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Hiroaki Yamane, Michihiro Ishida, Seisyu Banzai, Tetsushi Kubota, Soichiro Miyake, Yasuhiro Choda, Hitoshi Idani, Shigehiro Shiozaki, Masazumi Okajima
INTRODUCTION: Gastric cancer with features of a submucosal tumor (GCSMT) is rare, and the preoperative diagnosis is very difficult. We present a case of GCSMT diagnosed by endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) and boring biopsy (deeper biopsy), successfully treated with distal gastrectomy and lymph node dissection. PRESENTATION OF CASE: An 81-year-old man with a history of myocardial infarction and type 2 diabetes mellitus was admitted to our hospital for further examination of a gastric submucosal tumor...
February 8, 2019: International Journal of Surgery Case Reports
Saniyya Khan, Syeedul Hasan Arif, Imrana Naseem
Riboflavin (Rf) or vitamin B₂ is a known photosensitizer whose photophysical and photochemical properties are well established. Aminophylline (Am) is a phosphodiesterase inhibitor and is currently used as a bronchodilator. Although there are several reports of haemolytic and proteolytic interaction of photoilluminated riboflavin with aminophylline, the cytotoxicity of this system against malignant tissue is not well defined and fully unravelled. Here, we are evaluating anticancer activity of this system against B(a)P induced lung carcinoma in swiss albino mice...
February 15, 2019: Chemico-biological Interactions
Toshimitsu Iwasaki, Nobuyoshi Hiraoka, Yoshinori Ino, Kosei Nakajima, Yoji Kishi, Satoshi Nara, Minoru Esaki, Kazuaki Shimada, Hitoshi Katai
Neural invasion is one of the malignant features contributing to locally advanced and/or metastatic disease progression in patients with pancreatic ductal adenocarcinoma (PDAC). Few studies exist about the distribution and state of nerve fibers in PDAC tissue and about their clinicopathological impacts. The aim of this study was to investigate the clinicopathological characteristics and prognostic value of intrapancreatic neural alterations in patients with PDAC. We retrospectively analyzed 256 patients with PDAC who underwent macroscopic curative surgery...
February 18, 2019: Cancer Science
Yan L Ge, Cong H Liu, Meng H Wang, Li Q Li, Xiao Y Zhu, Zhen Z Li, Hong L Li, Hua L Yu, Qian Zhang, Zi Y Cui, Hai F Zhang, Xue Zhang, Ai-S Fu, Hong Y Wang
BACKGROUND: To report a case of broncholithiasis with recurrent hemoptysis and fever initially misdiagnosed as active tuberculosis. METHODS: The chest contrast-enhanced CT scan, electronic bronchoscope, and ultrathin bronchoscope were performed leading to the diagnosis of broncholithiasis, open lung lobectomy was done after thoracic surgery consultation. RESULTS: The chest contrast-enhanced CT scan showed a high-density intratracheal shadow and calcified lymph nodes...
January 1, 2019: Clinical Laboratory
Yan L Ge, Cong H Liu, Meng H Wang, Xiao Y Zhu, Qian Zhang, Zhen Z Li, Hong L Li, Zi Y Cui, Hai F Zhang, Xue Zhang, Hua L Yu, Ai S Fu, Hong Y Wang
BACKGROUND: High serum neuron-specific enolase (NSE) level has been in use as a tumor marker; however, some physicians may ignore NSE levels in serum, especially when the patients are asymptomatic. Here we report a case that a 51 year old female patient with no respiratory symptoms who had a NSE level which increased extremely over three months and was eventually diagnosed small cell lung cancer (SCLC). METHODS: Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in right pulmonary hilar enlarged lymph node was performed for diagnosis...
January 1, 2019: Clinical Laboratory
Kazuhiro Kobayashi, Naoki Watanabe, Teruaki Oka, Hiroyuki Tomita, Natsuko Suzui, Yasunori Oumi, Akira Hara, Tatsuhiko Miyazaki
A 73-year-old Japanese man, who worked at a confectionery company for more than 20 years, was diagnosed with a 28 mm nodular lesion in the superior lobe of the right lung by whole-body computed tomography examination. A biopsy revealed the presence of adenocarcinoma. With a diagnosis of a primary lung cancer, a right upper lobectomy was performed. A nodular lesion, 25 × 23 mm in size, was observed in the upper right lobe lung field, and was diagnosed histopathologically as a papillary adenocarcinoma...
February 18, 2019: Pathology International
Xiaoliu Liang, Ka Wu, Meizhen Liu, Bin Yang
Carbon tetrachloride (CCl4 ), a potent hepatotoxin, is linked to the histopathological outcomes of inflammatory or oxidative stress, and cell death. However, further study of additional dysmetabolism induced by CCl 4 toxicant has not yet been investigated. In current study, chronical and acute exposures of CCl 4 in mice were used to unmask the biological molecular mechanism responsible for insulin-dependent metabolic disorder. In experimental methods, a number of biochemical assays were used in assessment of biological impacts on insulin-produced pancreas and insulin-responsive hepatocyte after long- and short-term exposures of CCl 4 toxicant, respectively...
February 18, 2019: Journal of Cellular Biochemistry
Ahmet Altan, Mutan Hamdi Aras, İbrahim Damlar, Hasan Gökçe, Oğuzhan Özcan, Cansu Alpaslan
Purpose: This study aims to investigate the histopathological and biochemical effects of the topical application of Hypericum perforatum on the healing of surgical wounds created in the oral mucosa of rats with experimentally induced diabetes mellitus. Materials and methods: The study was carried out on 48 adult male Wistar albino rats. The animals were divided into two main groups as control and study groups. Two main groups were divided into three subgroups according to the sacrification days...
September 2018: European oral research
Nabeel Humayun Hassan, Rahila Usman, Muhammad Yousuf, Ahmad Nawaz Ahmad, Ismail Hirani
Objective: To determine the accuracy of transoral flexible laryngoscope (TFL) biopsy and also to identify the safety as office based procedure in terms of complications. Methods: This is a diagnostic study; the type of intervention is outpatient department based biopsy of laryngeal lesions. All patients seen in ENT outpatient department of Lyari General Hospital with suspicious lesions of Larynx were referred for Transoral Flexible Laryngoscopy Biopsy under local anesthesia...
March 2019: World Journal of Otorhinolaryngology—Head and Neck Surgery
Chinenye Jane Ugwah-Oguejiofor, Charles Ogbonna Okoli, Michael Oguejiofor Ugwah, Millicent Ladi Umaru, Chiedozie Smart Ogbulie, Halilu Emmanuel Mshelia, Mohammed Umar, Anoka Ayembe Njan
Caralluma dalzielii N. E. Brown (Asclepiadaceae) is a cactus-like shaped shrub widely used in traditional medicine for the treatment of rheumatoid arthritis, diabetes, infertility and impotence. The present study evaluated the potential toxicity of aqueous extract of aerial parts of Caralluma dalzielii (AECD) through acute and sub-acute oral administration in mice and rats. During acute toxicity study, female mice and rats were orally administered with AECD at single doses of 175, 500 and 2000 mg/kg according to OECD Guidelines 425...
January 2019: Heliyon
Ana Maria Hoyos Cadavid, Tathyane Harumi Nakajima Teshima, Clóvis Antônio Lopes Pinto, Cláudia Malheiros Coutinho Camillo, Silvia Vanessa Lourenço
Ameloblastoma with granular cell pattern (AGC) is classified as an unusual histological subtype of solid/multicystic ameloblastoma, characterized by granular changes in stellate-like cells located within the inner portion of the epithelial follicles. Studies have revealed that lysosomal overload causes cytoplasmic granularity; however, the mechanism involved remains poorly understood. Here we report on eight cases of granular cell ameloblastoma, in the posterior region of the mandible. The age of the patients included in this case series ranged from 35 -64 years old and 87...
October 2018: Autopsy & Case Reports
Priscila Lie Tobouti, Fernando Kendi Horikawa, Bruno Fernandes Matuck, Suzana Cantanhede Orsini Machado de Sousa, Fábio Abreu Alves
Oral focal mucinosis (OFM) is an uncommon, asymptomatic, submucosal, slow-growing nodule representing a counterpart of the cutaneous focal mucinosis (CFM). OFM has a female predilection with the highest prevalence in the fifth decade of life. About 68% of OFMs occur in the gingiva and 14% in the palate. We present the case of a 41-year-old woman presenting a progressively growing mass on the palate, since the last 8 months. The diagnostic workup led to the diagnosis of an unusual OFM with the clinical presentation involving the gingiva and hard palate...
October 2018: Autopsy & Case Reports
Lucinda Calheiros Guimarães, Priscila Leandro Garcia, João Badaró Castro, Antonio Carlos Oliveira Meneses
High-grade endometrial carcinomas are aggressive neoplasms of difficult histological classification. Neuroendocrine differentiation in endometrial carcinomas is rare. This is the report of an endometrial large cell neuroendocrine carcinoma with foci of melanocytic differentiation in a 75-year-old woman with abnormal post-menopausal uterine bleeding for 2 years. Two initial biopsies were inconclusive. Histopathological examination of the uterus revealed large cell neuroendocrine carcinoma associated with endometrioid carcinoma and foci of melanocytic differentiation, pT3a (FIGO IIIA)...
October 2018: Autopsy & Case Reports
Cristina Vico-Alonso, Uxúa Floristán-Muruzábal, Reyes Gamo-Villegas
No abstract text is available yet for this article.
January 2019: Dermatology Practical & Conceptual
Aris Spathis, Alexander C Katoulis, Vasileia Damaskou, Aikaterini I Liakou, Christine Kottaridi, Danai Leventakou, Dimitrios Sgouros, Andreas Mamantopoulos, Dimitrios Rigopoulos, Petros Karakitsos, Ioannis G Panayiotides
Background: BRAF mutations are a common finding in malignant melanoma (MM). Nevertheless, apart from their significance as a therapeutic target in advanced melanoma, their prognostic value is still debated. Objective: To assess BRAF mutation status in primary, recurrent, or metastatic MM and its correlations with histopathological findings. Methods: We analyzed 203 samples from 178 consecutive patients: 129 primary cutaneous MM, 49 metastatic and recurrent MM of unknown primary site, and 25 cases of recurrences or metastases of primary MM...
January 2019: Dermatology Practical & Conceptual
Maitseo K Nwako-Mohamadi, John E Masenga, David Mavura, Ola F Jahanpour, Eva Mbwilo, Andreas Blum
Background: Papulosquamous skin diseases can be challenging to diagnose, especially in dark skin. Dermoscopy is reported to be helpful, but few data are available on its use in skin type IV or darker. Objective: To describe dermoscopic features in plaque-type psoriasis (PP), lichen planus (LP), and pityriasis rosea (PR) patients attending the Regional Dermatology Training Centre in Moshi, Northern Tanzania, and to compare findings with published data. Methods: A descriptive cross-sectional study was conducted at a tertiary hospital from October 2016 to June 2017...
January 2019: Dermatology Practical & Conceptual
Michela Starace, Aurora Alessandrini, Nicolò Brandi, Bianca Maria Piraccini
The term melanonychia describes a black-brown-gray pigmentation of the nail plate that, in most cases, appears as a longitudinal band. Melanonychia can be observed at any age, affecting one digit or several digits, in both fingernails and toenails. Its causes can be difficult to differentiate clinically and depend on the number of bands and on their color, edge, and width. For this reason, especially in adults and when the pigmentation is localized in one single digit, biopsy and histopathological examination still represent the gold standard for a definitive diagnosis...
January 2019: Dermatology Practical & Conceptual
Marina Romero Navarrete, María-Elisa Vega Memije, Roberto Arenas Guzmán, Aureliano Castillo Solana, Gloria E Reyes López, Julieta Ruiz Esmenjaud
No abstract text is available yet for this article.
January 2019: Dermatology Practical & Conceptual
Mayank Goswami, Xinlei Wang, Pengfei Zhang, Wenwu Xiao, Sarah J Karlen, Yuanpei Li, Robert J Zawadzki, Marie E Burns, Kit S Lam, Edward N Pugh
In cancer research there is a fundamental need for animal models that allow the in vivo longitudinal visualization and quantification of tumor development, nanotherapeutic delivery, the tumor microenvironment including blood vessels, macrophages, fibroblasts, immune cells, and extracellular matrix, and the tissue response to treatment. To address this need, we developed a novel mouse ocular xenograft model. Green fluorescent protein (GFP) expressing human glioblastoma cells (between 500 and 10,000) were implanted into the subretinal space of immunodeficient mice (56 eyes)...
January 1, 2019: Biomedical Optics Express
Xu Feng, Matthew C Fox, Jason S Reichenberg, Fabiana C P S Lopes, Katherine R Sebastian, Mia K Markey, James W Tunnell
Achieving adequate margins during tumor margin resection is critical to minimize the recurrence rate and maximize positive patient outcomes during skin cancer surgery. Although Mohs micrographic surgery is by far the most effective method to treat nonmelanoma skin cancer, it can be limited by its inherent required infrastructure, including time-consuming and expensive on-site histopathology. Previous studies have demonstrated that Raman spectroscopy can accurately detect basal cell carcinoma (BCC) from surrounding normal tissue; however, the biophysical basis of the detection remained unclear...
January 1, 2019: Biomedical Optics Express
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