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High iron levels

Marina Dorigatti Borges, Dulcineia Martins de Albuquerque, Carolina Lanaro, Fernando Ferreira Costa, Kleber Yotsumoto Fertrin
Aceruloplasminemia is a rare form of brain iron overload of autosomal recessive inheritance that results from mutations in the CP gene, encoding the iron oxidase ceruloplasmin. Homozygous aceruloplasminemia causes progressive neurodegenerative disease, anemia, and diabetes, and is usually diagnosed late in life upon investigation of anemia, high ferritin, or movement disorders, but its heterozygous state is less characterized and believed to be silent. Here we report two heterozygotes for new mutations causing aceruloplasminemia from whom peripheral blood samples were collected for complete blood counts, iron studies, and genotyping by automated sequencing...
March 22, 2019: American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics
Helena C Reinardy, Kristine B Pedersen, Jasmine Nahrgang, Marianne Frantzen
In Norway, mine tailings waste can be deposited by coastal submarine dispersal. Mine tailings slurry include fine particles <10 µm with elevated levels of metals (e.g. copper, iron) from residual mineral ore. Prolonged suspension of small particles in the water column may bring them into contact with locally spawned pelagic fish eggs, including Atlantic cod, Gadus morhua. Newly-fertilised cod embryos were exposed to suspended mine tailings particles up to 3.2 mg/L in flow-through aquaria for a total of 21 days...
March 22, 2019: Environmental Toxicology and Chemistry
Thomas J Smith, Bimal H Ashar
Turmeric is increasingly studied as an anti-inflammatory and anti-neoplastic agent. It binds to ferric iron in the gut and causes iron deficiency in mice. We report here a possible case of iron deficiency anemia in a human taking turmeric. A 66-year-old physician treated himself for an osteoarthritis flare after steroids with six turmeric extract capsules (538 mg) daily, to help with inflammation. During this time, his hemoglobin never rose above 12 and his iron and ferritin levels were consistent with iron deficiency...
January 9, 2019: Curēus
Matthew Atongbiik Achaglinkame, Ruth Olaide Aderibigbe, Oliver Hensel, Barbara Sturm, Joseph Kudadam Korese
Malnutrition has been a serious issue in Ghana and Africa as a whole. However, the potential of many indigenous fruits to combat it has not yet been tested. Therefore, this study aimed to determine the nutritional characteristics of four underutilized wild fruits ( Gardenia erubescens , Sclerocarya birrea, Diospyros mespiliformis , and Balanites aegyptiaca ) of dietary interest in Ghana. The nutritional and antinutritional characteristics of the fruits were analyzed according to standard methods (laid down by the Association of Official Analytical Chemists and other well-known researchers) on a dry weight (dw) basis...
March 20, 2019: Foods (Basel, Switzerland)
Dev Ram Sunuwar, Raj Kumar Sangroula, Nani Shova Shakya, Renu Yadav, Narendra Kumar Chaudhary, Pranil Man Singh Pradhan
BACKGROUND: Anemia during pregnancy is a major public health problem globally with multiple causes including inadequate dietary intakes. The aim of the study was to assess the effect of nutrition education on nutritional knowledge, hemoglobin level and dietary intake of anemic pregnant women. MATERIALS AND METHODS: A quasi-experimental study was conducted among 115 mild to moderately anemic pregnant women attending ante natal clinics. Pregnant women were consecutively enrolled and assigned to receive nutrition education and diet plan in intervention group (n = 58) and general education only in control group (n = 57)...
2019: PloS One
Ali Nemati, Reza Alipanah Moghadam, Mohammad Mazani, Akram Darvishi
OBJECTIVE: To investigate the efficacy of L-carnitine (LC) and conjugated linoleic acid (CLA) supplements on haemoglobin levels and inflammatory markers in chronic kidney disease (CKD) patients with different haptoglobin (HP) genotypes. METHODS: This clinical trial study was conducted at Imam Khomeini Hospital, Ardabil, and Labbafinejad Hospital, Tehran, Iran, from March 2014 to March 2015, and comprised male patients with CKD and anaemia. Anthropometric factors were recorded and demographic data was collected using general questionnaires...
March 2019: JPMA. the Journal of the Pakistan Medical Association
Milene Dalmina, Frederico Pittella, Jelver Alexander Sierra, Gabriela Regina Rosa Souza, Adny Henrique Silva, André Avelino Pasa, Tânia Beatriz Creczynski-Pasa
Short interfering RNA (siRNA) showed to be a viable alternative to a better prognosis in cancer therapy. Nevertheless, the successful application of this strategy still depends on the development of nanocarriers for the safe delivery of siRNA into the diseased tissue, which mostly occurs by passive accumulation. When an external magnetic field is applied, magnetic nanoparticles biodistribution is partially modulated to favor accumulation in a target tissue. In this work we designed a novel magnetic responsive siRNA nanocarrier...
June 2019: Materials Science & Engineering. C, Materials for Biological Applications
Lian Jin, David M Frazer, Yan Lu, Sarah J Wilkins, Scott Ayton, Ashley Bush, Gregory J Anderson
Manganese is an essential metal that is required for a wide range of biological functions. Ferroportin (FPN), the only known cellular exporter of iron, has also been proposed to play a role in manganese export, but this relationship is incompletely understood. To investigate this in more detail in vivo, we examined the relative distributions of manganese and iron in TMPRSS6 deficient mice, which are characterized by constitutively high expression of the iron regulatory hormone hepcidin and, consequently, very low FPN levels in their tissues...
March 19, 2019: Metallomics: Integrated Biometal Science
F Oduber, A I Calvo, C Blanco-Alegre, A Castro, T Nunes, C Alves, M Sorribas, D Fernández-González, A M Vega-Maray, R M Valencia-Barrera, F Lucarelli, S Nava, G Calzolai, E Alonso-Blanco, B Fraile, P Fialho, E Coz, A S H Prevot, V Pont, R Fraile
Saharan air masses can transport high amounts of mineral dust particles and biological material to the Iberian Peninsula. During winter, this kind of events is not very frequent and usually does not reach the northwest of the Peninsula. However, between 21 and 22 February 2016 and between 22 and 23 February 2017, two exceptional events were registered in León (Spain), which severely affected air quality. An integrative approach including: i) typical synoptic conditions; ii) aerosol chemical composition; iii) particle size distributions; iv) pollen concentration; v) aerosol optical depth (AOD); vi) radiative forcing and vii) estimation of the impact of aerosols in the respiratory tract, was carried out...
February 27, 2019: Science of the Total Environment
Shu-Meng Hao, Ming-Yuan Yu, Yu-Jiao Zhang, Yasmine Abdelkrim, Jin Qu
Self-sacrificial biomass-derived silica is a rising and promising approach to fabricate large metal silicates, which are practical water treatment agents ascribed for easy sedimentation and separation. However, the original biomass architecture is difficult to be maintained and utilized. Furthermore, sufficient ion diffusion pathways need to be created to satisfy massive mass transport in large bulk materials. Herein, a series of metal silicates, including cobalt silicate (CoSiOx ), copper silicate, nickel silicate, iron silicate, and magnesium silicate, are synthesized from Indocalamus tessellatus leaf as the biomass-derived silica source and investigated as catalysts in sulfate-radical-based advanced oxidization processes (SR-AOPs) for the first time...
March 7, 2019: Journal of Colloid and Interface Science
Maja Lazarus, Pavao Gančević, Tatjana Orct, Delko Barišić, Klemen Jerina, Nikica Šprem
Muscle, liver and kidney of 21 Barbary sheep (Ammotragus lervia) from Mosor Mountain, Croatia, were sampled to quantify the activity of caesium and potassium radionuclides and five toxic and ten essential stabile elements in order to establish reference values for this species and to evaluate the potential of Barbary sheep tissues to reflect environmental pollution. We also assessed seasonal diet (botanical composition and dry matter content) of Barbary sheep based on analyses of a rumen content of culled animals...
March 14, 2019: Environmental Science and Pollution Research International
Huiwen Wang, Ximin Zeng, Yiming Mo, Bin He, Hening Lin, Jun Lin
Enterobactin (Ent)-mediated high affinity iron acquisition is critical for Gram-negative bacteria to survive in the host. Given the bacteriostatic effect of lipocalin resulting from its potent Ent-binding ability, immune intervention directly targeting Ent is promising for iron-dependent pathogen control. Recently, an Ent conjugate vaccine was reported but it still has several significant weaknesses. In this study, we aimed to develop an innovative Ent conjugate vaccine that can induce high level of antibodies directed against Ent, and to provide solid evidence demonstrating siderophore-binding capacity of Ent-specific antibodies...
March 15, 2019: Applied and Environmental Microbiology
Tao Wang, Zhaomo Tian, Anders Tunlid, Per Persson
The interactions between dissolved organic matter (DOM) and mineral particles are critical for the stabilization of soil organic matter in terrestrial ecosystems. The processing of DOM by ectomycorrhizal fungi contributes to the formation of mineral-stabilized SOM by two contrasting pathways: extracellular transformation of DOM ( ex vivo pathway) and the secretion of mineral-surface reactive metabolites ( in vivo pathway). In this study, we examined how changes in nitrogen (N) availability affected the formation of mineral-associated carbon (C) from these two pathways...
March 15, 2019: Applied and Environmental Microbiology
Edna Maria Vissoci Reiche, Jair Roberto Gelinksi, Daniela Frizon Alfieri, Tamires Flauzino, Marcio Francisco Lehmann, Maria Caroline Martins de Araújo, Marcell Alysson Batisti Lozovoy, Andrea Name Colado Simão, Elaine Regina Delicato de Almeida, Michael Maes
The aim of the study was to define new immune-inflammatory, oxidative stress and biochemical biomarkers, which predict mortality within a period of 3 months after acute ischemic stroke (AIS). We recruited 176 healthy volunteers and 145 AIS patients, categorized as AIS survivors and non-survivors, and measured interleukin (IL)-6, high sensitivity C-reactive protein (hsCRP), ferritin, iron, total serum protein (TSP), erythrocyte sedimentation rate (ESR), white blood cells (WBC), 25 hydroxyvitamin D [25(OH)D], lipid hydroperoxides (CL-LOOH), insulin, glucose and high-density lipoprotein (HDL)-cholesterol...
March 14, 2019: Metabolic Brain Disease
Àngela Carrió-Seguí, Paco Romero, Catherine Curie, Stéphane Mari, Lola Peñarrubia
Copper (Cu) deficiency affects iron (Fe) homeostasis in several plant processes, including the increased Fe requirements due to cuproprotein substitutions for the corresponding Fe counterpart. Loss-of-function mutants from Arabidopsis thaliana high affinity copper transporter COPT5 and Fe transporters NATURAL RESISTANCE-ASSOCIATED MACROPHAGE PROTEIN 3/4 (NRAMP3 and NRAMP4) were used to study the interaction between metals internal pools. A physiological characterisation showed that the copt5 mutant is sensitive to Fe deficiency, and that nramp3nramp4 mutant growth was severely affected under limiting Cu...
March 15, 2019: Scientific Reports
Jessy Hasna, Roland Abi Nahed, Frédéric Sergent, Nadia Alfaidy, Alexandre Bouron
BACKGROUND/AIMS: Transient receptor potential canonical 6 (TRPC6) protein is a nonselective cation channel permitting the uptake of essential elements such as iron (Fe) and zinc (Zn). TRPC6 is found throughout the body with high expression levels in the placenta. However, its role in this organ is still to be determined. To further advance our understanding of the physiological relevance of TRPC6, we have studied the placental histology, pregnancy outcome and the Fe and Zn status of organs (placenta, brain, kidney, liver and lung) collected from TRPC6 deficient (TRPC6-/- ) mice and sex and age-matched C57Bl6/J and B6129SF2/J mice...
2019: Cellular Physiology and Biochemistry
Emily C Keats, Batool A Haider, Emily Tam, Zulfiqar A Bhutta
BACKGROUND: Multiple-micronutrient (MMN) deficiencies often coexist among women of reproductive age in low- and middle-income countries. They are exacerbated in pregnancy due to the increased demands of the developing fetus, leading to potentially adverse effects on the mother and baby. A consensus is yet to be reached regarding the replacement of iron and folic acid supplementation with MMNs. Since the last update of this Cochrane Review in 2017, evidence from several trials has become available...
March 14, 2019: Cochrane Database of Systematic Reviews
Lilian Varricchio, Antanas Planutis, Deepa Manwani, Julie Jaffray, W Beau Mitchell, Anna Rita Miglicaccio, James J Bieker
Congenital dyserythropoietic anemia type IV is caused by a heterozygous mutation, Glu325Lys (E325K), in the KLF1 transcription factor. A molecular understanding of this disease is absent, partly due to its rarity. We expanded erythroid cells from a patient's peripheral blood and analyzed its global expression pattern. We find that a large number of erythroid pathways are disrupted, particularly those related to membrane transport, globin regulation, and iron utilization. The altered genetics lead to significant deficits in differentiation...
March 14, 2019: Haematologica
Catherine A Chenard, Linda M Rubenstein, Linda G Snetselaar, Terry L Wahls
Multiple sclerosis (MS) is an incurable degenerative disease that attacks the central nervous system. Roy Swank proposed a low saturated fat diet to treat MS around 1950 and showed delayed disease progression in his patients. However, there is insufficient evidence to recommend this diet for MS and default dietary recommendations are the Dietary Guidelines for Americans (DGA). This study assessed the nutritional adequacy of seven-day menus developed by Swank and their compliance with the DGA; menus were modeled for comparison with the DGA Healthy US-Style Eating Pattern (HEP) for males and females 31⁻50 years...
March 13, 2019: Nutrients
Samra Irem, Ejazul Islam, Frans J M Maathuis, Nabeel Khan Niazi, Tingqiang Li
High concentration of arsenic (As) in rice is a serious problem worldwide. Pot experiments were conducted to assess the potential dietary toxicity of arsenic and effect of various soil amendments on arsenic accumulation in rice grains. Two basmati rice genotypes were used to conduct pot experiments using various levels of arsenic (10, 25, 50 and 100 mg kg-1 soil). In addition, plants were exposed to soil collected from a well documented arsenic contaminated site. Contrasting results for growth, yield and grain arsenic concentration were obtained for basmati-385 (Bas-385), exhibiting tolerance (56% yield improvement at 10 mg As kg-1 ), while genotype BR-1 showed 18% yield decline under same conditions...
March 2, 2019: Chemosphere
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