Erica Mark, Werner Kempf, Joan Guitart, Melissa Pulitzer, Christina Mitteldorf, Alexandra Hristov, Carlos Torres-Cabala, Enrica Marchi, Thomas Cropley, Socorro Maria Rodriguez Pinilla, Teresa Griffin, Rony Fernandez, Stefano Pileri, Alessandro Pileri, Valentina Tabanelli, Lisa Borretta, Antonio Subtil, Jose Antonio Plaza, Jose A Miguel Angel Piris, Andrew L Feldman, Lorenzo Cerroni, Alejandro A Gru
Lymphomatoid papulosis (LyP) has several histopathologic presentations. LyP featuring gamma-delta (γδ) T-cell receptor expression may masquerade as and may be misdiagnosed as aggressive cutaneous T-cell lymphoma, particularly primary cutaneous γδ T-cell lymphoma (PCGDTL) or γδ mycosis fungoides. We performed a clinicopathologic analysis of the largest series of LyP featuring γδ T-cell expression. We identified 26 patients with a diagnosis of LyP with γδ T cells from our institutions, as well as through a comprehensive review of the literature, and characterized these cases...
March 27, 2024: American Journal of Surgical Pathology