Kasper Yde Jensen, Jakob Lindberg Nielsen, Per Aagaard, Mikkel Jacobsen, Anders Nørkær Jørgensen, Rune Dueholm Bech, Ulrik Frandsen, Louise Pyndt Diederichsen, Henrik Daa Schrøder
Sporadic inclusion body myositis (sIBM) is a subgroup of idiopathic inflammatory myopathies characterised by progressive muscle weakness and skeletal muscle inflammation. Quantitative data on the myofibre morphology in sIBM remains scarce. Further, no previous study has examined fibre type association of satellite cells (SC), myonuclei number, macrophages, capillaries, and myonuclear domain (MD) in sIBM patients. Muscle biopsies from sIBM patients (n = 18) obtained previously (NCT02317094) were included in the analysis for fibre type-specific myofibre cross-sectional area (mCSA), SCs, myonuclei and macrophages, myonuclear domain, and capillarisation...
April 6, 2024: Rheumatology International