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transferrin biomarkers in diabetic nephropathy

Joanne Sloan-Lancaster, Eyas Raddad, Mark A Deeg, Michelle Eli, Amy Flynt, James Tumlin
Two phase 1 studies (TGAA and TGAB) evaluated the safety, pharmacokinetics, pharmacodynamics, and efficacy of LY3016859 (LY), a monoclonal antibody that binds epiregulin and transforming growth factor α (TGF-α), administered intravenously or subcutaneously. In TGAA, 56 healthy subjects received a single dose of LY (0.1-750 mg intravenously, 50 mg subcutaneously) or placebo. In TGAB part A, 15 patients with diabetic nephropathy (DN) received 2 doses of LY (10-750 mg intravenously) or placebo, and in TGAB part B, 45 patients with DN received 5 doses of LY (50-750 mg intravenously) or placebo...
September 2018: Clinical Pharmacology in Drug Development
Khalid Al-Rubeaan, Khalid Siddiqui, Mohammed A Al-Ghonaim, Amira M Youssef, Ahmed H Al-Sharqawi, Dhekra AlNaqeb
Albuminuria is widely used to indicate early phases of diabetic nephropathy although it is limited by the fact that structural damage might precede albumin excretion. This necessitates identifying better biomarkers that diagnose or predict diabetic nephropathy. This is a cross-sectional hospital based study recruiting type 2 diabetic patients cohort aged 35-75 years with diabetes duration of ≥10 years. Out of total eligible 467 patients, 200 patients were with normal albumin excretion, 184 patients with microalbuminuria and 83 patients with macroalbuminuria...
June 2, 2017: Scientific Reports
Cristina Gluhovschi, Gheorghe Gluhovschi, Ligia Petrica, Romulus Timar, Silvia Velciov, Ioana Ionita, Adriana Kaycsa, Bogdan Timar
Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM). Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis. Towards this aim, biomarkers for detecting early DN can be used. Microalbuminuria has been proven a remarkably useful biomarker, being used for diagnosis of DN, for assessing its associated condition-mainly cardiovascular ones-and for monitoring its progression. New researches are pointing that some of these biomarkers (i.e., glomerular, tubular, inflammation markers, and biomarkers of oxidative stress) precede albuminuria in some patients...
2016: Journal of Diabetes Research
Hideyuki Ito, Hiroki Fujita, Takamune Takahashi
Clinical management and therapeutic intervention from the earlier stage of diabetic nephropathy (DN) is of major importance to prevent the progression of DN to end stage renal disease. At present, the measurement of albuminuria is used as a standardized non-invasive test for the diagnosis of early DN. Diabetic kidney disease, however, is not detected by this test in some cases. Hence, efforts have been made to find better diagnostic biomarkers of DN. These investigations have identified several proteins that can be used as diagnostic biomarkers of DN, including urinary immunoglobulin G, transferrin, ceruloplasmin and serum cystatin-C...
February 2008: Expert Opinion on Medical Diagnostics
M E Hellemons, J Kerschbaum, S J L Bakker, H Neuwirt, B Mayer, G Mayer, D de Zeeuw, H J Lambers Heerspink, M Rudnicki
Novel biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes have been recently identified. We performed a systematic review to assess the validity of biomarkers predicting onset or progression of nephropathy in patients with Type 2 diabetes in longitudinal studies. The methodological quality of the studies was scored using Standards for Reporting of Diagnostic Accuracy (STARD) criteria and the independent predictive value of the biomarkers beyond conventional risk factors was scored according to the adjustment for these risk factors...
May 2012: Diabetic Medicine: a Journal of the British Diabetic Association
Agnès Matheson, Mark D P Willcox, Judith Flanagan, Bradley J Walsh
Diabetes mellitus is one of the most challenging health concerns of the 21st century. With at least 30% of the diabetic population remaining undiagnosed, effective and early diagnosis is of critical concern. Development of a diagnostic test, more convenient and reliable than those currently used, would therefore be highly beneficial. Urine as a diagnostic medium allows for non-invasive detection of biomarkers, including some associated with type 2 diabetes and its complications. This review provides a synopsis of those urinary biomarkers that potentially may provide a basis for the development of improved diagnostic tests...
March 2010: Diabetes/metabolism Research and Reviews
Sanju A Varghese, T Brian Powell, Milos N Budisavljevic, Jim C Oates, John R Raymond, Jonas S Almeida, John M Arthur
Diagnosis of the type of glomerular disease that causes the nephrotic syndrome is necessary for appropriate treatment and typically requires a renal biopsy. The goal of this study was to identify candidate protein biomarkers to diagnose glomerular diseases. Proteomic methods and informatic analysis were used to identify patterns of urine proteins that are characteristic of the diseases. Urine proteins were separated by two-dimensional electrophoresis in 32 patients with FSGS, lupus nephritis, membranous nephropathy, or diabetic nephropathy...
March 2007: Journal of the American Society of Nephrology: JASN
Hiroyuki Yokota, Masashi Hiramoto, Hirokazu Okada, Yoshihiko Kanno, Masatoshi Yuri, Shuji Morita, Masanori Naitou, Atsushi Ichikawa, Masao Katoh, Hiromichi Suzuki
To search for biomarkers of IgA nephropathy, protein profiles of urine samples from patients with IgA nephropathy and normal volunteers were compared using two-dimensional DIGE. Most of the 172 spots identified in the urine were serum proteins, and their amounts in IgA nephropathy urine were much higher than those in normal urine; this can be explained as proteinuria caused by glomerular dysfunction. However, only alpha(1)-microglobulin, also one of the major serum proteins, in IgA nephropathy urine was not higher in amount than that in normal urine...
April 2007: Molecular & Cellular Proteomics: MCP
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