Hansen Liu, Zhenzhen Yan, Deyu Zhu, Haiyan Xu, Feng Liu, Tian Chen, Honghai Zhang, Yi Zheng, Bingyu Liu, Lei Zhang, Wei Zhao, Chengjiang Gao
cGAS/DncV-like nucleotidyltransferase (CD-NTase) family members are immune sensors that synthesize diverse nucleotide signals to initiate antiviral response in bacteria and animals. As a founding member of CD-NTase enzyme, cGAS has been identified as a key sensor for cytoplasmic DNA and type I interferons (IFNs) signaling in metazoan. However, the functions of other metazoan CD-NTases remain enigmatic. Here, we showed that Mab-21 domain-containing protein 2 (MB21D2), another member of the CD-NTase family, plays a positive role in modulating the cGAS-STING signaling in myeloid cells...
April 2023: Cell Death and Differentiation