Scott S Lee, Nicole Senft Everson, Maureen Sanderson, Rebecca Selove, William J Blot, Stephen King, Karen Gilliam, Suman Kundu, Mark Steinwandel, Sarah J Sternlieb, Qiuyin Cai, Shaneda Warren Andersen, Debra L Friedman, Erin Connors Kelly, Mary Kay Fadden, Matthew S Freiberg, Quinn S Wells, Juan Canedo, Rachel F Tyndale, Robert P Young, Raewyn J Hopkins, Hilary A Tindle
BACKGROUND: The feasibility of precision smoking treatment in socioeconomically disadvantaged communities has not been studied. METHODS: Participants in the Southern Community Cohort Study who smoked daily were invited to join a pilot randomized controlled trial of three smoking cessation interventions: guideline-based care (GBC), GBC plus nicotine metabolism-informed care (MIC), and GBC plus counseling guided by a polygenic risk score (PRS) for lung cancer. Feasibility was assessed by rates of study enrollment, engagement, and retention, targeting > 70% for each...
March 15, 2024: Addiction Science & Clinical Practice