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Keywords Glioblastoma , breast cancer, ...

Glioblastoma , breast cancer, prostate cancer

https://read.qxmd.com/read/38458555/multifaced-roles-of-the-long-non-coding-rna-draic-in-cancer-progression
#1
REVIEW
Kouhei Sakurai, Hiroyasu Ito
Long non-coding RNAs (lncRNA) are functional RNAs, with over 200 nucleotides in length and lacking protein-coding potential. Studies have indicated that lncRNAs are important gene regulators under physiological conditions. Aberrant lncRNA expression is associated with the initiation and progression of various diseases, including cancers. High-throughput transcriptome analyses have revealed thousands of lncRNAs as putative tumor suppressors or promoters in various cancers, but the detailed molecular mechanisms of each lncRNA remain unclear...
March 6, 2024: Life Sciences
https://read.qxmd.com/read/38391963/subtype-transdifferentiation-in-human-cancer-the-power-of-tissue-plasticity-in-tumor-progression
#2
REVIEW
Monica Fedele, Laura Cerchia, Sabrina Battista
The classification of tumors into subtypes, characterized by phenotypes determined by specific differentiation pathways, aids diagnosis and directs therapy towards targeted approaches. However, with the advent and explosion of next-generation sequencing, cancer phenotypes are turning out to be far more heterogenous than initially thought, and the classification is continually being updated to include more subtypes. Tumors are indeed highly dynamic, and they can evolve and undergo various changes in their characteristics during disease progression...
February 17, 2024: Cells
https://read.qxmd.com/read/38321173/systematic-pan-cancer-analyses-of-the-potential-function-of-the-golgi-scaffold-protein-paqr3
#3
JOURNAL ARTICLE
Zhe-Nan Ling, Lian-Lian Hong, Jian Wu, Zhi-Qiang Ling
Progesterone and AdipoQ Receptor 3 (PAQR3) is a member of the AdipoQ receptor. Our previous studies have found that PAQR3 plays a role as a candidate inhibitor in cardiac adenocarcinoma, breast cancer, gastric cancer and colorectal cancer, but the systematic analysis of PAQR3 in tumors is currently lacking. The objective of this study was to investigate the prognostic and therapeutic value of PAQR3 in 31 tumors. Through the analysis of TCGA, UALCAN, GEO, GEPIA2, TIMER, Kaplan-Meier plotter, TISIDB and other databases, it was found that the expression level of PAQR3 changed significantly in different tumor types, and the expression level of Neuroblastoma was very high...
February 6, 2024: Scientific Reports
https://read.qxmd.com/read/38023152/cd147-an-integral-and-potential-molecule-to-abrogate-hallmarks-of-cancer
#4
REVIEW
Alphonce M K Nyalali, Angela U Leonard, Yongxiang Xu, Huayu Li, Junlin Zhou, Xinrui Zhang, Tibera K Rugambwa, Xiaohan Shi, Feng Li
CD147 also known as EMMPRIN, basigin, and HAb18G, is a single-chain type I transmembrane protein shown to be overexpressed in aggressive human cancers of CNS, head and neck, breasts, lungs, gastrointestinal, genitourinary, skin, hematological, and musculoskeletal. In these malignancies, the molecule is integral to the diverse but complimentary hallmarks of cancer: it is pivotal in cancerous proliferative signaling, growth propagation, cellular survival, replicative immortality, angiogenesis, metabolic reprogramming, immune evasion, invasion, and metastasis...
2023: Frontiers in Oncology
https://read.qxmd.com/read/38007705/apobec3c-is-a-novel-target-for-the-immune-treatment-of-lower-grade-gliomas
#5
JOURNAL ARTICLE
Shufa Zhao, Yuntao Li, Jie Xu, Liang Shen
BACKGROUND: Apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC) type 3C (A3C) has been identified as a cancer molecular biomarker in the past decade. However, the practical role of A3C in lower-grade gliomas (LGGs) in improving the clinical outcome remains unclear. This study aims to discuss the function of A3C in immunotherapy in LGGs. METHODS: The RNA-Sequencing (RNA-seq) and corresponding clinical data were extracted from UCSC Xena and the results were verified in the Chinese Glioma Genome Atlas (CGGA)...
November 26, 2023: Neurological Research
https://read.qxmd.com/read/37905329/comprehensive-exploration-of-biochanin-a-as-an-oncotherapeutics-potential-in-the-treatment-of-multivarious-cancers-with-molecular-insights
#6
REVIEW
Md Sohel
Cancer is considered a leading cause of mortality. This rising cancer death rate and several existing limitations like side effects, poor efficacies, and high cost of the present chemotherapeutic agents have increased the demand for more potent and alternative cancer treatments. This review elucidated a brief overview of Biochanin A (BCA) and its potentiality on various cancers with details of anticancer mechanism. According to our review, a number of studies including in silico, in vitro, pre-clinical, and clinical trials have tested to evaluate the efficacy of BCA...
October 31, 2023: Phytotherapy Research: PTR
https://read.qxmd.com/read/37894767/cancer-stem-cells-and-androgen-receptor-signaling-partners-in-disease-progression
#7
REVIEW
Juan Carlos Quintero, Néstor Fabián Díaz, Mauricio Rodríguez-Dorantes, Ignacio Camacho-Arroyo
Cancer stem cells exhibit self-renewal, tumorigenesis, and a high differentiation potential. These cells have been detected in every type of cancer, and different signaling pathways can regulate their maintenance and proliferation. Androgen receptor signaling plays a relevant role in the pathophysiology of prostate cancer, promoting cell growth and differentiation processes. However, in the case of prostate cancer stem cells, the androgen receptor negatively regulates their maintenance and self-renewal. On the other hand, there is evidence that androgen receptor activity positively regulates the generation of cancer stem cells in other types of neoplasia, such as breast cancer or glioblastoma...
October 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37818043/multiomics-and-bioinformatics-identify-differentially-expressed-effectors-in-the-brain-of-toxoplasma-gondii-infected-masked-palm-civet
#8
JOURNAL ARTICLE
Hao Yuan, Tiantian Jiang, Wei-Dong Zhang, Zipeng Yang, Shengjun Luo, Xiaohu Wang, Xiaojing Zhu, Shuting Qi, Yasser S Mahmmod, Xiu-Xiang Zhang, Zi-Guo Yuan
INTRODUCTION: The masked palm civet ( Paguma larvata ) serves as a reservoir in transmitting pathogens, such as Toxoplasma gondii , to humans. However, the pathogenesis of T. gondii infection in masked palm civets has not been explored. We studied the molecular changes in the brain tissue of masked palm civets chronically infected with T. gondii ME49. METHODS: The differentially expressed proteins in the brain tissue were investigated using iTRAQ and bioinformatics...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/37805766/-pan-cancer-analysis-of-ubiquitin-specific-protease-7-and-its-expression-changes-in-the-carcinogenesis-of-scar-ulcer
#9
JOURNAL ARTICLE
S Y Zhang, J J Ruan, D M Jin, N Chen, W G Xie, Q F Ruan
Objective: To explore the biological role and clinical significance of ubiquitin-specific protease 7 (USP7) in the carcinogenesis of scar ulcer. Methods: A retrospective observational study combined with bioinformatics analysis was used. The RNA expression profile data of USP7 in tumor and/or its corresponding paracancular normal tissue were obtained from The Cancer Genome Atlas (TCGA) database and the Gene Expression Omnibus database, and the RNA sequencing data were transformed by log2 . The variations of USP7 gene were analyzed by cBioPortal database...
June 20, 2023: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://read.qxmd.com/read/37792220/risk-of-developing-glioblastoma-following-non-cns-primary-cancer-a-seer-analysis-between-2000-and-2018
#10
JOURNAL ARTICLE
David Y A Dadey, Zachary A Medress, Mayur Sharma, Beatrice Ugiliweneza, Dengzhi Wang, Adrian Rodrigues, Jonathon Parker, Eric Burton, Brian Williams, Summer S Han, Maxwell Boakye, Stephen Skirboll
BACKGROUND: Patients with a prior malignancy are at elevated risk of developing subsequent primary malignancies (SPMs). However, the risk of developing subsequent primary glioblastoma (SPGBM) in patients with a prior cancer history is poorly understood. METHODS: We used the Surveillance, Epidemiology, and End Results (SEER) database and identified patients diagnosed with non-CNS malignancy between 2000 and 2018. We calculated a modified standardized incidence ratio (M-SIR), defined as the ratio of the incidence of SPGBM among patients with initial non-CNS malignancy to the incidence of GBM in the general population, stratified by sex latency, and initial tumor location...
October 4, 2023: Journal of Neuro-oncology
https://read.qxmd.com/read/37787188/regulatory-role-of-mirnas-on-wnt-%C3%AE-catenin-signaling-in-tumorigenesis-of-glioblastoma
#11
REVIEW
Farzad Rahmani, Pedram Hashemian, Ayda Tadayyon Tabrizi, Zeynab Ghorbani, Aghigh Ziaeemehr, Sajede Alijannejad, Gordon A Ferns, Amir Avan, Soodabeh Shahidsales
Glioblastoma (GBM) is one of the most aggressive tumors in the brain with high mortality worldwide. Despite recent advances in therapeutic strategies, the survival rate remains low in patients with GBM. The pathogenesis of GBM is a very complicated process involving various genetic mutations affecting several oncogenic signaling pathways like Wnt/β-catenin axis. Overactivation of the Wnt/β-catenin signaling pathway is associated with decreased survival and poor prognosis in patients with GBM. MicroRNAs (miRNAs) were shown to play important roles in the regulation of cell proliferation, differentiation, apoptosis, and tumorigenesis by modulating the expression of their target genes...
2023: Indian Journal of Cancer
https://read.qxmd.com/read/37757910/care-pathway-analysis-to-inform-the-earliest-stages-of-technology-development-scoping-oncological-indications-in-need-of-innovation
#12
JOURNAL ARTICLE
Mirre Scholte, Jan Heidkamp, Gerjon Hannink, M A W Thijs Merkx, Janneke P C Grutters, Maroeska M Rovers
BACKGROUND: Identifying unmet needs for innovative solutions across disease contexts is challenging, but important for directing funding and research efforts and informing early-stage decisions during the innovation process. Our aim was to study the merits of care pathway analysis to scope disease contexts and guide the development of innovative devices. We used oncologic surgery as a case study, for which many intraoperative imaging techniques are under development. METHODS: Care pathway analysis is a mapping process which produces graphical maps of clinical pathways using important outcomes and subsequent consequences...
September 25, 2023: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
https://read.qxmd.com/read/37627957/sternum-metastases-from-case-identifying-strategy-to-multidisciplinary-management
#13
REVIEW
Mara Carsote, Dana Terzea, Florina Vasilescu, Anca-Pati Cucu, Adrian Ciuche, Claudiu Nistor
We aimed to overview the most recent data on sternal metastases from a multidisciplinary approach (diagnosis strategies, outcome, and histological reports). This narrative review based on a PubMed search (between January 2020 and 22 July 2023) using key words such as "sternal", "manubrium", and "metastasis" within the title and/or abstract only included original papers that specifically addressed secondary sternal spreading of cancer in adults, for a total of 48 original articles (14 studies and 34 single case reports)...
August 17, 2023: Diagnostics
https://read.qxmd.com/read/37626712/beyond-prostate-cancer-an-androgen-receptor-splice-variant-expression-in-multiple-malignancies-non-cancer-pathologies-and-development
#14
REVIEW
Kimberley D Katleba, Paramita M Ghosh, Maria Mudryj
Multiple studies have demonstrated the importance of androgen receptor (AR) splice variants (SVs) in the progression of prostate cancer to the castration-resistant phenotype and their utility as a diagnostic. However, studies on AR expression in non-prostatic malignancies uncovered that AR-SVs are expressed in glioblastoma, breast, salivary, bladder, kidney, and liver cancers, where they have diverse roles in tumorigenesis. AR-SVs also have roles in non-cancer pathologies. In granulosa cells from women with polycystic ovarian syndrome, unique AR-SVs lead to an increase in androgen production...
August 7, 2023: Biomedicines
https://read.qxmd.com/read/37626597/a-holistic-approach-to-hard-to-treat-cancers-the-future-of-immunotherapy-for-glioblastoma-triple-negative-breast-cancer-and-advanced-prostate-cancer
#15
REVIEW
Carles Puig-Saenz, Joshua R D Pearson, Jubini E Thomas, Stéphanie E B McArdle
Immunotherapy represents an attractive avenue for cancer therapy due to its tumour specificity and relatively low frequency of adverse effects compared to other treatment modalities. Despite many advances being made in the field of cancer immunotherapy, very few immunotherapeutic treatments have been approved for difficult-to-treat solid tumours such as triple negative breast cancer (TNBC), glioblastoma multiforme (GBM), and advanced prostate cancer (PCa). The anatomical location of some of these cancers may also make them more difficult to treat...
July 25, 2023: Biomedicines
https://read.qxmd.com/read/37594087/targeting-the-deubiquitinase-usp2-for-malignant-tumor-therapy-review
#16
JOURNAL ARTICLE
Shilong Zhang, Yi Guo, Shenjie Zhang, Zhi Wang, Yewei Zhang, Shi Zuo
The ubiquitin‑proteasome system is a major degradation pathway for >80% of proteins in vivo . Deubiquitylases, which remove ubiquitinated tags to stabilize substrate proteins, are important components involved in regulating the degradation of ubiquitinated proteins. In addition, they serve multiple roles in tumor development by participating in physiological processes such as protein metabolism, cell cycle regulation, DNA damage repair and gene transcription. The present review systematically summarized the role of ubiquitin‑specific protease 2 (USP2) in malignant tumors and the specific molecular mechanisms underlying the involvement of USP2 in tumor‑associated pathways...
October 2023: Oncology Reports
https://read.qxmd.com/read/37365789/synthesis-and-anticancer-activity-of-novel-indole-derivatives-as-dual-egfr-src-kinase-inhibitors
#17
JOURNAL ARTICLE
Sureyya Olgen, Sevde Nur Biltekin Kaleli, Banu Taktak Karaca, Ural U Demirel, Hacer Karatas Bristow
BACKGROUND: Recent studies showed that the cooperation between c-SRC and EGFR is responsible for more aggressive phenotype in diverse tumors, including glioblastomas and carcinomas of the colon, breast, and lung. Studies show that combination of SRC and EGFR inhibitors can induce apoptosis and delay the acquired resistance to chemotherapy. Therefore, such combination may lead to a new therapeutic strategy for the treatment of EGFR-mutant lung cancer. Osimertinib was developed as a third-generation EGFR-TKI to combat the toxicity of EGFR mutant inhibitors...
June 26, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37353377/chimeric-antigen-receptor-t-cell-therapy-for-solid-tumors
#18
REVIEW
Jeremiah A Wala, Glenn J Hanna
We review chimeric antigen receptor (CAR) T-cell therapy for solid tumors. We discuss patient selection factors and aspects of clinical management. We describe challenges including physical and molecular barriers to trafficking CAR-Ts, an immunosuppressive tumor microenvironment, and difficulty finding cell surface target antigens. The application of new approaches in synthetic biology and cellular engineering toward solid tumor CAR-Ts is described. Finally, we summarize reported and ongoing clinical trials of CAR-T therapies for select disease sites such as head and neck (including thyroid cancer), lung, central nervous system (glioblastoma, neuroblastoma, glioma), sarcoma, genitourinary (prostate, renal, bladder, kidney), breast and ovarian cancer...
June 21, 2023: Hematology/oncology Clinics of North America
https://read.qxmd.com/read/37317914/in-silico-studies-on-natural-products-and-derivatives-against-different-types-of-cancer
#19
JOURNAL ARTICLE
Alex France Messias Monteiro, Fábia Martins da Silva, Teresa Carolliny Moreira Lustoza Rodrigues, Clécio Sousa Ramos, Marcus Tullius Scotti, Luciana Scotti
According to the World Health Organization (WHO), cancer is the second cause of death worldwide, responsible for almost 10 million deaths and accounting for one in every six deaths. It is a disease that can affect any organ or tissue with rapid progression to the final stage, which is metastasis, in which the disease spreads to different regions of the body. Many studies have been carried out to find a cure for cancer. Early diagnosis contributes to the individual achieving the cure; however, deaths are increasing considerably due to late diagnosis...
June 14, 2023: Current Medicinal Chemistry
https://read.qxmd.com/read/37317692/robust-formation-of-optimal-single-spheroids-towards-cost-effective-in-vitro-three-dimensional-tumor-models
#20
JOURNAL ARTICLE
Kinana Habra, Joshua R D Pearson, Stéphanie E B McArdle
While useful for fundamental in vitro studies, monolayer cell cultures are not physiologically relevant. Spheroids, a complex three-dimensional (3D) structure, more closely resemble in vivo tumor growth. Spheroids allow the results obtained relating to proliferation, cell death, differentiation, metabolism, and various antitumor therapies to be more predictive of in vivo outcomes. In the protocol herein, a rapid and high-throughput method is discussed for the generation of single spheroids using various cancer cell lines, including brain cancer cells (U87 MG, SEBTA-027, SF188), prostate cancer cells (DU-145, TRAMP-C1), and breast cancer cells (BT-549, Py230) in 96-round bottom-well plates...
April 19, 2023: FEBS Open Bio
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