Jorge Fernando Silva de Menezes, Andrei Marcelino Sá Pires Silva, Edna Aparecida Faria de Almeida, Ananias Freire da Silva, Julia Morais Bomfim De Lima, Antonio Wlisses da Silva, Maria Kueirislene Amâncio Ferreira, Jane Eire Silva Alencar de Menezes, Hélcio Silva Dos Santos, Emmanuel Silva Marinho, Gabrielle Silva Marinho, Aluísio Marques da Fonseca
Anxiety-related mental health problems are estimated at 3.6% globally, benzodiazepines (BZDs) are the class of drugs indicated for the treatment of anxiety, including lorazepam and diazepam. However, concerns have been raised about the short- and long-term risks associated with BZDs. Therefore, despite anxiolytic and antidepressant drugs, there is a need to develop more effective pharmacotherapies with fewer side effects than existing drugs. The present work reported the synthesis, anxiolytic activity, mechanism of action in Adult Zebrafish ( Danio rerio ) and in silico study of a europium metallic complex with Lapachol, [Eu(DBM)3 ...
April 8, 2023: Journal of Biomolecular Structure & Dynamics