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Joseph Catapano, Simon S M Fung, William Halliday, Cecilia Jobst, Douglas Cheyne, Emily S Ho, Ronald M Zuker, Gregory H Borschel, Asim Ali
AIM: To report clinical outcomes and evidence of corneal innervation in patients with neurotrophic keratopathy (NK) treated with minimally invasive corneal neurotisation (MICN) using a sural nerve graft and donor sensory nerves from the face. METHODS: Patients undergoing MICN at The Hospital for Sick Children, Toronto, Canada were prospectively recruited. Data on central corneal sensation (CCS, measured with Cochet-Bonnet aesthesiometer), best-corrected visual acuity (BCVA) and corneal epithelial integrity were collected...
February 15, 2019: British Journal of Ophthalmology
Refik Kunt, Mustafa Kürşad Kutluk, Bedile İrem Tiftikçioğlu, Nazire Afşar, Ali Kemal Erdemoğlu, Muhteşem Gedizlioğlu, Vesile Öztürk
Background/aim: This study aimed to investigate the consistency between stroke and general neurologists in subtype assignment using the Trial of ORG-10172 in Acute Stroke Treatment (TOAST) and Causative Classification of Stroke (CCS) systems. Materials and methods: Fifty consecutive acute ischemic stroke patients admitted to the stroke unit were recruited. Patients were classified by two stroke and two general neurologists, each from different medical centers, according to TOAST followed by the CCS...
February 11, 2019: Turkish Journal of Medical Sciences
Petra Borilova Linhartova, Hana Poskerova, Marie Tomandlova, Jirina Bartova, Katerina Kankova, Antonin Fassmann, Lydie Izakovicova Holla
Recent studies have suggested a bidirectional relationship between chronic periodontitis (CP) and diabetes mellitus (DM). Immunoregulatory factors such as cytokines play an important role in etiopathogenesis of both diseases. The aim of this study was to analyze variability in interleukin-1 ( IL-1 ) gene cluster and IL-1 β plasma levels in patients with CP, DM, and a combination of both diseases. A total of 1016 individuals participating in this case-control study-225 healthy controls, 264 patients with CP, 132 with type 1 diabetes (T1DM), and 395 patients with type 2 diabetes (T2DM)-were genotyped using methods based on polymerase chain reaction for IL-1 gene polymorphisms ( IL-1A (-889C/T, rs1800587), IL-1B (+3953C/T, rs1143634), and IL-1RN (gene for IL-1 receptor antagonist, IL-1RA, 86 bp tandem repeats in intron 2))...
2019: International Journal of Dentistry
M H Hoque, F I Kabir, J Arzu, M R Amin, S M Zaman, S M Ear-E-Mahabub, A I Joarder, C K Singha, R S Banerjee
Ischaemic cardiomyopathy (ICM) remains a major health problem, both in developed and developing countries like Bangladesh where it causes a significant number of morbidity and mortality. The treatment and outcome of ICM chiefly depends on the presence and extent of hibernating myocardium. In this regard addressing anginal symptoms is the key to patients' comfort as well to achieving the goal of treatment. Glyceryl trinitrate (GTN) and trimetazidine (TMZ) are two widely used drugs for relieving angina. This pilot study was designed to answer some of the confusions and controversies regarding their use and to bring precision in decision making in the treatment of ICM...
January 2019: Mymensingh Medical Journal: MMJ
Kenneth Jung, Sylvia E K Sudat, Nicole Kwon, Walter F Stewart, Nigam H Shah
Timely outreach to individuals in an advanced stage of illness offers opportunities to exercise decision control over health care. Predictive models built using Electronic health record (EHR) data are being explored as a way to anticipate such need with enough lead time for patient engagement. Prior studies have focused on hospitalized patients, who typically have more data available for predicting care needs. It is unclear if prediction driven outreach is feasible in the primary care setting. In this study, we apply predictive modeling to the primary care population of a large, regional health system and systematically examine the impact of technical choices, such as requiring a minimum number of health care encounters (data density requirements) and aggregating diagnosis codes using Clinical Classifications Software (CCS) groupings to reduce dimensionality, on model performance in terms of discrimination and positive predictive value...
February 9, 2019: Journal of Biomedical Informatics
Philip Lavenburg, Gregg Cantor, Olufunmilayo Agunloye, Aditi Bhagat, Erin Taub, Getu Teressa
BACKGROUND: The aim of this study was to evaluate whether pretest probability (PTP) assessment using the Diamond-Forrester Model (DFM) combined with coronary calcium scoring (CCS) can safely rule out obstructive coronary artery disease (CAD) and 30-day major adverse cardiovascular events (MACE) in acute chest pain patients. METHODS: We retrospectively evaluated consecutive patients, age ≥18 years, with no known CAD, negative initial electrocardiogram, and troponin level...
March 2019: Critical Pathways in Cardiology
Maria A Battistone, Maria Merkulova, Yoo-Jin Park, Maria A Peralta, Flavia Gombar, Dennis Brown, Sylvie Breton
KEY POINTS: In the epididymis, elaborate communication networks between epithelial cells are important to establish an optimal acidic luminal environment for the maturation and storage of spermatozoa, which is essential for male fertility. Proton secretion by epididymal clear cells is achieved via the proton pumping V-ATPase located in their apical membrane. Here, we dissect the molecular mechanisms by which clear cells respond to luminal ATP and adenosine to modulate their acidifying activity via the adenosine receptor ADORA2B and the pH-sensitive ATP receptor P2 × 4...
February 12, 2019: Journal of Physiology
C Hontoria, I García-González, M Quemada, A Roldán, M M Alguacil
Intensive agricultural practices are responsible for soil biological degradation. By stimulating indigenous arbuscular mycorrhizal fungi (AMF), cover cropping enhances soil health and promotes agroecosystem sustainability. Still, the legacy effects of cover crops (CCs) and the major factors driving the AM fungal community are not well known; neither is the influence of the specific CC. This work describes a field experiment established in Central Spain to test the effect of replacing winter fallow by barley (Hordeum vulgare L...
April 10, 2019: Science of the Total Environment
Ilje Pikaar, Jo de Vrieze, Korneel Rabaey, Mario Herrero, Pete Smith, Willy Verstraete
To adhere to the Paris Agreement of 2015, we need to store several Gigatonnes (Gt) of carbon annually. In the last years, a variety of technologies for carbon capture and storage (CCS) and carbon capture and usage (CCU) have been demonstrated. While conventional CCS and CCU are techno-economically feasible, their climate change mitigation potentials are limited, due to limited amount of CO2 that can be captured. Hence, there is an urgent need to explore other CCS and CCU routes. Here we discuss an interesting alternative route for capture of carbon dioxide from industrial point sources, using CO2 -binding, so-called autotrophic aerobic bacteria to produce microbial biomass as a C-storage product...
December 10, 2018: Science of the Total Environment
Philippe Grieshaber, Sina Möller, Borros Arneth, Peter Roth, Bernd Niemann, Harald Renz, Andreas Böning
BACKGROUND:  Prediction, early diagnosis, and therapy of cardiac surgery-associated acute kidney injury (CSA-AKI) are challenging. We prospectively tested a staged approach to identify patients at high risk for CSA-AKI combining clinical risk stratification and early postoperative quantification of urinary biomarkers for AKI. METHODS:  All patients, excluding those on chronic hemodialysis, undergoing scheduled surgery with cardiopulmonary bypass between August 2015 and July 2016 were included...
February 11, 2019: Thoracic and Cardiovascular Surgeon
Sean M Colby, Dennis G Thomas, Jamie R Nuñez, Douglas J Baxter, Kurt R Glaesemann, Joseph M Brown, Meg A Pirrung, Niranjan Govind, Justin G Teeguarden, Thomas O Metz, Ryan S Renslow
High throughput, comprehensive, and confident identifications of metabolites and other chemicals in biological and environmental samples will revolutionize our understanding of the role these chemically diverse molecules play in biological systems. Despite recent technological advances, metabolomics studies still result in the detection of a disproportionate number of features that cannot be confidently assigned to a chemical structure. This inadequacy is driven by the single most significant limitation in metabolomics: the reliance on reference libraries constructed by analysis of authentic reference materials with limited commercial availability...
February 11, 2019: Analytical Chemistry
Rubén Aldaco, Isabela Butnar, María Margallo, Jara Laso, Marta Rumayor, Antonio Dominguez-Ramos, Angel Irabien, Paul E Dodds
Low carbon options for the chemical industry include switching from fossil to renewable energy, adopting new low-carbon production processes, along with retrofitting current plants with carbon capture for ulterior use (CCU technologies) or storage (CCS). In this paper, we combine a dynamic Life Cycle Assessment (d-LCA) with economic analysis to explore a potential transition to low-carbon manufacture of formic acid. We propose new methods to enable early technical, environmental and economic assessment of formic acid manufacture by electrochemical reduction of CO2 (CCU), and compare this production route to the conventional synthesis pathways and to storing CO2 in geological storage (CCS)...
January 31, 2019: Science of the Total Environment
R López-Andújar, J Maupoey, J Escrig, P Granero, J J Vila, V Ibáñez, A Boscá, M García-Eliz, S Benlloch, J F Orbis, E M Montalvá
BACKGROUND AND AIMS: T-tube placement during choledochocholedochostomy (CCS) associated with liver transplantation (LT) remains controversial. This study was designed to validate the results of an earlier prospective randomized controlled trial (RCT) on use versus nonuse of the T-tube during CCS associated with LT. METHODS: Prospective cohort study. The primary outcome was the overall incidence of biliary complications (BCs). RESULTS: In total, 405 patients were included, and the median overall monitoring period was 29 months (interquartile range: 13-47 months)...
January 2019: Transplantation Proceedings
Fernanda A Sala, Gareth S A Wright, Svetlana V Antonyuk, Richard C Garratt, S Samar Hasnain
Superoxide dismutase-1 (SOD1) maturation comprises a string of posttranslational modifications which transform the nascent peptide into a stable and active enzyme. The successive folding, metal ion binding, and disulphide acquisition steps in this pathway can be catalysed through a direct interaction with the copper chaperone for SOD1 (CCS). This process confers enzymatic activity and reduces access to noncanonical, aggregation-prone states. Here, we present the functional mechanisms of human copper chaperone for SOD1 (hCCS)-catalysed SOD1 activation based on crystal structures of reaction precursors, intermediates, and products...
February 8, 2019: PLoS Biology
Thomas P Scherer, Sebastian Hoechel, Magdalena Müller-Gerbl, Andrej M Nowakowski
Background: Preoperative planning of total knee arthroplasty is usually performed using knee-centred computed tomography (CT) data sets. The disadvantage of these data sets is having no account of the biomechanical axis of the lower extremity, known as Mikulicz line. It aligns the femoral head to the middle of the talocrural joint. For optimal prosthesis arrangement, the knee CT data set must therefore be brought in congruency with this line of loading to achieve the best results and eliminate rotational malalignments...
January 2019: Journal of Orthopaedic Translation
Ulrich Gergs, Theresa Trapp, Hasan Bushnaq, Andreas Simm, Rolf-Edgar Silber, Joachim Neumann
Heart failure and aging of the heart show many similarities regarding hemodynamic and biochemical parameters. There is evidence that heart failure in experimental animals and humans is accompanied and possibly exacerbated by increased activity of protein phosphatase (PP) 1 and/or 2A. Here, we wanted to study the age-dependent protein expression of major members of the protein phosphatase family in human hearts. Right atrial samples were obtained during bypass surgery. Patients ( n =60) were suffering from chronic coronary artery disease (CCS 2-3; New York Heart Association (NYHA) stage 1-3)...
2019: Advances in Medicine
Eugenia Mylona, Oscar Acosta, Thibaut Lizee, Caroline Lafond, Gilles Crehange, Nicolas Magné, Sophie Chiavassa, Stéphane Supiot, Juan David Arango Ospina, Borris Campillo-Gimenez, Joel Castelli, Renaud de Crevoisier
BACKGROUND AND PURPOSE: To apply a voxel-based analysis to identify urethro-vesical symptom-related subregions (SRSs) associated with acute and late urinary toxicity in prostate cancer radiotherapy. MATERIALS AND METHODS: A total of 272 prostate cancer patients treated with IMRT/IGRT were prospectively analyzed. Each patient's CT was spatially normalized to a common coordinate system (CCS) via nonrigid registration. The obtained deformation fields were used to map the dose of each patient to the CCS...
February 1, 2019: International Journal of Radiation Oncology, Biology, Physics
Serhat Ilbey, Can Baris Top, Alper Gungor, Tolga Cukur, Emine Ulku Saritas, H Emre Guven
Magnetic particle imaging (MPI) is a relatively new medical imaging modality, which detects the nonlinear response of magnetic nanoparticles (MNPs) that are exposed to external magnetic fields. The system matrix (SM) method for MPI image reconstruction requires a time consuming system calibration scan prior to image acquisition, where a single MNP sample is measured at each voxel position in the field-of-view (FOV). The scanned sample has the maximum size of a voxel so that the calibration measurements have relatively poor signal-to-noise ratio (SNR)...
January 31, 2019: IEEE Transactions on Medical Imaging
Dale N Segal, Zachary J Grabel, John G Heller, John M Rhee, Keith W Michael, S Tim Yoon, Amit Jain
Background: The objective of this study is to demonstrate the epidemiology and trends in management of patients with central cord syndrome (CCS) who present to the emergency department. Recent literature has reported that surgical treatment for CCS have increased over the previous decades. Methods: The National Emergency Department Sample (NEDS) was queried from 2009 through 2012 to generate national estimates of patients who presented to the emergency department in the United States and were diagnosed with CCS...
December 2018: Journal of Spine Surgery (Hong Kong)
Dongwan Lim, Yunjae Park, Rakwoo Chang, Arif Ahmed, Sunghwan Kim
RATIONALE: Molecular dynamics (MD) simulations with finite temperature were performed to improve the theoretical prediction of collisional cross section (CCS) values, especially for aromatic compounds containing long alkyl chains. METHODS: In this study, the CCS values of 11 aromatic compounds with long alkyl chains were calculated by MD simulation while considering internal energy at 300, 500, and 700 K, and the results were compared with experimentally determined values...
February 1, 2019: Rapid Communications in Mass Spectrometry: RCM
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