Barbara Tomasello, Francesco Bellia, Irina Naletova, Antonio Magrì, Giovanni Tabbì, Francesco Attanasio, Marianna Flora Tomasello, Warren R L Cairns, Mariagrazia Fortino, Adriana Pietropaolo, Valentina Greco, Diego La Mendola, Sebastiano Sciuto, Giuseppe Arena, Enrico Rizzarelli
Neurotrophins are a family of growth factors that play a key role in the development and regulation of the functioning of the central nervous system. Their use as drugs is made difficult by their poor stability, cellular permeability, and side effects. Continuing our effort to use peptides that mimic the neurotrophic growth factor (NGF), the family model protein, and specifically the N-terminus of the protein, here we report on the spectroscopic characterization and resistance to hydrolysis of the 14-membered cyclic peptide reproducing the N-terminus sequence (SSSHPIFHRGEFSV (c-NGF(1-14))...
April 11, 2024: ACS Chemical Neuroscience