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“Kidney cancer in Brazil”

Jessica L Castilho, Maria M Escuder, Valdiléa Veloso, Jackeline O Gomes, Karu Jayathilake, Sayonara Ribeiro, Rosa A Souza, Maria L Ikeda, Paulo R de Alencastro, Unai Tupinanbas, Carlos Brites, Catherine C McGowan, Alexandre Grangeiro, Beatriz Grinsztejn
INTRODUCTION: People living with HIV (PLHIV) on antiretroviral therapy (ART) experience high rates of non-communicable diseases (NCDs). These co-morbidities often accumulate and older adults may suffer from multimorbidity. Multimorbidity has been associated with loss of quality of life, polypharmacy, and increased risk of frailty and mortality. Little is known of the trends or predictors NCD multimorbidity in PLHIV in low- and middle-income countries. METHODS: We examined NCD multimorbidity in adult PLHIV initiating ART between 2003 and 2014 using a multi-site, observational cohort in Brazil...
January 2019: Journal of the International AIDS Society
Antonio Anax Falcão de Oliveira, Tiago Franco de Oliveira, Michelle Francini Dias, Marisa Helena Gennari Medeiros, Paolo Di Mascio, Mariana Veras, Miriam Lemos, Tania Marcourakis, Paulo Hilário Nascimento Saldiva, Ana Paula Melo Loureiro
BACKGROUND: The Metropolitan Area of São Paulo has a unique composition of atmospheric pollutants, and positive correlations between exposure and the risk of diseases and mortality have been observed. Here we assessed the effects of ambient fine particulate matter (PM2.5 ) on genotoxic and global DNA methylation and hydroxymethylation changes, as well as the activities of antioxidant enzymes, in tissues of AJ mice exposed whole body to ambient air enriched in PM2.5 , which was concentrated in a chamber near an avenue of intense traffic in São Paulo City, Brazil...
October 19, 2018: Particle and Fibre Toxicology
Luciano Monteiro Prado Júnior, Fiorella Menegatti Marino, Renato Barra, Leonardo Fonseca Monteiro do Prado, Alaor Barra Sobrinho
Objective: To show the initial (first-year) experience with 68 Ga-PSMA PET/CT at a clinic in Brazil. Materials and Methods: Over a one-year period, 96 examinations with 68 Ga-PSMA PET/CT (85 related to prostate cancer and 11 related to kidney cancer) were performed in 90 patients. Results: In the prostate and kidney cancer patients alike, the main clinical indication for 68 Ga-PSMA PET/CT was suspicion of recurrence during follow-up (in 65...
May 2018: Radiologia Brasileira
Jessica Fernandes Cirelli, Fernanda Garanhani Surita, Maria Laura Costa, Mary Angela Parpinelli, Samira Maerrawi Haddad, José Guilherme Cecatti
OBJECTIVE:  The aim of this study is to evaluate the burden of indirect causes of maternal morbidity/mortality in Brazil. METHODS:  Secondary analysis of a multicenter cross-sectional study conducted in 27 referral obstetric units within the Brazilian Network for Surveillance of Severe Maternal Morbidity. RESULTS:  A total of 82,388 women were surveilled: 9,555 women with severe maternal morbidity were included, and 942 (9.9%) of them had indirect causes of morbidity/mortality...
March 2018: Revista Brasileira de Ginecologia e Obstetrícia
Frederico José Ribeiro Teixeira, Sergio Dias do Couto Netto, André Luis de Freitas Perina, Fabio C M Torricelli, Luciana Ragazzo Teixeira, Antonio Eduardo Zerati, Fabio de Oliveira Ferreira, Eduardo Hiroshi Akaishi, William Carlos Nahas, Edivaldo Massazo Utiyama
Leiomyosarcoma (LMS) of inferior vena cava (IVC) is a rare neoplasm affecting approximately 1/100,000 people. The prognosis is poor and potential curative intent occurs through challenging operations, such as vena cava resection, occasionally multivisceral when required, and vascular reconstruction. There are few retrospective series regarding this retroperitoneal neoplasm, and the aim of the present study was to discuss the experience at the São Paulo Cancer Institute and Clinics Hospital of University of São Paulo Medical School, São Paulo, Brazil...
October 2017: Oncology Letters
Marcus Vinicius Silva Araújo Gurgel, Josualdo Alves, Guilherme Bruno Fontes Vieira, Felipe de Castro Dantas Sales, Marcos Venício Alves Lima
Objective: to identify predictors of mortality in patients submitted to nephrectomy for non-metastatic renal cancer. Methods: we conducted a retrospective cohort study based on the records of patients with renal cancer submitted to radical or partial nephrectomy at the Ceará Cancer Institute. Results: we studied 117 patients, with mean and median age of 59.14 and 59 years, respectively. The male gender was slightly predominant. The right kidney was most frequently affected (64%)...
May 2017: Revista do Colégio Brasileiro de Cirurgiões
Flávia R Ferreira, Marilia M Ogawa, Luiz F C Nascimento, Jane Tomimori
BACKGROUND: Nonmelanoma skin cancer (NMSC) is the most common tumor in humans, and its incidence increases among renal transplant recipients (RTRs). The aims of this study were to characterize the RTRs with NMSC, to identify risk factors, and to calculate the probability of this tumor in this population. METHODS: This was a hospital-based case-control study. Epidemiological and clinical variables were evaluated. Hierarchical logistic regression was used, and a mathematical model was built...
February 2017: International Journal of Dermatology
William B Grant
UNLABELLED: Rates of Alzheimer's disease (AD) are rising worldwide. The most important risk factors seem to be linked to diet. For example, when Japan made the nutrition transition from the traditional Japanese diet to the Western diet, AD rates rose from 1% in 1985 to 7% in 2008. Foods protective against AD include fruits, vegetables, grains, low-fat dairy products, legumes, and fish, whereas risk factors include meat, sweets, and high-fat dairy products. The evidence comes from ecological and observational studies as well as investigations of the mechanisms whereby dietary factors affect risk...
July 2016: Journal of the American College of Nutrition
Sílvia Fernandes Mauricio, Helem Sena Ribeiro, Maria Isabel Toulson Davisson Correia
The aim of this study was to verify the relationship between weight loss, handgrip strength (HGS) and phase angle (PA) before the beginning of chemotherapy with overall survival in cancer patients. Patients diagnosed with gastrointestinal and breast cancer who were over 18 years old and were scheduled to undergo adjuvant treatment at Hospital Borges da Costa/Brazil were evaluated. The exclusion criteria were neoadjuvant treatment, patients with kidney and liver disease and using diuretics. Weight, HGS and PA tests were performed by trained dietitians...
August 2016: Nutrition and Cancer
Nak Yoon Sung, Mi-Yeon Kim, Jae Youl Cho
Flavonoids are plant pigments that have been demonstrated to exert various pharmacological effects including anti-cancer, anti-diabetic, anti-atherosclerotic, anti-bacterial, and anti-inflammatory activities. However, the molecular mechanisms in terms of exact target proteins of flavonoids are not fully elucidated yet. In this study, we aimed to evaluate the anti-inflammatory mechanism of scutellarein (SCT), a flavonoid isolated from Erigeron breviscapus, Clerodendrum phlomidis and Oroxylum indicum Vent that have been traditionally used to treat various inflammatory diseases in China and Brazil...
September 2015: Korean Journal of Physiology & Pharmacology
Carolina Pereira Gonçalves, Beatriz Moritz Trope, Marcia Ramos-E-Silva
BACKGROUND: Non-melanoma skin cancer (NMSC) after kidney transplantation is common and can result in significant morbidity and mortality. Their incidence and risk factors in renal transplant recipients (RTRs) vary depending on geographic location and there is a scarcity of literature describing the features of NMSC in Brazil. METHODS: NMSC data were retrospectively reviewed in charts of RTRs at the Clementino Fraga Filho University Hospital from January 2004 to December 2005, with the objectives of: 1) evaluating the occurrence of NMSC in RTRs transplanted between 2004 and 2005 at a reference center in Brazil; 2) verifying the frequency of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in these patients according to sex, race, age, and tumor site; and 3) determining the time between transplantation and neoplasia...
2015: Clinical, Cosmetic and Investigational Dermatology
Marina Zoega Hayashida, Victor Miguel Coutinho Fernandes, Diana Rosa de Melo Fernandes, Marília Marufuji Ogawa, Jane Tomimori
BACKGROUND: Non-melanoma skin cancer (NMSC) is very common among renal transplant recipients (RTRs) as a result of the immunosuppressed status of these patients and other factors. Few studies have examined the clinical characteristics and evolution of NMSC in RTRs in tropical countries. OBJECTIVES: The aim of this study was to characterize the epidemiology and clinical evolution of NMSC in RTRs. METHODS: We conducted a retrospective study including 68 RTRs with NMSC diagnosed from July 2004 to December 2009 with a minimum follow-up of three years...
October 2015: International Journal of Dermatology
Diego R Falci, Franciane B da Rosa, Alessandro C Pasqualotto
Amphotericin B (AmB) use is limited by the occurrence of kidney toxicity. Here, we evaluated the incidence and impact of nephrotoxicity in a large series of patients receiving therapy with amphotericin B deoxycholate (d-AmB), liposomal AmB (L-AmB), or AmB lipid complex (ABLC), in a clinical practice scenario. In a retrospective cohort study, patients treated with different AmB formulations between 2003 and 2012 were evaluated. Medical records and laboratory data were reviewed. Nephrotoxicity was determined according to modified RIFLE criteria...
February 2015: Mycoses
Márcio Soares, Suzana Margarete Ajeje Lobo, André Peretti Torelly, Patricia Veiga de Carvalho Mello, Ulisses Silva, José Mário Meira Teles, Eliézer Silva, Pedro Caruso, Gilberto Friedman, Paulo César Pereira de Souza, Alvaro Réa-Neto, Arthur Oswaldo Vianna, José Raimundo Azevedo, Erico Vale, Leila Rezegue, Michele Godoy, Marcelo Oliveira Maia, Jorge Ibrain Figueira Salluh
OBJECTIVES: Critically ill cancer patients are at increased risk for acute kidney injury, but studies on these patients are scarce and were all single centered conducted in specialized intensive care units. The objective was to evaluate the characteristics and outcomes in a prospective cohort of cancer patients admitted to several intensive care units with acute kidney injury. METHODS: Prospective multicenter cohort study conducted in intensive care units from 28 hospitals in Brazil over a two-month period...
September 2010: Revista Brasileira de Terapia Intensiva
Lucíola de Barros Pontes, Yuri Philippe Pimentel Vieira Antunes, Diogo Diniz Gomes Bugano, Theodora Karnakis, Auro Del Giglio, Rafael Aliosha Kaliks
OBJECTIVE: To estimate the prevalence of abnormal glomerular filtration rate in elderly patients with solid tumors. METHODS: A retrospective study with patients aged >65 years diagnosed with solid tumors between January 2007 and December 2011 in a cancer center. The following data were collected: sex, age, serum creatinine at the time of diagnosis and type of tumor. Renal function was calculated using abbreviated Modification of Diet in Renal Disease (MDRD) formulae and then staged in accordance with the clinical practice guidelines published by the Working Group of the National Kidney Foundation...
September 2014: Einstein
Flávia Regina Ferreira, Marilia Marufuji Ogawa, Luiz Fernando Costa Nascimento, Jane Tomimori
BACKGROUND: Nonmelanoma skin cancer is the most common form of cancer in humans and also the malignant disease that is increasingly common among kidney transplant recipients. OBJECTIVE: To determine the epidemiological characteristics of renal transplant recipients with nonmelanoma skin cancer seen at a referral transplantation center. METHODS: Cross-sectional descriptive study with renal transplant recipients presenting nonmelanoma skin cancer, treated at a transplantation referral center between 08/01/2004 and 08/31/2009...
September 2014: Anais Brasileiros de Dermatologia
Imran H A Ali, Derek P Brazil
Bone morphogenetic proteins (BMPs) are members of the TGFβ superfamily of secreted cysteine knot proteins that includes TGFβ1, nodal, activins and inhibins. BMPs were first discovered by Urist in the 1960s when he showed that implantation of demineralized bone into intramuscular tissue of rabbits induced bone and cartilage formation. Since this seminal discovery, BMPs have also been shown to play key roles in several other biological processes, including limb, kidney, skin, hair and neuronal development, as well as maintaining vascular homeostasis...
August 2014: British Journal of Pharmacology
Marcione Aparecida de Souza Moura, Anke Bergmann, Suzana Sales de Aguiar, Luiz Claudio Santos Thuler
OBJECTIVES: To estimate the magnitude of association and identify the aetiological fraction (AF) attributable to smoking in the development of different types of cancers in Brazil. SETTING: We conducted a case-control study, including 231 102 patients registered in the Cancer Hospital Registries (CHR) in the period from 1998 to 2011. PARTICIPANTS: A total of 204 131 cancer cases relating to 30 topographies were compared with 26 971 cases of non-melanoma skin cancer...
2014: BMJ Open
André V E de Carvalho, Renan R Bonamigo, Cristina M da Silva, Angela C De Zorzi Pinto
BACKGROUND: Renal transplant patients have a higher incidence of non-melanoma skin cancer (NMSC). Previous studies hypothesized that human leukocyte antigen (HLA), especially types DR1, DR4, and DR7, may influence the incidence of these tumors. This study investigates the association between NMSC and the presence of HLA DR1, DR4, and DR7 in renal transplant patients in southern Brazil. METHODS: In a historical cohort study, 1032 patients who underwent renal transplantation during the period from January 1993 to December 2006 were examined to identify occurrences of NMSC and HLA status prior to transplant...
December 2012: International Journal of Dermatology
S V Brito, D L Sales, J G M Costa, F F G Rodrigues, F S Ferreira, E C Angélico, J E Carvalho, W O Almeida, L A Anjos, H D M Coutinho
CONTEXT: Amphibian skins have wide variety of biologically active compounds associated with the natural defenses of these animals. OBJECTIVES: To study the in vitro anticancer activity of methanol extracts of the skin of Rhinella jimi Stevaux (Anura: Bufonidae). MATERIAL AND METHODS: The extract was obtained by cold methanol extraction for 96 h using dried skins (295 mg). The methanol skin extract was dried under reduced pressure, giving a 5...
August 2012: Pharmaceutical Biology
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