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https://read.qxmd.com/read/30764798/complete-biopsy-proven-resolution-of-deposits-in-recurrent-proliferative-glomerulonephritis-with-monoclonal-igg-deposits-pgnmigd-following-rituximab-treatment-in-renal-allograft
#1
Jon Von Visger, Clarissa Cassol, Uday Nori, Gerardo Franco-Ahumada, Tibor Nadasdy, Anjali A Satoskar
BACKGROUND: Proliferative glomerulonephritis with monoclonal IgG deposits (PGNMIGD) is a disease entity classified under the group of "Monoclonal gammopathy-related kidney diseases", and can recur after transplant. Clinical remission of proteinuria in patients with PGNMIGD has been previously shown following anti-B cell and/or anti-plasma cell therapies. Our case is the first to show complete histologic resolution of the glomerular monoclonal IgG kappa deposits in a case of recurrent PGNMIGD in renal allograft after rituximab and steroid treatment...
February 14, 2019: BMC Nephrology
https://read.qxmd.com/read/30760090/antibodies-to-m-type-phospholipase-a2-receptor-pla-2-r-in-membranous-lupus-nephritis
#2
E Garcia-Vives, C Solé, T Moliné, A M Alvarez-Rios, M Vidal, I Agraz, J Ordi-Ros, J Cortés-Hernández
BACKGROUND: Antibodies to M-type phospholipase A2 receptor (a-PLA2 R) have been identified in most patients with idiopathic membranous nephropathy, but the prevalence in membranous lupus nephritis (MLN) is still unclear. The objective of this study was to assess the prevalence of a-PLA2 R antibodies in a large cohort of patients with lupus nephritis. METHODS: a-PLA2 R antibodies were measured by ELISA in serum from patients with systemic lupus erythematosus ( n = 190), of whom 37 had a biopsy-proven MLN...
February 13, 2019: Lupus
https://read.qxmd.com/read/30755143/choroid-thickness-profile-in-patients-with-lupus-nephritis
#3
J Braga, R Rothwell, M Oliveira, D Rodrigues, S Fonseca, R Varandas, L Ribeiro
BACKGROUND: Choroidopathy is a rare manifestation of systemic lupus erythematosus (SLE). This entity is associated with active phases of severe SLE and it is frequently accompanied by acute kidney failure, central nervous system involvement and coagulopathy. PURPOSE: To evaluate the choroid thickness of patients with lupus nephritis (LN) without choroidopathy, and to compare this with that of age-matched SLE patients without LN and healthy control subjects. STUDY DESIGN: Cross-sectional case control study...
February 12, 2019: Lupus
https://read.qxmd.com/read/30742448/cytokine-profiles-in-autoantibody-defined-subgroups-of-systemic-lupus-erythematosus-sle
#4
Frida Torell, Susanna Eketjäll, Helena Idborg, Per-Johan Jakobsson, Iva Gunnarsson, Elisabet Svenungsson, Johan Trygg
The aim of this study was to evaluate how the cytokine profiles differed between autoantibody based subgroups of systemic lupus erythematosus (SLE). SLE is a systemic autoimmune disease, characterized by periods of flares (active disease) and remission (inactive disease). The disease can affect many organ systems, e.g. skin, joints, kidneys, heart and the central nervous system (CNS). SLE patients often have an overproduction of cytokines, e.g. interferons, chemokines and interleukins. The high cytokine levels are part of the systemic inflammation which can lead to tissue injury...
February 11, 2019: Journal of Proteome Research
https://read.qxmd.com/read/30738732/-lupus-nephritis
#5
Quentin Raimbourg, Éric Daugas
Systemic lupus erythematosus is the most characteristic of auto-immune disorders that can lead to tissue damage in many organs, including kidney. Lupus nephritis occurs in 10 to 40% of lupus patients. Its clinical hallmark is the appearance of a proteinuria as soon as a 0.5 g/g or 0.5 g/d threshold, which calls for a renal histological evaluation in order to determine the lupus nephritis severity and the need for specific therapy. More than half of renal biopsies lead to the diagnosis of active lupus nephritis-class III or class IV A according to the ISN/RPS classification-that are the most severe in regards to renal prognosis and mortality...
February 7, 2019: Néphrologie & Thérapeutique
https://read.qxmd.com/read/30721117/interleukin-2-deficiency-associated-with-renal-impairment-in-systemic-lupus-erythematosus
#6
Miao Shao, Jing He, Ruijun Zhang, Xia Zhang, Yue Yang, Chun Li, Xiaoyun Liu, Xiaolin Sun, Zhanguo Li
Impaired interleukin-2 (IL-2) production was reported in systemic lupus erythematosus (SLE). The aim of this study was to investigate the clinical relevance of serum IL-2 and therapeutic effects of recombinant IL-2 (rIL-2) in SLE, especially in lupus nephritis (LN). Decreased serum IL-2 was found in patients with active LN (P = 0.014) and correlated with 24-h urine protein excretion (r = -0.281, P = 0.026). Compared with LN patients with decreased levels of serum IL-2, patients with increased levels had better remission rate (P = 0...
February 2019: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/30712924/urinary-levels-of-the-leukocyte-surface-molecule-cd11b-associate-with-glomerular-inflammation-in-lupus-nephritis
#7
Akimitsu Kitagawa, Naotake Tsuboi, Yuki Yokoe, Takayuki Katsuno, Hidekazu Ikeuchi, Hiroshi Kajiyama, Nobuhide Endo, Yuriko Sawa, Junya Suwa, Yutaka Sugiyama, Asaka Hachiya, Toshihide Mimura, Keiju Hiromura, Shoichi Maruyama
Noninvasive biomarkers of disease activity are needed to monitor response to therapy and predict disease recurrence in patients with glomerulonephritis. The leukocyte surface markers integrin Mac-1 and CD16b have been implicated in the pathogenesis of lupus nephritis (LN). Mac-1 comprises a unique α subunit (CD11b) complexed with a common β2 subunit, which are released along with CD16b from specific leukocyte subsets under inflammatory conditions including glomerulonephritis. We investigated the association of urinary CD11b and CD16b with histopathological activity in 272 patients with biopsy-proven glomerular diseases, including 118 with LN...
January 26, 2019: Kidney International
https://read.qxmd.com/read/30704507/igg4-igg-rna-ratio-differentiates-active-disease-from-remission-in-granulomatosis-with-polyangiitis-a-new-disease-activity-marker-a-cross-sectional-and-longitudinal-study
#8
A Al-Soudi, M E Doorenspleet, R E Esveldt, L T Burgemeister, A E Hak, B J H van den Born, S W Tas, R F van Vollenhoven, P L Klarenbeek, N de Vries
OBJECTIVES: An important limitation in granulomatosis with polyangiitis (GPA) is the lack of disease activity markers. Immunoglobulin G4-positive (IgG4+ ) B cells and plasma cells are implicated in the pathogenesis of GPA. We hypothesized that the presence of these cells in peripheral blood could serve as disease activity parameter in GPA. METHODS: We included 35 proteinase 3-antineutrophil cytoplasmic antibodies-positive patients with GPA in a cross-sectional study...
January 31, 2019: Arthritis Research & Therapy
https://read.qxmd.com/read/30682900/early-stage-predictors-for-treatment-responses-in-patients-with-active-lupus-nephritis
#9
G Liu, H Wang, J Le, L Lan, Y Xu, Y Yang, J Chen, F Han
OBJECTIVE: We analyzed data of lupus nephritis (LN) patients to find parameters that can predict remission. METHODS: Sixty-four LN patients who were diagnosed with class III, IV, V or V + III/IV by renal biopsy and were followed up for more than six months in our center were enrolled retrospectively. Receiver operating characteristic curves were used to test the predictive values of urinary protein-to-creatinine ratio (UPCR), serum albumin and complement C3 at the first, second and third months as predictors for remission at the sixth month...
January 25, 2019: Lupus
https://read.qxmd.com/read/30679978/significance-and-impact-of-dietary-factors-on-systemic-lupus-erythematosus-pathogenesis
#10
REVIEW
Maria-Magdalena Constantin, Iuliana Elena Nita, Rodica Olteanu, Traian Constantin, Stefana Bucur, Clara Matei, Anca Raducan
Systemic lupus erythematosus (SLE) is an autoimmune disease of unknown etiology, although its mechanisms involve genetic, epigenetic and environmental risk factors. Considering that SLE pathogenesis is yet to be explored, recent studies aimed to investigate the impact of diet, in terms of triggering or altering the course of the disease. To study the impact of diet on SLE pathogenesis, we conducted a search on Pubmed using the keywords 'diet and autoimmune diseases', 'diet and lupus', 'caloric restriction and lupus', 'polyunsaturated fatty acids and lupus', 'vitamin D and lupus', 'vitamin C and lupus' 'vitamin E and lupus' 'vitamin A and lupus' 'vitamin B and lupus', 'polyphenols and lupus', 'isoflavones and lupus', 'minerals and lupus', 'aminoacids and lupus', 'curcumin and lupus' and found 10,215 papers, from which we selected 47 relevant articles...
February 2019: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/30678605/remission-and-low-disease-activity-state-ldas-are-protective-of-intermediate-and-long-term-outcomes-in-sle-patients-results-from-lumina-lxxviii-a-multiethnic-multicenter-us-cohort
#11
G S Alarcón, M F Ugarte-Gil, G Pons-Estel, L M Vilá, J D Reveille, G McGwin
OBJECTIVE: The objective of this report is to determine the impact of remission and low disease activity state (LDAS) on damage accrual and mortality in systemic lupus erythematosus (SLE) patients. PATIENTS AND METHODS: Visits from the Lupus in Minority populations: Nature vs. Nurture (LUMINA) cohort were categorized into remission (Systemic Lupus Activity Measure (SLAM) score = 0 and prednisone ≤ 5 mg/day and no immunosuppressants), LDAS ((not on remission), SLAM score ≤ 3, prednisone ≤ 7...
January 24, 2019: Lupus
https://read.qxmd.com/read/30673078/assessment-of-clinical-response-to-janus-kinase-inhibition-in-patients-with-familial-chilblain-lupus-and-trex1-mutation
#12
Nick Zimmermann, Christine Wolf, Reiner Schwenke, Anne Lüth, Franziska Schmidt, Kerstin Engel, Min Ae Lee-Kirsch, Claudia Günther
Importance: Familial chilblain lupus is a monogenic autosomal dominant form of cutaneous lupus erythematosus that in most cases is caused by mutations in the 3 prime repair exonuclease 1 (TREX1). Familial chilblain lupus presents in early childhood with cold-induced painful erythematous infiltrates leading to mutilation and is associated with systemic involvement illustrated by an elevated type I interferon (IFN) signature in the skin and blood. Effective treatment is currently not available...
January 23, 2019: JAMA Dermatology
https://read.qxmd.com/read/30669757/-correlation-between-the-changes-of-innate-lymphoid-cells-in-peripheral-blood-of-systemic-lupus-erythematosus-and-its-clinical-significance
#13
H Chu, X Fang, Z Tan, X Zhen, R L Wu, X P Li, G S Wang, Y P Wang, X M Li
Objective: To explore the function and role of innate lymphoid cells in the pathogenesis of systemic lupus erythematosus (SLE) at different disease activity levels. Methods: From Nov 2017 to May 2018, 40 patients with SLE and 15 age-matched healthy non-immune-related diseases controls were enrolled from Anhui provincial hospital. According to the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)-2K, the patients were divided into active group ( n= 20) and remission group ( n= 20). The frequency of ILCs, B cells, CD4+T and CD8+T cells from peripheral blood mononuclear cells (PBMCs) was detected by flow cytometry...
January 15, 2019: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://read.qxmd.com/read/30630711/the-role-of-5-methoxytryptophan-in-pediatric-onset-lupus-nephritis-a-retrospective-cohort-study
#14
Ting-Chun Lin, Cheng-Chin Kuo, Chao-Yi Wu, Kuo-Wei Yeh, Ming-Ling Kuo, Jing-Long Huang
BACKGROUND: This clinical study investigates the role of 5-methoxytryptophan (5-MTP) in pediatric systemic lupus erythematosus (SLE), with a particular interest in lupus nephritis (LN). PATIENTS AND METHODS: One hundred ten children with SLE were enrolled in the cohort study. Among the patients, seventy-seven (70%) had active LN and thirty-three (30%) were not present with LN during their first visit to the clinic. The diagnoses of LN were biopsy-proven. Serum samples were collected before and after administration of immunosuppressive medications to evaluate 5-MTP levels and regular laboratory data...
December 19, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://read.qxmd.com/read/30630495/common-mechanisms-and-holistic-care-in-atherosclerosis-and-osteoporosis
#15
REVIEW
Zoltán Szekanecz, Hennie G Raterman, Zsófia Pethő, Willem F Lems
Cardiovascular (CV) disease and osteoporosis (OP) have become increasing challenges in the aging population and even more in patients with inflammatory rheumatic diseases, such as rheumatoid arthritis, spondyloarthropathies, and systemic lupus erythematosus. In this review, we discuss how the epidemiology and pathogenesis of CV events and OP are overlapping. Smoking, diabetes mellitus, physical inactivity as conventional risk factors as well as systemic inflammation are among the modifiable risk factors for both CV events and bone loss...
January 10, 2019: Arthritis Research & Therapy
https://read.qxmd.com/read/30630230/-clinical-and-pathological-characteristics-and-outcome-of-46-children-with-autoimmune-hepatitis
#16
L L Cao, M Zhang, S S Zhu, Y Dong, Z Q Xu, D W Chen, L M Wang, F C Wang, Y Gan, J G Yan, P Wang, A Q Li
Objective: To review and analyze the clinical and pathological data of children with autoimmune hepatitis (AIH). Methods: Medical records of 46 patients hospitalized in Pediatric Liver Diseases Treatment and Research Center, Fifth Medical Center, General Hospital of People's Liberation Army(PLA) from April 2012 to April 2018 were extracted. Medical data included type of AIH, clinical manifestations, biochemical parameters, liver biopsy results, and outcomes of treatment were analyzed retrospectively. Among 46 children, 19 were males and 27 were females...
January 2, 2019: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://read.qxmd.com/read/30588061/the-potential-diagnostic-utility-of-coexpression-of-ki-67-and-p53-in-the-renal-biopsy-in-pediatric-lupus-nephritis
#17
Mahtab H Rahbar, Maryam R Rahbar, Nyousha Mardanpour, Sourena Mardanpour
Background: The proliferative activity as well as apoptosis has been suggested to play a role in the pathogenesis of lupus nephritis (LN). The aim of the study was to investigate the coexpression of Ki-67-triggered marked proliferation and P53-induced apoptosis in renal biopsy of childhood lupus nephritis (cLN) and to compare the coexpression of proliferative and apoptotic indices between different subgroups and clinicopathologic patterns of renal disease. Methods: Renal biopsy specimens of 33 children with lupus nephritis (LN) and 10 healthy subjects were retrospectively evaluated...
2018: International Journal of Nephrology and Renovascular Disease
https://read.qxmd.com/read/30583682/malignancy-in-systemic-lupus-erythematosus-sle-patients
#18
Rizna Abdul Cader, Amy Khoo Mei Yee, Azrul Yassin, Ismail Ahmad, Siti Nurfatin Haron
Background: Malignancies are among the leading causes of death in Systemic Lupus Erythematosus (SLE) patients with studies reporting a higher prevalence of malignancy in SLE patients compared to the general population. We wanted to determine the frequency of cancer in a cohort of SLE patients and identify its associated risk factors. Methods: Cross-sectional study involving SLE patients attending the nephrology outpatient clinic, Universiti Kebangsaan Malaysia Medical Centre between January and June 2014. Results: We recruited 228 patients (207 female, 21 male), aged 40...
December 25, 2018: Asian Pacific Journal of Cancer Prevention: APJCP
https://read.qxmd.com/read/30570242/the-association-between-serum-prolactin-levels-and-interleukin-6-and-systemic-lupus-erythematosus-activity
#19
W A Wan Asyraf, M S Mohd Shahrir, W Asrul, A W Norasyikin, O Hanita, W Y Kong, M T Azmi
Based on the recent evidence of association between hyperprolactinemia and systemic lupus erythematosus disease activity (SLEDAI), a study was conducted to analyze the association of hyperprolactinemia with lupus nephritis disease activity. In this cross-sectional study, the analysis was conducted on SLE patients who visited the University Kebangsaan Malaysia Medical Centre (UKMMC) Nephrology Clinic from August 2015 till February 2016. The disease activity was measured using the SLEDAI score, with more than 4 indicating active lupus nephritis...
December 20, 2018: Reumatismo
https://read.qxmd.com/read/30563559/immunosuppressive-therapy-influences-the-accelerated-age-dependent-t-helper-cell-differentiation-in-systemic-lupus-erythematosus-remission-patients
#20
Matthias Schaier, Claudius Gottschalk, Lorenz Uhlmann, Claudius Speer, Florian Kälble, Volker Eckstein, Carsten Müller-Tidow, Stefan Meuer, Karsten Mahnke, Hanns-Martin Lorenz, Martin Zeier, Andrea Steinborn
BACKGROUND: CD4+ T cells are of great importance in the pathogenesis of systemic lupus erythematosus (SLE), as an imbalance between CD4+ regulatory T cells (Tregs) and CD4+ responder T cells (Tresps) causes flares of active disease in SLE patients. In this study, we aimed to find the role of aberrant Treg/Tresp cell differentiation for maintaining Treg/Tresp cell balance and Treg functionality. METHODS: To determine differences in the differentiation of Tregs/Tresps we calculated the percentages of CD45RA+ CD31+ recent thymic emigrant (RTE) Tregs/Tresps and CD45RA+ CD31- mature naive (MN) Tregs/Tresps, as well as CD45RA- CD31+ and CD45RA- CD31- memory Tregs/Tresps (CD31+ and CD31- memory Tregs/Tresps) within the total Treg/Tresp pool of 78 SLE remission patients compared with 94 healthy controls of different ages...
December 18, 2018: Arthritis Research & Therapy
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