Rodolfo Molina-Pena, Natalia Ferreira, Charlotte Roy, Loris Roncali, Mathie Najberg, Sylvie Avril, Mariana Zarour, William Bourgeois, Alba Ferreiros, Chiara Lucchi, Francesco Cavalieri, François Hindré, Giovani Tosi, Giuseppe Biagini, Franco Valzania, François Berger, Miguel Abal, Audrey Rousseau, Frank Boury, Carmen Alvarez-Lorenzo, Emmanuel Garcion
In view of inevitable recurrences despite resection, glioblastoma (GB) is still an unmet clinical need. Dealing with the stromal-cell derived factor 1-alpha (SDF-1α)/CXCR4 axis as a hallmark of infiltrative GB tumors and with the resection cavity situation, the present study described the effects and relevance of a new engineered micro-nanostructured SF-HA-Hep aerogel sponges, made of silk fibroin (SF), hyaluronic acid (HA) and heparin (Hep) and loaded with SDF-1α, to interfere with the GB ecosystem and residual GB cells, attracting and confining them in a controlled area before elimination...
October 20, 2023: Acta Biomaterialia