Ji Xia, Ning Ma, Qian Shi, Qin-Cheng Liu, Wei Zhang, Hui-Jun Cao, Yi-Kang Wang, Qian-Wen Zheng, Qian-Zhi Ni, Sheng Xu, Bing Zhu, Xiao-Song Qiu, Kai Ding, Jing-Yi Huang, Xin Liang, Yu Chen, Yan-Jun Xiang, Xi-Ran Zhang, Lin Qiu, Wei Chen, Dong Xie, Xiang Wang, Lingyun Long, Jing-Jing Li
Metastasis is the main cause of colorectal cancer (CRC)-related death, and the 5-year relative survival rate for CRC patients with distant metastasis is only 14%. X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a zinc-rich protein belonging to the interferon (IFN)-induced gene family. Here, we report a metastasis-promoting role of XAF1 in CRC by acting as a novel adaptor of valosin-containing protein (VCP). XAF1 facilitates VCP-mediated deubiquitination of the E3 ligase RING finger protein 114 (RNF114), which promotes K48-linked ubiquitination and subsequent degradation of junction plakoglobin (JUP)...
February 5, 2024: Journal of Cell Biology