keyword
https://read.qxmd.com/read/35830775/omega-3-polyunsaturated-fatty-acid-biomarkers-and-risk-of-type-2-diabetes-cardiovascular-disease-cancer-and-mortality
#21
JOURNAL ARTICLE
Hong Jiang, Lina Wang, Duolao Wang, Ni Yan, Chao Li, Min Wu, Fan Wang, Baibing Mi, Fangyao Chen, Wanru Jia, Xi Liu, Jiaxin Lv, Yan Liu, Jing Lin, Le Ma
BACKGROUND & AIMS: Considerable attention has focused on the role of omega-3 polyunsaturated fatty acids (PUFA) in the prevention of cardiometabolic diseases, which has led to dietary recommendations to increase omega-3 fatty acid intake. A meta-analysis was conducted to summarize evidence from prospective studies regarding associations between omega-3 PUFA biomarkers and risk of developing major chronic diseases. METHODS: Four electronic databases were searched for articles from inception to March 1, 2022...
August 2022: Clinical Nutrition
https://read.qxmd.com/read/35818085/evidence-based-recommendations-for-an-optimal-prenatal-supplement-for-women-in-the-us-vitamins-and-related-nutrients
#22
REVIEW
James B Adams, Jasmine K Kirby, Jacob C Sorensen, Elena L Pollard, Tapan Audhya
The blood levels of most vitamins decrease during pregnancy if un-supplemented, including vitamins A, C, D, K, B1, B3, B5, B6, folate, biotin, and B12. Sub-optimal intake of vitamins from preconception through pregnancy increases the risk of many pregnancy complications and infant health problems. In the U.S., dietary intake of vitamins is often below recommended intakes, especially for vitamin D, choline and DHA. Many studies suggest that insufficient vitamin intake is associated with a wide range of pregnancy complications (anemia, Cesarean section, depression, gestational diabetes, hypertension, infertility, preeclampsia, and premature rupture of membranes) and infant health problems (asthma/wheeze, autism, low birth weight, congenital heart defects, intellectual development, intrauterine growth restriction, miscarriage, neural tube defects, orofacial defects, and preterm birth)...
July 11, 2022: Maternal Health, Neonatology and Perinatology
https://read.qxmd.com/read/35772387/interventions-for-the-prevention-of-preterm-premature-rupture-of-membranes-a-systematic-review-and-meta-analysis
#23
Vanessa El-Achi, Sangita Aggarwal, Jon Hyett
INTRODUCTION: Preterm prelabour rupture of membranes (PPRoM) is a significant cause of maternal and perinatal morbidity and mortality. The aim of this project was to identify interventions that reduce the prevalence of PPRoM. METHODS: Search strategy included a systematic literature search of MEDLINE, EMBASE, PubMed, and Cochrane Library. The selection criteria included randomized control studies that compared a therapy to standard care (no therapy or placebo) in pregnancy and included PPRoM as an outcome...
2022: Fetal Diagnosis and Therapy
https://read.qxmd.com/read/35739258/characterization-of-lipoproteins-and-associated-lipidome-in-very-preterm-infants-a-pilot-study
#24
JOURNAL ARTICLE
Alice Küster, Mikael Croyal, Thomas Moyon, Dominique Darmaun, Khadija Ouguerram, Véronique Ferchaud-Roucher
BACKGROUND: Preterm birth is associated with higher risks of suboptimal neurodevelopment and cardiometabolic disease later in life. Altered maternal-fetal lipid supply could play a role in such risks. Our hypothesis was that very preterm infants born with very low birth weight (VLBW) have altered lipidome and apolipoprotein profiles, compared with term infants. METHODS: Seven mothers of VLBW infants born at <32 GA and 8 full-term mother-infant dyads were included...
June 23, 2022: Pediatric Research
https://read.qxmd.com/read/35728584/effect-of-enteral-long-chain-polyunsaturated-fatty-acids-on-retinopathy-of-prematurity-a-systematic-review-and-meta-analysis
#25
Shivashankar Diggikar, Abhishek Somasekhara Aradhya, Ravi Shankar Swamy, Arunkumar Namachivayam, Manigandan Chandrasekaran
BACKGROUND: Long-chain polyunsaturated fatty acids (LCPUFA) are critical for the maturation of the brain and retina. Retinopathy of prematurity (ROP) is a preventable cause of blindness in preterm infants. LCPUFA have anti-inflammatory, antioxidant, and antiangiogenesis effects. Supplementation of enteral LCPUFA might mitigate the incidence of ROP in these infants. Available limited randomized studies showed promising results. We aimed to assess the effect of enteral supplementation of LCPUFA on ROP in preterm infants...
2022: Neonatology
https://read.qxmd.com/read/35644107/effects-of-omega-3-6-9-fatty-acid-supplementation-on-behavior-and-sleep-in-preterm-toddlers-with-autism-symptomatology-secondary-analysis-of-a-randomized-clinical-trial
#26
RANDOMIZED CONTROLLED TRIAL
Kelly M Boone, Mark A Klebanoff, Lynette K Rogers, Joseph Rausch, Daniel L Coury, Sarah A Keim
BACKGROUND: Children born extremely preterm disproportionately experience sequelae of preterm birth compared to those born at later gestational ages, including higher prevalence of autism spectrum disorder (ASD) and associated behaviors. AIM: Explore effects of combined dietary docosahexaenoic acid, eicosapentaenoic acid, gamma-linolenic acid, and oleic acid (omega 3-6-9) on caregiver-reported behavior and sleep in toddlers born at ≤29 weeks' gestation who were exhibiting symptoms commonly seen with ASD...
June 2022: Early Human Development
https://read.qxmd.com/read/35495419/evaluation-of-the-retinopathy-of-prematurity-activity-scale-rop-acts-in-a-randomised-controlled-trial-aiming-for-prevention-of-severe-rop-a-substudy-of-the-mega-donna-mega-trial
#27
RANDOMIZED CONTROLLED TRIAL
Aldina Pivodic, Helena Johansson, Lois Eh Smith, Chatarina Löfqvist, Kerstin Albertsson-Wikland, Staffan Nilsson, Ann Hellström
OBJECTIVE: The current grading of retinopathy of prematurity (ROP) does not sufficiently discriminate disease severity for evaluation of trial interventions. The published ROP Activity Scales (original: ROP-ActS and modified: mROP-ActS), describing increasing severity of ROP, versus the categorical variables severe ROP, stage, zone and plus disease were evaluated as discriminators of the effect of an ROP preventive treatment. METHODS AND ANALYSIS: The Mega Donna Mega trial investigated ROP in infants born <28-week gestational age (GA), randomised to arachidonic acid (AA) and docosahexaenoic acid (DHA) supplementation or no supplementation...
2022: BMJ Open Ophthalmology
https://read.qxmd.com/read/35054885/maternal-and-neonatal-polyunsaturated-fatty-acid-intake-and-risk-of-neurodevelopmental-impairment-in-premature-infants
#28
REVIEW
Rory J Heath, Susanna Klevebro, Thomas R Wood
The N3 and N6 long chain polyunsaturated fatty acids (LCPUFA) docosahexaenoic acid (DHA) and arachidonic acid (AA) are essential for proper neurodevelopment in early life. These fatty acids are passed from mother to infant via the placenta, accreting into fetal tissues such as brain and adipose tissue. Placental transfer of LCPUFA is highest in the final trimester, but this transfer is abruptly severed with premature birth. As such, efforts have been made to supplement the post-natal feed of premature infants with LCPUFA to improve neurodevelopmental outcomes...
January 9, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/34819793/impact-of-docosahexaenoic-acid-supplementation-on-proinflammatory-cytokines-release-and-the-development-of-necrotizing-enterocolitis-in-preterm-neonates-a-randomized-controlled-study
#29
JOURNAL ARTICLE
Dina Khaled Abou El Fadl, Marwa Adel Ahmed, Yasmin Af Aly, Ebtissam Abdel Ghaffar Darweesh, Nagwa A Sabri
INTRODUCTION: Preterm neonates have under-developed immune-regulatory system; consequently, there is a risk for developing chronic inflammation. Necrotizing enterocolitis (NEC) is an acute devastating neonatal intestinal inflammatory disorder. Due to the obscure multifactorial etiology, early diagnosis and effective treatment of NEC are limited. Consequently, effective strategies in the prevention of NEC, including nutritional approaches, are critically needed. The current study was conducted to assess the potential immunomodulatory effect of Docosahexaenoic Acid (DHA) supplementation in preterm neonates at neonatal intensive care unit (NICU) and subsequently its effect on preventing or reducing NEC incidence...
November 2021: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/34728723/docosahexaenoic-acid-rich-algae-oil-supplementation-on-breast-milk-fatty-acid-profile-of-mothers-who-delivered-prematurely-a-randomized-clinical-trial
#30
RANDOMIZED CONTROLLED TRIAL
Hélène Fougère, Jean-François Bilodeau, Pascal M Lavoie, Ibrahim Mohamed, Iwona Rudkowska, Etienne Pronovost, David Simonyan, Line Berthiaume, Mireille Guillot, Bruno Piedboeuf, Pierre Julien, Isabelle Marc
Preterm infants are deficient in long-chain polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), a fatty acid (FA) associated with an increase in bronchopulmonary dysplasia (BPD). In two previous randomized control trials, DHA supplementation did not reduce the risk of BPD. We examined the breast milk FA profile, collected 14 days after birth, of mothers who delivered before 29 weeks of gestation and who were supplemented with DHA-rich algae oil or a placebo within 72 h after birth as part of the MOBYDIck trial...
November 2, 2021: Scientific Reports
https://read.qxmd.com/read/34648010/association-of-docosahexaenoic-acid-and-arachidonic-acid-serum-levels-with-retinopathy-of-prematurity-in-preterm-infants
#31
JOURNAL ARTICLE
Ann Hellström, Aldina Pivodic, Lotta Gränse, Pia Lundgren, Ulrika Sjöbom, Anders K Nilsson, Helena Söderling, Anna-Lena Hård, Lois E H Smith, Chatarina Alice Löfqvist
Importance: Supplementing preterm infants with long-chain polyunsaturated fatty acids (LC-PUFA) has been inconsistent in reducing the severity and incidence of retinopathy of prematurity (ROP). Furthermore, few studies have measured the long-term serum lipid levels after supplementation. Objective: To assess whether ROP severity is associated with serum levels of LC-PUFA, especially docosahexaenoic acid (DHA) and arachidonic acid (AA), during the first 28 postnatal days...
October 1, 2021: JAMA Network Open
https://read.qxmd.com/read/34436603/investigation-of-mechanisms-responsible-for-decreased-susceptibility-of-aztreonam-avibactam-activity-in-clinical-isolates-of-enterobacterales-collected-in-europe-asia-and-latin-america-in-2019
#32
JOURNAL ARTICLE
Rodrigo E Mendes, Timothy B Doyle, Jennifer M Streit, Francis F Arhin, Helio S Sader, Mariana Castanheira
BACKGROUND: The combination aztreonam/avibactam is currently under Phase 3 trials for the treatment of serious infections caused by Gram-negative bacteria including those with MBLs. OBJECTIVES: To investigate the resistance mechanisms in Enterobacterales exhibiting aztreonam/avibactam MICs of ≥4 mg/L. METHODS: Among 8787 Enterobacterales, 17 (0.2%) isolates exhibited an aztreonam/avibactam MIC of ≥4 mg/L. Isolates were sequenced and screened for β-lactamases...
October 11, 2021: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/34308309/higher-dose-docosahexaenoic-acid-supplementation-during-pregnancy-and-early-preterm-birth-a-randomised-double-blind-adaptive-design-superiority-trial
#33
JOURNAL ARTICLE
Susan E Carlson, Byron J Gajewski, Christina J Valentine, Elizabeth H Kerling, Carl P Weiner, Michael Cackovic, Catalin S Buhimschi, Lynette K Rogers, Scott A Sands, Alexandra R Brown, Dinesh Pal Mudaranthakam, Sarah A Crawford, Emily A DeFranco
BACKGROUND: Several meta analyses have concluded n-3 fatty acids, including docosahexaenoic acid (DHA), reduce early preterm birth (EPB, < 34 weeks), however, the amount of DHA required is unclear. We hypothesized that 1000 mg DHA per day would be superior to 200 mg, the amount in most prenatal supplements. METHODS: This randomised, multicentre, double-blind, adaptive-design, superiority trial was conducted in three USA medical centres. Women with singleton pregnancies and 12 to 20 weeks gestation were eligible...
June 2021: EClinicalMedicine
https://read.qxmd.com/read/34229049/mfsd2a-overexpression-alleviates-vascular-dysfunction-in-diabetic-retinopathy
#34
JOURNAL ARTICLE
Chun-Lin Zhang, Hai-Ling Wang, Peng-Cheng Li, Can-Dong Hong, An-Qi Chen, Yan-Mei Qiu, Ai-Ping Zeng, Yi-Fan Zhou, Bo Hu, Ya-Nan Li
Diabetic retinopathy (DR) is one of the common complications in diabetic patients. Nowadays, VEGF pathway is subject to extensive research. However, about 27% of the patients have a poor visual outcome, with 50% still having edema after two years' treatment of diabetic macular edema (DME) with ranibizumab. Docosahexaenoic acid (DHA), the primary ω-3 long-chain polyunsaturated fatty acid (LC-PUFA), reduces abnormal neovascularization and alleviates neovascular eye diseases. A study reported that fish oil reduced the incidence of retinopathy of prematurity (ROP) by about 27...
September 2021: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://read.qxmd.com/read/34074642/lipid-intake-and-neurodevelopment-in-preterm-infants
#35
JOURNAL ARTICLE
Katherine M Ottolini, Nickie Andescavage, Catherine Limperopoulos
Preterm infants are born before the critical period of lipid accretion and brain development that occurs during the third trimester of pregnancy. Dietary lipids serve as an important source of energy and are involved in complex processes that are essential for normal central nervous system development. In addition to traditional neurodevelopmental testing, novel quantitative magnetic resonance imaging (MRI) techniques are now available to evaluate the impact of nutritional interventions on early preterm brain development...
June 2021: NeoReviews
https://read.qxmd.com/read/33932340/lancls-add-glutathione-to-dehydroamino-acids-generated-at-phosphorylated-sites-in-the-proteome
#36
JOURNAL ARTICLE
Kuan-Yu Lai, Sébastien R G Galan, Yibo Zeng, Tianhui Hina Zhou, Chang He, Ritu Raj, Jitka Riedl, Shi Liu, K Phin Chooi, Neha Garg, Min Zeng, Lyn H Jones, Graham J Hutchings, Shabaz Mohammed, Satish K Nair, Jie Chen, Benjamin G Davis, Wilfred A van der Donk
Enzyme-mediated damage repair or mitigation, while common for nucleic acids, is rare for proteins. Examples of protein damage are elimination of phosphorylated Ser/Thr to dehydroalanine/dehydrobutyrine (Dha/Dhb) in pathogenesis and aging. Bacterial LanC enzymes use Dha/Dhb to form carbon-sulfur linkages in antimicrobial peptides, but the functions of eukaryotic LanC-like (LanCL) counterparts are unknown. We show that LanCLs catalyze the addition of glutathione to Dha/Dhb in proteins, driving irreversible C-glutathionylation...
May 13, 2021: Cell
https://read.qxmd.com/read/33844264/comparison-of-polish-and-international-guidelines-on-diet-supplements-in-pregnancy-review
#37
REVIEW
Damian Skrypnik, Malgorzata Moszak, Ewa Wender-Ozegowska, Pawel Bogdanski
Proper nutrition is an important element that determines the course of pregnancy. Unfortunately, the everyday diet is not always able to cover the increased in pregnancy essential vitamins and minerals requirements. Therefore, pregnant women often use dietary supplements. This study aimed to compare Polish and international recommendations regarding dietary supplementation during pregnancy. The Polish Society of Gynaecologists and Obstetricians (PSGO) recommends in every pregnant woman the dietary supplementation of folates, vitamin D and iodine...
2021: Ginekologia Polska
https://read.qxmd.com/read/33841720/role-of-n-3-long-chain-polyunsaturated-fatty-acids-in-human-nutrition-and-health-review-of-recent-studies-and-recommendations
#38
REVIEW
Peter Van Dael
Long-chain (LC) n-3 polyunsaturated fatty acids (n-3 PUFAs), in particular docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are nutrients involved in many metabolic and physiological processes, and are referred to as n-3 LCPUFA. They have been extensively studied for their effects in human nutrition and health. This paper provides an overview on metabolism, sources, dietary intake, and status of n-3 LCPUFA. A summary of the dietary recommendations for n-3 LCPUFAs for different age groups as well as specific physiological conditions is provided...
April 2021: Nutrition Research and Practice
https://read.qxmd.com/read/33713860/fluorescent-nanocarriers-targeting-vcam-1-for-early-detection-of-senescent-endothelial-cells
#39
JOURNAL ARTICLE
Eugenia Belcastro, Asad Ur Rehman, Lamia Remila, Sin-Hee Park, Dal Seong Gong, Nicolas Anton, Cyril Auger, Olivier Lefebvre, Jacky G Goetz, Mayeul Collot, Andrey S Klymchenko, Thierry F Vandamme, Valérie B Schini-Kerth
Endothelial senescence has been identified as an early event in the development of endothelial dysfunction, a hallmark of cardiovascular disease. This study developed theranostic nanocarriers (NC) decorated with VCAM-1 antibodies (NC-VCAM-1) in order to target cell surface VCAM-1, which is overexpressed in senescent endothelial cells (ECs) for diagnostic and therapeutic purposes. Incubation of Ang II-induced premature senescent ECs or replicative senescent ECs with NC-VCAM-1 loaded with lipophilic fluorescent dyes showed higher fluorescence signals than healthy EC, which was dependent on the NC size and VCAM-1 antibodies concentration, and not observed following masking of VCAM-1...
June 2021: Nanomedicine: Nanotechnology, Biology, and Medicine
https://read.qxmd.com/read/33684737/omega-3-fatty-acids-reduce-cardiometabolic-risk-in-first-episode-schizophrenia-patients-treated-with-antipsychotics-findings-from-the-offer-randomized-controlled-study
#40
RANDOMIZED CONTROLLED TRIAL
Tomasz Pawełczyk, Marta Grancow-Grabka, Natalia Żurner, Agnieszka Pawełczyk
Metabolic syndrome (MetS) increases the risk of premature mortality observed in schizophrenia (SCZ). N-3 polyunsaturated fatty acid (PUFA) deficiency has been reported in different stages of schizophrenia. N-3 PUFA supplementation was found to be beneficial in both chronic SCZ and MetS. No intervention studies based on n-3 PUFA as add-on therapy to antipsychotics have examined the changes in MetS risk in first-episode schizophrenia. AIM: This randomized placebo-controlled trial assesses the effect of a 26-week intervention composed of either 2...
April 2021: Schizophrenia Research
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