Marco Neves, Joana Marinho-Dias, Joana Ribeiro, Marlene Esteves, Elsa Maltez, Inês Baldaque, Eduardo Breda, Eurico Monteiro, Rui Medeiros, Hugo Sousa
Variations in the genome sequence of Epstein-Barr Virus (EBV) are thought to lead to differential interaction with host cells, immune evasion, and transformation. The discussion regarding EBV strains as having a geographic or disease-association has been increasing and the majority of studies are performed in Asiatic populations. We developed a case-control study with 139 individuals, including 96 subjects with different malignancies and 43 healthy individuals, from the North region of Portugal. We have used PCR protocols for the characterization of EBV strains (type A or B) based on EBNA3C genome variation and for the LMP1 30bp-deletion variants (wt-LMP1 or del-LMP1)...
August 2015: Journal of Medical Virology