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https://read.qxmd.com/read/30763957/-prophylaxis-of-recurrent-cytomegalovirus-uveitis-with-topical-ganciclovir
#1
Christof Hänsli, Fabio Meier, Daniel Barthelmes, Christian Böni
PURPOSE: Cytomegalovirus (CMV) can cause recurrent or chronic hypertensive anterior uveitis in immunocompetent patients. Antiviral treatment options include topical ganciclovir or systemic valganciclovir. However, recurrences are common after stopping treatment. We evaluated the efficacy of long-term topical ganciclovir therapy as prophylaxis for recurrent activity. METHODS AND PATIENTS: Retrospective analysis of all CMV uveitis patients seen between 2011 and 2018 at Zurich University Hospital...
February 14, 2019: Klinische Monatsblätter Für Augenheilkunde
https://read.qxmd.com/read/30763278/tricuspid-regurgitation-and-the-right-ventricle-risk-stratification-and-timing-of-intervention
#2
REVIEW
Bushra Rana, Shaun Robinson, Rajeevan Francis, Mark Toshner, Martin J Swaans, Sharad Agarwal, Ravi De Silva, Amer A Rana, Petros Nihoyannopoulos
Tricuspid regurgitation natural history and treatment remain poorly understood. Right ventricular function is a key factor in determining prognosis, timing for intervention and longer-term outcome. The right ventricle is a thin-walled chamber with a predominance of longitudinal fibres and a shared ventricular septum. In health, the low-pressure pulmonary circulation results in a highly compliant RV well equipped to respond to changes in preload but sensitive to even small alterations in afterload. In the first of two articles, discussion focuses on key principles of ventricular function assessment and the importance of right ventricular chamber size, volumes and ejection fraction, particularly in risk stratification in tricuspid regurgitation...
February 1, 2019: Echo Research and Practice
https://read.qxmd.com/read/30755356/numerical-model-of-aqueous-humor-drainage-effects-of-collector-channel-position
#3
G J Martínez Sánchez, C Escobar Del Pozo, J A Rocha Medina
Glaucoma is a progressive and a degenerative eye disease that gradually deteriorates the vision. The origin of glaucoma is still under debate. Recent studies report that 50% of the aqueous humor outflow resistance resides on collector channels and Schlemm's canal (SC). This paper provides a descriptive analysis of the aqueous humor outflow through the anterior chamber, the trabecular meshwork (TM) and the SC. The aim of this work is to determine the influence of the collector channels position on the intraocular pressure (IOP) and its contribution to the development of glaucoma...
February 9, 2019: Medical Engineering & Physics
https://read.qxmd.com/read/30755202/srage-and-early-signs-of-cardiac-target-organ-damage-in-mild-hypertensives
#4
Andrea Maria Maresca, Luigina Guasti, Sara Bozzini, Christian Mongiardi, Nicolò Tandurella, Rossana Corso, Francesco G Zerba, Alessandro Squizzato, Leonardo Campiotti, Francesco Dentali, Catherine Klersy, Anna M Grandi, Colomba Falcone
BACKGROUND: Soluble Receptor for Advanced Glycation End Products (sRAGE) may be considered a marker inversely related to inflammation and its participation has been established in patients with advanced atherosclerotic vascular diseases. However, it is still unknown whether sRAGE reduction could be early metabolic change in the first stage of hypertension and initial hypertension-associated cardiac damage. We sought to determine the sRAGE values in otherwise healthy, untreated and recently diagnosed mild hypertensives and evaluate their association with blood pressure (BP) values, metabolic parameters, and with subclinical initial signs of cardiac target organ damage (TOD)...
February 12, 2019: Cardiovascular Diabetology
https://read.qxmd.com/read/30753867/dacomitinib-a-new-pan-egfr-inhibitor-is-effective-in-attenuating-pulmonary-vascular-remodeling-and-pulmonary-hypertension
#5
Xiufeng Yu, Xijuan Zhao, Junting Zhang, YiYing Li, Ping Sheng, Cui Ma, Lixin Zhang, XueWei Hao, XiaoDong Zheng, Yan Xing, Hui Qiao, Lihui Qu, Daling Zhu
Accumulating evidence suggests that epidermal growth factor receptor (EGFR) plays a role in the progression of pulmonary arterial hypertension (PAH). Clinically-approved epidermal growth factor inhibitors such as gefitinib, erlotinib, and lapatinib have been explored for PAH . However, None of them were able to attenuate PAH . So, we explored the role of dacomitinib, a new pan-EGFR inhibitor, in PAH. Adult male Sprague-Dawley rats were used to study hypoxia- or monocrotaline-induced right ventricular remodeling as well as systolic function and hemodynamics using echocardiography and a pressure-volume admittance catheter...
February 9, 2019: European Journal of Pharmacology
https://read.qxmd.com/read/30747546/how-to-predict-intraocular-pressure-reduction-after-cataract-surgery-a-prospective-study
#6
Claudio I Perez, Sunee Chansangpetch, Anwell Nguyen, Max Feinstein, Marta Mora, Mai Badr, Marisse Masis, Travis Porco, Shan C Lin
Purpose/Aim: To evaluate the best formula to predict intraocular pressure (IOP) reduction after cataract surgery. MATERIALS AND METHODS: Prospective longitudinal study. We included consecutive patients with or without glaucoma, either with open or narrow angles but without peripheral anterior synechiae, who underwent phacoemulsification. Clinical factors and anterior segment parameters measured with optical biometry and optical coherence tomography were evaluated as preoperative predictors for IOP reduction at 6 months postoperatively...
February 12, 2019: Current Eye Research
https://read.qxmd.com/read/30746828/hyperoxygenation-revitalizes-alzheimer-s-disease-pathology-through-the-upregulation-of-neurotrophic-factors
#7
Juli Choi, Hye-Jin Kwon, Jung-Eun Lee, Yunjin Lee, Ju-Young Seoh, Pyung-Lim Han
Alzheimer's disease (AD) is a neurodegenerative disease characterized by Aβ-induced pathology and progressive cognitive decline. The incidence of AD is growing globally, yet a prompt and effective remedy is not available. Aging is the greatest risk factor for AD. Brain aging proceeds with reduced vascularization, which can cause low oxygen (O2 ) availability. Accordingly, the question may be raised whether O2 availability in the brain affects AD pathology. We found that Tg-APP/PS1 mice treated with 100% O2 at increased atmospheric pressure in a chamber exhibited markedly reduced Aβ accumulation and hippocampal neuritic atrophy, increased hippocampal neurogenesis, and profoundly improved the cognitive deficits on the multiple behavioral test paradigms...
February 11, 2019: Aging Cell
https://read.qxmd.com/read/30737530/hemodynamics-of-paradoxical-severe-aortic-stenosis-insight-from-a-pressure-volume-loop-analysis
#8
Michael Gotzmann, Sabine Hauptmann, Maximilian Hogeweg, Dinah S Choudhury, Fabian Schiedat, Johannes W Dietrich, Timm H Westhoff, Martin Bergbauer, Andreas Mügge
BACKGROUND: Controversy exists about the pathophysiology of different hemodynamic subgroups of AS. In particular, the mechanism of the paradoxical low-flow, low-gradient (PLFLG) AS with preserved ejection fraction (EF) is unclear. METHODS: A total of 41 patients with severe, symptomatic AS were divided into the following 4 subgroups based on the echocardiographically determined hemodynamics: (1) normal-flow, high-gradient (NFHG) AS; (2) low-flow, high-gradient AS; (3) paradoxical low-flow, low-gradient (PLFLG) AS with preserved EF and (4) low-flow, low-gradient (LFLG) AS with reduced EF...
February 8, 2019: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://read.qxmd.com/read/30717452/correction-of-experimental-retinal-ischemia-by-l-isomer-of-ethylmethylhydroxypyridine-malate
#9
Anna Peresypkina, Anton Pazhinsky, Mikhail Pokrovskii, Evgenya Beskhmelnitsyna, Anna Pobeda, Mikhail Korokin
An important task of pharmacology and ophtalmology is to find specific and highly effective agents for correcting retinal ischemia. The objective of this study is to increase the effectiveness of pharmacological correction of retinal ischemia by using new 3-hydroxypyridine derivative⁻l-isomer of ethylmethylhydroxypyridine malate. A modification to the retinal ischemia-reperfusion model was used, in which an increase in intraocular pressure is carried out by mechanical pressure (110 mmHg) to the front chamber of the eye for 30 min...
February 3, 2019: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/30717224/micro-surface-and-interfacial-tensions-measured-using-the-micropipette-technique-applications-in-ultrasound-microbubbles-oil-recovery-lung-surfactants-nanoprecipitation-and-microfluidics
#10
REVIEW
David Needham, Koji Kinoshita, Anders Utoft
This review presents a series of measurements of the surface and interfacial tensions we have been able to make using the micropipette technique. These include: equilibrium tensions at the air-water surface and oil-water interface, as well as equilibrium and dynamic adsorption of water-soluble surfactants and water-insoluble and lipids. At its essence, the micropipette technique is one of capillary-action, glass-wetting, and applied pressure. A micropipette, as a parallel or tapered shaft, is mounted horizontally in a microchamber and viewed in an inverted microscope...
February 1, 2019: Micromachines
https://read.qxmd.com/read/30716332/the-heart-function-as-a-motor-brake-system
#11
Ivan Colorado Cervantes, Vittorio Sansalone, Luciano Teresi
The controversy between passive and active ventricular filling has been debated for decades and the question about the existence of an active diastole remains open. In this work, we advocate the model of active diastole by considering the heart as a suction pump and we add some more clues to support this point of view by the analysis of the pressure-volume (PV) loops of the left heart, comprising of the left ventricle (LV) and atrium (LA). Our working hypothesis is based on the dichotomy motor-brake: the cardiac muscle can act as a motor, when shortening against a load, or as a brake, when lengthening to a load...
February 1, 2019: Journal of Theoretical Biology
https://read.qxmd.com/read/30713266/deionized-water-can-substitute-common-bleaching-agents-for-nonvital-tooth-bleaching-when-treated-with-non-thermal-atmospheric-plasma
#12
Burak Çelik, İsmail D Çapar, Fatma İbiş, Necdet Erdilek, Utku K Ercan
The bleaching efficacy of common bleaching agents and deionized water treated with non-thermal atmospheric pressure plasma in the pulp chamber for nonvital tooth bleaching was evaluated. A total of 120 extracted human maxillary first incisors were stained using human blood. Teeth were randomly divided into eight groups (n = 15). In the first four groups, teeth were bleached using 35% hydrogen peroxide gel, 37% carbamide peroxide gel, 2:1 (w/v) sodium perborate paste, and deionized water for 30 min. In the remaining groups, bleaching agents were treated with non-thermal atmospheric plasma for 5 min inside the pulp chamber...
February 1, 2019: Journal of Oral Science
https://read.qxmd.com/read/30710956/conversational-speech-levels-and-signal-to-noise-ratios-in-realistic-acoustic-conditions
#13
Adam Weisser, Jörg M Buchholz
Estimating the basic acoustic parameters of conversational speech in noisy real-world conditions has been an elusive task in hearing research. Nevertheless, these data are essential ingredients for speech intelligibility tests and fitting rules for hearing aids. Previous surveys did not provide clear methodology for their acoustic measurements and setups, were opaque about their samples, or did not control for distance between the talker and listener, even though people are known to adapt their distance in noisy conversations...
January 2019: Journal of the Acoustical Society of America
https://read.qxmd.com/read/30709226/a-washer-gun-plasma-system-for-microwave-plasma-interaction-experiments
#14
Anitha V P, Priyavandana J Rathod, Jayesh Raval, Renu Bahl, Y C Saxena
A washer-gun based plasma system has been developed to enable high power microwave (HPM)-plasma interaction in a system for microwave plasma experiments. The critical pre-requisites of the plasma are density, ne ∼ (1-10) × 1017 m-3 , uniformity over a radial extent ≈10 cm and axial extent ≈20-30 cm, an axial density gradient of scale-length Ln ≈ wavelength of HPM, and ambient pressure low enough to maintain electron-neutral collision frequency much less than plasma frequency. The system developed deploys a ten stage pulse forming network, discharged to the washer-gun to produce pulsed (τpulse ∼ 100 μs) discharges that get ejected into an experimental chamber...
January 2019: Review of Scientific Instruments
https://read.qxmd.com/read/30707718/axial-length-and-its-associations-in-a-russian-population-the-ural-eye-and-medical-study
#15
Mukharram M Bikbov, Gyulli M Kazakbaeva, Timur R Gilmanshin, Rinat M Zainullin, Inga I Arslangareeva, Venera F Salavatova, Guzel M Bikbova, Songhomitra Panda-Jonas, Nikolai A Nikitin, Artur F Zaynetdinov, Ildar F Nuriev, Renat I Khikmatullin, Yulia V Uzianbaeva, Dilya F Yakupova, Said K Aminev, Jost B Jonas
PURPOSE: To assess the normal distribution of axial length and its associations in a population of Russia. METHODS: The population-based Ural Eye and Medical Study included 5,899 (80.5%) individuals out of 7328 eligible individuals aged 40+ years. The participants underwent an ocular and systemic examination. Axial length was measured sonographically (Ultra-compact A/B/P ultrasound system, Quantel Medical, Cournon d'Auvergne, France). RESULTS: Biometric data were available for 5707 (96...
2019: PloS One
https://read.qxmd.com/read/30707382/effect-of-hydrogen-addition-on-performance-emission-and-combustion-characteristics-of-deccan-hemp-oil-and-its-methyl-ester-fuelled-ci-engine
#16
Kamalakannan Jayaraman, Geetha Narayanasamy Babu, Gopinath Dhandapani, Edwin Geo Varuvel
A vegetable oil-fueled diesel engine operation is characterized by low brake thermal efficiency and relatively high smoke emission. Conversion of vegetable oil to biodiesel results in slight improvement in efficiency and smoke emission, but the values are not comparable with diesel. In this work, a single-cylinder diesel engine's performance is evaluated by inducting hydrogen in small quantities in the intake manifold along with Deccan hemp oil (DHO) and its methyl ester (DHOME) as the pilot fuel. The tests were conducted at part-load and full-load conditions at an engine speed of 1500 rpm...
February 1, 2019: Environmental Science and Pollution Research International
https://read.qxmd.com/read/30702893/synchrotron-radiation-applied-to-real-time-studies-of-the-kinetics-of-growth-of-aluminum-nitride-thin-multilayers
#17
Javier García Molleja, Juan Bürgi, Guinther Kellermann, Aldo F Craievich, Regis Neuenschwander, Pierre-Yves Jouan, Mohamed Abdou Djouadi, Mattia Piccoli, Edoardo Bemporad, Daniele De Felicis, Jorge N Feugeas
This article reports the design, construction and first use of an experimental device consisting of a specially designed vacuum chamber equipped with a reactive sputtering magnetron (RSM) to be used for controlled deposition of thin films on a Si (100) flat substrate. The setup was designed to allow for in situ and real-time recordings of X-ray diffraction patterns during the growth of the deposited films and was installed in the X-ray Diffraction and Spectroscopy beam line emerging from a superconducting wiggler source at the Brazilian Synchrotron Light Laboratory...
January 31, 2019: Journal of Physical Chemistry. B
https://read.qxmd.com/read/30701715/twenty-years-of-clinical-experience-with-cardiac-myxomas-diagnosis-treatment-and-follow-up
#18
Tomás Francisco Cianciulli, Alberto Cozzarin, Juan Bautista Soumoulou, María Cristina Saccheri, Ricardo José Méndez, Martín Alejandro Beck, Juan Alberto Gagliardi, Jorge Alberto Lax
BACKGROUND: Cardiac myxomas are the most frequent cardiac tumors. Although histologically benign, in some cases myxomas may be lethal, due to impairment of cardiac dynamics and their thromboembolic potential. The study aimed to assess the clinical presentation of cardiac myxomas and their correlation with echocardiographic features and to describe the perioperative results and long-term outcome of surgically treated patients. METHODS: A prospective study of 53 patients with cardiac myxomas who were operated the Hospital Argerich, followed clinically and with echocardiography from 1993 until 2013...
January 2019: Journal of cardiovascular imaging
https://read.qxmd.com/read/30701662/ophthalmic-findings-in-a-captive-population-of-panamanian-golden-frogs-atelopus-zeteki
#19
Lindsey N Pelych, Wynona Shellabarger, Mark Vassallo, Erica Noland, Dodd Sledge, Susette E Aquino
PURPOSE: The aim of this study was to describe normal ocular morphology and establish parameters for select diagnostics in a population of Panamanian Golden Frogs (PGF) Atelopus zeteki maintained at the Detroit Zoo. METHOD: A total of 22 toads free of ocular disease were included in this study. Ophthalmic diagnostic tests included as follows: endodontic absorbent paper point tear test (EAPPTT), assessment of intraocular pressures (IOP), Rose Bengal stain, palpebral fissure width, blink rate and corneal cultures...
January 30, 2019: Veterinary Ophthalmology
https://read.qxmd.com/read/30697430/the-nd-yag-laser-as-first-line-treatment-for-fibrin-pupillary-block-glaucoma-following-uncomplicated-cataract-surgery
#20
Selina Khan, Mohamed Elashry
A 43-year-old lady presented with painful, loss of vision in the right eye 2 weeks after cataract surgery. This is on a background of previous central retinal vein occlusion in the right eye and bilateral diabetic retinopathy. Her past medical history included mixed connective tissue disease for which she is on systemic immunosuppressants. Ocular examination revealed significant corneal oedema, a shallow anterior chamber with an intraocular pressure of 45 mmHg. Intraocular pressure lowering medications were administered and repeat examination identified a fine fibrinous membrane attached to the pupillary margin with a substantial third space that had formed between the posterior edge of the membrane and the anterior lens surface...
January 2019: Oxford Medical Case Reports
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