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Tiago Gregorio, Inês Albuquerque, Vasco Neves, Rui Reinas, Sara Pipa, Luís Azevedo, Paulo Castro Chaves
BACKGROUND: Intracerebral haemorrhage (ICH) is a devastating condition, with more than half of patients dying or becoming dependent after such an event. Natriuretic peptides, frequently used in the management of heart failure, have been shown to correlate with disease severity and prognosis in brain disorders. The aim of this study was to test the hypothesis that NT-pro-BNP correlates with disease severity and is an independent prognostic marker for non-traumatic ICH patients. METHODS: A consecutive sample of 201 non-traumatic ICH patients, who were non-comatose on admission and medically treated in a stroke unit, were evaluated for in-hospital mortality and three-month functional dependency (modified Rankin Scale >2)...
February 8, 2019: Journal of the Neurological Sciences
Reina Mizuno, Takumi Maruhashi, Daisuke Sugiura, Kenji Shimizu, Mizuki Watada, Il-Mi Okazaki, Taku Okazaki
Cancer immunotherapies targeting programmed cell death 1 (PD-1) and cytotoxic T-lymphocyte antigen 4 revolutionized cancer treatment and instigated various trials to develop new cancer immunotherapies with higher therapeutic efficacy. Agonistic Abs against tumor necrosis factor receptor super family (TNFRSF) molecules are highly expected due to their high potential to enhance survival, proliferation, and effector function of T cells. To date, agonistic antibodies (Abs) against CD27, GITR, OX40, and 4-1BB have been reported to increase the efficacy of anti-PD-1 therapy in animal models and clinical trials of these combinatorial therapies are underway...
February 13, 2019: Biochemical and Biophysical Research Communications
Maria Isabel Perez-Lopez, Rudy Mendez-Reina, Steve Trier, Cornelia Herrfurth, Ivo Feussner, Adriana Bernal, Manu Forero-Shelton, Chad Leidy
Bacteria are often found in close association with surfaces, resulting in the formation of biofilms. In Staphylococcus aureus (S. aureus), biofilms are implicated in the resilience of chronic infections, presenting a serious clinical problem world-wide. Here, S. aureus biofilms are grown under flow within clinical catheters at 37 °C. The lipid composition and biophysical properties of lipid extracts from these biofilms are compared with those from exponential growth and stationary phase cells. Biofilms show a reduction in iso and anteiso branching compensated by an increase in saturated fatty acids compared to stationary phase...
February 13, 2019: Biochimica et biophysica acta. Biomembranes
M Aguilar, L Ali Cavasonza, G Ambrosi, L Arruda, N Attig, P Azzarello, A Bachlechner, F Barao, A Barrau, L Barrin, A Bartoloni, L Basara, S Başeğmez-du Pree, R Battiston, U Becker, M Behlmann, B Beischer, J Berdugo, B Bertucci, V Bindi, W de Boer, K Bollweg, B Borgia, M J Boschini, M Bourquin, E F Bueno, J Burger, W J Burger, X D Cai, M Capell, S Caroff, J Casaus, G Castellini, F Cervelli, Y H Chang, G M Chen, H S Chen, Y Chen, L Cheng, H Y Chou, V Choutko, C H Chung, C Clark, G Coignet, C Consolandi, A Contin, C Corti, M Crispoltoni, Z Cui, K Dadzie, Y M Dai, A Datta, C Delgado, S Della Torre, M B Demirköz, L Derome, S Di Falco, F Dimiccoli, C Díaz, P von Doetinchem, F Dong, F Donnini, M Duranti, A Egorov, A Eline, T Eronen, J Feng, E Fiandrini, P Fisher, V Formato, Y Galaktionov, R J García-López, C Gargiulo, H Gast, I Gebauer, M Gervasi, F Giovacchini, D M Gómez-Coral, J Gong, C Goy, V Grabski, D Grandi, M Graziani, K H Guo, S Haino, K C Han, Z H He, M Heil, T H Hsieh, H Huang, Z C Huang, M Incagli, Yi Jia, H Jinchi, K Kanishev, B Khiali, Th Kirn, C Konak, O Kounina, A Kounine, V Koutsenko, A Kulemzin, G La Vacca, E Laudi, G Laurenti, I Lazzizzera, A Lebedev, H T Lee, S C Lee, C Leluc, J Q Li, Q Li, T X Li, Z H Li, C Light, C H Lin, T Lippert, F Z Liu, Hu Liu, Z Liu, S Q Lu, Y S Lu, K Luebelsmeyer, F Luo, J Z Luo, Xi Luo, S S Lyu, F Machate, C Mañá, J Marín, T Martin, G Martínez, N Masi, D Maurin, A Menchaca-Rocha, Q Meng, D C Mo, M Molero, P Mott, L Mussolin, T Nelson, J Q Ni, N Nikonov, F Nozzoli, A Oliva, M Orcinha, M Palermo, F Palmonari, M Paniccia, A Pashnin, M Pauluzzi, S Pensotti, C Perrina, H D Phan, N Picot-Clemente, V Plyaskin, M Pohl, V Poireau, A Popkow, L Quadrani, X M Qi, X Qin, Z Y Qu, P G Rancoita, D Rapin, A Reina Conde, S Rosier-Lees, A Rozhkov, D Rozza, R Sagdeev, C Solano, S Schael, S M Schmidt, A Schulz von Dratzig, G Schwering, E S Seo, B S Shan, J Y Shi, T Siedenburg, J W Song, Z T Sun, M Tacconi, X W Tang, Z C Tang, J Tian, Samuel C C Ting, S M Ting, N Tomassetti, J Torsti, T Urban, V Vagelli, E Valente, E Valtonen, M Vázquez Acosta, M Vecchi, M Velasco, J P Vialle, J Vizán, L Q Wang, N H Wang, Q L Wang, X Wang, X Q Wang, Z X Wang, J Wei, Z L Weng, H Wu, R Q Xiong, W Xu, Q Yan, Y Yang, H Yi, Y J Yu, Z Q Yu, M Zannoni, S Zeissler, C Zhang, F Zhang, J H Zhang, Z Zhang, F Zhao, Z M Zheng, H L Zhuang, V Zhukov, A Zichichi, N Zimmermann, P Zuccon
Precision measurements of cosmic ray positrons are presented up to 1 TeV based on 1.9 million positrons collected by the Alpha Magnetic Spectrometer on the International Space Station. The positron flux exhibits complex energy dependence. Its distinctive properties are (a) a significant excess starting from 25.2±1.8  GeV compared to the lower-energy, power-law trend, (b) a sharp dropoff above 284_{-64}^{+91}  GeV, (c) in the entire energy range the positron flux is well described by the sum of a term associated with the positrons produced in the collision of cosmic rays, which dominates at low energies, and a new source term of positrons, which dominates at high energies, and (d) a finite energy cutoff of the source term of E_{s}=810_{-180}^{+310}  GeV is established with a significance of more than 4σ...
February 1, 2019: Physical Review Letters
Reina Hoshi, Shuichiro Uehara, Kako Ono, Kensuke Ohashi, Tsugumichi Koshinaga
No abstract text is available yet for this article.
February 15, 2019: Pediatrics International: Official Journal of the Japan Pediatric Society
Batoul Jaber, Reina Remman, Nayla Matar
INTRODUCTION: A patient's voice can vary from one moment to another, and these variations cannot be captured by a one-time assessment. Multiple assessments may give a more holistic idea of the severity of the patient's dysphonia and by asking the patient to do the recordings he becomes involved in his therapeutic plan from the beginning. AIM: This study aims to evaluate the added value of a repetitive assessment outside the speech therapist's (SLP) clinic, to have a broader vision of the voice disorder and identify parameters that change after working hours to be able to explain this disorder and find solutions for it...
February 11, 2019: Journal of Voice: Official Journal of the Voice Foundation
José Carlos Reina, Marta Torres, Inmaculada Llamas
Many Gram-negative aquacultural and agricultural pathogens control virulence factor expression through a quorum-sensing (QS) mechanism involving the production of N-acylhomoserine (AHL) signalling molecules. Thus, the interruption of QS systems by the enzymatic degradation of signalling molecules, known as quorum quenching (QQ), has been proposed as a novel strategy to combat these infections. Given that the symbiotic bacteria of marine invertebrates are considered to be an important source of new bioactive molecules, this study explores the presence of AHL-degrading bacteria among 827 strains previously isolated from the microbiota of anemones and holothurians...
February 14, 2019: Marine Biotechnology
Soumi De Montijo-Prieto, David J Castro, Jose C Reina, Maria Jimenez-Valera, Alfonso Ruiz-Bravo
Lactobacillus plantarum C4 (CECT 9567) was isolated from kefir and has been extensively studied because of its probiotic properties. Here we report the genome sequence of this strain. The genome consists of 3,221,350 bp, and contains 3058 CDSs with an average G + C content of 44.5%. The genome harbors genes encoding the AraC-family transcription regulator, the penicillin-binding protein Pbp2A, and the Na+/H+ antiporter NapA3, which have important roles in the survival of lactobacilli in the gastrointestinal tract...
February 13, 2019: Archives of Microbiology
Michael J Passineau, Phillip H Gallo, Gretchen Williams, Reina Perez, Raymond L Benza
A variety of pathologies lead to pulmonary hypertension (PH), which is defined as a mean pulmonary artery pressure exceeding 25 mmHg at rest. To further diagnose and manage PH, patients undergo repeated right heart catheterizations (RHC) wherein a Swan-Ganz catheter is advanced into a branch of the pulmonary artery and a balloon is inflated to wedge the catheter tip. This article illustrates a protocol whereby pulmonary artery endothelial cells (PAECs) may be harvested from the balloon tips of Swan-Ganz catheters after RHC, and purified with an anti- CD146 affinity column technique to purify putative PAECs...
January 23, 2019: Journal of Visualized Experiments: JoVE
Raquel Alonso Gómez, Laureano Lorenzo Reina, Inés Flores Méndez, Jaime Martín García, Laura García Briñol
From the model of Integral Primary Care and under the principle of continuity of care, the development of channels of communication and integration between the first and second level of care in relation to mental health care is proposed. It presents the pioneering experience established in the Health Service of Lanzarote in which the figure of the clinical psychologist has been moved to the Health Centres to develop a joint community program from the Primary Care. The lines of action have focused on direct work with the patient, as well as with the staff, both individually and as a group...
February 4, 2019: Atencion Primaria
Delia Reina, Carmen Gómez-Vaquero, Cesar Díaz-Torné, Joan Miquel Nolla Solé
Rheumatoid arthritis (RA) has been related to an impairment of the nutritional status. Body mass index (BMI) has been used but questions arise about how to properly evaluate nutritional status in RA patients. Few studies have evaluated it by dual-energy X-ray absorptiometry.In women with RA, to analyze:Case-control study including 89 women with RA. The control group was composed by 100 patients affected by non-inflammatory rheumatic disorders. Study variables included age, RA duration, history, activity and disability, and in relation to nutritional status: BMI, serum albumin (ALB), whole body DXA assessment, and skeletal muscle index (SMI)...
February 2019: Medicine (Baltimore)
Marta Torres, Kar-Wai Hong, Teik-Min Chong, José Carlos Reina, Kok-Gan Chan, Yves Dessaux, Inmaculada Llamas
The Alteromonas stellipolaris strains PQQ-42 and PQQ-44, previously isolated from a fish hatchery, have been selected on the basis of their strong quorum quenching (QQ) activity, as well as their ability to reduce Vibrio-induced mortality on the coral Oculina patagonica. In this study, the genome sequences of both strains were determined and analyzed in order to identify the mechanism responsible for QQ activity. Both PQQ-42 and PQQ-44 were found to degrade a wide range of N-acylhomoserine lactone (AHL) QS signals, possibly due to the presence of an aac gene which encodes an AHL amidohydrolase...
February 4, 2019: Scientific Reports
Masahiro Katsurada, Tatsuya Nagano, Motoko Tachihara, Tatsunori Kiriu, Koichi Furukawa, Kiyoko Koyama, Takehiro Otoshi, Reina Sekiya, Daisuke Hazama, Daisuke Tamura, Kyosuke Nakata, Naoko Katsurada, Masatsugu Yamamoto, Kazuyuki Kobayashi, Yoshihiro Nishimura
BACKGROUND/AIM: Immune checkpoint inhibitors (ICI) are a novel medication for non-small cell lung cancer (NSCLC). Recent reports indicated that baseline tumor size (BTS) relates to the efficacy of ICI therapy for melanoma, but no study exists for NSCLC. This study aimed to evaluate the utility of BTS for ICI therapy. PATIENTS AND METHODS: Data from 58 patients diagnosed with NSCLC who underwent ICI monotherapy, were retrospectively analyzed. Patients were divided into two groups according to BTS (below 101 mm, above 101 mm)...
February 2019: Anticancer Research
Alejandro Espejo-Reina, José Aguilera, María Josefa Espejo-Reina, María Pilar Espejo-Reina, Alejandro Espejo-Baena
PURPOSE: To analyze, in a long series of patients with knee injuries, the meniscal tear patterns in both stable and unstable knees to ascertain the exact proportion of such injuries that could have been repaired. METHODS: A descriptive cross-sectional study was undertaken by reviewing the clinical reports of arthroscopic knee operations carried out in 1 hospital. A total of 2,066 consecutive patients were included in the study. An analysis of clinical and anatomical data of knee lesions, including the shape of the meniscal tears and the surrounding injuries, was performed...
January 29, 2019: Arthroscopy: the Journal of Arthroscopic & related Surgery
C G Salib, N Reina, K I Perry, M J Taunton, D J Berry, M P Abdel
AIMS: Concurrent hip and spine pathologies can alter the biomechanics of spinopelvic mobility in primary total hip arthroplasty (THA). This study examines how differences in pelvic orientation of patients with spine fusions can increase the risk of dislocation risk after THA. PATIENTS AND METHODS: We identified 84 patients (97 THAs) between 1998 and 2015 who had undergone spinal fusion prior to primary THA. Patients were stratified into three groups depending on the length of lumbar fusion and whether or not the sacrum was involved...
February 2019: Bone & Joint Journal
Giacomo Reina, Amalia Ruiz, Diane Murera, Yuta Nishina, Alberto Bianco
The last decade has seen an increase in the application of graphene oxide (GO) in the biomedical field. GO has been successfully exploited for its ability to deliver many kinds of drugs into target cells. However, GO toxicity assessment is still controversial. Several studies demonstrated that GO protein coating is crucial to alleviate the material's toxicity. Besides, coronation leads to the formation of big agglomerates, reducing the cellular uptake of the material and thus its therapeutic efficiency. In this work, we propose a simple and efficient method based on rapid (Ultra-Turrax, UT) mixing to control protein corona formation...
January 29, 2019: ACS Applied Materials & Interfaces
Juan Carlos Sierra, Ana Álvarez-Muelas, Ana Isabel Arcos-Romero, Cristóbal Calvillo, Reyna Torres-Obregón, Reina Granados
OBJECTIVE: The level of agreement between subjective and objective measures of sexual arousal is referred as sexual concordance. Sex is one of the principal moderators and there is a higher level of correspondence in men than in women. The aim of this study is to evaluate the predictive validity of the scales Ratings of Sexual Arousal (RSA) and Ratings of Genital Sensations (RGS), relating their scores with the genital response to visual sexual stimuli in men and women. MATERIAL AND METHOD: A sample of 159 young heterosexuals was used (69 men and 90 women) which completed, firstly, a sociodemographic and sexual story questionnaire, the Sexual Inhibition/Sexual Excitation Scales Short-Form and the SOS-6...
January 2019: Revista Internacional de Andrología
Takeaki Wajima, Reina Kinugawa, Tetsuya Yamada, Hideaki Ikoshi, Norihisa Noguchi
BACKGROUND: In traditional Chinese medicine, Panax notoginseng is used to treat inflammation and bleeding but has not been shown to affect bacterial pathogens. OBJECTIVES: Our aim was to assess the antibacterial potential of Panax notoginseng extract (PNE) against bacterial pathogens. METHODS: PNE was dissolved in autoclaved distilled water. Antimicrobial activity was measured by the disc diffusion test and bacterial growth curve assays, in which the concentration of bacterial colony forming units was monitored at several time points in the presence or absence of PNE...
January 28, 2019: Pharmacology
Sergi Iglesia Reina, Juan Uría González-Tova, Ismael Cerdà Calafat, Francesc García Cuyàs
OBJECTIVE: To evaluate differences in the degree of satisfaction among professionals who participate in health care and in the management of health organizations in relation to the electronic medical record (EMR) used in their organizations. METHODS: We surveyed healthcare professionals, managers and information technology professionals who work with an EMR in any health or social organization in Catalonia. Among 312 contacted professionals, the participation rate was 60...
January 2019: Archivos de Prevención de Riesgos Laborales
Mark Zimmerman, Reina Kiefer, Sophie Kerr, Caroline Balling
BACKGROUND: To evaluate the efficacy of rapidly effective treatments it is necessary to use measures that are designed to assess symptom severity over short intervals. In the present report from the Rhode Island Methods to Improve Diagnostic Assessment and Services (MIDAS) project, we modified our previously published anxiety scale and examined the reliability and validity of a daily version of the Clinically Useful Anxiety Outcome Scale (CUXOS-D, D indicates daily version). METHODS: Two thousand four hundred and ninety-one patients presenting for treatment to a partial hospital program completed the CUXOS-D as part of their initial paperwork and on a daily basis thereafter...
December 28, 2018: Comprehensive Psychiatry
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