keyword
https://read.qxmd.com/read/38191872/nasal-bots-carry-relevant-titers-of-cwd-prions-in-naturally-infected-white-tailed-deer
#21
JOURNAL ARTICLE
Paulina Soto, Francisca Bravo-Risi, Carlos Kramm, Nazaret Gamez, Rebeca Benavente, Denise L Bonilla, J Hunter Reed, Mitch Lockwood, Terry R Spraker, Tracy Nichols, Rodrigo Morales
Chronic wasting disease (CWD) is a prion disease affecting farmed and free-ranging cervids. CWD is rapidly expanding across North America and its mechanisms of transmission are not completely understood. Considering that cervids are commonly afflicted by nasal bot flies, we tested the potential of these parasites to transmit CWD. Parasites collected from naturally infected white-tailed deer were evaluated for their prion content using the protein misfolding cyclic amplification (PMCA) technology and bioassays...
January 8, 2024: EMBO Reports
https://read.qxmd.com/read/38181246/anemia-among-malaria-patients-with-and-without-soil-transmitted-helminths-in-arba-minch-town-health-facilities-a-comparative-cross-sectional-study
#22
JOURNAL ARTICLE
Birhanu Genanew, Fasil Getu, Muluken Walle, Asrat Hailu
Anemia is one of the severe clinical outcomes associated with concomitant infection of malaria and soil-transmitted helminths (STH). Since STH infections mostly share similar geographical areas with malaria, the influence of co-infections on the epidemiology and course of Anemia deserves greater consideration to assess the impact of interventions, the adequacy of strategies implemented, and the progress made in the fight against Anemia. So, this study was done to investigate Anemia among STH-negative malaria patients and malaria patients co-infected with single or multiple STHs, in 3 health facilities of Arba Minch, 2020 to 2021...
January 5, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38151172/a-severe-case-of-hyperinfection-by-strongyloides-stercoralis-in-a-pet-dog-from-romania
#23
Georgiana Deak, Angela Monica Ionică, Marian Taulescu, Andrada Negoescu, Constantin Ifteme, Mădălina Roșoiu, Andrei Daniel Mihalca
Strongyloides stercoralis is a zoonotic soil-transmitted nematode affecting mainly humans and dogs but identified also in non-human primates, cats and wild carnivores. It has a cosmopolitan distribution being endemic in tropical and subtropical areas. In Romania, the infection was reported on several occasions in dogs with low prevalence (3.5% -3.8%), assessed by coproscopy and it was confirmed in human patients with no travel history. A 2-year-old male Boston Terrier dog presented to a private clinic due to severe digestive problems, in July 2022...
December 25, 2023: Parasitology International
https://read.qxmd.com/read/38089690/optimal-control-analysis-of-a-transmission-interruption-model-for-the-soil-transmitted-helminth-infections-in-kenya
#24
JOURNAL ARTICLE
Collins Okoyo, Idah Orowe, Nelson Onyango, Antonio Montresor, Charles Mwandawiro, Graham F Medley
Kenya is among the countries endemic for soil-transmitted helminthiasis (STH) with over 66 subcounties and over 6 million individuals being at-risk of infection. Currently, the country is implementing mass drug administration (MDA) to all the at-risk groups as the mainstay control strategy. This study aimed to develop and analyze an optimal control (OC) model, from a transmission interruption model, to obtain an optimal control strategy from a mix of three strategies evaluated. The study used the Pontryagin's maximum principle to solve, numerically, the OC model...
2023: Curr Res Parasitol Vector Borne Dis
https://read.qxmd.com/read/38087679/measuring-heterogeneities-in-soil-transmitted-helminth-transmission-and-control
#25
REVIEW
Rosie Maddren, Roy M Anderson
The global effort over the past decade to control soil-transmitted helminths (STH) has resulted in communities with endemic infection reaching low prevalence levels suitable for the validation of elimination as a public health problem (EPHP), defined by the World Health Organisation (WHO) as <2% of infections classified as moderate or heavy intensity. The spatial scale in which this is validated is currently undefined. As the burden of STH infection decreases, the degree of aggregation of infection within individuals in a population increases...
December 11, 2023: Trends in Parasitology
https://read.qxmd.com/read/38075422/enterococcal-meningitis-associated-with-strongyloides-infection-a-case-report-and-literature-review
#26
Lavinia Cosimi, Stefano Di Bella, Roberto Luzzati, Catrin Theresia Simeth, Maurizio Pinamonti, Franco Cominotto, Ugo Giulio Sisto
Strongyloides stercoralis is an intestinal nematode endemic throughout tropical and subtropical areas, with a life cycle consisting of free-living and parasitic components. Unlike other soil-transmitted nematodes, it is capable of self-infection, which can cause chronic disease that lasts for decades, or cause overwhelming hyperinfection in people taking corticosteroids or other immunosuppressive drugs or who have impaired Th2 cell-mediated immunity, particularly those infected with human T-lymphotropic virus 1...
2023: Le Infezioni in Medicina
https://read.qxmd.com/read/38047835/key-contributions-by-the-swiss-tropical-and-public-health-institute-towards-new-and-better-drugs-for-tropical-diseases
#27
JOURNAL ARTICLE
Pascal Mäser, Sonja Bernhard, Reto Brun, Christian Burri, Sébastien Gagneux, Manuel W Hetzel, Marcel Kaiser, Christian Lengeler, Gerd Pluschke, Elisabeth Reus, Matthias Rottmann, Jürg Utzinger, Louisa Warryn, Sergio Wittlin, Jennifer Keiser
Thanks to its expertise in clinical research, epidemiology, infectious diseases, microbiology, parasitology, public health, translational research and tropical medicine, coupled with deeply rooted partnerships with institutions in low- and middle-income countries (LMICs), the Swiss Tropical and Public Health Institute (Swiss TPH) has been a key contributor in many drug research and development consortia involving academia, pharma and product development partnerships. Our know-how of the maintenance of parasites and their life-cycles in the laboratory, plus our strong ties to research centres and disease control programme managers in LMICs with access to field sites and laboratories, have enabled systems for drug efficacy testing in vitro and in vivo, clinical research, and modelling to support the experimental approaches...
September 20, 2023: Chimia
https://read.qxmd.com/read/38043533/paleoparasitology-research-on-ancient-helminth-eggs-and-larvae-in-the-republic-of-korea
#28
JOURNAL ARTICLE
Jong-Yil Chai, Min Seo, Dong Hoon Shin
Paleoparasitology is a discipline that applies existing conventional and molecular techniques to study parasites found in ancient ruins. This review focuses on the history of the discovery of parasites (mostly helminth eggs and larvae) in archaeological soil samples and mummies in Korea from the Three Kingdoms Period to the Joseon Dynasty (100 BCE-1910 CE). We also briefly review important milestones in global paleoparasitology. The helminth species reported so far in Korea included Ascaris lumbricoides, Trichuris trichiura, Strongyloides stercoralis (larva), Trichostrongylus sp...
November 2023: Parasites Hosts Dis
https://read.qxmd.com/read/38039279/improved-household-flooring-is-associated-with-lower-odds-of-enteric-and-parasitic-infections-in-low-and-middle-income-countries-a-systematic-review-and-meta-analysis
#29
JOURNAL ARTICLE
Hugo Legge, Rachel L Pullan, Benn Sartorius
Enteric and parasitic infections such as soil-transmitted helminths cause considerable mortality and morbidity in low- and middle-income settings. Earthen household floors are common in many of these settings and could serve as a reservoir for enteric and parasitic pathogens, which can easily be transmitted to new hosts through direct or indirect contact. We conducted a systematic review and meta-analysis to establish whether and to what extent improved household floors decrease the odds of enteric and parasitic infections among occupants compared with occupants living in households with unimproved floors...
2023: PLOS Glob Public Health
https://read.qxmd.com/read/38030120/maxent-modeling-of-the-potential-risk-of-schistosomiasis-in-the-philippines-using-bioclimatic-factors
#30
JOURNAL ARTICLE
Loida M Recopuerto-Medina, Franchesca Chiny U Gutierrez, Jose Antonio S San Diego, Nickhole Andrei E Alviar, Joseff Rayven M Santos, Nikki Heherson A Dagamac
Schistosomiasis is a parasitic infection caused by Schistosoma japonicum. It remains a principal local health issue in the Philippines, demonstrating endemicity in 28 provinces and afflicting thousands of Filipino individuals annually. Despite this, no clear distribution maps for the disease have been comprehensively reported. Therefore, species distribution modeling (SDM) employing the MaxEnt algorithm and GIS application techniques was utilized to denote the potential risk of schistosomiasis in the country...
November 27, 2023: Parasitology International
https://read.qxmd.com/read/38017569/influence-of-urbanization-on-schistosomiasis-infection-risk-in-anhui-province-based-on-sixteen-year-s-longitudinal-surveillance-data-a-spatio-temporal-modelling-study
#31
JOURNAL ARTICLE
Xin Liu, Yang Sun, Yun Yin, Xiaofeng Dai, Robert Bergquist, Fenghua Gao, Rui Liu, Jie Liu, Fuju Wang, Xiao Lv, Zhijie Zhang
BACKGROUND: Urbanization greatly affects the natural and social environment of human existence and may have a multifactoral impact on parasitic diseases. Schistosomiasis, a common parasitic disease transmitted by the snail Oncomelania hupensis, is mainly found in areas with population aggregations along rivers and lakes where snails live. Previous studies have suggested that factors related to urbanization may influence the infection risk of schistosomiasis, but this association remains unclear...
November 29, 2023: Infectious Diseases of Poverty
https://read.qxmd.com/read/38009931/discovery-of-new-broad-spectrum-anti-infectives-for-eukaryotic-pathogens-using-bioorganometallic-chemistry
#32
JOURNAL ARTICLE
Yan Lin, Hyeim Jung, Christina A Bulman, James Ng, Robin Vinck, Cillian O'Beirne, Shuai Zhong, Matthew S Moser, Nancy Tricoche, Ricardo Peguero, Robert W Li, Joseph F Urban, Patrice Le Pape, Fabrice Pagniez, Marco Moretto, Tobias Weil, Sara Lustigman, Kevin Cariou, Makedonka Mitreva, Judy A Sakanari, Gilles Gasser
Drug resistance observed with many anti-infectives clearly highlights the need for new broad-spectrum agents to treat especially neglected tropical diseases (NTDs) caused by eukaryotic parasitic pathogens, including fungal infections. Herein, we show that the simple modification of one of the most well-known antifungal drugs, fluconazole, with organometallic moieties not only improves the activity of the parent drug but also broadens the scope of application of the new derivatives. These compounds were highly effective in vivo against pathogenic fungal infections and potent against parasitic worms such as Brugia , which causes lymphatic filariasis and Trichuris , one of the soil-transmitted helminths that infects millions of people globally...
November 27, 2023: Journal of Medicinal Chemistry
https://read.qxmd.com/read/38008116/-strongyloides-omics-to-worm-free-populations
#33
JOURNAL ARTICLE
Dora Buonfrate, Vicky L Hunt, Peter Odermatt, Adrian Streit
This article is part of the Theo Murphy meeting issue ' Strongyloides : omics to worm-free populations'.
January 15, 2024: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://read.qxmd.com/read/38004944/enhancing-the-yield-of-a-lab-on-a-disk-based-single-image-parasite-quantification-device
#34
JOURNAL ARTICLE
Vyacheslav R Misko, Ramadhani Juma Makasali, Matthieu Briet, Filip Legein, Bruno Levecke, Wim De Malsche
The recently proposed single-image parasite quantification (SIMPAQ) platform based on a Lab-on-a-Disc (LOD) device was previously successfully tested in field conditions, demonstrating its efficiency in soil-transmitted helminth (STH) egg detection and analysis on the level delivered by the current state-of-the-art methods. Furthermore, the SIMPAQ provides relatively quick diagnostics and requires small amounts of sample and materials. On the other hand, in a recent related study, it was revealed that the performance of the SIMPAQ method can be limited due to the action of the tangential Euler and Coriolis forces, and the interaction of the moving eggs with the walls of the LOD chamber...
November 11, 2023: Micromachines
https://read.qxmd.com/read/37987591/surveillance-for-soil-transmitted-helminths-in-high-risk-county-mississippi-usa
#35
JOURNAL ARTICLE
Richard S Bradbury, Lora Martin, Lacy Malloch, Maygan Martin, John M Williams, Kayla Patterson, Cameron Sanders, Gurbaksh Singh, Irene Arguello, Eduardo Rodriguez, Paul Byers, Lisa Haynie, Yvonne Qvarnstrom, Charlotte V Hobbs
Recent reports of hookworm infection in Alabama, USA, has prompted surveillance in Mississippi, given the states' similar environmental conditions. We collected stool specimens from 277 children in Rankin County, Mississippi. Kato-Katz microscopic smear, agar plate culture, and quantitative PCR indicated no soil-transmitted helminths. Nevertheless, further surveillance in other high-risk Mississippi counties is warranted.
December 2023: Emerging Infectious Diseases
https://read.qxmd.com/read/37987581/cross-sectional-study-of-soil-transmitted-helminthiases-in-black-belt-region-of-alabama-usa
#36
JOURNAL ARTICLE
Claudette Poole, Troy Barker, Richard Bradbury, Drew Capone, Amy Hutson Chatham, Sukwan Handali, Eduardo Rodriguez, Yvonne Qvarnstrom, Joe Brown
We conducted a cross-sectional study to determine the prevalence of soil-transmitted helminthiases (STH) in areas of rural Alabama, USA, that have sanitation deficits. We enrolled 777 children; 704 submitted stool specimens and 227 a dried blood spot sample. We microscopically examined stool specimens from all 704 children by using Mini-FLOTAC for helminth eggs. We tested a subset by using molecular techniques: real-time PCR analysis for 5 STH species, TaqMan Array Cards for enteric helminths, and digital PCR for Necator americanus hookworm...
December 2023: Emerging Infectious Diseases
https://read.qxmd.com/read/37983246/epidemiology-of-intestinal-helminthiasis-with-an-emphasis-on-taeniasis-in-chipata-district-of-the-eastern-province-of-zambia
#37
JOURNAL ARTICLE
Gideon Zulu, Chummy S Sikasunge, Tamara M Welte, Martin C Simuunza, Dominik Stelzle, Veronika Schmidt, Alex Hachangu, Wilbroad Mutale, Maxwell Masuku, Mwelwa Chembensofu, Clarissa Prazeres da Costa, Kabemba E Mwape, Andrea S Winkler, Isaac K Phiri
BACKGROUND: Intestinal helminth infections are among the most common infections worldwide and have a negative impact on the health, education, nutrition and economic development of affected populations. This study aimed to estimate the prevalence of intestinal helminthiasis, including T. solium taeniasis, using a large-scale community-based study in Chiparamba area of Chipata District in the Eastern province of Zambia. METHODS/PRINCIPAL FINDINGS: A cross-sectional study was conducted between June 2019 and December 2022 in a rural community of 25 randomly selected villages known to be at risk for T...
November 20, 2023: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/37957984/a-study-on-the-monitoring-of-toxocara-spp-in-various-children-s-play-facilities-in-the-republic-of-korea-2016-2021
#38
JOURNAL ARTICLE
Young-Hwan Oh, Hae-Jin Sohn, Mi-Yeon Choi, Min-Woo Hyun, Seok-Ho Hong, Ji-Su Lee, Ah-Reum Ryu, Jong-Hyun Kim, Ho-Joon Shin
Toxocara spp. is a zoonotic soil-transmitted parasite that infects canids and felids, which causes toxocariasis in humans, migrating to organ systems, including the lungs, the ocular system, and the central nervous system. Since Toxocara spp. is usually transmitted through soil, children tend to be more susceptible to infection. In order to monitor contamination with Toxocara spp. in children's play facilities in the Republic of Korea, we investigated 11,429 samples of soil from daycare centers, kindergartens, elementary schools, and parks across the country from January 2016 to December 2021...
October 27, 2023: Healthcare (Basel, Switzerland)
https://read.qxmd.com/read/37957702/feasibility-and-safety-of-integrating-mass-drug-administration-for-helminth-control-with-seasonal-malaria-chemoprevention-among-senegalese-children-a-randomized-controlled-observer-blind-trial
#39
JOURNAL ARTICLE
Muhammed O Afolabi, Doudou Sow, Schadrac C Agbla, El Hadji Babacar Fall, Fatimata Bintou Sall, Amadou Seck, Isaac Akhénaton Manga, Ibrahima Marietou Mbaye, Mor Absa Loum, Baba Camara, Diatou Niang, Babacar Gueye, Doudou Sene, Ndéye M'backé Kane, Boubacar Diop, Awa Diouf, Ndéye Aida Gaye, Marie Pierre Diouf, Aminata Colle Lo, Brian Greenwood, Jean Louis A Ndiaye
BACKGROUND: The overlap in the epidemiology of malaria and helminths has been identified as a potential area to exploit for the development of an integrated control strategy that may help to achieve elimination of malaria and helminths. A randomized, controlled, observer-blind trial was conducted to assess the feasibility and safety of combining mass drug administration (MDA) for schistosomiasis and soil transmitted helminths (STH) with seasonal malaria chemoprevention (SMC) among children living in Senegal...
November 13, 2023: Malaria Journal
https://read.qxmd.com/read/37937980/human-strongyloidiasis-complexities-and-pathways-forward
#40
REVIEW
Dora Buonfrate, Richard S Bradbury, Matthew R Watts, Zeno Bisoffi
SUMMARY Strongyloidiasis is a World Health Organization neglected tropical disease usually caused by Strongyloides stercoralis , a parasitic worm with a complex life cycle. Globally, 300-600 million people are infected through contact with fecally contaminated soil. An autoinfective component of the life cycle can lead to chronic infection that may be asymptomatic or cause long-term symptoms, including malnourishment in children. Low larval output can limit the sensitivity of detection in stool, with serology being effective but less sensitive in immunocompromise...
December 20, 2023: Clinical Microbiology Reviews
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