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Aged 80 and older

Samuele Vaccari, Augusto Lauro, Maurizio Cervellera, Giorgio Palazzini, Giovanni Casella, Alberto Santoro, Domenico Mascagni, Pietro Ursi, Eliana Gulotta, Umberto D'errico, Alessandro Ussia, Nicolò De Siena, Stefania Bianchini, Vito D'andrea, Valeria Tonini
BACKGROUND: The number of surgical operations in elderly patients is increasing due to the aging demographics of western populations. The aim of the present study was to investigate the peri- operative outcome of octogenarian patients undergoing cholecystectomy for acute cholecystitis. METHODS: We performed a retrospective analysis including all patients who underwent cholecystectomy for acute cholecystitis from January 2013 to December 2017. Records were collected prospectively from two centers: "St Orsola Hospital - Emergency Surgery Unit - University of Bologna" and "Umberto I" Hospital - Department of Surgical Sciences - La Sapienza University of Rome...
February 13, 2019: Minerva Chirurgica
Mizuki Saito, Yoshihiro Shimazaki, Toshiya Nonoyama, Yasushi Tadokoro
AIM: Many studies have reported close relationships between oral and systemic health. We explored the association of the number of remaining teeth with medical costs and hospitalization duration in people aged 75 and 80 years. METHODS: Oral health examinations were carried out at dental clinics in 2014. Medical cost and hospitalization duration data for fiscal year 2015 were obtained from the Mie Prefecture health insurer. We analyzed the data of 4700 individuals who met our inclusion criteria: 2745 75-year-olds and 1955 80-year-olds...
February 14, 2019: Geriatrics & Gerontology International
Jonas Reinold, Francesca Palese, Federico Romanese, Giancarlo Logroscino, Oliver Riedel, Federica E Pisa
OBJECTIVES: To evaluate changes in the use of antipsychotics and medications with anticholinergic activity (MACs) during hospitalization in older adults with dementia and factors associated with antipsychotic prescriptions and increased anticholinergic burden (ACB). METHODS AND DESIGN: This retrospective cohort study included all patients aged ≥65 years with a discharge diagnosis of dementia hospitalized at the university hospital of Udine, Italy, 2012-2014. Medications dispensed within 3 months before and after hospitalization, respectively, were identified in community-pharmacy dispensations while those prescribed at discharge were collected from Hospital Electronic Medical Records (EMR)...
February 13, 2019: International Journal of Geriatric Psychiatry
In Cheol Hwang, Jeong Hun Bae, Joon Mo Kim
PURPOSE: To evaluate the association of body mass index (BMI), waist circumference, and body fat with diabetic retinopathy (DR) in Korean patients with type 2 diabetes. METHODS: Among the 1130 participants 19 years of age or older with type 2 diabetes enrolled in the nationwide survey, a total of 887 participants were included in the analyses after excluding patients with ungradable fundus images. The presence and severity of DR were graded with seven-field fundus photographs...
February 13, 2019: Eye
Christine G Parks, Armando Meyer, Laura E Beane Freeman, Jonathan Hofmann, Dale P Sandler
OBJECTIVES: Farming has been associated with rheumatoid arthritis (RA). Some studies have evaluated the effects of pesticides, but other agricultural exposures may also affect immune response. METHODS: We investigated non-pesticide agricultural exposures in relation to RA in licensed pesticide applicators (n=27 175, mostly male farmers) and their spouses (n=22 231) in the Agricultural Health Study (AHS) cohort (1993-1997) who completed at least one follow-up survey through 2015...
February 13, 2019: Occupational and Environmental Medicine
Victor Tran, Emile Latour, Alison Palumbo
PURPOSE: Off-label prescribing of oral oncology agents has been explored in the treatment of soft tissue sarcoma. The time for a prior authorization approval or rejection for an off-label use can be lengthy. The purpose of this study is to capture this burden by comparing the time it takes for patients to receive off-label versus on-label treatment for their soft tissue sarcoma. PATIENTS AND METHODS: In this retrospective chart review study, patients aged 18 and older who received a new prescription for an oral oncology agent for soft tissue sarcoma from one of three sarcoma providers at Oregon Health & Science University oncology clinics between March 2014 and February 2016 were included...
February 13, 2019: Journal of Oncology Pharmacy Practice
Martin Niedermeier, Simone Herzog, Prisca Kopp-Wilfling, Martin Burtscher, Martin Kopp
Increasing evidence suggests positive associations between physical activity, social support, and quality of life in later life. However, the role of physical activity and social support in the influence on quality of life is unclear. In this viewpoint, definitions of central terms and key research findings on factors influencing quality of life in older adults are provided. We highlight the importance of both a physically active lifestyle and high social support in positively influencing quality of life. However, we question the direct effect of physical activity on quality of life and present data of a cross-sectional study to support the assumption that the effect of physical activity on quality of life might be influenced by perceived social support...
February 13, 2019: Gerontology
Huanhuan Hu, Tohru Nakagawa, Toru Honda, Shuichiro Yamamoto, Hiroko Okazaki, Makoto Yamamoto, Toshiaki Miyamoto, Masafumi Eguchi, Takeshi Kochi, Makiko Shimizu, Taizo Murakami, Kentaro Tomita, Takayuki Ogasawara, Naoko Sasaki, Akihiko Uehara, Keisuke Kuwahara, Isamu Kabe, Tetsuya Mizoue, Tomofumi Sone, Seitaro Dohi
AIMS/INTRODUCTION: We examined a prospective association between serum creatinine levels and diabetes. MATERIALS AND METHODS: This study included 31,343 male workers without diabetes and aged between 20 and 64 years old at baseline. We calculated the cumulative average of their serum creatinine over the study period. We defined diabetes as either HbA1c levels ≥6.5%, random glucose levels ≥200 mg/dL, fasting glucose levels ≥126 mg/dL, or receiving antidiabetic treatment...
February 12, 2019: Journal of Diabetes Investigation
Silvia Canivell, Manel Mata-Cases, Jordi Real, Josep Franch-Nadal, Bogdan Vlacho, Kamlesh Khunti, Mònica Gratacòs, Dídac Mauricio
AIMS: To assess glycaemic control after treatment intensification in patients with type 2 diabetes uncontrolled on ≥2 non-insulin antidiabetic drugs (NIADS). METHODS: Retrospective cohort study, using electronic health records from the SIDIAP database (2010-2014). Intensification was defined as the prescription of any new antidiabetic drug in patients treated with ≥2 NIADS and HbA1c >7%. The primary outcome was the absolute change in HbA1c 6 to 12 months after any intensification...
February 12, 2019: Diabetes, Obesity & Metabolism
Antonietta Filia, Antonino Bella, Fortunato D'Ancona, Massimo Fabiani, Cristina Giambi, Caterina Rizzo, Lorenza Ferrara, Maria Grazia Pascucci, Maria Cristina Rota
BackgroundPaediatrician recommendations are known to influence parental vaccine decisions.AimOur aim was to examine vaccination knowledge, attitudes and practices among paediatricians in Italy and identify factors associated with their confidence in addressing parental questions.MethodsAn electronic questionnaire survey was conducted from February to March 2016, among a sample of Italian paediatricians.ResultsThe survey was completed by 903 paediatricians (mean age: 56 years). Of 885 who responded to the specific question, 843 (95...
February 2019: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Mark D Huffman, Padinhare P Mohanan, Raji Devarajan, Abigail S Baldridge, Dimple Kondal, Lihui Zhao, Mumtaj Ali, John A Spertus, Paul S Chan, Syam Natesan, Jabir Abdullakutty, Mangalath N Krishnan, Abhilash Tp, Sujay Renga, Eapen Punnoose, Govindan Unni, Dorairaj Prabhakaran, Donald M Lloyd-Jones
BACKGROUND: Despite a high cardiovascular disease burden, data on patient-reported health status outcomes among individuals with cardiovascular disease in India are limited. METHODS AND RESULTS: Between November 2014 and November 2016, we collected health-related quality of life data among 1261 participants in the ACS QUIK trial (Acute Coronary Syndrome Quality Improvement in Kerala). We used a translated, validated version of the Seattle Angina Questionnaire administered 30 days after discharge for acute myocardial infarction, wherein higher scores represent better health status...
February 2019: Circulation. Cardiovascular Quality and Outcomes
Jill Q Dworsky, Christopher P Childers, Melinda Maggard-Gibbons, Marcia M Russell
The population is aging and more geriatric patients are undergoing surgery. The national burden and age-specific outcomes of previously defined high-risk colorectal procedures (HRCP) remain unknown. Using the 2014 National Inpatient Sample, patients were stratified into nongeriatric (NG, <65 years), younger geriatric (YG, 65-79 years), and older geriatric (OG, ≥80 years) cohorts. Cases were grouped into nonelective admissions (NA) and elective admissions (EA). Nationally representative outcomes were compared across age group and admission type...
October 1, 2018: American Surgeon
Pasquale Palmiero, Annapaola Zito, Maria Maiello, Annagrazia Cecere, Anna Vittoria Mattioli, Roberto Pedrinelli, Pietro Scicchitano, Marco Matteo Ciccone
Primary prevention of cardiovascular events in older adults is a relevant problem, because of lack of evidence for safe and efficacious therapy, its costs and elderly quality of life, Italy's aging population is constantly increasing, so cardiovascular disease (CVD) primary prevention in the elderly is a prime objective. Life expectancy has dramatically increased over the last 2 decades,the proportion of individuals aged 80 years and older has grown rapidly in Europe and United States,but cost / effective ratio of CVD prevention through risk factors control is debated...
February 11, 2019: Current Hypertension Reviews
Natalie Cho, Laura Boland, Daniel I McIsaac
BACKGROUND: Sex and gender inequality is prevalent in health care, and affects receipt of health care services and outcomes. Our objective was to measure the association between sex and receipt of evidence-based perioperative care for hip fracture in Ontario. METHODS: This was a population-based retrospective cross-sectional analysis. We identified all Ontario residents aged 66 years and older who had hip fracture surgery between 2014 and 2016. After protocol registration, we measured the adjusted association between female sex and perioperative geriatric care (primary outcome), anesthesia consultations, regional analgesia and neuraxial anesthesia (secondary outcomes) using multilevel multivariable adjusted logistic regression...
February 11, 2019: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
Rachael Frost, Angela Beattie, Cini Bhanu, Kate Walters, Yoav Ben-Shlomo
BACKGROUND: Depressive symptoms are common in later life and increase both the risk of functional and cognitive decline and the use of healthcare services. Despite older people expressing preferences for talking therapies, they are less likely to be referred than younger adults, particularly when aged ≥80 years. AIM: To explore how healthcare professionals (HCPs) manage older people in relation to depression and referrals to psychological therapies. DESIGN AND SETTING: Systematic review and thematic synthesis of qualitative studies...
February 11, 2019: British Journal of General Practice: the Journal of the Royal College of General Practitioners
Nicolas Mansencal, Hazrije Mustafic, Marie Hauguel-Moreau, Simon Lannou, Catherine Szymanski, Olivier Dubourg
Dobutamine stress echocardiography (DSE) is a widely used examination for assessment of coronary ischemia, but several complications have been reported. The aim of this study was to assess the incidence of atrial fibrillation (AF) during DSE, and a systematic review and meta-analysis were also performed to determine an accurate estimate of the AF incidence. Over a 16-year period, we reviewed all patients referred for DSE. We systematically analyzed all ECG performed during DSE to detect AF during the examination...
January 31, 2019: American Journal of Cardiology
Kathrin Zürcher, Marie Ballif, Lukas Fenner, Sonia Borrell, Peter M Keller, Joachim Gnokoro, Olivier Marcy, Marcel Yotebieng, Lameck Diero, E Jane Carter, Neesha Rockwood, Robert J Wilkinson, Helen Cox, Nicholas Ezati, Alash'le G Abimiku, Jimena Collantes, Anchalee Avihingsanon, Kamon Kawkitinarong, Miriam Reinhard, Rico Hömke, Robin Huebner, Sebastien Gagneux, Erik C Böttger, Matthias Egger
BACKGROUND: Drug resistance is a challenge for the global control of tuberculosis. We examined mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of results from drug susceptibility testing done locally and in a reference laboratory. METHODS: This multicentre cohort study was done in Côte d'Ivoire, Democratic Republic of the Congo, Kenya, Nigeria, South Africa, Peru, and Thailand. We collected Mycobacterium tuberculosis isolates and clinical data from adult patients aged 16 years or older...
February 7, 2019: Lancet Infectious Diseases
Tristan W Dorey, Myles W O'Brien, Derek S Kimmerly
Long-term endurance training is associated with an increased risk of atrial arrhythmia in older adults (OA). We tested the hypothesis that Aerobically-Fit OA would have prolonged indices related to atrial arrhythmias (e.g. PR-intervals and P durations) compared to younger adults (YA) and Aerobically-Unfit OA. 10-minute stable supine electrocardiogram (ECG) recordings were collected at 1000 Hz in 15 YA (4F, 22 ± 2 years, 50.7 ± 8.5 ml/kg/min), 11 Aerobically-Unfit OA (6♀, 63 ± 7 years, 25...
March 2019: Autonomic Neuroscience: Basic & Clinical
Daniele Didino, Ekaterina A Taran, Galina A Barysheva, Fabio Casati
BACKGROUND: The development of measures of psychological functioning has received less attention in Russia compared to other countries. Moreover, despite the growing interest in the psychological well-being of older adults, there is a lack of research on this segment of the population in Siberia. Therefore, in this study we aimed to evaluate the psychometric properties of the Russian version of the Flourishing Scale (FS) and to measure psychological functioning in a sample of older adults living in Siberia...
February 11, 2019: Health and Quality of Life Outcomes
Mhairi A Macfadyen, Zoe Daniel, Sara Kelly, Tim Parr, John M Brameld, Andrew J Murton, Simon W Jones
BACKGROUND: Preclinical osteoarthritis models where damage occurs spontaneously may better reflect the initiation and development of human osteoarthritis. The aim was to assess the commercial pig as a model of spontaneous osteoarthritis development by examining pain-associated behaviour, joint cartilage integrity, as well as the use of porcine cartilage explants and isolated chondrocytes and osteoblasts for ex vivo and in vitro studies. METHODS: Female pigs (Large white x Landrace x Duroc) were examined at different ages from 6 weeks to 3-4 years old...
February 11, 2019: BMC Musculoskeletal Disorders
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