Giovanna Nascimento Scatolin, Hao Ming, Yinjuan Wang, Rajan Iyyappan, Emilio Gutierrez-Castillo, Linkai Zhu, Masroor Sagheer, Chao Song, Kenneth Bondioli, Zongliang Jiang
Supporting healthy pregnancy outcomes requires a comprehensive understanding of the molecular and cellular programs of peri-implantation development, when most pregnancy failure occurs. Here, we present single-cell transcriptomes of bovine peri-implantation embryo development at day 12, 14, 16, and 18 post-fertilization. We defined the cellular composition and gene expression of embryonic disc, hypoblast, and trophoblast lineages in bovine peri-implantation embryos, and identified markers and pathway signaling that represent distinct stages of bovine peri-implantation lineages; the expression of selected markers was validated in peri-implantation embryos...
April 19, 2024: IScience