Alphonce M K Nyalali, Angela U Leonard, Yongxiang Xu, Huayu Li, Junlin Zhou, Xinrui Zhang, Tibera K Rugambwa, Xiaohan Shi, Feng Li
CD147 also known as EMMPRIN, basigin, and HAb18G, is a single-chain type I transmembrane protein shown to be overexpressed in aggressive human cancers of CNS, head and neck, breasts, lungs, gastrointestinal, genitourinary, skin, hematological, and musculoskeletal. In these malignancies, the molecule is integral to the diverse but complimentary hallmarks of cancer: it is pivotal in cancerous proliferative signaling, growth propagation, cellular survival, replicative immortality, angiogenesis, metabolic reprogramming, immune evasion, invasion, and metastasis...
2023: Frontiers in Oncology