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Lars Eichhorn, Marcus Thudium, Björn Jüttner
BACKGROUND: The symptoms of carbon monoxide (CO) poisoning are nonspecific, ranging from dizziness and headache to unconsciousness and death. A German national guideline on the diagnosis and treatment of this condition is lacking at present. METHODS: This review is based on a selective literature search in the PubMed and Cochrane databases, as well as on existing guidelines from abroad and expert recommendations on diagnosis and treatment. RESULTS: The initiation of 100% oxygen breathing as early as possible is the most important treatment for carbon monoxide poisoning...
December 24, 2018: Deutsches Ärzteblatt International
Stephen R Thom, Veena M Bhopale, Ming Yang
Hyperbaric oxygen (HBO2 ) became a mainstay for treating decompression sickness (DCS) because bubbles are associated with the disorder. Inflammatory processes including production of circulating microparticles (MPs) have now been shown to occur with DCS, leading to questions regarding pathophysiology and the role for HBO2 . We investigated effects of HBO2 on mice exposed to 790 kPa air pressure for 2 hours, which triggers elevations of MPs ladened with interleukin (IL)-1β that cause diffuse vascular injuries...
February 14, 2019: Journal of Applied Physiology
Antonio Costa Carneiro, Priscila Diaz, Mariana Vieira, Madalena Silva, Isa Silva, Marta Custodio, Magda Faria
Cerebral venous air embolism (CVAE) is an extremely rare phenomenon. Most reports of cerebral air embolism focus on the arterial territory, and consequently CVAE has remained poorly understood, especially regarding its pathophysiology and treatment. The authors describe an elderly male patient who was admitted through the Emergency Department with subacute confusion. A brain computed tomography (CT) showed multiple cerebral venous gas emboli. No potential causes were found apart from previous peripheral vein cannulation and intravenous medication administration...
2019: European Journal of Case Reports in Internal Medicine
Ivana Resanovic, Zoran Gluvic, Bozidarka Zaric, Emina Sudar-Milovanovic, Aleksandra Jovanovic, Davorka Milacic, Radmilo Isakovic, Esma R Isenovic
This study aimed at examining the early effects of hyperbaric oxygen therapy (HBOT) on inducible nitric oxide synthase (iNOS) activity/expression in lymphocytes of type 1 diabetes mellitus (T1DM) patients. A group of 19 patients (mean age: 63 ± 2.1) with T1DM and with the peripheral arterial disease were included in this study. Patients were exposed to 10 sessions of HBOT in the duration of 1 h to 100% oxygen inhalation at 2.4 ATA. Blood samples were collected for the plasma C-reactive protein (CRP), plasma free fatty acid (FFA), serum nitrite/nitrate, and serum arginase activity measurements...
2019: International Journal of Endocrinology
Nicol Bush, Warren Snodgrass
PURPOSE: Increased complications following failed hypospadias repairs suggest impaired wound healing is a contributing factor. We used perioperative hyperbaric oxygen therapy (HBOT) to promote wound healing determined by graft take in staged tubularized autograft (STAG) reoperations using oral graft. METHODS: HBOT was recommended in patients having 3 or more failed hypospadias repairs, comprising 20 preoperative and 10 postoperative sessions. All underwent reoperative STAG repair using oral mucosa...
February 7, 2019: Journal of Urology
Roberto Casale, Gennaro Boccia, Zaira Symeonidou, Fabiola Atzeni, Allberto Batticciotto, Fausto Salaffi, Piercarlo Sarzi-Puttini, Paolo Riccardo Brustio, Alberto Rainoldi
OBJECTIVES: Neuromuscular efficiency (NME) is impaired in fibromyalgia (FM). Hyperbaric oxygen therapy (HBOT) is a medical treatment using 100% of oxygen through an oxygen mask. HBOT in FM induces changes in cortical excitability and a secondary reduction in pain and muscle fatigue. However, there are still no direct data indicating changes in muscle fatigue. The aim of this study was to assess whether the reduction in muscle fatigue so far attributed to a central effect of HBOT can be directly detected by means of non-invasive sEMG as a change in NME...
January 2019: Clinical and Experimental Rheumatology
Fabiola Atzeni, Roberto Casale, Alessandra Alciati, Ignazio Francesco Masala, Alberto Batticciotto, Rossella Talotta, Maria Chiara Gerardi, Fausto Salaffi, Piercarlo Sarzi-Puttini
OBJECTIVES: Fibromyalgia (FM) is a syndrome of unknown aetiology that is characterised by widespread musculoskeletal pain, fatigue and disordered sleep, and often associated with neuropsychiatric and cognitive symptoms. Current treatment options are only partially effective, but hyperbaric oxygen therapy (HBOT) seems to be capable of relieving some of the symptoms. The aim of this study was to evaluate the efficacy and safety of HBOT after fewer sessions than generally used, chosen on the basis of pre-clinical and clinical data showing its rapid and sustained antinociceptive effect...
January 2019: Clinical and Experimental Rheumatology
Giuliana Guggino, Claudia Schinocca, Marianna Lo Pizzo, Diana Di Liberto, Domenico Garbo, Stefania Raimondo, Riccardo Alessandro, Filippo Brighina, Piero Ruscitti, Roberto Giacomelli, Guido Sireci, Giovanni Triolo, Roberto Casale, Piercarlo Sarzi-Puttini, Francesco Dieli
OBJECTIVES: Hyperbaric oxygen therapy (HBOT) has been used as treatment for different clinical conditions, including fibromyalgia (FM). HBOT modulates brain activity, ameliorates chronic pain and modifies the ratio of immune cells. Clinical studies have provided evidence that FM is associated with immune system dysregulation. In the present study we aimed to evaluate the effect of HBOT on immune system and on the quality of life-style of FM patients. METHODS: Patients with primary FM and controls were treated with HBOT...
January 2019: Clinical and Experimental Rheumatology
Thijs T Wingelaar, Pieter-Jan A M van Ooij, Paul Brinkman, Rob A van Hulst
Introduction: Exposure to hyperbaric hyperoxic conditions can lead to pulmonary oxygen toxicity. Although a decrease in vital capacity has long been the gold standard, newer diagnostic modalities may be more accurate. In pulmonary medicine, much research has focussed on volatile organic compounds (VOCs) associated with inflammation in exhaled breath. In previous small studies after hyperbaric hyperoxic exposure several methyl alkanes were identified. This study aims to identify which VOCs mark the development of pulmonary oxygen toxicity...
2019: Frontiers in Physiology
Yongsheng Wang, Yinliang Qi, Xiang Wei, Shaolong Chen, Ning Jia, Qing Zhou, Sumei Zhang, Shuyu Gui, Yuan Wang
Hypoxia induces vigorous growth and a higher malignant phenotype in solid tumors. Hyperoxic treatment using hyperbaric oxygen (HBO) has previously been shown as a highly effective method to attenuate hypoxia. We aimed to investigate the effect of HBO on hypoxia-induced malignancy of lung cancer cells. Cobalt chloride (CoCl2 ) was used to induce chemical hypoxia in lung cancer cell line A549. Hypoxic inducible factor-1α (HIF-1α) expression, lactate dehydrogenase (LDH) activity, migration and invasion capacity, expression profiles of epithelial-mesenchymal transition (EMT) markers and apoptotic markers were assessed in CoCl2 -treated A549 cells, with or without HBO treatment...
February 10, 2019: Experimental Lung Research
Julie Vinkel, Nicolai Lohse, Ole Hyldegaard
INTRODUCTION: Patients with diabetic foot ulcers (DFU) suffer from diabetes-related complications and comor-bidities. Hyperbaric oxygen therapy (HBOT) is a treatment modality with limited capacity used in the treatment of DFUs. It is important to ensure that HBOT is offered to patients who are suitable for this treatment regarding effect, compliance and life expectancy. The objective of the present study was to describe the population of patients with DFU who were referred to HBOT in Denmark in the 1999-2016 period...
February 2019: Danish Medical Journal
Peter F Day, Monty Duggal, Hani Nazzal
BACKGROUND: Traumatic dental injuries are common. One of the most severe injuries is when a permanent tooth is knocked completely out of the mouth (avulsed). In most circumstances the tooth should be replanted as quickly as possible. There is uncertainty on which interventions will maximise the survival and repair of the replanted tooth. This is an update of a Cochrane Review first published in 2010. OBJECTIVES: To compare the effects of a range of interventions for managing traumatised permanent front teeth with avulsion injuries...
February 5, 2019: Cochrane Database of Systematic Reviews
U Gedikli, E Emektar, S K Corbacioglu, S Dagar, H Uzunosmanoglu, S Ozdogan, Y Cevik
OBJECTIVE: The aim of the study was to assess netrin-1 levels in carbon monoxide (CO) poisoning to determine its relationship with poisoning severity and neurotoxicity. METHODS: This is a cross-sectional prospective study. The patients older than 18 years with CO poisoning were included. The patients were categorized into two groups on the basis of neurological involvement. Both the patient and the control groups were sampled for netrin-1 at 0th hour, and the patient group only was sampled for netrin-1 at 4th hour...
February 5, 2019: Human & Experimental Toxicology
Paul G Harch, Edward F Fogarty
A 58-year-old female was diagnosed with Alzheimer's dementia (AD) which was rapidly progressive in the 8 months prior to initiation of hyperbaric oxygen therapy (HBOT). 18 Fluorodeoxyglucose (18 FDG) positron emission tomography (PET) brain imaging demonstrated global and typical metabolic deficits in AD (posterior temporal-parietal watershed and cingulate areas). An 8-week course of HBOT reversed the patient's symptomatic decline. Repeat PET imaging demonstrated a corresponding 6.5-38% regional and global increase in brain metabolism, including increased metabolism in the typical AD diagnostic areas of the brain...
October 2018: Medical Gas Research
Qi-Zhong Lu, Xiang Li, Jun Ouyang, Jin-Quan Li, Gang Chen
Hyperbaric oxygen therapy (HBOT) has been used as an adjuvant treatment for multiple pathological states, which involves hypoxic conditions. Over the past 50 years, HBOT has been recommended and used in a wide variety of medical conditions, clinically in the treatment of ischemic or nonhealing wounds and radiation-injured tissue, and in the treatment of malignancy. The mechanism of this treatment is providing oxygen under pressure which is higher than the atmosphere thus increasing tissue oxygen concentration...
October 2018: Medical Gas Research
M Aldiwani, T Tharakan, A Al-Hassani, N Gibbons, J Pavlu, D Hrouda
BACKGROUND: BK virus is a major cause of late onset haemorrhagic cystitis in patients undergoing Haematopoietic Cell Transplantation (HCT). The evidence for the management of BK Virus Associated Haemorrhagic Cystitis (BKV-HC) is limited. Much of the published data consists of non-randomised case series and case reports. To our knowledge this is the first systematic review for the management of BKV-HC in both paediatric and adult populations. Our primary outcome was to examine the evidence for strategies of 1) prevention and 2) cessation of haematuria associated with BKV...
January 31, 2019: International Journal of Surgery
Signe Agnete Møller, Peter Østrup Jensen, Niels Høiby, Oana Ciofu, Kasper Nørskov Kragh, Thomas Bjarnsholt, Mette Kolpen
BACKGROUND: Pseudomonas aeruginosa is a major pathogen of the chronic lung infections in cystic fibrosis (CF) patients. These persistent bacterial infections are characterized by bacterial aggregates with biofilm-like properties and are treated with nebulized or intravenous tobramycin in combination with other antibiotics. However, the chronic infections are close to impossible to eradicate due to reasons that are far from fully understood. Recent work has shown that re‑oxygenation of hypoxic aggregates by hyperbaric oxygen (O2 ) treatment (HBOT: 100% O2 at 2...
January 30, 2019: Journal of Cystic Fibrosis: Official Journal of the European Cystic Fibrosis Society
Christina L Costantino, Abraham D Geller, Cameron D Wright, Harald C Ott, Ashok Muniappan, Douglas J Mathisen, Michael Lanuti
OBJECTIVES: Complete resection of neoplasms involving the carina are technically challenging and have high operative morbidity and mortality. This study examines the last 2 decades of clinical experience at our institution. METHODS: Medical records were retrospectively reviewed between 1997 and 2017 to identify all patients who underwent carinal resection. Primary outcome measures include risk factors for complications and overall survival. RESULTS: In total, 45 carinal resections were performed with a median follow-up of 3...
December 15, 2018: Journal of Thoracic and Cardiovascular Surgery
Morihiko Oya, Yutaka Tadano, Yasuhiro Takihata, Wakana Murakami, Shigenori Fujii, Kenji Tamai, Yuji Morimoto, Fumitaka Ikomi, Tetsuji Tokunaga
We aimed to determine whether the composition of the fecal microbiota changes under hyperbaric conditions. In this study, we collected fecal samples from 6 healthy divers at three points during deep diving training (before, 2.1 MPa, end). The frequency of Clostridium cluster XVIII tended to be increased after compression. The frequencies of Clostridium cluster IV and subcluster XIVa were inversely correlated with that of Bacteroides . The compositional changes in the fecal microbiota exhibited interindividual variability...
2019: Bioscience of Microbiota, Food and Health
Chi-Chien Niu, Song-Shu Lin, Li-Jen Yuan, Meng-Ling Lu, Steve W N Ueng, Chuen-Yung Yang, Tsung-Ting Tsai, Po-Liang Lai
BACKGROUND: The expression of both high-mobility group box 1 (HMGB1) and receptor for advanced glycation end-products (RAGE) is upregulated in degenerated discs. HMGB1 is known to function as a coupling factor between hypoxia and inflammation in arthritis, and this inflammatory response is modulated by microRNAs (miRNAs), with miR-107 expression downregulated during hypoxia. In this study, we investigated the regulation of the miR-107/HMGB1/RAGE pathway in degenerated nucleus pulposus cells (NPCs) after hyperbaric oxygen (HBO) treatment...
January 31, 2019: Arthritis Research & Therapy
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