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Neuropathy Optic

Puyao C Li, Norbert J Liebsch, Andrzej Niemierko, Drosoula Giantsoudi, Simmons Lessell, Barbara C Fullerton, Judith Adams, Helen A Shih
INTRODUCTION: Radiation-induced optic neuropathy (RION) is a complication of radiation therapy (RT) that causes blindness. We aimed to define the tolerance of the anterior optic pathway to fractionated RT and identify risk factors for RION. MATERIALS/METHODS: Patients with chordoma or chondrosarcoma of the skull base treated with proton and photon therapy between 1983 and 2013, who received a minimum of 30 Gy (relative biologic effectiveness [RBE]) to the anterior optic pathway were assessed...
February 2019: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Yair M Gozal, Gmaan Alzhrani, Hussam Abou-Al-Shaar, Mohammed A Azab, Michael T Walsh, William T Couldwell
OBJECTIVECavernous sinus meningiomas are complex tumors that offer a perpetual challenge to skull base surgeons. The senior author has employed a management strategy for these lesions aimed at maximizing tumor control while minimizing neurological morbidity. This approach emphasizes combining "safe" tumor resection and direct decompression of the roof and lateral wall of the cavernous sinus as well as the optic nerve. Here, the authors review their experience with the application of this technique for the management of cavernous sinus meningiomas over the past 15 years...
February 15, 2019: Journal of Neurosurgery
Jed Lusthaus, Ivan Goldberg
Glaucoma is an irreversible progressive optic neuropathy, for which the major proven treatment is to lower the intraocular pressure (IOP). Five groups of IOP-lowering eye drops have varying mechanisms of action. Some drops, such as β-blockers and α-2 agonists, have potentially serious systemic side effects. Acetazolamide is the only available oral agent; it is effective at lowering IOP, but significant side effects relegate its use usually to refractory glaucoma. Two new eye drops, netarsudil and latanoprostene bunod, have recently been approved by the United States Food and Drug Administration...
February 14, 2019: Medical Journal of Australia
Makoto Ito, Yasuhiro Takahashi, Eisuke Katsuda, Yukihiko Oshima, Arisa Takeuchi, Toshie Mori, Souichirou Abe, Yoshimasa Mori, Hirohiko Kakizaki, Kojiro Suzuki
To identify predictive factors of prognosis after radiotherapy with concurrent steroid pulse therapy for thyroid eye disease, retrospective analyses were performed among 77 patients. Clinical activity score and magnetic resonance imaging were used to evaluate degrees of orbital inflammation. As a pre-treatment work-up, the thyroid-stimulating antibody (TSAb) level was measured. During a median follow-up of 25.0 months, the 2-year cumulative relapse-free rate (CRFR) was 80.9%. In the univariate analysis, a worse 2-year CRFR was significantly associated with the presence of optic neuropathy (P = 0...
February 14, 2019: Scientific Reports
Elie Côté, Ari Aharon Shemesh, Lili Tong, Cindy T Y Lam, Edward Margolin
BACKGROUND/OBJECTIVES: No guidelines exist for the investigation of treatable causes of chronic optic neuropathy, including sarcoidosis, lupus, and syphilis. The purpose of this study was to determine the diagnostic yield of screening blood work (ACE (Angiotensin Converting Enzyme) for sarcoidosis, Antinuclear Antibodies (ANA) for lupus, CMIA (chemiluminescence microparticle enzyme immunoassay) for syphilis) and contrast-enhanced MRI brain and orbits in atypical unilateral chronic optic neuropathy...
February 13, 2019: Eye
Nathalie Stéphanie Meneguette, J Emanuel Ramos de Carvalho, Axel Petzold
BACKGROUND: Detection of a relative afferent pupillary defect (RAPD) by the swinging-light test can be challenging in clinical practice (dark eyes, anisocoria, dark environment). We developed a new method of RAPD quantification based on the recording of the infrared pupillary asymmetry (IPA) with a standard optical coherence tomography (OCT) device. METHODS: The diagnostic value of the IPA for detection of the RAPD was determined by receiver-operating characteristic (ROC) curves and area under the curve (AUC)...
February 12, 2019: Journal of Neurology
Byung Joo Lee, Hyoung Oh Jun, Jin Hyoung Kim, Jeong Hun Kim
Ischemic retinopathies and optic neuropathies are important causes of vision loss. The neuroprotective effect of erythropoietin (EPO) in ischemic neuronal injury and the expression of EPO and its receptor in retinal tissue have been well documented. However, the exact regulatory mechanism of EPO expression in retinal ischemia still remains to be elucidated. In this study, we investigated the role of cystine/glutamate antiporter (system xc- ) in the regulation of astrocytic EPO expression by using both in vitro and in vivo models...
February 11, 2019: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Aaron Pariente, Alexis Guédon, Sonia Alamowitch, Sara Thietart, Fabrice Carrat, Stephen Delorme, Jean Capron, Carlotta Cacciatore, Michael Soussan, Azeddine Dellal, Olivier Fain, Arsene Mekinian
Acute cerebrovascular ischemic events are a rare and severe complication of giant cell arteritis (GCA). We aimed to determine the prevalence of GCA-related stroke, the overall survival and the relapse-free survival in patients with GCA. A multicentric retrospective analysis was performed on 129 patients with GCA diagnosed between September 2010 and October 2018 in two University Hospitals. Among 129 GCA patients, 18 (16%) presented an acute ischemic cerebrovascular event. Patients with stroke were older (83 [67-96] years versus 76 [58-96]; p = 0...
February 5, 2019: Journal of Autoimmunity
Tiago Maio, José Lemos, Jorge Moreira, Filipa Sampaio, Sara Pereira
Hypotension is the most frequent complication of haemodialysis. We report a case of acute visual impairment after one session of haemodialysis in a context of an acute optic neuropathy. The immunological and serological studies were negative. The records of hypotension greater than usual after the dialysis session that coincided with the visual complaints strongly suggest the dialysis-induced hypotension is the underlying mechanism of this non-arteritic anterior ischemic optic neuropathy.
February 2019: Neuro-ophthalmology
Shikha Talwar Bassi, Veena Noronha, Swatee Halbe
Authors describe a case of traumatic pseudoaneurysm of cavernous internal carotid artery in a young male who presented with complaints of progressive decrease in vision, inability to move the eye, and delayed epistaxis 8 months after the head injury sustained during a motor vehicle accident. The presence of optic atrophy and epistaxis in the setting of head trauma alerted the authors to look for this potentially life-threatening condition. Timely intervention in the form of endovascular coil occlusion of the internal carotid artery was performed and the epistaxis stopped without any ischaemic or thromboembolic sequaelae...
February 2019: Neuro-ophthalmology
C Orssaud, S Bidot, C Lamirel, D Brémond Gignac, V Touitou, C Vignal
INTRODUCTION: Leber's Hereditary Optic Neuropathy (LHON) causes a rapid and severe decrease in visual acuity. Raxone® (Idebenone, Santhera) is the only drug to have a European Marketing Authorization for the treatment of this optic neuropathy. It can be proposed in the first months after the onset of this optic neuropathy, according to an international consensus meeting. PATIENTS AND METHODS: Retrospective study of the efficacy of Raxone® on the visual acuity of patients with genetically confirmed LHON who were followed in four Parisian hospitals...
January 31, 2019: Journal Français D'ophtalmologie
F de Borja Domínguez-Serrano, E Jiménez-López, M Ramos Jiménez, B Ponte-Zuñiga, A Gómez-Escobar, M J Díaz-Granda, E Gutiérrez-Sánchez, M J Morillo-Sánchez, C Menéndez-de-León, E Rodríguez-de-la-Rúa-Franch
BACKGROUND AND OBJECTIVE: The diagnosis of retinal dystrophies is complex and is based on complete ophthalmological study, genetic study and electrophysiological studies (EPS). In this study, we intend to evaluate the role of electrophysiological and medical tests in the diagnosis of retinal dystrophies. MATERIAL AND METHODS: A retrospective observational study was conducted on 50 selected patients that attended the Neurophysiology Department of the University Hospital Virgen Macarena...
January 30, 2019: Archivos de la Sociedad Española de Oftalmología
Ako Matsuhashi, Kenichi Usami, Eitaro Ishisaka, Hideki Ogiwara
We present a 3-year-old girl with decreased visual acuity of the left eye. Radiological studies revealed a mass lesion at the roof of the left optic canal with bony erosion, which compressed the left optic nerve. Gross total resection of the mass and decompression of the optic canal were performed. Histopathological study was consistent with nodular fasciitis. This is the first report of nodular fasciitis at the roof of the optic canal in a young child. Nodular fasciitis compressing the optic nerve should be included in differential diagnoses of optic neuropathy in young children...
February 1, 2019: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Noriyuki Miyaue, Yuki Yamanishi, Satoshi Tada, Rina Ando, Hayato Yabe, Masahiro Nagai, Masahiro Nomoto
•LHON cases can show brainstem lesions without visual impairment.•There can be inconsistency between MRI finding and clinical symptom in LHON cases.•Auditory pathways may be often involved in LHON cases.
March 2019: ENeurologicalSci
Xu Cao, Jasmine Yung, Heather Mak, Christopher K S Leung
Efficient transduction of the retinal ganglion cells (RGCs) is a prerequisite to maximize therapeutic outcomes in any form of gene therapy for optic neuropathies. Whereas subretinal injection of adeno-associated virus 2 (AAV2) has been well-characterized, the serotype, viral load, and promoter combinations that govern RGC transduction efficiency following intravitreal injection remains poorly understood. We evaluated the transduction efficiency of seven AAV2 serotypes (AAV2/1, AAV2/2, AAV2/4, AAV2/5, AAV2/6, AAV2/8, and AAV2/9) for the RGCs at 4 weeks following intravitreal injection in C57BL/6J mice...
January 28, 2019: Gene Therapy
Liyung Tiffany Chou, Derek Horkey, Mark Slabaugh
Wilson's disease (WD), also known as hepatolenticular degeneration, is a rare autosomal recessive condition of excess copper accumulation that is most commonly associated with hepatic, neurologic, psychiatric, and ocular manifestations. While Kayser-Fleischer rings and sunflower cataracts are well known in WD, visual impairment is very rare. We report the case of a 20-year-old female who presented with acute liver failure and associated monocular vision loss. WD was found to be a cause of her liver disease and decreased vision...
September 2018: Case Reports in Ophthalmology
Pia De Stefano, Agustina M Lascano, Manuel Schibler, Aikaterini Fitsiori, Jean-Paul Janssens, Patrice H Lalive, Markus Gschwind
No abstract text is available yet for this article.
January 15, 2019: Multiple Sclerosis and related Disorders
Amanda D Henderson, Hong Jiang, Jianhua Wang
Background: Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of acute optic neuropathy in patients over 50 years of age, and many affected individuals are left with permanent visual deficits. Despite the frequency of NAION and its often devastating effects on vision, no effective treatment has been established. Further understanding of the acute vascular effects in NAION, using advanced ophthalmic imaging techniques like the retinal function imager, may shed light on potential treatment targets...
2019: Eye and Vision (London, England)
Sarah Chaoying Xu, Randy H Kardon, Jacqueline A Leavitt, Eoin P Flanagan, Sean J Pittock, John J Chen
OBJECTIVE: To explore sensitivity of optical coherence tomography (OCT) in detecting prior unilateral optic neuritis. METHODS: This is a retrospective, observational clinical study of all patients who presented from January 1, 2014, to January 6, 2017, with unilateral optic neuritis and OCT available at least 3 months after the attack. We compared OCT retinal nerve fiber layer (RNFL) and ganglion cell inner plexiform layer (GCIPL) thicknesses between affected and unaffected contralateral eyes...
January 23, 2019: Neurology
Alexander J Heckman, Ali A Alsaad, Michael W Stewart, Michael J Maniaci
BACKGROUND Systemic lupus erythematosus (SLE) causes sight-threatening, ophthalmologic problems that are frequently challenging to manage. Optic neuropathy is a rare ophthalmological complication of SLE that can progress to total bilateral vision loss if not identified and treated rapidly. We describe a patient with SLE who presented with an acute, painless unilateral optic neuropathy who subsequently experienced partial recovery of vision when treated with high-dose intravenous corticosteroids. CASE REPORT A 44-year-old female with known SLE presented with 4 days of painless, complete, and gradual vision loss in the right eye...
January 23, 2019: American Journal of Case Reports
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