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Aaron T Whiteley, James B Eaglesham, Carina C de Oliveira Mann, Benjamin R Morehouse, Brianna Lowey, Eric A Nieminen, Olga Danilchanka, David S King, Amy S Y Lee, John J Mekalanos, Philip J Kranzusch
Cyclic dinucleotides (CDNs) have central roles in bacterial homeostasis and virulence by acting as nucleotide second messengers. Bacterial CDNs also elicit immune responses during infection when they are detected by pattern-recognition receptors in animal cells. Here we perform a systematic biochemical screen for bacterial signalling nucleotides and discover a large family of cGAS/DncV-like nucleotidyltransferases (CD-NTases) that use both purine and pyrimidine nucleotides to synthesize a diverse range of CDNs...
February 20, 2019: Nature
Anna Lundh, Jan Kowalski, Carl Johan Sundberg, Mikael Landén
The aim of this study was to compare two methods to conduct CGAS rater training. A total of 648 raters were randomized to training (CD or seminar), and rated five cases before and 12 months after training. The ICC at baseline/end of study was 0.71/0.78 (seminar), 0.76/0.78 (CD), and 0.67/0.79 (comparison). There were no differences in training effect in terms of agreement with expert ratings, which speaks in favor of using the less resource-demanding CD. However, the effect was modest in both groups, and untrained comparison group improved of the same order of magnitude, which proposes more extensive training...
November 2012: Administration and Policy in Mental Health
Gabriele Masi, Annarita Milone, Giovanna Canepa, Stefania Millepiedi, Maria Mucci, Filippo Muratori
The most severe forms of conduct disorder (CD) are highly stable and disabling disorders, more likely to persist in time and to evolve into disruptive or antisocial behaviors. One crucial issue in the prognosis of these forms of CD is the high resistance to both non-pharmacological and pharmacological treatments, with antipsychotic drugs being frequently used in refractory cases. Aim of this study was: (1) to explore efficacy and tolerability of olanzapine treatment in adolescents with severe CD; (2) to identify predictors of olanzapine treatment outcome...
January 2006: European Psychiatry: the Journal of the Association of European Psychiatrists
F J Kochman, E G Hantouche, P Ferrari, S Lancrenon, D Bayart, H S Akiskal
INTRODUCTION: Although several recent studies suggest that bipolar disorder most commonly begins during childhood or adolescence, the illness still remains under-recognized and under-diagnosed in this age group. As part of the French Bipolar network and in line with the hypothesis that juvenile depression is pre-bipolar , we evaluated the rate of onset of bipolar disorders in a naturalistic 2-year prospective study of consecutive, clinically depressed children and adolescents, and to test whether the cyclothymic temperament underlies such onset...
March 2005: Journal of Affective Disorders
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