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https://read.qxmd.com/read/30764801/immediate-term-cognitive-impairment-following-intravenous-iv-chemotherapy-a-prospective-pre-post-design-study
#1
Omar F Khan, Ellen Cusano, Soundouss Raissouni, Mica Pabia, Johanna Haeseker, Nicholas Bosma, Jenny J Ko, Haocheng Li, Aalok Kumar, Michael M Vickers, Patricia A Tang
BACKGROUND: Cognitive impairment is commonly reported in patients receiving chemotherapy, but the acuity of onset is not known. This study utilized the psychomotor vigilance test (PVT) and trail-making test B (TMT-B) to assess cognitive impairment immediately post-chemotherapy. METHODS: Patients aged 18-80 years receiving first-line intravenous chemotherapy for any stage of breast or colorectal cancer were eligible. Patient symptoms, peripheral neuropathy and Stanford Sleepiness Scale were assessed...
February 14, 2019: BMC Cancer
https://read.qxmd.com/read/30759125/alcohol-and-breast-cancer-risk-middle-aged-women-s-logic-and-recommendations-for-reducing-consumption-in-australia
#2
Samantha B Meyer, Kristen Foley, Ian Olver, Paul R Ward, Darlene McNaughton, Lillian Mwanri, Emma R Miller
BACKGROUND: We aimed to understand the factors shaping alcohol consumption patterns in middle-aged women (45-64), and to identify participant-driven population- and policy-level strategies that may be used to addresses alcohol consumption and reduce breast cancer risk. METHODS: Semi-structured interviews (n = 35) were conducted with 'middle-aged' women conversant in English and living in South Australia with no history of breast cancer diagnosis. Data were deductively coded using a co-developed framework including variables relevant to our study objectives...
2019: PloS One
https://read.qxmd.com/read/30758044/a-prospective-study-of-health-conditions-related-to-alcohol-consumption-cessation-among-97-852-drinkers-aged-45-and-over-in-australia
#3
Peter Sarich, Karen Canfell, Emily Banks, Ellie Paige, Sam Egger, Grace Joshy, Rosemary Korda, Marianne Weber
BACKGROUND: Evidence suggests that people who develop serious health conditions are likely to cease drinking alcohol (sometimes known as 'sick-quitters'). We quantified the likelihood of quitting drinking in relation to the onset of a variety of health conditions. METHODS: Odds ratios (OR) and 95% confidence intervals (CI) of ceasing alcohol consumption after diagnosis of 28 health conditions and four general indicators of health were derived from logistic regression among 97,852 drinkers aged ≥45 years between baseline (2006-2009) and median 5...
February 13, 2019: Alcoholism, Clinical and Experimental Research
https://read.qxmd.com/read/30748013/the-impact-of-reducing-alcohol-consumption-in-australia-an-estimate-of-the-proportion-of-potentially-avoidable-cancers-2013-2037
#4
Louise F Wilson, Peter D Baade, Adele C Green, Susan J Jordan, Bradley J Kendall, Rachel E Neale, Catherine M Olsen, Danny R Youlden, Penelope M Webb, David C Whiteman
The International Agency for Research on Cancer first concluded that alcohol causes cancer in humans in 1988. The World Cancer Research Fund has declared that alcohol causes cancer of the oral cavity, pharynx, larynx, oesophagus (squamous cell carcinoma), female breast, colon, rectum, stomach and liver. It recommended that alcohol be avoided altogether to prevent cancer. We aimed to quantify the impact of reducing alcohol consumption on future cancer incidence in Australia. We used PREVENT 3.01 simulation modelling software to estimate the proportion of cancers that could potentially be prevented over a 25-year period under two hypothetical intervention scenarios and two latency periods (20 and 30 years)...
February 12, 2019: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/30732703/a-45-year-old-woman-with-multiple-pulmonary-nodules-and-sj%C3%A3-gren-syndrome
#5
Jonathan Z Xian, Sujith V Cherian, Modupe Idowu, Lei Chen, Rosa M Estrada-Y-Martin
A 45-year-old woman presented for evaluation for 3 months of coughing and dyspnea. A recent chest CT scan done for workup of her symptoms revealed a 2-cm right-sided pulmonary nodule. She had a medical history of Sjögren syndrome, hypertension, and obesity. She also noted a weight loss of 30 lb over the last 3 years. She denied smoking, alcohol consumption, illicit drug use, or occupational exposures. A chest radiograph done 3 years prior did not reveal any pulmonary nodules. She had no personal or family history of arteriovenous malformations, hamartomas, or any malignancies and had been up to date with her breast cancer screening...
February 2019: Chest
https://read.qxmd.com/read/30680689/association-between-alcohol-consumption-and-mammographic-density-a-hospital-based-cross-sectional-study
#6
Takahide Okamoto, Akemi Ito
BACKGROUND: Mammographic density (MD), the proportion of radiological dense breast, has been reported to be a strong risk factor for breast cancer in many studies. Epidemiological evidence indicates that alcohol consumption increases the risk of breast cancer. In Western countries, a positive association between alcohol consumption and MD has been reported. METHODS: To investigate the effect of alcohol consumption on MD, we conducted a cross-sectional analysis of healthy women enrolled in a breast cancer screening program at the Ebina Health Service Center, Japan, in 2012, comprising 477 premenopausal women and 308 postmenopausal women...
January 24, 2019: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30659908/associations-between-cervical-breast-and-colorectal-cancer-screening-uptake-chronic-diseases-and-health-related-behaviours-data-from-the-italian-passi-nationwide-surveillance
#7
Francesco Venturelli, Letizia Sampaolo, Giuliano Carrozzi, Marco Zappa, Paolo Giorgi Rossi
Screening programmes have been proposed as a privileged setting for health promotion interventions. We aim to assess the associations between behavioural risk factors, chronic conditions and diseases and cervical, breast and colorectal cancer screening uptake. Secondly, we aim to assess whether these associations are due to underlying differences in socioeconomic characteristics. In Italy, a random sample was interviewed by the PASSI surveillance (106,000 interviews) in 2014-2016. Screening uptake adjusted for age and gender alone and for age, gender and socioeconomic characteristics (educational attainment and self-reported economic difficulties) were estimated using multivariate Poisson regression models...
January 16, 2019: Preventive Medicine
https://read.qxmd.com/read/30647438/folate-intake-and-the-risk-of-breast-cancer-an-up-to-date-meta-analysis-of-prospective-studies
#8
Jie Zeng, Kun Wang, Fayin Ye, Lin Lei, Yun Zhou, Jia Chen, Guohua Zhao, Hui Chang
Epidemiological studies focusing on the association between folate and breast cancer risk reported inconsistent findings. We conducted a systematic search of the literature using PubMed and EMBASE databases. A total of 23 prospective studies involving 41,516 cases and 1,171,048 individuals were included for meta-analysis. Folate intake may decrease the risk of oestrogen receptor (ER) negative (-) and ER-/progesterone receptor (PR)- breast cancer, with pooled risk ratios (RRs) of 0.88 [95% confidence interval (CI): 0...
January 15, 2019: European Journal of Clinical Nutrition
https://read.qxmd.com/read/30603873/mortality-by-cause-of-death-and-risk-behaviors-in-farmers-versus-non-farmers-the-importance-of-avoiding-the-healthy-worker-effect
#9
Guanlan Zhao, Elena Ronda, Lucía Cea, José Pulido, Gregorio Barrio, Enrique Regidor
OBJECTIVES: To compare mortality by cancer sites and by other specific causes of death, and the prevalence of risk behaviors in farmers and non-farmers in Spain. METHODS: Mortality by cause of death was calculated based on a longitudinal study with 10-years follow-up of 9.5 million men and 6 million women aged 20-64 years who were employed in 2001. The prevalence of risk behaviors was calculated from the 2001 National Health Survey in the 6464 employed men and 5573 employed women aged 20-64...
January 2, 2019: International Archives of Occupational and Environmental Health
https://read.qxmd.com/read/30597481/healthy-lifestyle-and-breast-cancer-risk-a-case-control-study-in-morocco
#10
Mohamed Khalis, Véronique Chajès, Aurelie Moskal, Carine Biessy, Inge Huybrechts, Sabina Rinaldi, Laure Dossus, Hafida Charaka, Nawfel Mellas, Chakib Nejjari, Joan Dorn, Amr S Soliman, Isabelle Romieu, Karima El Rhazi, Barbara Charbotel
BACKGROUND: Some modifiable risk factors have been independently associated with breast cancer (BC) risk in Moroccan women, but no studies have investigated their joint association. This study aimed to investigate the association between a Healthy Lifestyle Index (HLI) score and BC risk among Moroccan women. METHODS: In this case-control study, 300 incident BC cases and 300 controls, matched by age and area of residence were recruited. Cases were women newly-diagnosed with histopathologically-confirmed BC at the University Hospital in Fez, Morocco...
December 28, 2018: Cancer Epidemiology
https://read.qxmd.com/read/30583347/relationship-between-health-literacy-and-adherence-to-recommendations-to-undergo-cancer-screening-and-health-related-behaviors-among-insured-women-in-japan
#11
Eiko Goto, Hirono Ishikawa, Tsuyoshi Okuhara, Takahiro Kiuchi
Background: Health literacy serves as a major barrier to effective preventive health behaviors, such as cancer screening, and this relationship has not been studied among insured women in Japan. We examined the relationship between health literacy and adherence to recommendations to undergo cancer screening, and health-related behaviors, among Japanese women who were insured by a health insurance society. Methods: We conducted a cross-sectional observation study of 670 insured Japanese women. For this, we used a self-administered questionnaire to assess environments, self-rated health status, cancer screening behavior, health-related behaviors (dietary behavior, exercise frequency, alcohol consumption and smoking behavior), and health literacy...
December 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/30560460/prevalence-of-breast-cancer-related-risk-factors-in-underweight-premenopausal-women-the-korea-national-health-and-nutrition-examination-survey-iv-vi
#12
Joo Heung Kim, Kwang Hyun Yoon, Ho Hur, Seho Park, Jee Ye Kim, Hyung Seok Park, Seung Ii Kim, Young Up Cho, Byeong-Woo Park
PURPOSE: This study aimed to examine the prevalence and trends of breast cancer-related risk factors and characteristics in premenopausal underweight Korean women according to birth year cohort. METHODS: Socioeconomic and breast cancer-related risk factors were investigated in 13,415 premenopausal women using nationwide cross-sectional surveys performed between 2007 and 2015. Underweight was defined as body mass index < 18.5 kg/m2 . Multivariable models were created using complex sample procedures...
December 17, 2018: Breast Cancer Research and Treatment
https://read.qxmd.com/read/30539373/invasive-breast-cancers-in-adolescent-and-young-adult-women-show-more-aggressive-immunohistochemical-and-clinical-features-than-those-in-women-aged-40-44-years
#13
Ai Hironaka-Mitsuhashi, Hitoshi Tsuda, Masayuki Yoshida, Chikako Shimizu, Sota Asaga, Takashi Hojo, Kenji Tamura, Takayuki Kinoshita, Toshikazu Ushijima, Nobuyoshi Hiraoka, Yasuhiro Fujiwara
BACKGROUND: Limited knowledge exists concerning the clinicopathological features of breast cancers (BCs) occurring in adolescent and young adult (AYA) women. We evaluated tumor characteristics in AYA women in comparison with those in middle-aged premenopausal women. METHODS: From consecutive AYA patients (< 35-year-old) with invasive BC in a single institute, 82 patients first treated with surgery were examined. As the control group, 82 tumors from middle-aged premenopausal patients (40-44 years) were selected by matching pathological T and N factors...
December 11, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://read.qxmd.com/read/30537646/transition-of-cancer-in-populations-in-india
#14
Aleyamma Mathew, Preethi Sara George, Jagathnath Krishna K M, Durga Vasudevan, Francis V James
BACKGROUND & OBJECTIVES: An assessment of transition of cancer in India during the past 30 years, according to changes in demographic and epidemiologic risk factors was undertaken. MATERIALS & METHODS: Cancer registry data (http://www.ncdirindia.org), (population coverage <10%), was compared with transition in life-expectancy and prevalence on smoking, alcohol and obesity. We fitted linear regression to the natural logarithm of the estimated incidence rates of various cancer registries in India...
December 8, 2018: Cancer Epidemiology
https://read.qxmd.com/read/30514381/the-association-between-early-onset-cardiac-events-caused-by-neoadjuvant-or-adjuvant-chemotherapy-in-triple-negative-breast-cancer-patients-and-some-novel-autophagy-related-polymorphisms-in-their-genomic-dna-a-real-world-study
#15
Binliang Liu, Tao An, Meiying Li, Zongbi Yi, Chunxiao Li, Xiaoying Sun, Xiuwen Guan, Lixi Li, Yanfeng Wang, Yuhui Zhang, Binghe Xu, Fei Ma, Yixin Zeng
BACKGROUND: An increasing number of cancer patients die of cardiovascular diseases. The cardiotoxicity of chemotherapy is particularly important in triple-negative breast cancer (TNBC) with limited therapeutic options. Cardiac autophagy is an important mechanism of cardiotoxicity. This research was aimed to investigate the cardiotoxicity of chemotherapy in TNBC, screen the susceptible population, and determine the relationship between cardiotoxicity and autophagy-related polymorphisms...
December 4, 2018: Cancer communications
https://read.qxmd.com/read/30477361/adherence-to-diet-and-body-weight-recommendations-among-cancer-survivors-after-completion-of-initial-cancer-treatment-a-systematic-review-of-the-literature
#16
Tjon A Joe Sheena, Pannekoek Sarai, Kampman Ellen, Hoedjes Meeke
This systematic review of the literature aimed to 1) provide an overview of the extent to which cancer survivors adhere to diet and body weight recommendations after completion of initial treatment and 2) gain insight into characteristics associated with adherence to these recommendations. Four databases were searched for relevant papers. We included observational studies describing adherence to recommendations on body mass index (BMI), waist-to-hip ratio and waist circumference, fruit and vegetable intake, and alcohol consumption of adult (≥18 yr) cancer survivors after the completion of initial treatment (i...
November 27, 2018: Nutrition and Cancer
https://read.qxmd.com/read/30473364/gathering-momentum-for-the-way-ahead-fifth-report-of-the-lancet-standing-commission-on-liver-disease-in-the-uk
#17
Roger Williams, Graeme Alexander, Richard Aspinall, Rachel Batterham, Neeraj Bhala, Nick Bosanquet, Katherine Severi, Anya Burton, Robyn Burton, Matthew E Cramp, Natalie Day, Anil Dhawan, John Dillon, Colin Drummond, Jessica Dyson, James Ferguson, Graham R Foster, Ian Gilmore, Jonny Greenberg, Clive Henn, Mark Hudson, Helen Jarvis, Deirdre Kelly, Jake Mann, Neil McDougall, Martin McKee, Kieran Moriarty, Joanne Morling, Philip Newsome, John O'Grady, Liz Rolfe, Peter Rice, Harry Rutter, Nick Sheron, Douglas Thorburn, Julia Verne, Jyotsna Vohra, John Wass, Andrew Yeoman
This report presents further evidence on the escalating alcohol consumption in the UK and the burden of liver disease associated with this major risk factor, as well as the effects on hospital and primary care. We reiterate the need for fiscal regulation by the UK Government if overall alcohol consumption is to be reduced sufficiently to improve health outcomes. We also draw attention to the effects of drastic cuts in public services for alcohol treatment, the repeated failures of voluntary agreements with the drinks industry, and the influence of the industry through its lobbying activities...
November 21, 2018: Lancet
https://read.qxmd.com/read/30412695/burden-of-cancer-attributable-to-obesity-type-2-diabetes-and-associated-risk-factors
#18
REVIEW
Alejandro López Suárez
Overweight and obesity constitute a global pandemic with devastating consequences that affect >2 billion people. Obesity plays a central role in morbidity and mortality of diseases of multiple organs and systems, and it is a major contributor to the growing incidence of cancer. There is now sufficient level of evidence for the association between overweight and 11 types of cancer, among which are two of the most common cancers worldwide, those of the colorectum and postmenopausal breast. Sedentary lifestyle, unhealthy diet, and excessive alcohol intake also account for the burden of cancer by promoting obesity...
November 6, 2018: Metabolism: Clinical and Experimental
https://read.qxmd.com/read/30396926/modified-nucleosides-molecular-markers-suitable-for-small-volume-cancer
#19
Philipp Opitz, Olf Herbarth, Annerose Seidel, Andreas Boehm, Milos Fischer, Christian Mozet, Andreas Dietz, Gunnar Wichmann
BACKGROUND: Modified nucleosides (mNS) in urine are shown to be encouraging markers in cancer, mostly in patients presenting with high tumor mass such is breast and lung cancer. To our knowledge, mNS have not been investigated in head and neck squamous cell carcinoma (HNSCC). HNSCC is characterized by early metastasis into locoregional lymph nodes and slow infiltrating growth, but even in the advanced stage exhibits only a relatively low cancer volume. Therefore, reliable distinction between HNSCC and healthy controls by urinary mNS might pose substantial analytical problems and even more as patients with HNSCC mostly have an increased exposure to tobacco smoke and excessive alcohol consumption which affect the renal mNS pattern...
November 2018: Anticancer Research
https://read.qxmd.com/read/30387004/molecular-mechanisms-linking-high-body-mass-index-to-breast-cancer-etiology-in-post-menopausal-breast-tumor-and-tumor-adjacent-tissues
#20
Yujing J Heng, Jun Wang, Thomas U Ahearn, Susan B Brown, Xuehong Zhang, Christine B Ambrosone, Victor Piana de Andrade, Adam M Brufsky, Fergus J Couch, Tari A King, Francesmary Modugno, Celine M Vachon, Natalie C DuPre, Montserrat Garcia-Closas, Melissa A Troester, David J Hunter, A Heather Eliassen, Rulla M Tamimi, Susan E Hankinson, Andrew H Beck
PURPOSE: In post-menopausal women, high body mass index (BMI) is an established breast cancer risk factor and is associated with worse breast cancer prognosis. We assessed the associations between BMI and gene expression of both breast tumor and adjacent tissue in estrogen receptor-positive (ER+) and estrogen receptor-negative (ER-) diseases to help elucidate the mechanisms linking obesity with breast cancer biology in 519 post-menopausal women from the Nurses' Health Study (NHS) and NHSII...
November 1, 2018: Breast Cancer Research and Treatment
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