesis from sensory neurons in vitro and prevent and/or reverse both structural and functional indices of neuropathy in rodent models of diabetes. We sought to translate this as a potential therapeutic approach against structural and functional indices of diabetic neuropathy using oxybutynin, a muscarinic antagonist approved for clinical use against overactive bladder. Studies were performed using sensory neurons maintained in vitro, rodent models of type 1 or type 2 diabetes and human subjects with type 2 diabetes and confirmed neuropathy...
March 25, 2024: Acta Neuropathologica
https://read.qxmd.com/read/38526550/impact-of-influenza-and-pneumococcal-vaccines-on-hiv-persistence-and-immune-dynamics-during-suppressive-antiretroviral-therapy
#30
JOURNAL ARTICLE
Sara Gianella, Christy Anderson, Antoine Chaillon, Alan Wells, Magali Porrachia, Gemma Caballero, Milenka Vargas, Joseph Lonergan, Brendon Woodworth, Noah Gaitan, Stephen A Rawlings, Leticia Muttera, Liliana Harkness, Susan J Little, Susanne May, Davey Smith
OBJECTIVE: :We sought to determine if standard influenza and pneumococcal vaccines can be used to stimulate HIV reservoirs during antiretroviral therapy (ART). DESIGN: :Prospective, randomized, double-blinded, placebo-controlled, crossover trial of two clinically recommended vaccines (influenza and pneumococcal). METHODS: :Persons with HIV on ART (N = 54) were enrolled in the clinical trial. Blood was collected at baseline and days 2,4,7,14 and 30 postimmunizations...
March 25, 2024: AIDS
https://read.qxmd.com/read/38526064/dual-intervention-on-the-gut-and-skin-microbiota-attenuates-facial-cutaneous-aging
#31
JOURNAL ARTICLE
Liujing Zhang, Shun Yu, Yin Guan, Dan Wang, Ju Yang, Jingling Li, Wei Zhao, Feng Zhang
The gut and skin microbiota are microbial barriers, resisting harmful foreign microorganisms and maintaining internal homeostasis. Dysbiosis of the gut and skin microbiota is involved in aging progression. However, interventions targeting facial skin wellness taking into account the gut-skin axis are scarce. In this study, the impact of an eight-week intervention with oral (O), topical (T), and both oral and topical (OT) xylo-oligosaccharides (XOS) by regulating gut and skin microbiota on facial cutaneous aging was investigated in a double-blind placebo-controlled trial in females...
March 25, 2024: Food & Function
https://read.qxmd.com/read/38526047/first-in-human-trial-evaluating-safety-and-pharmacokinetics-of-at-752-a-novel-nucleotide-prodrug-with-pan-serotype-activity-against-dengue-virus
#32
JOURNAL ARTICLE
Xiao-Jian Zhou, Jason Lickliter, Maureen Montrond, Laura Ishak, Keith Pietropaolo, Dayle James, Bruce Belanger, Arantxa Horga, Janet Hammond
UNLABELLED: AT-752 is a novel guanosine nucleotide prodrug inhibitor of the dengue virus (DENV) polymerase with sub-micromolar, pan-serotype antiviral activity. This phase 1, double-blind, placebo-controlled, first-in-human study evaluated the safety, tolerability, and pharmacokinetics of ascending single and multiple oral doses of AT-752 in healthy subjects. AT-752 was well tolerated when administered as a single dose up to 1,500 mg or when administered as multiple doses up to 750 mg three times daily (TID)...
March 25, 2024: Antimicrobial Agents and Chemotherapy
https://read.qxmd.com/read/38525752/-ophiocephalus-striatus-extract-supplementation-decreases-serum-il-6-levels-in-older-people-with-sarcopenia-a-single-center-experience
#33
JOURNAL ARTICLE
Nur Riviati, Legiran Legiran, Irsan Saleh, Taufik Indrajaya, Zulkhair Ali, Irfannuddin, Probosuseno
Sarcopenia, a condition characterized by muscle loss and decreased function in older adults, is a growing public health concern. This study aimed to investigate the effects of Ophiocephalus striatus extract on insulin-like growth factor-1 serum, interleukin-6 serum levels, and sarcopenia-related parameters in older adults with sarcopenia. This double-blind randomized controlled trial included 80 older adults with sarcopenia. Participants were randomly assigned to receive Ophiocephalus striatus extract or a placebo for two weeks...
March 7, 2024: Geriatrics
https://read.qxmd.com/read/38525728/a-systematic-review-of-naldemedine-and-naloxegol-for-the-treatment-of-opioid-induced-constipation-in-cancer-patients
#34
REVIEW
Ursula K Braun, Leanne K Jackson, Mary A Garcia, Syed N Imam
BACKGROUND: Opioid-induced constipation (OIC) is a pervasive and distressing side effect of chronic opioid therapy in patients with cancer pain, significantly impacting their quality of life. Peripherally acting μ-opioid receptor antagonists (PAMORAS) were developed for treatment-resistant OIC but most studies were conducted with non-cancer patients. OBJECTIVE: to discuss two oral formulations of PAMORAs, naldemedine and naloxegol, and to review available evidence of the effectiveness of these drugs for OIC in cancer patients...
March 6, 2024: Pharmacy (Basel, Switzerland)
https://read.qxmd.com/read/38525606/prospective-randomized-double-blind-comparative-study-of-topical-acetyl-zingerone-with-tetrahexyldecyl-ascorbate-versus-tetrahexyldecyl-ascorbate-alone-on-facial-photoaging
#35
JOURNAL ARTICLE
Nasima Afzal, Nhi Nguyen, Mildred Min, Caitlin Egli, Shabnam Afzal, Ratan K Chaudhuri, Waqas A Burney, Raja K Sivamani
BACKGROUND: Tetrahexydecyl ascorbate (THDA) is a lipophilic precursor to ascorbic acid that may be stabilized by acetyl zingerone (AZ). Studies have shown that the topical application of THDA may have photoprotective effects. Similarly, AZ has been shown to mitigate oxidative and inflammatory stress, thereby improving the appearance of photoaging. AIMS: To examine the effects of THDA and AZ (THDA-AZ) on skin photoaging compared to THDA alone. PATIENTS/METHODS: In this double-blind, randomized controlled trial, healthy individuals aged 30 to 65 were included and 44 participants were randomized to receive either THDA-AZ (THDA 5% + AZ 1%) or THDA only (THDA 5%) for 8 weeks...
March 25, 2024: Journal of Cosmetic Dermatology
https://read.qxmd.com/read/38525376/transcutaneous-auricular-vagus-nerve-stimulation-with-task-oriented-training-improves-upper-extremity-function-in-patients-with-subacute-stroke-a-randomized-clinical-trial
#36
JOURNAL ARTICLE
Meng-Huan Wang, Yi-Xiu Wang, Min Xie, Li-Yan Chen, Meng-Fei He, Feng Lin, Zhong-Li Jiang
BACKGROUND: Transcutaneous auricular vagus nerve stimulation (taVNS) has emerged as a promising brain stimulation modality in poststroke upper extremity rehabilitation. Although several studies have examined the safety and reliability of taVNS, the mechanisms underlying motor recovery in stroke patients remain unclear. OBJECTIVES: This study aimed to investigate the effects of taVNS paired with task-oriented training (TOT) on upper extremity function in patients with subacute stroke and explore the potential underlying mechanisms...
2024: Frontiers in Neuroscience
https://read.qxmd.com/read/38525254/hype-or-hope-high-placebo-response-in-major-depression-treatment-with-ketamine-and-esketamine-a-systematic-review-and-meta-analysis
#37
Alexandros Matsingos, Marcel Wilhelm, Laila Noor, Cüneyt Yildiz, Winfried Rief, Stefan G Hofmann, Irina Falkenberg, Tilo Kircher
BACKGROUND: Ketamine and esketamine offer a novel approach in the pharmacological treatment of major depressive disorder (MDD). This meta-analysis aimed to investigate the placebo response in double-blind, randomized controlled studies (RCTs) on patients with MDD receiving ketamine or esketamine. METHODS: For this systematic review and meta-analysis Medline (PubMed), Cochrane Central Register of Controlled Trials (CENTRAL), PsycInfo and Embase databases were systematically searched for citations published up to March 17, 2023...
2024: Frontiers in Psychiatry
https://read.qxmd.com/read/38525193/effects-of-continuous-supplementation-of-acanthopanax-senticosus-harms-on-the-cardiac-autonomic-function-of-community-dwelling-elderly-individuals-during-resting-and-standing-tests-a-randomized-controlled-trial
#38
JOURNAL ARTICLE
Takeru Sato, Takumi Aoki, Yuki Ito, Kan Oishi, Masaki Fujishima, Eri Okumura, Kojiro Ishii
BACKGROUND: Cardiac autonomic function (CAF) decreases with aging, and Acanthopanax senticosus Harms (ASH) consumption reportedly induces anti-stress effects. This study aimed to assess the effect of continuous supplementation of ASH on CAF during resting and standing tests in the elderly population. METHODS: This double-blind, randomized controlled trial was conducted in the morning in a laboratory setting and was carried out between June 2017 and July 2017 at Kambaikan, Doshisha University (Karasuma-higashi-iru, Imadegawa-dori, Kamigyo-ku, Kyoto 602-8580, Japan)...
2024: Frontiers in Cardiovascular Medicine
https://read.qxmd.com/read/38524686/effect-of-aggressive-warming-versus-routine-thermal-management-on-the-incidence-of-perioperative-hypothermia-in-patients-undergoing-thyroid-surgery-a-prospective-randomized-double-blind-controlled-trial
#39
JOURNAL ARTICLE
Yue Zhang, Yafan Bai, Yi Zhang, Yingjie Du, Min Liu, Jiayu Zhu, Guyan Wang
PURPOSE: Despite the implementation of various insulation measures, the incidence of hypothermia during thyroid surgery remains high. This randomized controlled study aimed to evaluate the effects of aggressive thermal management combined with resistive heating mattresses to prevent perioperative hypothermia in patients undergoing thyroid surgery. PATIENTS AND METHODS: 142 consecutive patients scheduled for elective thyroid surgery were enrolled in the study. They were randomly and equally allocated to the aggressive warming or routine care groups (n = 71)...
2024: Therapeutics and Clinical Risk Management
https://read.qxmd.com/read/38524025/efficacy-and-safety-of-astaxanthin-in-the-management-of-oral-submucous-fibrosis-a-preliminary-randomized-controlled-trial
#40
JOURNAL ARTICLE
Elumalai Perumal, Santosh Patil, Mohmed Isaqali Karobari
BACKGROUND: Oral submucous fibrosis (OSMF) is a chronic, potentially malignant disorder characterized by progressive fibrosis of the oral mucosa, leading to restricted mouth opening and discomfort. This study investigates the efficacy and safety of astaxanthin, a potent antioxidant and anti-inflammatory carotenoid, in the comprehensive management of OSMF. METHODS: A randomized, double-blind, placebo-controlled trial was conducted with 68 eligible participants diagnosed with OSMF...
February 2024: Curēus
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