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Chenyang Zhang, Liang Yan, Xin Wang, Xinghua Dong, Ruyi Zhou, Zhanjun Gu, Yuliang Zhao
Traditional radiotherapy can induce injury to the normal tissue around the tumor, so the development of novel radiosensitizer with high selectivity and controllability that can lead to more effective and reliable radiotherapy is highly desirable. Herein, a new smart radiosensitizer based on Cu2(OH)PO4 nanocrystals that can simultaneously respond to endogenous stimulus (H2O2) and exogenous stimulus (X-ray) is reported. First, Cu2(OH)PO4 nanocrystals can generate CuI sites under X-ray irradiation through X-ray-induced photoelectron transfer process...
February 18, 2019: Nano Letters
Xuguang Hu, Dan Ding, Jiayi Zhang, Jianguo Cui
Radiotherapy is a major therapeutic strategy for breast cancer, while cancer radioresistance remains an obstacle for the successful control of the tumor. Novel radiosensitizing targets are to be developed to overcome radioresistance. Recently, long non-coding RNAs (lncRNAs) were proved to play critical roles in cancer progression. Among all, lncRNA HOTAIR was found to participate in cancer metastasis and chemoresistance. In the present study, we aimed to investigate the radiosensitizing effects of targeting HOTAIR and the underlying mechanism...
November 14, 2018: Bioscience Reports
Ji-Wei Ma, Xiao Wang, Lei Chang, Xue-Yun Zhong, Haiyan Jing, Xiaolong Zhu, Shaoxiang Wang, WeiWei Xiao
CD44, a glycoprotein, has been reported to have relationship with resistance to radiation in prostate cancer (Cap) cells. However, its molecular mechanism remains unknown. In this study, we demonstrated that inhibited CD44 enhanced the radiosentivity in Cap cells. It has been hypothesized that CD44 combine with ERBB2 and activate downstream phosphated protein to mediate DNA damage repair. Therefore, we conducted a detailed analysis of effects of radiation by clonogenic assay and immunofluorescence stain for p-H2AX foci...
September 1, 2018: Experimental Cell Research
Jonathan Khalifa, Arya Amini, Sanjay Popat, Laurie E Gaspar, Corinne Faivre-Finn
Brain metastases (BMs) will develop in a large proportion of patients with NSCLC throughout the course of their disease. Among patients with NSCLC with oncogenic drivers, mainly EGFR activating mutations and anaplastic lymphoma receptor tyrosine kinase gene (ALK) rearrangements, the presence of BM is a common secondary localization of disease both at the time of diagnosis and at relapse. Because of the limited penetration of a wide range of drugs across the blood-brain barrier, radiotherapy is considered the cornerstone of treatment of BMs...
October 2016: Journal of Thoracic Oncology
François Chevalier, Jordane Depagne, Sonia Hem, Sylvie Chevillard, Julie Bensimon, Pascale Bertrand, Jérôme Lebeau
Secreted proteins play a key role in cell signaling and communication. We recently showed that ionizing radiations induced a delayed cell death of breast cancer cells, mediated by the death receptor pathways through the expression of soluble forms of "death ligands." Using the same cell model, the objective of our work was the identification of diffusible factors, secreted following cell irradiation, potentially involved in cell death signaling. Differential proteomic analysis of conditioned media using 2DE resulted in detection of numerous spots that were significantly modulated following cell irradiation...
June 2012: Proteomics
Géraldine Le Duc, Imen Miladi, Christophe Alric, Pierre Mowat, Elke Bräuer-Krisch, Audrey Bouchet, Enam Khalil, Claire Billotey, Marc Janier, François Lux, Thierry Epicier, Pascal Perriat, Stéphane Roux, Olivier Tillement
Ultrasmall gadolinium-based nanoparticles (GBNs) induce both a positive contrast for magnetic resonance imaging and a radiosentizing effect. The exploitation of these characteristics leads to a greater increase in lifespan of rats bearing brain tumors since the radiosensitizing effect of GBNs can be activated by X-ray microbeams when the gadolinium content is, at the same time, sufficiently high in the tumor and low in the surrounding healthy tissue. GBNs exhibit therefore an interesting potential for image-guided radiotherapy...
December 27, 2011: ACS Nano
Julia Rousseau, Jean François Adam, Pierre Deman, Ting Di Wu, Jean Luc Guerquin-Kern, Barbara Gouget, Rolf F Barth, François Estève, Hélène Elleaume
Iodine-enhanced synchrotron stereotactic radiotherapy takes advantage of the radiation dose-enhancement produced by high-Z elements when irradiated with mono-energetic beams of synchrotron X-rays. In this study it has been investigated whether therapeutic efficacy could be improved using a thymidine analogue, 5-iodo-2'-deoxyuridine (IUdR), as a radiosentizing agent. IUdR was administered intracerebrally over six days to F98 glioma-bearing rats using Alzet osmotic pumps, beginning seven days after tumor implantation...
July 2009: Journal of Synchrotron Radiation
Gustavo Arruda Viani, Gustavo Borges Manta, Ellen Carrara Fonseca, Ligia Issa De Fendi, Sergio Luis Afonso, Eduardo Jose Stefano
PURPOSE: To study the efficacy of whole brain radiotherapy (WBRT) with radiosensitizer in comparison with WBRT alone for patients with brain metastases in terms of overall survival, disease progression, response to treatment and adverse effects of treatment. METHODS: A meta-analysis of randomized controlled trials (RCT) was performed in order to compare WBRT with radiosensitizer for brain metastases and WBRT alone. The MEDLINE, EMBASE, LILACS, and Cochrane Library databases, in addition to Trial registers, bibliographic databases, and recent issues of relevant journals were researched...
January 6, 2009: Journal of Experimental & Clinical Cancer Research: CR
Takayuki Suzuki, Kayoko Nakamura, Takatsugu Kawase, Atsushi Kubo
PURPOSE: Oxygenation status of tumor tissue is an important factor to discriminate it with respect to its radiosensitivity. 99mTc-4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime (99mTc-HL91) is retained in hypoxic tissues, making it possible to use it as hypoxic imaging agent. We evaluated if the accumulation of 99mTc-HL91 in tumors could aid in the prediction of sensitivity of radiation therapy of cancers. METHODS: Human tumors (the gastric cancer cell line: MKN45, the epidermoid carcinoma cell line: KB-31, and the lung adenocarcinoma cell line: HLC) were xenografted into the thigh of athymic mice and irradiated with a 4 MV linear accelerator...
April 2003: Annals of Nuclear Medicine
G M Avetisov, G P Zharkova, R N Zaĭtseva
No abstract text is available yet for this article.
May 1978: Radiobiologiia
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