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DERMAL FAT

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https://read.qxmd.com/read/30702342/cd36-mediates-albumin-transcytosis-by-dermal-but-not-lung-microvascular-endothelial-cells-role-in-fatty-acid-delivery
#1
Hira Raheel, Siavash Ghaffari, Negar Khosraviani, Victoria Mintsopoulos, Derek Auyeung, Changsen Wang, Yun Hye Kim, Brendan Mullen, Hoon-Ki Sung, May Ho, Gregory Fairn, Dante Neculai, Maria Febbraio, Bryan Heit, Warren L Lee
In healthy blood vessels, albumin crosses the endothelium to leave the circulation by transcytosis. However, little is known about the regulation of albumin transcytosis or how it differs in different tissues; its physiological purpose is also unclear. Using total internal reflection fluorescence microscopy, we quantified transcytosis of albumin across primary human microvascular endothelial cells from both lung and skin. We then validated our in vitro findings using a tissue-specific knockout mouse model. We observed that albumin transcytosis was saturable in the skin but not the lung microvascular endothelial cells, implicating a receptor-mediated process...
January 31, 2019: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/30684232/oncoplastic-breast-surgery-combining-partial-mastectomy-with-immediate-breast-reshaping-using-multiple-local-flaps-for-a-patient-with-slim-body
#2
Yuko Kijima, Munetsugu Hirata, Yoshiaki Shinden, Toshiaki Utsumi, Zenichi Morise, Shoji Natsugoe
Oncoplastic breast surgery (OBS), which combines the concepts of oncologic and plastic surgery, is becoming more common worldwide. We report the results of OBS in a Japanese patient with early breast cancer located on the outer lower quadrant area. We performed OBS combining partial mastectomy with immediate breast reshaping using multiple adipofascial cutaneous flaps and free dermal fat graft because she refused any other OBS. We selected three local flaps to repair the defect. Perioperative and postoperative complications were not seen...
January 25, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30681799/open-label-study-evaluating-efficacy-safety-and-effects-on-perception-of-age-after-injectable-20-mg-ml-hyaluronic-acid-gel-for-volumization-of-facial-temples
#3
Leslie S. Baumann, Edmund M. Weisberg, Melissa Mayans, Erika Arcuri
Objective: To study the safety, efficacy, optimal volume, and longevity of an injectable hyaluronic acid (HA) gel dermal filler to treat facial temporal fossa fat loss. Methods and materials: This open-label, single-site, 12-month study used 20 mg/mL HA gel to correct volume loss in both temples in 30 subjects. Touch-ups were allowed at week 2. At each visit, the investigator completed a Frontal Temporal Fossa Scale and a 7-point satisfaction scale. Subjects completed a 7-point satisfaction scale, Subject Global Aesthetic Improvement Scale (GAIS), and self-perception of age assessment...
January 1, 2019: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/30678729/mechanical-micronization-of-lipoaspirates-for-the-treatment-of-hypertrophic-scars
#4
Jing Wang, Yunjun Liao, Jing Xia, Zijue Wang, Xiaopei Mo, Jingwei Feng, Yunfan He, Xihang Chen, Ye Li, Feng Lu, Junrong Cai
BACKGROUND: Hypertrophic scars cause cosmetic and functional problems for patients, and their treatment remains challenging. Mechanical micronization of adipose tissue can remove adipocytes and concentrate functional cells. Stromal vascular fraction (SVF)-gel is obtained by a series of simple mechanical processes, including shifting between syringes and centrifugation. This study aimed to assess the therapeutic effect of SVF-gel on hypertrophic scars. METHODS: A model of hypertrophic scars was established in rabbit ears...
January 24, 2019: Stem Cell Research & Therapy
https://read.qxmd.com/read/30670293/novel-approaches-for-the-assessment-of-relative-body-weight-and-body-fat-in-diagnosis-and-treatment-of-anorexia-nervosa-a-cross-sectional-study
#5
Sonja Lackner, Sabrina Mörkl, Wolfram Müller, Alfred Fürhapter-Rieger, Andreas Oberascher, Michael Lehofer, Claudia Bieberger, Willibald Wonisch, Omid Amouzadeh-Ghadikolai, Maximilian Moser, Harald Mangge, Sieglinde Zelzer, Sandra Johanna Holasek
BACKGROUND & AIMS: Anorexia nervosa (AN) is a severe psychosomatic disease that seriously affects nutritional status. Therapeutic approaches primarily aim for rapid weight restoration by high caloric diets and activity restriction. This often promotes abdominal body fat gain, which potentially negatively influences the patient's compliance and increases the risk of relapse. This study focused on the evaluation of body weight and subcutaneous adipose tissue (SAT) in AN patients by novel approaches...
January 10, 2019: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://read.qxmd.com/read/30632214/identification-of-a-closed-cutaneous-injury-after-mechanical-trauma-caused-by-collision
#6
Moon Young Park, Jun Suk Choi, Kyung Sook Kim, Sungsoo Rhim, Hyung Jin Park, Min Kyung Shin
PURPOSE: Robotics has evolved rapidly in terms of mechanical design and control in the past few years. Collaborative robots that have direct contact with humans are being introduced in various fields, including industrial and medical services. Because collaborative robot systems are being introduced rapidly, the safety of the humans who work with them is becoming an important issue. In this study, we investigated skin injuries resulting from a collision between robots and humans using a freefall experiment system...
January 11, 2019: Skin Research and Technology
https://read.qxmd.com/read/30624243/adipose-infiltration-of-the-dermis-involving-the-arrector-pili-muscle-and-dermal-displacement-of-eccrine-sweat-coils-new-histologic-observations-in-frontal-fibrosing-alopecia
#7
Mariya Miteva, David Castillo, Samar Sabiq
BACKGROUND: Frontal fibrosing alopecia (FFA) is an irreversible scarring alopecia, and its incidence has reached epidemic size. Immune privilege collapse of the bulge and epithelial mesenchymal transition play a role in the pathogenesis. We have noted adipose tissue in the dermis in several specimens from FFA. OBJECTIVE: Our primary objective was to verify the presence of adipose tissue at the isthmus level in biopsies from FFA. Additional objectives included the presence of deep inflammation and position of the sweat coils...
January 3, 2019: American Journal of Dermatopathology
https://read.qxmd.com/read/30615553/characterizing-lower-extremity-lymphedema-and-lipedema-with-cutaneous-ultrasonography-and-an-objective-computer-assisted-measurement-of-dermal-echogenicity
#8
Emily Iker, Cory K Mayfield, Daniel J Gould, Ketan M Patel
BACKGROUND: Sonographic findings differ in patients with primary lipedema from those with lymphedema. This project was designed to quantify those differences and objectively characterize findings of lipedema and lymphedema in the lower extremity. METHODS AND RESULTS: Patients with a clinical diagnosis of ISL stage I-II lipedema or lower extremity lymphedema that received ultrasound evaluation were included in this study. Thickness and echogenicity of the skin and subcutaneous fat layer were measured at the level of the ankle, calf, and thigh in each patient...
January 7, 2019: Lymphatic Research and Biology
https://read.qxmd.com/read/30597607/utility-of-cd123-immunohistochemistry-in-differentiating-lupus-erythematosus-from-cutaneous-t-cell-lymphoma
#9
Stephanie J T Chen, Julie Y Tse, Paul W Harms, Alexandra C Hristov, May P Chan
AIMS: Histopathologic overlap between lupus erythematosus and certain types of cutaneous T-cell lymphoma (CTCL) is well documented. CD123+ plasmacytoid dendritic cells (PDCs) are typically increased in lupus erythematosus, but have not been well studied in CTCL. We aimed to compare CD123 immunostaining and histopathologic features in these conditions. METHODS AND RESULTS: Skin biopsies of cutaneous lupus erythematosus (CLE, n=18), lupus erythematosus panniculitis (LEP, n=17), mycosis fungoides (MF, n=25) and subcutaneous panniculitis-like T-cell lymphoma (SPTCL, n=9) were retrospectively reviewed and immunostained with CD123...
December 31, 2018: Histopathology
https://read.qxmd.com/read/30594464/age-related-loss-of-innate-immune-antimicrobial-function-of-dermal-fat-is-mediated-by-transforming-growth-factor-beta
#10
Ling-Juan Zhang, Stella Xiang Chen, Christian F Guerrero-Juarez, Fengwu Li, Yun Tong, Yuqiong Liang, Marc Liggins, Xu Chen, Hao Chen, Min Li, Tissa Hata, Ye Zheng, Maksim V Plikus, Richard L Gallo
Dermal fibroblasts (dFBs) resist infection by locally differentiating into adipocytes and producing cathelicidin antimicrobial peptide in response to Staphylococcus aureus (S. aureus). Here, we show that neonatal skin was enriched with adipogenic dFBs and immature dermal fat that highly expressed cathelicidin. The pool of adipogenic and antimicrobial dFBs declined after birth, leading to an age-dependent loss of dermal fat and a decrease in adipogenesis and cathelidicin production in response to infection...
December 18, 2018: Immunity
https://read.qxmd.com/read/30540605/the-potential-of-acellular-dermal-matrix-combined-with-neural-stem-cells-induced-from-human-adipose-derived-stem-cells-in-nerve-tissue-engineering
#11
Wei-Ze Syu, Shyi-Gen Chen, James Yi-Hsin Chan, Chih-Hsin Wang, Niann-Tzyy Dai, Shih-Ming Huang
INTRODUCTION: Reconstruction of segmental peripheral nerve gap is still challenging when the autografts are unavailable owing to limited availability of donor site and functional recovery. The creation of artificial conduits composed of biological or synthetic materials is still developing. Acellular dermal matrix (ADM) has been widely studied and its extension and plasticity properties may become suitable nerve conduits under different forms of nerve gaps. Adipose-derived stem cells (ADSCs) have the potential to differentiate into various cell types of different germ layers including neural stem cells (NSCs)...
January 2019: Annals of Plastic Surgery
https://read.qxmd.com/read/30534488/a-single-visit-approach-using-fillers-and-incobotulinumtoxin-a-full-face-enhancement-in-asian-patients
#12
Yates Y Y Chao
A 3-dimensional, multi-layered approach combining modalities targeting different manifestations is recommended for achieving optimal esthetic outcomes. To date, studies reporting same-day treatment with dermal fillers and botulinum toxin have not been published. This article documents the practical use of a single-visit, pan-facial multimodal approach in addressing the varying esthetic needs of 8 Asian adults. The case series included male or female patients of varying age and degrees of facial fat, who received combination treatment with calcium hydroxylapatite filler, polydensified hyaluronic acid filler, and incobotulinumtoxin A in a single visit in August 2016 at a treatment center in Taiwan...
October 2018: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/30442054/aesthetic-improvements-of-radial-forearm-flap-donor-site-by-autologous-fat-transplantation
#13
Benedetto Longo, Michail Sorotos, Rosaria Laporta, Fabio Santanelli di Pompeo
Despite its reliability, radial forearm (RF) flap is still affected by high donor site morbidity with poor cosmetic and functional outcomes after coverage with skin grafts. Having fat grafting demonstrated promising and effective filling and rejuvenating properties, we considered and tested it as a valuable alternative to dermal substitutes for the aesthetic improvement of RF flap donor site. Thirty-three patients with previous RF free flap reconstruction and poor donor site outcomes after full-thickness skin grafting to RF region were evaluated for secondary fat injection to improve outcomes...
November 16, 2018: Journal of Plastic Surgery and Hand Surgery
https://read.qxmd.com/read/30431578/progressive-large-pediatric-corneal-limbal-dermoid-management-with-tissue-glue-assisted-monolayer-amniotic-membrane-transplantation-a-case-report
#14
Wan-Hua Cho, Ming-Tse Sung, Pei-Wen Lin, Hun-Ju Yu
RATIONALE: Limbal dermoids are choristomas known as congenital benign tumors found in abnormal locations. Despite the benign nature, enlarging limbal dermoids may cause visual abnormalities by cornea infiltration with fat component, visual axis invasion, gradually induced corneal astigmatism, and finally result in anisometropic amblyopia. Here we report a rare case of progressive, large pediatric corneal limbal dermoid in a newborn, managed with tissue glue-assisted monolayer amniotic membrane transplantation...
November 2018: Medicine (Baltimore)
https://read.qxmd.com/read/30415840/identity-noise-and-adipogenic-traits-characterize-dermal-fibroblast-aging
#15
Marion Claudia Salzer, Atefeh Lafzi, Antoni Berenguer-Llergo, Catrin Youssif, Andrés Castellanos, Guiomar Solanas, Francisca Oliveira Peixoto, Camille Stephan-Otto Attolini, Neus Prats, Mònica Aguilera, Juan Martín-Caballero, Holger Heyn, Salvador Aznar Benitah
During aging, stromal functions are thought to be impaired, but little is known whether this stems from changes of fibroblasts. Using population- and single-cell transcriptomics, as well as long-term lineage tracing, we studied whether murine dermal fibroblasts are altered during physiological aging under different dietary regimes that affect longevity. We show that the identity of old fibroblasts becomes undefined, with the fibroblast states present in young skin no longer clearly demarcated. In addition, old fibroblasts not only reduce the expression of genes involved in the formation of the extracellular matrix, but also gain adipogenic traits, paradoxically becoming more similar to neonatal pro-adipogenic fibroblasts...
November 3, 2018: Cell
https://read.qxmd.com/read/30382375/impact-of-human-mesenchymal-cells-of-different-body-site-origins-on-the-maturation-of-dermo-epidermal-skin-substitutes
#16
Katarzyna Michalak-Micka, Agnes S Klar, Sophie Böttcher-Haberzeth, Ernst Reichmann, Martin Meuli, Thomas Biedermann
AIM OF THE STUDY: The use of autologous bio-engineered dermo-epidermal skin substitutes (DESS) yields a pivotal opportunity to cover large skin defects in human patients. These skin grafts consist of both epidermal and dermal compartments necessary for robust and permanent functional wound closure. In this study, we investigated the impact of mesenchymal cells derived from different body site origins on the expression pattern of diverse markers within DESS. METHODS: Human keratinocytes were obtained from interfollicular epidermis, and mesenchymal cells were isolated from foreskin, palmar skin, fat tissue, and tonsils...
October 31, 2018: Pediatric Surgery International
https://read.qxmd.com/read/30372477/sebaceous-gland-abnormalities-in-fatty-acyl-coa-reductase-2-far2-null-mice-result-in-primary-cicatricial-alopecia
#17
John P Sundberg, Tong Shen, Oliver Fiehn, Robert H Rice, Kathleen A Silva, Victoria E Kennedy, Nicholas E Gott, Louise A Dionne, Lesley S Bechtold, Stephen A Murray, Raoul Kuiper, C Herbert Pratt
In a large scale screen for skin, hair, and nail abnormalities in null mice generated by The Jackson Laboratory's KOMP center, homozygous mutant Far2tm2b(KOMP)Wtsi/2J (hereafter referrred to as Far2-/-) mice were found to develop focal areas of alopecia as they aged. As sebocytes matured in wildtype C57BL/NJ mice they became pale with fine, uniformly sized clear lipid containing vacuoles that were released when sebocytes disintegrated in the duct. By contrast, the Far2-/- null mice had sebocytes that were similar within the gland but become brightly eosinophilic when the cells entered the sebaceous gland duct...
2018: PloS One
https://read.qxmd.com/read/30360664/platelet-rich-plasma-to-rescue-an-ulcerated-orbital-dermal-fat-graft
#18
Tania Andrea Chaparro Tapias, Alberto Luis Díaz Díaz, Roberto Secondi, Helena Coy Villamil, Juan Carlos Sánchez España
INTRODUCTION: Central graft ulceration is a rare complication of an orbital dermal fat graft caused by diminished blood supply to the implant. This study reports on the efficacy and safety of the use of a single subconjunctival injection of autologous platelet-rich plasma to rescue an ulcerated orbital dermal fat graft. METHODS: Three patients, who had undergone autologous dermal fat graft to treat their anophthalmic socket, were given a 2-mL subconjunctival platelet-rich plasma injection in the exposed graft margins...
October 26, 2018: European Journal of Ophthalmology
https://read.qxmd.com/read/30349778/quadruped-and-dermal-bridge-flap-for-nipple-reconstruction
#19
Daisuke Fujisawa, Hirotaka Asato, Yasutoshi Suzuki, Koki Hasegawa
Background: This report describes the authors' novel preferred method of nipple reconstruction over 10 years. Methods: The procedure was used in 39 patients (unilateral 38, bilateral 1). The circle is designed as the new nipple cap. Then, 4 fan-shapes (one-quarter of the circle) are drawn so that the base portion is in contact with the circumference. These fanshapes are deepithelialized, and their linear portions are cut with full thickness of skin and elevated as dermal flaps...
September 2018: Plastic and Reconstructive Surgery. Global Open
https://read.qxmd.com/read/30332890/a-surgical-approach-to-linear-scleroderma-using-medpor-and-dermal-fat-graft
#20
Keun Tae Kim, Hook Sun, Eui Han Chung
Linear scleroderma en coup de sabre (LScs) is a variant of localized scleroderma. This disease typically occurs in patients in their 20s or younger individuals and predominantly occurs in the forehead area. A 26-year-old man with linear scleroderma was surgically treated at our center with Medpor (porous polyethylene) and dermal fat graft for the forehead lesion. After 26 months of postoperative follow-up, the depressed lesion that appeared scarred as well as the margins improved significantly. The surgical treatment of LScs using Medpor and dermal fat graft is an effective treatment modality that can increase patient satisfaction...
October 16, 2018: Archives of Craniofacial Surgery
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