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Aleha Aziz, Cynthia Gyamfi-Bannerman, Zainab Siddiq, Jason D Wright, Dena Goffman, Jean-Ju Sheen, Mary E D'Alton, Alexander M Friedman
BACKGROUND: Maternal race may be an important risk factor for postpartum readmissions and associated adverse outcomes. OBJECTIVE: To determine the association of race with serious complications during postpartum readmissions. STUDY DESIGN: This repeated cross sectional analysis utilized the National (Nationwide) Inpatient Sample from the Healthcare Cost and Utilization Project from 2012 to 2014. Women ages 15 to 54 readmitted postpartum after a delivery hospitalization were identified by Centers for Disease Control and Prevention criteria...
February 13, 2019: American Journal of Obstetrics and Gynecology
Örjan Åkerborg, Rapolas Spalinskas, Sailendra Pradhananga, Anandashankar Anil, Pontus Höjer, Flore-Anne Poujade, Lasse Folkersen, Per Eriksson, Pelin Sahlén
BACKGROUND: Genetic variant landscape of coronary artery disease (CAD) is dominated by non-coding variants among which many occur within putative enhancers regulating the expression levels of relevant genes. It is crucial to assign the genetic variants to their correct genes both to gain insights into perturbed functions and better assess the risk of disease. METHODS: In this study, we generated high-resolution genomic interaction maps (~750 bases) in aortic endothelial, smooth muscle cells and THP-1 macrophages stimulated with lipopolysaccharide using Hi-C coupled with sequence capture targeting 25,429 features including variants associated with CAD...
February 20, 2019: Circulation. Genomic and precision medicine
Lía Nattero-Chávez, Sandra Redondo López, Sara Alonso Díaz, Marta Garnica Ureña, Elena Fernández-Durán, Héctor F Escobar-Morreale, Manuel Luque-Ramírez
CONTEXT: Cardiovascular autonomic (CAN) neuropathy appears to contribute to peripheral arterial stiffness (AS) in type 1 diabetes. If CAN in patients with AS is associated to concomitant asymptomatic atherosclerotic disease (aPAD) remains unclear. OBJECTIVE: To assess the risk of CAN in patients with type 1 diabetes and AS and its potential association to atherosclerosis. DESIGN: Cross-sectional study. SETTING: Type 1 Diabetes clinic from an academic hospital...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
R C Huang, K A Lillycrop, L J Beilin, K M Godfrey, D Anderson, T A Mori, S Rauschert, J M Craig, W H Oddy, O T Ayonrinde, C E Pennell, J D Holbrook, P E Melton
BACKGROUND: 'Accelerated ageing', assessed by adult DNA methylation predicts cardiovascular disease (CVD). Adolescent accelerated aging might predict CVD earlier. We investigated whether epigenetic age acceleration (assessed age 17-years) associated with adiposity/CVD-risk measured (ages 17, 20, 22-years), and projected CVD by middle-age. METHODS: DNA methylation measured in peripheral blood provided 2 estimates of epigenetic age acceleration; intrinsic (IEAA, (preserved across cell types) and extrinsic (EEAA, dependent on cell admixture and methylation levels within each cell type)...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
David S Schade, R Philip Eaton
CLINICAL ISSUE: Cardiovascular disease remains the number one cause of morbidity and mortality in the United States despite major advances in our understanding of its pathogenesis and prevention. One reason for this continued epidemic is the poor adherence to treatment guidelines by caregivers and the lack of understanding by patients relative to its reversibility with treatment. Current guidelines are complex and often contradictory as there are at least 21 organizations publishing guidelines...
February 20, 2019: Journal of Clinical Endocrinology and Metabolism
Patricia Rarau, Justin Pulford, Hebe Gouda, Suparat Phuanukoonnon, Chris Bullen, Robert Scragg, Bang Nguyen Pham, Barbara McPake, Brian Oldenburg
[This corrects the article DOI: 10.1371/journal.pone.0211068.].
2019: PloS One
Daniza M Ivanovic, Atilio F Almagià, Violeta C Arancibia, Camila V Ibaceta, Vanessa F Arias, Tatiana R Rojas, Ofelia C Flores, Francisca S Villagrán, Liliana U Tapia, Javiera A Acevedo, Gladys I Morales, Víctor C Martínez, Cristián G Larraín, Claudio F A Silva, Rodrigo B Valenzuela, Cynthia R Barrera, Pablo B Billeke, Francisco M Zamorano, Yasna Z Orellana
The aim of this study was to quantitate the relative impact of nutritional, intellectual, brain development, cardiovascular risk, socio-economic, demographic and educational variables on the results of the 2009 Quality Education Measurement System (SIMCE) tests of language and mathematics for scholastic achievement (SA) applying a multifactorial approach, in school-age children of the 2010 5th elementary school grade (5ESG) and of the 1st grade of high school (1HSG). The purposes were: i) to test the hypothesis that intellectual ability, the level of SA of the educational establishments in the 2009 SIMCE tests, sex, parental schooling levels, and head circumference-for-age Z-score are the most relevant parameters associated with 2009 SIMCE outcomes; ii) to determine the predictive ability of the 2009 SIMCE results in determining the 2013 SIMCE outcomes for the 2010 5ESG cohort (when they graduated from elementary school, 8th grade) and for determining the 2013 University Selection Test (PSU) outcomes for the 2010 1HSG group (for university admission, when they graduated from high school, 4th grade); iii) to determine the association between the 2009 SIMCE results with the 2017 PSU outcomes for the 2010 5ESG group (for university admission, when they graduated from high school, 4th grade)...
2019: PloS One
Gilles R Dagenais, Hyejung Jung, Peter Bogaty, Jackie Bosch, Salim Yusuf, Hertzel C Gerstein
The impact of insulin or omega-3 supplements on the incidence and progression of peripheral artery disease (PAD) in patients with dysglycemia has not been well studied. The ORIGIN trial randomized participants with dysglycemia and cardiovascular risk factors to titrated insulin glargine versus standard care, and to either 1 g of omega-3 per day or placebo. We assessed incident PAD, defined as the composite of either asymptomatic or symptomatic PAD according to the randomized interventions in 11,119 ORIGIN participants whose baseline ankle-brachial index (ABI) was >0...
February 20, 2019: Diabetes, Obesity & Metabolism
Tina Vilsbøll, Thomas C Blevins, Esteban Jodar, Neil Poulter, Nikolaos Tentolouris, Bue F Ross Agner, Lucine Lehmann, Lawrence A Leiter
This post hoc analysis investigated effects of insulin degludec/liraglutide fixed-ratio combination (IDegLira) versus comparators on cardiovascular (CV) risk markers from DUAL II (versus insulin degludec), DUAL V (versus insulin glargine 100 units/mL) and DUAL VII (versus basal-bolus therapy) in patients grouped by sex, age (<65 years, ≥65 years) and diabetes duration (<10 years, ≥10 years). Treatment contrasts were in favour of IDegLira in many subgroups for changes from baseline in HbA1c (DUAL II, DUAL V), body weight (all three trials), systolic blood pressure (BP; all three trials), high-density lipoprotein cholesterol (DUAL VII) and low-density lipoprotein cholesterol (LDL-C; DUAL II, DUAL V)...
February 20, 2019: Diabetes, Obesity & Metabolism
Alexander A Leung, Tracey Bushnik, Deirdre Hennessy, Finlay A McAlister, Douglas G Manuel
BACKGROUND: Hypertension (or high blood pressure) affects almost one in four adults in Canada. Quantifying risk factors associated with hypertension may help to inform prevention efforts. DATA AND METHODS: Data from the first four cycles of the Canadian Health Measures Survey (including 13,407 respondents) were used to identify hypertension status by systolic and diastolic blood pressure levels and the use of antihypertensive medications. Logistic regression analysis was employed to estimate the association between six cardiovascular risk factors (individually and as a composite score) and hypertension...
February 20, 2019: Health Reports
I M Bensenor
Thyroid disorders are common diseases, both in Brazil and worldwide. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a prospective cohort study that investigates cardiovascular diseases, diabetes, and associated factors, including non-classical cardiovascular risk factors such as thyroid function. Thyroid function was classified according to thyrotropin stimulating hormone (TSH), free thyroxine (FT4), and use of medication to treat thyroid disorders, after excluding participants who reported use of any medication that could alter the results of the TSH and FT4 tests...
February 14, 2019: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Mehmet Akif Dündar, Yasemin Altuner Torun, Serkan Fazlı Çelik, Emine Kaygı Tartıcı, Çiğdem Karakükçü
OBJECTIVE: Vitamin B12 deficiency induces hyper-hyperhomocysteinemia by inhibiting intracellular methionine re-methylation. Hyper-hyperhomocysteinemia increases the risk of atherosclerosis. Asymmetric dimethylarginine is an endogenous inhibitor of nitric oxide synthase and its level elevates in cardiovascular diseases. In this study, we aimed to examine the relationship between asymmetric dimethylarginine and arterial stiffness and atherosclerosis in adolescents with vitamin B12 deficiency...
February 2019: Cardiology in the Young
Jing Liu, Tianxiang Li, Hui Wu, Haoze Shi, Jinmei Bai, Wei Zhao, Donghui Jiang, Xiufeng Jiang
Obstructive sleep apnea (OSA) and high salt content in modern diet has been particularly implicated in systemic hypertension, leading to increased morbidity and mortality. Gut dysbiosis, associated with increased risk of systemic immunological imbalance, plays a causal role in the development of cardiovascular diseases. Here, we investigated the effect of Lactobacillus rhamnosus GG strain (LGG) on the development of hypertension induced by OSA and high salt diet. In this study, hypertension was modeled in rats by feeding a high salt diet (HSD) for 6 wk and exposuring to chronic intermittent hypoxia (CIH) during the sleep cycle...
February 18, 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xiaoling Xu, Liuhong Shi, Xiuqing Ma, Hua Su, Guofeng Ma, Xiaohong Wu, Kejing Ying, Ruifeng Zhang
INTRODUCTION: Acute pulmonary embolism (APE) is a cardiovascular disease with high morbidity and mortality. Although the anatomical obstruction of the pulmonary vascular bed initiates APE, recent studies have suggested that vasoconstrictors in the renin-angiotensin system (RAS) play a role in the severity of APE. MATERIALS AND METHODS: We performed a 5-year retrospective clinical study to analyze the key RAS components in APE patients, including angiotensin converting enzyme (ACE), ACE2, angiotensin II (Ang II) and angiotensin 1-7(Ang(1-7))...
February 15, 2019: Thrombosis Research
Ryan Kipp, Mariam Askari, Jun Fan, Michael E Field, Mintu P Turakhia
OBJECTIVES: In this study the authors investigated effectiveness and safety of an initial treatment strategy with class IC or class III antiarrhythmic drugs (AAD) for newly diagnosed atrial fibrillation (AF) or atrial flutter (AFL). BACKGROUND: There is limited evidence to guide optimal AAD selection for rhythm control in newly diagnosed AF/AFL. METHODS: Using data from TREAT-AF (The Retrospective Evaluation and Assessment of Therapies in AF), the authors performed a retrospective cohort study of patients with AF/AFL from 2004 to 2014 and class IC or class III AAD prescription within 90 days following diagnosis...
February 2019: JACC. Clinical Electrophysiology
Ming Fang, Yanfei Li, Yingbiao Wu, Zhongping Ning, Xuejun Wang, Xinming Li
BACKGROUND: Atherosclerosis (AS) is a major risk factor for cardiovascular disease. microRNAs play a key role in gene regulation in the formation and development of atherosclerotic plaques. Herein, the role and target gene of miR-185 in AS were explored. MATERIALS AND METHODS: Cell viability, migration and invasion were examined by cell counting kit-8 (CCK-8) and transwell assay. The relative luciferase activity was measured by luciferase reporter assay. The levels of miR-185, STIM1, vascular endothelial growth factor (VEGF) and matrix metalloprotein-9 (MMP-9) were evaluated by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) and Western blot...
February 20, 2019: Cell Cycle
Kathleen Nolte, Christoph Herrmann-Lingen, Lars Platschek, Volker Holzendorf, Stefan Pilz, Andreas Tomaschitz, Hans-Dirk Düngen, Christiane E Angermann, Gerd Hasenfuß, Burkert Pieske, Rolf Wachter, Frank Edelmann
AIMS: Vitamin D deficiency is prevalent in heart failure (HF), but its relevance in early stages of heart failure with preserved ejection fraction (HFpEF) is unknown. We tested the association of 25-hydroxyvitamin D [25(OH)D] serum levels with mortality, hospitalizations, cardiovascular risk factors, and echocardiographic parameters in patients with asymptomatic diastolic dysfunction (DD) or newly diagnosed HFpEF. METHODS AND RESULTS: We measured 25(OH)D serum levels in outpatients with risk factors for DD or history of HF derived from the DIAST-CHF study...
February 19, 2019: ESC Heart Failure
Sara Samadi, Mehrane Mehramiz, Theodoros Kelesidis, Majid Ghayour Mobarhan, Amir Hosein Sahebkar, Habibollah Esmaily, Mohsen Moohebati, Zahra Farjami, Gordon A Ferns, Amir Hooshang Mohammadpour, Amir Avan
High-density lipoprotein (HDL) function rather than level may better predict cardiovascular disease (CVD). However, the contribution of the impaired antioxidant function of HDL that is associated with increased HDL lipid peroxidation (HDLox) to the development of clinical CVD remains unclear. We have investigated the association between serum HDLox with incident CVD outcomes in Mashhad cohort. Three-hundred and thirty individuals who had a median follow-up period of 7 years were recruited as part of the cohort...
February 19, 2019: Journal of Cellular Physiology
A S Kosovtseva, Т А Bairova, L V Rychkova, V M Polyakov, L I Kolesnikova
We present prognostic risk models for structural and functional cardiovascular disorders in Caucasian adolescents (Russians) with essential hypertension aged 14-17 years (15.92±1.12) taking into account biochemical (catecholamines and cortisol) and genetic parameters (carriage of polymorphic variants of α2A-adrenergic receptor gene ARA2A (-1291С>G), norepinephrine transporter NET (-1287G>A), and D2-dopamine receptor DRD2 (-141C Ins/Del) and the data of psychological testing. Prognostically significant risk factors for increased specific peripheral vascular resistance and variability of daytime systolic BP were a combination of [CC+AA] genotypes of ADRA2A -1291C>G and NET -1287G>A polymorphisms, cortisol level, anxiety, and proneness to conflict...
February 19, 2019: Bulletin of Experimental Biology and Medicine
Saurabh Sharma, Suniti Yadav, Ketaki Chandiok, Radhey Shyam Sharma, Vandana Mishra, Kallur Nava Saraswathy
Background: Metabolic syndrome (MeS), a constellation of metabolic adversities, and history of miscarriage make women at a higher risk for cardiovascular diseases (CVDs). However, molecular evidence indicating a link between the two phenotypes (history of miscarriage and MeS) among women would offer an opportunity to predict the risk factor for CVDs at an early stage. Thus, the present retrospective study attempts to identify the proteins signatures (if any) to understand the connection between the history of miscarriage and MeS...
2019: PeerJ
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