keyword
https://read.qxmd.com/read/38533234/titanium-mesh-cranioplasty-for-cosmetically-disfiguring-cranio-facial-tumours-in-a-resource-limited-setting
#1
JOURNAL ARTICLE
C O Anele, S A Balogun, C O Ezeaku, T O Ajekwu, H E Omon, G O Ejembi, E O Komolafe
BACKGROUND: The aesthetic reconstruction of disfiguring cranio-facial defects after tumour excision can be quite challenging to the neurosurgeon with limited resources. The choice of cranioplasty implant, intraoperative technicalities and the patients' postoperative appearance are critical considerations in management. There are a number of synthetic materials available for cranioplasty, however, the customised implants are not readily available in our practice setup. They are also mostly constructed and contoured after the bony defect has been created or require sophisticated software construction pre-operatively...
July 2024: World neurosurgery: X
https://read.qxmd.com/read/38527238/bergaptol-inhibits-glioma-cell-proliferation-and-induces-apoptosis-via-stat3-bcl-2-pathway
#2
JOURNAL ARTICLE
Hao Huang, Junrong Zhang, Jianbing Wu, Chunfu Du, Bo Zheng, Zhangchao Guo, Ligang Chen, Deming Zhang, Luotong Liu
Glioblastoma (GBM) is the most common primary malignant brain tumour and lacks therapeutic options with significant effects. The aberrant activation of STAT3 is a critical factor in glioma progression via activating multiple signalling pathways that promote glioma. Among them, the antiapoptotic gene Bcl-2 could be upregulated by p-STAT3, which is an important reason for the continuous proliferation of glioma. We previously reported that bergaptol, a natural furanocoumarin widely found in citrus products, exerts antineuroinflammatory effects by inhibiting the overactivation of STAT3...
March 22, 2024: Anti-cancer Drugs
https://read.qxmd.com/read/38523543/evaluation-of-efficacy-of-curcumin-and-caffeic-acid-phenethyl-ester-in-breast-cancer-by-preclinical-studies
#3
JOURNAL ARTICLE
Sumit Singh Verma, Avadhesh, Ankit Srivastava, Anusmita Shekher, Anupam Dhasmana, Acharan Singh Narula, Subash Chandra Gupta
UNLABELLED: ims: The aim of this study was to evaluate the combined and comparative efficacy of Caffeic acid phenethyl ester (CAPE) and curcumin in breast cancer. BACKGROUND: CAPE and curcumin are a class of phenolics. While curcumin is obtained from turmeric, CAPE is found in Baccharis sarothroides and Populus deltoides. Both agents are reported to produce activities in some cancer types. The combined and comparative effects of the two agents in breast cancer have not yet reported...
March 21, 2024: Current Medicinal Chemistry
https://read.qxmd.com/read/38519394/integrin-%C3%AE-v%C3%AE-6-targeted-peptide-toxin-therapy-in-a-novel-%C3%AE-v%C3%AE-6-expressing-immunocompetent-model-of-pancreatic-cancer
#4
JOURNAL ARTICLE
Nicholas F Brown, Elizabeth R Murray, Lauren C Cutmore, Philip Howard, Luke Masterson, Francesca Zammarchi, John A Hartley, Patrick H van Berkel, John F Marshall
Previously we reported that a novel αvβ6-specific peptide-drug conjugate (SG3299) could eliminate established human pancreatic ductal adenocarcinoma (PDAC) xenografts. However the development of effective therapies for PDAC, which is an essential need, must show efficacy in relevant immunocompetent animals. Previously we reported that the KPC mouse transgenic PDAC model that closely recapitulates most stages of development of human PDAC, unlike in humans, failed to express αvβ6 on their tumours or metastases...
February 24, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38448658/lyophilized-lymph-nodes-for-improved-delivery-of-chimeric-antigen-receptor-t-cells
#5
JOURNAL ARTICLE
Jiaqi Shi, Wei Wu, Dong Chen, Ziyan Liao, Tao Sheng, Yanfang Wang, Yuejun Yao, Qing Wu, Feng Liu, Ruyi Zhou, Chaojie Zhu, Xinyuan Shen, Zhengwei Mao, Yuan Ding, Weilin Wang, Gianpietro Dotti, Jie Sun, Xiao Liang, Weijia Fang, Peng Zhao, Hongjun Li, Zhen Gu
Lymph nodes are crucial organs of the adaptive immune system, orchestrating T cell priming, activation and tolerance. T cell activity and function are highly regulated by lymph nodes, which have a unique structure harbouring distinct cells that work together to detect and respond to pathogen-derived antigens. Here we show that implanted patient-derived freeze-dried lymph nodes loaded with chimeric antigen receptor T cells improve delivery to solid tumours and inhibit tumour recurrence after surgery. Chimeric antigen receptor T cells can be effectively loaded into lyophilized lymph nodes, whose unaltered meshwork and cytokine and chemokine contents promote chimeric antigen receptor T cell viability and activation...
March 6, 2024: Nature Materials
https://read.qxmd.com/read/38413842/zebrafish-tumour-xenograft-models-a-prognostic-approach-to-epithelial-ovarian-cancer
#6
JOURNAL ARTICLE
Gabriel Lindahl, Sebastian Fjellander, Karthik Selvaraj, Malin Vildeval, Zaheer Ali, Rusul Almter, Anna Erkstam, Gabriela Vazquez Rodriguez, Annelie Abrahamsson, Åsa Rydmark Kersley, Anna Fahlgren, Preben Kjølhede, Stig Linder, Charlotta Dabrosin, Lasse Jensen
Epithelial ovarian cancer (EOC) is the gynaecological malignancy with highest mortality. Although adjuvant treatment with carboplatin and paclitaxel leads to an objective response in ~80% of these patients, a majority will relapse within two years. Better methods for assessing long-term treatment outcomes are needed. To address this, we established safe and efficacious doses of carboplatin and paclitaxel using IGROV-1 zebrafish-CDX models. Then fluorescently-labelled cell suspensions from 83 tumour biopsies collected at exploratory laparotomy of women with suspected EOC were generated and 37 (45%) were successfully implanted in zebrafish larvae...
February 27, 2024: NPJ Precision Oncology
https://read.qxmd.com/read/38391962/real-time-multiphoton-intravital-microscopy-of-drug-extravasation-in-tumours-during-acoustic-cluster-therapy
#7
JOURNAL ARTICLE
Jessica Lage Fernandez, Sofie Snipstad, Astrid Bjørkøy, Catharina de Lange Davies
Optimising drug delivery to tumours remains an obstacle to effective cancer treatment. A prerequisite for successful chemotherapy is that the drugs reach all tumour cells. The vascular network of tumours, extravasation across the capillary wall and penetration throughout the extracellular matrix limit the delivery of drugs. Ultrasound combined with microbubbles has been shown to improve the therapeutic response in preclinical and clinical studies. Most studies apply microbubbles designed as ultrasound contrast agents...
February 16, 2024: Cells
https://read.qxmd.com/read/38312958/dentinogenic-ghost-cell-tumour-in-childhood-involving-the-temporomandibular-joint-considerations-and-therapy
#8
JOURNAL ARTICLE
Jan Rustemeyer, Alexander Busch, Klaus Junker
BACKGROUND: Although the uncommon dentinogenic ghost cell tumour (DGCT) is a benign entity, it possesses the ability to cause widespread destruction of the jaws and to recur after bone-preserving therapy. Hence, clear margins should be achieved upon surgery, and reconstruction techniques must often be used to restore osseous defects. However, this can be challenging in cases with involvement of the temporomandibular joint (TMJ), and especially in children. CASE REPORT: We present a case of a DGCT in a 12-year-old boy with wide infiltration of the mandible and the TMJ...
February 2024: Journal of Maxillofacial and Oral Surgery
https://read.qxmd.com/read/38302657/a-clinically-relevant-computed-tomography-ct-radiomics-strategy-for-intracranial-rodent-brain-tumour-monitoring
#9
JOURNAL ARTICLE
Kate Connor, Emer Conroy, Kieron White, Liam P Shiels, Simon Keek, Abdalla Ibrahim, William M Gallagher, Kieron J Sweeney, James Clerkin, David O'Brien, Jane B Cryan, Philip J O'Halloran, Josephine Heffernan, Francesca Brett, Philippe Lambin, Henry C Woodruff, Annette T Byrne
Here, we establish a CT-radiomics based method for application in invasive, orthotopic rodent brain tumour models. Twenty four NOD/SCID mice were implanted with U87R-Luc2 GBM cells and longitudinally imaged via contrast enhanced (CE-CT) imaging. Pyradiomics was employed to extract CT-radiomic features from the tumour-implanted hemisphere and non-tumour-implanted hemisphere of acquired CT-scans. Inter-correlated features were removed (Spearman correlation > 0.85) and remaining features underwent predictive analysis (recursive feature elimination or Boruta algorithm)...
February 1, 2024: Scientific Reports
https://read.qxmd.com/read/38275817/a-new-systemic-disease-mouse-model-for-glioblastoma-capable-of-single-tumour-cell-detection
#10
JOURNAL ARTICLE
Thomas M B Ware, Rodney B Luwor, Hong-Jian Zhu
BACKGROUND: Glioblastoma is characterised by extensive infiltration into the brain parenchyma, leading to inevitable tumor recurrence and therapeutic failure. Future treatments will need to target the specific biology of tumour recurrence, but our current understanding of the underlying mechanisms is limited. Significantly, there is a lack of available methods and models that are tailored to the examination of tumour recurrence. METHODS: NOD-SCID mice were orthotopically implanted with luciferase-labelled donor U87MG or MU20 glioblastoma cells...
January 19, 2024: Cells
https://read.qxmd.com/read/38168770/gut-microbial-metabolite-facilitates-colorectal-cancer-development-via-ferroptosis-inhibition
#11
JOURNAL ARTICLE
Weiwei Cui, Meng Guo, Dong Liu, Peng Xiao, Chuancheng Yang, Haidi Huang, Chunhui Liang, Yinghong Yang, Xiaolong Fu, Yudan Zhang, Jiaxing Liu, Shuang Shi, Jingjing Cong, Zili Han, Yunfei Xu, Lutao Du, Chengqian Yin, Yongchun Zhang, Jinpeng Sun, Wei Gu, Renjie Chai, Shu Zhu, Bo Chu
The gut microbiota play a pivotal role in human health. Emerging evidence indicates that gut microbes participate in the progression of tumorigenesis through the generation of carcinogenic metabolites. However, the underlying molecular mechanism is largely unknown. In the present study we show that a tryptophan metabolite derived from Peptostreptococcus anaerobius, trans-3-indoleacrylic acid (IDA), facilitates colorectal carcinogenesis. Mechanistically, IDA acts as an endogenous ligand of an aryl hydrocarbon receptor (AHR) to transcriptionally upregulate the expression of ALDH1A3 (aldehyde dehydrogenase 1 family member A3), which utilizes retinal as a substrate to generate NADH, essential for ferroptosis-suppressor protein 1(FSP1)-mediated synthesis of reduced coenzyme Q10...
January 2, 2024: Nature Cell Biology
https://read.qxmd.com/read/38165447/is-there-still-an-indication-for-the-birmingham-hip-resurfacing-in-femoral-head-osteonecrosis
#12
JOURNAL ARTICLE
Serhat Akçaalan, Mehmet Can Kengil, Ceyhun Çağlar, Mahmut Uğurlu
PURPOSE: Osteonecrosis of the femoral head (ONFH) is a progressive hip disease. Hip resurfacing arthroplasty (HRA) is a preferred surgical procedure among hip arthroplasty performed in young patients. The aim of this study is to show the long-term clinical and radiological results of HRA procedures performed for patients suffering from ONFH. METHODS: Forty-five patients who underwent hip resurfacing with the diagnosis of femoral head osteonecrosis were included in the study...
January 2, 2024: International Orthopaedics
https://read.qxmd.com/read/38137959/long-term-survival-of-cellulose-sulphate-encapsulated-cells-and-metronomic-ifosfamide-control-tumour-growth-in-pancreatic-cancer-models-a-prelude-to-treating-solid-tumours-effectively-in-pets-and-humans
#13
JOURNAL ARTICLE
Brian Salmons, Walter H Gunzburg
BACKGROUND: The use of encapsulated cells for the in vivo delivery of biotherapeutics is a promising new technology to potentiate the effectiveness of cell-based therapies for veterinary and human application. One use of the technology is to locally activate chemotherapeutics to their short-lived highly active forms. We have previously shown that a stable clone of HEK293 cells overexpressing a cytochrome P450 enzyme that has been encapsulated in immunoprotective cellulose sulphate beads can be implanted near solid tumours in order to activate oxazaphosphorines such as ifosfamide and cyclophosphamide to the tumour-killing metabolite phosphoramide mustard...
December 18, 2023: Life
https://read.qxmd.com/read/38131275/oxygen-and-ph-responsive-theragnostic-liposomes-for-early-stage-diagnosis-and-photothermal-therapy-of-solid-tumours
#14
JOURNAL ARTICLE
Siyi Li, Qinglin Wang, Yingying Ren, Pengfei Zhong, Pengtao Bao, Shanyue Guan, Xiaochen Qiu, Xiaozhong Qu
The development of cancer treatment is of great importance, especially in the early stage. In this work, we synthesized a pH-sensitive amphiphilic ruthenium complex containing two alkyl chains and two PEG chains, which was utilized as an oxygen sensitive fluorescent probe for co-assembly with lipids to harvest a liposomal delivery system (RuPC) for the encapsulation of a photothermal agent indocyanine green (ICG). The resultant ICG encapsulated liposome (RuPC@ICG) enabled the delivery of ICG into cells via a membrane fusion pathway, by which the ruthenium complex was localized in the cell membrane for better detection of the extracellular oxygen concentration...
December 22, 2023: Biomaterials Science
https://read.qxmd.com/read/38101502/suppression-of-tumour-growth-from-transplanted-astrocytoma-cells-transfected-with-luciferase-in-mice-by-bioluminescence-mediated-systemic-photodynamic-therapy
#15
JOURNAL ARTICLE
Jane Ng, Nico Henriquez, Neil Kitchen, Norman Williams, Marco Novelli, Dahmane Oukrif, Alexander MacRobert, Stephen Bown
BACKGROUND: Grade 4 astrocytomas are usually incurable due to their diffusely infiltrative nature. Photodynamic therapy (PDT) is a promising therapeutic option, but external light delivery is impractical when cancer cells infiltrate unknown areas of normal brain. Hence the search for endogenous sources to generate light at cancer cells. In vitro, astrocytoma cells, transfected with firefly luciferase, can be killed by bioluminescence-mediated PDT (bPDT). This study asks if bPDT can suppress tumour growth in vivo, when all components of treatment are administered systemically...
December 13, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/38062911/obesity-worsens-mitochondrial-quality-control-and-does-not-protect-against-skeletal-muscle-wasting-in-murine-cancer-cachexia
#16
JOURNAL ARTICLE
Thomas D Cardaci, Brandon N VanderVeen, Brooke M Bullard, Sierra J McDonald, Christian A Unger, Reilly T Enos, Daping Fan, Kandy T Velázquez, Norma Frizzell, Espen E Spangenburg, E Angela Murphy
BACKGROUND: More than 650 million people are obese (BMI > 30) worldwide, which increases their risk for several metabolic diseases and cancer. While cachexia and obesity are at opposite ends of the weight spectrum, leading many to suggest a protective effect of obesity against cachexia, mechanistic support for obesity's benefit is lacking. Given that obesity and cachexia are both accompanied by metabolic dysregulation, we sought to investigate the impact of obesity on skeletal muscle mass loss and mitochondrial dysfunction in murine cancer cachexia...
December 7, 2023: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38048743/an-engineered-lymph-node-comprising-porous-collagen-scaffold-with-hybridized-biological-signals-embedded-in-b-cell-membrane-coatings
#17
JOURNAL ARTICLE
Bangheng Liu, Min Jin, Cheng Ma, Zhen Zhang, Liang Ma, Yi Zhang, Dong-An Wang
Complications can arise from damaging or removing lymph nodes after surgeries for malignant tumours. Our team has developed an innovative solution to recreate lymph nodes via an engineering approach. Using a Type II collagen scaffold coated with B cell membranes for the sake of attracting T cells in different regions, we could mimic the thymus-dependent and thymus-independent areas in vitro. This engineering strategy based on biophysical mimicry has a great potential for clinical applications. By further conjugating biological signals, anti-CD3/28, onto the scaffold coated with the B cell membrane, we achieved an 11...
November 30, 2023: Biomaterials
https://read.qxmd.com/read/37988238/sesamin-inhibits-rankl-induced-osteoclastogenesis-and-attenuates-lps-induced-osteolysis-via-suppression-of-erk-and-nf-%C3%AE%C2%BAb-signalling-pathways
#18
JOURNAL ARTICLE
Xiaolong Yu, Jiawei Hu, Xinming Yang, Qiang Xu, Hangjun Chen, Ping Zhan, Bin Zhang
Infection by bacterial products in the implant and endotoxin introduced by wear particles activate immune cells, enhance pro-inflammatory cytokines production, and ultimately promote osteoclast recruitment and activity. These factors are known to play an important role in osteolysis as well as potential targets for the treatment of osteolysis. Sesamin has been shown to have a variety of biological functions, such as inhibiting inflammation, anti-tumour and involvement in the regulation of fatty acid and cholesterol metabolism...
November 21, 2023: Journal of Cellular and Molecular Medicine
https://read.qxmd.com/read/37986043/risks-and-benefits-of-tips-in-hcc-and-other-liver-malignancies-a-literature-review
#19
REVIEW
Anna Fichtl, Thomas Seufferlein, Eugen Zizer
BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) is a well-validated treatment option for clinically significant portal hypertension (CSPH) in the context of liver cirrhosis. Its high efficacy and safety in the management of treatment-refractory ascites and variceal bleeding have been extensively proven. Contraindications for TIPS include severe right heart failure, hepatic encephalopathy, and sepsis. However, the role of liver malignancy in TIPS is debatable. Mostly, primary liver malignancies such as hepatocellular carcinoma (HCC) emerge from advanced liver diseases...
November 20, 2023: BMC Gastroenterology
https://read.qxmd.com/read/37982087/histopathology-and-indicators-of%C3%A2-borderline-ovarian-tumours-with-microinvasion-in%C3%A2-bitches
#20
Peter Makovicky, Peter Bolgac, Maria Makovicka, Karol Kajo, Zuzana Krchnikova, Jaroslav Pokoradi, Pavol Makovicky, Zuzana Stanova, Kristina Vaskova, Kvetoslava Rimarova
The authors present two cases of borderline ovarian tumours with microinvasion in bitches with variable clinical significance. The first case documents a four-year-old female Weimaraner diagnosed with a tumour on the right ovary during a veterinary check-up, using ultrasound (USG) examination, which was then surgically removed. Histological examination revealed a clear cell borderline tumour of the ovary with microinvasion. The second case is represented by a necropsy sample from a 52-month-old female German Shepherd who died a day before the planned hysterectomy due to undertreated pyometra...
April 2023: Veterinární Medicína
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