Wenhui Chen, Wei Mao, Yuqi Yin, Ziyu Ma, Meiqi Song, Zixiao Ma, Tingting Li, Jia Zhu, Chang Liu, Hui Yu, Sheng Tang, Wei Shen
To avoid the unexpected aggregation and reduce the cytotoxicity of nanomaterials as optical probes in cell imaging applications, we propose a programmed DNA-cube as a carrier for silver nanoparticles (Ag NPs) to construct a specific hydrogen sulfide (H2 S) responsive platform (Ag NP@DNA-cube) for diagnosing colorectal cancer (CRC) in this study. The DNA-cube maintains good dispersion of Ag NPs while providing excellent biocompatibility. Based on the characteristic overexpression of endogenous H2 S in CRC cells, the Ag NPs are etched by H2 S within target cells into silver sulfide quantum dots, thereby selectively illuminating the target cells...
April 17, 2024: Chemical Communications: Chem Comm