Sooyoung Chung, Il Hwan Kim, Dongmin Lee, Kyungjoon Park, Joo Yeon Kim, Yeon Kyung Lee, Eun Joo Kim, Hyun Woo Lee, June-seek Choi, Gi Hoon Son, Woong Sun, Ki Soon Shin, Hyun Kim
Inositol 1,4,5-trisphosphate 3-kinase A (IP3K-A) is a molecule enriched in the brain and neurons that regulates intracellular calcium levels via signaling through the inositol trisphosphate receptor. In the present study, we found that IP3K-A expression is highly enriched in the central nucleus of the amygdala (CeA), which plays a pivotal role in the processing and expression of emotional phenotypes in mammals. Genetic abrogation of IP3K-A altered amygdala gene expression, particularly in genes involved in key intracellular signaling pathways and genes mediating fear- and anxiety-related behaviors...
April 7, 2016: Scientific Reports