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https://read.qxmd.com/read/30896825/the-pi3k-inhibitor-buparlisib-suppresses-osteoclast-formation-and-tumour-cell-growth-in-bone-metastasis-of-lung-cancer-as-evidenced-by-multimodality-molecular-imaging
#1
Shengfei Wang, Xiaomin Niu, Xiao Bao, Qin Wang, Jianping Zhang, Shun Lu, Yongjun Wang, Ling Xu, Mingwei Wang, Jie Zhang
Non‑small cell lung cancer (NSCLC) metastasis commonly occurs in bone, which often results in pathological fractures. Sustained phosphoinositide‑3‑kinase (PI3K) signalling promotes the growth of PI3K‑dependent NSCLC and elevates osteoclastogenic potential. The present study investigated the effects of a PI3K inhibitor on NSCLC growth in bone and osteoclast formation, and aimed to determine whether it could control symptoms associated with bone metastasis. A bone metastasis xenograft model was established by implanting NCI‑H460‑luc2 lung cancer cells, which contain a phosphatidylinositol‑​4,5‑bisphosphate 3‑kinase catalytic subunit α mutation, into the right tibiae of mice...
March 20, 2019: Oncology Reports
https://read.qxmd.com/read/30896772/outcomes-associated-with-sustained-release-intraocular-fluocinolone-implants-in-a-case-of-melanoma-associated-retinopathy-treated-without-systemic-immunosuppression
#2
Eleni Karatsai, Anthony G Robson, Simon R J Taylor
Importance: Melanoma-associated retinopathy (MAR) is a paraneoplastic syndrome in which antiretinal antibodies crossreact with retinal ON-bipolar cells, resulting in night blindness and progressive visual field loss. Current therapeutic options include cytoreductive surgery in combination with immunoglobulin, corticosteroids, or plasmapheresis, but their effectiveness is limited and may be contraindicated, given the possible protective role of circulating autoantibodies against metastatic spread...
March 21, 2019: JAMA Ophthalmology
https://read.qxmd.com/read/30896172/mitochondria-and-nuclei-dual-targeted-hollow-carbon-nanospheres-for-cancer-chemo-photodynamic-synergistic-therapy
#3
Ruizhi Xie, Shu Lian, Huayi Peng, Changhe OuYang, Shuhui Li, Yusheng Lu, Xuning Cao, Chen Zhang, Jianhua Xu, Lee Jia
Dual-targeted nanoparticles are gaining increasing importance as a more effective anticancer strategy by attacking double key sites of tumor cells, especially in chemo-photodynamic therapy. To retain the nuclei inhibition effect and enhance DOX-induced apoptosis by mitochondrial pathways simultaneously, we synthesized the novel nanocarrier (HKH) based on hollow carbon nitride nanosphere (HCNS) modified with hyaluronic acid (HA) and the mitochondrial localizing peptide D[KLAKLAK]2 (KLA). DOX-loaded HKH nanoparticles (HKHD) showed satisfactory drug loading efficiency, excellent solubility and very low hemolytic effect...
March 21, 2019: Molecular Pharmaceutics
https://read.qxmd.com/read/30896076/p34hb-electrospun-fibres-promote-bone-regeneration-in-vivo
#4
Na Fu, Zhaosong Meng, Tiejun Jiao, Xiaoding Luo, Zisheng Tang, Bofeng Zhu, Lei Sui, Xiaoxiao Cai
OBJECTIVE: Bone tissue engineering was introduced in 1995 and provides a new way to reconstruct bone and repair bone defects. However, the design and fabrication of suitable bionic bone scaffolds are still challenging, and the ideal scaffolds in bone tissue engineering should have a three-dimensional porous network, good biocompatibility, excellent biodegradability and so on. The purpose of our research was to investigate whether a bioplasticpoly3-hydroxybutyrate4-hydroxybutyrate (P34HB) electrospun fibre scaffold is conducive to the repair of bone defects, and whether it is a potential scaffold for bone tissue engineering...
March 21, 2019: Cell Proliferation
https://read.qxmd.com/read/30895713/sinus-floor-elevation-using-particulate-plga-coated-biphasic-calcium-phosphate-bone-graft-substitutes-a-prospective-histological-and-radiological-study
#5
Antonio J Flichy-Fernández, Juan A Blaya-Tárraga, Francisco O'Valle, Miguel Padial-Molina, Miguel Peñarrocha-Diago, Pablo Galindo-Moreno
BACKGROUND: Poly (lactic-co-glycolic acid) (PLGA) is widely used for the development of delivery systems for drugs and therapeutic biomolecules in tissue engineering applications. Particles of biphasic calcium phosphate can be covered by PLGA to change their manipulating characteristics. PURPOSE: Aim of this study was to investigate the radiological and histomorphometric results of the use of PLGA-coated biphasic calcium phosphate granules in sinus floor elevation and to analyze the underlying molecular processes by immunohistochemical staining...
March 20, 2019: Clinical Implant Dentistry and related Research
https://read.qxmd.com/read/30895145/dynamic-imaging-of-the-effect-of-mesenchymal-stem-cells-on-osteoclast-precursor-cell-chemotaxis-for-bone-defects-in-the-mouse-skull
#6
Takaharu Abe, Keisuke Sumi, Ryo Kunimatsu, Nanae Oki, Yuji Tsuka, Kengo Nakajima, Kotaro Tanimoto
Background/purpose: Mesenchymal stem cells (MSCs) transplantation has previously been used in the field of regenerative medicine. Although bone regeneration is known to occur through the interaction between osteoblasts and osteoclasts, the effect of MSCs on osteoclasts is unknown. Therefore, the purpose of this study was to investigate the effect of MSCs on the chemotaxis of osteoclast precursor cells (RAW264 macrophage cells). Materials and methods: Bone defects were created in mice skulls, and MSCs and a scaffold of carbonated hydroxyapatite were transplanted into the bone defects...
December 2018: Journal of Dental Sciences
https://read.qxmd.com/read/30895131/the-effect-of-plasma-treatment-on-the-osseointegration-of-rough-titanium-implant-a-histo-morphometric-study-in-rabbits
#7
Wan-Ching Chou, Rex C-C Wang, Chih-Ling Huang, Tzer-Min Lee
Abstract Background/purpose: The surface properties, such as hydrophilicity and functional OH groups, play an important role in bone fixation in vivo . In our previous study, the plasma treatments of large grit and acid etching (SLA) method produce functional OH groups on the rough surface. There is no report in discussing the integration between basic Ti-OH groups and bone-to-implant contact (BIC). The aim of this study was to evaluate the effect of the functional OH groups on the rough surface both in vitro and in vivo ...
September 2018: Journal of Dental Sciences
https://read.qxmd.com/read/30894630/a-novel-ex-vivo-tumor-system-identifies-src-mediated-invasion-and-metastasis-in-mesenchymal-tumor-cells-in-non-small-cell-lung-cancer
#8
Aparna Padhye, Christin Ungewiss, Jared J Fradette, B Leticia Rodriguez, Jacob L Albritton, Jordan S Miller, Don L Gibbons
Lung cancer is the foremost cause of cancer related deaths in the U.S. It is a heterogeneous disease composed of genetically and phenotypically distinct tumor cells surrounded by heterotypic cells and extracellular matrix dynamically interacting with the tumor cells. Research in lung cancer is often restricted to patient-derived tumor specimens, in vitro cell cultures and limited animal models, which fail to capture the cellular or microenvironment heterogeneity of the tumor. Therefore, our knowledge is primarily focused on cancer-cell autonomous aberrations...
March 20, 2019: Scientific Reports
https://read.qxmd.com/read/30894514/resveratrol-inhibits-decidualization-by-accelerating-downregulation-of-the-crabp2-rar-pathway-in-differentiating-human-endometrial-stromal-cells
#9
Asako Ochiai, Keiji Kuroda, Rie Ozaki, Yuko Ikemoto, Keisuke Murakami, Joanne Muter, Akemi Matsumoto, Atsuo Itakura, Jan J Brosens, Satoru Takeda
Pregnancy critically depends on the transformation of the human endometrium into a decidual matrix that controls embryo implantation and placenta formation, a process driven foremost by differentiation and polarization of endometrial stromal cells into mature and senescent decidual cells. Perturbations in the decidual process underpin a spectrum of prevalent reproductive disorders, including implantation failure and early pregnancy loss, emphasizing the need for new therapeutic interventions. Resveratrol is a naturally occurring polyphenol, widely used for its antioxidant and anti-inflammatory properties...
March 20, 2019: Cell Death & Disease
https://read.qxmd.com/read/30893909/mechanical-and-cytocompatibility-evaluation-of-uhmwpe-pcl-bioglass-%C3%A2-fibrous-composite-for-acetabular-labrum-implant
#10
Adhi Anindyajati, Philip Boughton, Andrew J Ruys
In this study, a fibrous composite was developed as synthetic graft for labral reconstruction treatment, comprised of ultra-high molecular weight polyethylene (UHMWPE) fabric, ultrafine fibre of polycaprolactone (PCL), and 45S5 Bioglass® . This experiment aimed to examine the mechanical performance and cytocompatibility of the composite. Electrospinning and a slurry dipping technique were applied for composite fabrication. To assess the mechanical performance of UHMWPE, tensile cyclic loading test was carried out...
March 19, 2019: Materials
https://read.qxmd.com/read/30893783/prototype-orthopedic-bone-plates-3d-printed-by-laser-melting-deposition
#11
Diana Chioibasu, Alexandru Achim, Camelia Popescu, George E Stan, Iuliana Pasuk, Monica Enculescu, Stefana Iosub, Liviu Duta, Andrei Popescu
Laser melting deposition is a 3D printing method usually studied for the manufacturing of machine parts in the industry. However, for the medical sector, although feasible, applications and actual products taking advantage of this technique are only scarcely reported. Therefore, in this study, Ti6Al4V orthopedic implants in the form of plates were 3D printed by laser melting deposition. Tuning of the laser power, scanning speed and powder feed rate was conducted, in order to obtain a continuous deposition after a single laser pass and to diminish unwanted blown powder, stuck in the vicinity of the printed elements...
March 19, 2019: Materials
https://read.qxmd.com/read/30892939/integrin-%C3%AE-7-signaling-regulates-connexin-43-m-cadherin-and-myoblast-fusion
#12
Michael J McClure, Allison N Ramey, Mashaba Rashid, Barbara D Boyan, Zvi Schwartz
Regenerative medicine treatments for severe skeletal muscle injuries are limited, resulting in persistent functional deficits. Clinical options include neglecting the wound with the expectation that fibrosis will develop, or using an autologous muscle graft with minimal functional improvement. A regenerative matrix can be used, but muscle fiber development on these matrices remains a challenge in vivo. Here, we explored the fundamental mechanisms that mediate cell-substrate signaling and its effect on cell-cell communication during myoblast fusion and tube formation in order to improve outcomes following implantation of matrices used to stimulate muscle regeneration...
March 20, 2019: American Journal of Physiology. Cell Physiology
https://read.qxmd.com/read/30892289/cell-phone-radiation-effect-on-bone-to-implant-osseointegration-a-preliminary-histologic-evaluation-in-rabbits
#13
M Kavyashree, P V Harish, Sunil Kumar Mishra, Ramesh Chowdhary
BACKGROUND AND PURPOSE: The increased use of cell phones has raised many questions as to whether their use is safe for patients with dental implants. This study aimed to assess the consequences of cell phone-emitted radiation on bone-to-implant osseointegration during the healing phase. MATERIALS AND METHODS: Twelve rabbits were grouped into three groups of four. Group 1 (control) was not exposed to electromagnetic radiation; group 2 (test) was exposed for 8 hours/day in speech mode and 16 hours/day in standby mode; and group 3 (test) was exposed for 24 hours continuously in standby mode for 3 months...
February 19, 2019: International Journal of Oral & Maxillofacial Implants
https://read.qxmd.com/read/30892225/highly-adherent-parylene-c-coatings-with-nanostructuring-for-enhanced-cell-adhesion-and-growth
#14
Silvan Staufert, Harun Torlakcik, Salvador Pane, Christofer Hierold
Parylene-C is a frequently used polymeric thinfilm coating in medical applications and is known for its excellent biocompatibility and flexible deposition process. However, its use in long-term implants is limited due to its poor adhesion to metals in liquid environments. In this work we present a strategy to anchor Parylene-C to medical grade titanium (Ti) by means of nanostructuring the Ti substrates surface prior to Parylene coating. We observe that, after aging in physiological salt solution for 3 days, Parylene coating lose their adhesion to bare titanium surfaces...
March 15, 2019: IEEE Transactions on Nanobioscience
https://read.qxmd.com/read/30891583/anti-leukemic-and-anti-angiogenic-effects-of-d-limonene-on-k562-implanted-c57bl-6-mice-and-the-chick-chorioallantoic-membrane-model
#15
Bhavini B Shah, Ruma Baksi, Kiranj K Chaudagar, Manish Nivsarkar, Anita A Mehta
Background: d-Limonene, a monoterpene from citrus fruit has been found to have chemopreventive and chemotherapeutic activities in various types of cancers. In this study, we evaluated the in vivo effect of d-Limonene on a K562-induced model of chronic myeloid leukemia (CML) in C57BL/6 mice. Method: The tail vein injection model of K562 cells in immunocompromised C57BL/6 mice was developed and evaluated for characteristics of the disease. The mice were treated with d-Limonene and evaluated for haematological parameters...
December 2018: Animal Models and Experimental Medicine
https://read.qxmd.com/read/30890745/effect-of-trans-no-oh-ruft-cl-oh-no-pf-6-ruthenium-nitrosyl-complex-on-methicillin-resistant-staphylococcus-epidermidis
#16
Mathilde Bocé, Marine Tassé, Sonia Mallet-Ladeira, Flavien Pillet, Charlotte Da Silva, Patricia Vicendo, Pascal G Lacroix, Isabelle Malfant, Marie-Pierre Rols
Antibiotic resistance is becoming a global scourge with 700,000 deaths each year and could cause up to 10 million deaths by 2050. As an example, Staphylococcus epidermidis has emerged as a causative agent of infections often associated with implanted medical devices. S. epidermidis can form biofilms, which contribute to its pathogenicity when present in intravascular devices. These staphylococci, embedded in the biofilm matrix, are resistant to methicillin, which had long been the recommended therapy and which has nowadays been replaced by less toxic and more stable therapeutic agents...
March 19, 2019: Scientific Reports
https://read.qxmd.com/read/30890311/amniotic-fluid-an-effective-factor-for-umbilical-cord-blood-hematopoietic-stem-cells-in-cell-culture-an-approach-for-bone-marrow-transplantation
#17
Tayebe Torabi, Saeid Abroun
Bone marrow transplantation is a treatment used for hematologic and non-hematologic disorders. A theory suggests that proliferation of cells in non-body condition helps to increase the efficiency of bone marrow transplant. There are different ways for proliferation of stem cells, in which, most studies have focused on stem cell culture in body-like conditions. The use of amniotic fluid as a rich resource of growth factors is developing in repair of tissues cornea. With regards to this condition, we discuss about the influence of amniotic fluid in proliferation and implantation of blood stem cells...
January 25, 2019: Transfusion and Apheresis Science
https://read.qxmd.com/read/30890265/influence-of-bioactive-glass-coating-of-zirconia-implant-surfaces-on-human-osteoblast-behavior-in-vitro
#18
Nadja Rohr, J Barbara Nebe, Fredy Schmidli, Petra Müller, Michael Weber, Horst Fischer, Jens Fischer
OBJECTIVE: The recently developed bioactive glass PC-XG3, which is suitable to coat zirconia implant surfaces with high adhesion strength may reduce the time of osseointegration and the marginal bone loss following implantation. The glass composition has been previously evaluated for cytotoxicity on fibroblast cells, and will now be used to evaluate the cell behavior of osteoblast cells. METHODS: Three different surface morphologies were created with PC-XG3 on zirconia discs...
March 16, 2019: Dental Materials: Official Publication of the Academy of Dental Materials
https://read.qxmd.com/read/30890220/preparation-of-adenosine-loaded-electrospun-nanofibers-and-their-application-in-bone-regeneration
#19
Lin Zhong, DanRong Hu, Ying Qu, JinRong Peng, KangKang Huang, MinYi Lei, Tinkui Wu, Yao Xiao, YingChun Gu, ZhiYong Qian
The possibility of composite nanofibers being able to regenerate bone is an attractive proposition. Adenosine, which occurs naturally in humans, has been shown to promote the osteogenic differentiation of mesenchymal stem cells (MSCs) and osteoprogenitor cells. In this study, electrospun nanofibers of poly(3-hydroxybutyrate- co -3-hydroxybutyrate) (PHBV) doped with adenosine were demonstrated to exhibit excellent capacity for bone regeneration, after optimization of the electrospinning process. The biomechanical properties, hydrophilicity, biocompatibility, cellular performance of the nanofibers and adenosine release profile from the composite nanofibers were evaluated...
May 1, 2019: Journal of Biomedical Nanotechnology
https://read.qxmd.com/read/30889930/antimicrobial-films-based-on-nanocomposites-of-chitosan-poly-vinyl-alcohol-graphene-oxide-for-biomedical-applications
#20
Sebastián Ruiz, Julián Andrés Tamayo, Johannes Delgado Ospina, Diana Paola Navia Porras, Mayra Eliana Valencia Zapata, José Herminsul Mina Hernandez, Carlos Humberto Valencia, Fabio Zuluaga, Carlos David Grande Tovar
Today, tissue regeneration is one of the greatest challenges in the field of medicine, since it represents hope after accidents or illnesses. Tissue engineering is the science based on improving or restoring tissues and organs. In this work, five formulations of chitosan/poly(vinyl alcohol)/graphene oxide (CS/PVA/GO) nanocomposites were studied for the development of biodegradable films with potential biomedical applications. The characterization of the films consisted of Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS)...
March 18, 2019: Biomolecules
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