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Preterm formula

Fatma A Alzaree, Mones M AbuShady, Mohamed Abdel Atti, Gihan A Fathy, Essam M Galal, Alaa Ali, Tahany R Elias
BACKGROUND: Insulin-like growth factor 1 (IGF-1) is one of the essential intrauterine hormonal mediators of growth, and its serum values are often low after preterm delivery. AIM: To evaluate the influence of immediate breast milk feeding on serum IGF-1 in preterm newborns. SUBJECTS AND METHODS: This prospective, observational cohort study included 60 premature infants born < 32 weeks of gestation, divided into group A and B regarding breastfeeding or formula feeding...
January 15, 2019: Open Access Macedonian Journal of Medical Sciences
Pitiporn Siripattanapipong, Buranee Yangthara, Sopapan Ngerncham
BACKGROUND: The nutritional content of preterm human milk (HM) can be increased by adding human milk fortifier (HMF). Premature formula (PF) has been used as an alternative to HMF due to the high cost of HMF in some countries. However, the osmolality of HM after fortification remains a matter of concern. AIM: To evaluate the osmolality of fortified preterm HM. METHODS: This was a cross-sectional study. HM was collected from 28 mothers of infants with a gestational age of <32 weeks or birthweight <1500 g...
February 11, 2019: Paediatrics and International Child Health
Ozgun Uygur, Mehmet Yalaz, Nazmiye Can, Ozge Altun Koroglu, Nilgun Kultursay
PURPOSE: Feeding intolerance is one of the most frequent problems among preterm infants. These infants are fed with expressed breast milk or preterm formulas of which the temperature is not routinely measured. In this study, we aimed to examine the effects of feeds with warm milk versus room temperature milk in preterm infants. MATERIALS AND METHODS: Infants with a birth weight ≤1,500 g or gestational age ≤34 weeks were included in the study and assigned to two different feeding temperature groups (22-24°C and 32-34°C)...
February 5, 2019: Breastfeeding Medicine: the Official Journal of the Academy of Breastfeeding Medicine
M T K Zia, S Golombek, L Lemon, S Nitkowski Keever, U Paudel
BACKGROUND: Breastfeeding (BF) neonates generally lose weight after birth. Neonatal factors like gestational age, birth weight and mode of delivery can affect the neonatal weight loss after birth. Similarly, maternal age, parity and illness may contribute to newborn weight loss. However, influence of the time of birth and season on changes in weight is not well elucidated. OBJECTIVE: The aim of this study is to determine the effect of birth time and the seasonal variations on weight loss in BF newborns...
January 28, 2019: Journal of Neonatal-perinatal Medicine
Stephanie Merlino-Barr, Sharon Groh-Wargo
Expressed breast milk (EBM) is the gold standard of infant nutrition, but is not always available for use for preterm infants in the NICU setting. Donor breast milk (DBM) is often a preferred alternative for preterm and very low birth weight (VLBW) infants when maternal milk is not available. This article discusses the composition of DBM, reviews its advantages compared to formula, discusses challenges related to its long-term use, and identifies strategies to utilize DBM in the context of total nutritional management of preterm and VLBW infants...
January 2019: Neonatal Network: NN
Rebecca Hoban, Michael E Schoeny, Anita Esquerra-Zwiers, Tanyaporn K Kaenkumchorn, Gina Casini, Grace Tobin, Alan H Siegel, Kousiki Patra, Matthew Hamilton, Jennifer Wicks, Paula Meier, Aloka L Patel
Mother's own milk (MOM) reduces the risk of morbidities in very low birth weight (VLBW) infants. When MOM is unavailable, donor breastmilk (DM) is used, with unclear impact on short- and long-term growth. This retrospective analysis compared anthropometric data at six time points from birth to 20⁻24 months corrected age in VLBW infants who received MOM supplements of preterm formula ( n = 160) versus fortified DM ( n = 161) during neonatal intensive care unit (NICU) hospitalization. The cohort was 46% female; mean birth weight and gestational age (GA) were 998 g and 27...
January 22, 2019: Nutrients
Sergio Verd, Jaume Ponce-Taylor, Gemma Ginovart
It is unclear to what extent highly complex biomedical systems can be mathematically modelled. Algorithms are a new player in this field. A new algorithm can accelerate predictions that were previously out of reach, but unfortunately there is no secret formula for generating its initial parameters. Wirth et al. (1) demonstrate that the WINROP algorithm helps to identify preterm infants at high-risk of developing retinopathy of prematurity. This article is protected by copyright. All rights reserved.
January 17, 2019: Acta Paediatrica
Celia Taylor, Yaseen Joolay, Abigail Buckle, Richard Lilford
The use of donor human breast milk instead of formula reduces the risk of necrotising enterocolitis in preterm infants when their mother's own milk is insufficient. Use of donor milk is limited by the cost of establishing a milk bank and a lack of donors, but the optimal rationing of limited donor milk is unclear. This paper uses an economic model to explore how a limited donor milk supply should be allocated across very low birthweight infants in South Africa considering 2 outcomes: maximising lives saved and minimising costs...
December 2018: Maternal & Child Nutrition
Caroline Kadji, Mieke M Cannie, Serena Resta, David Guez, Fouad Abi Khalil, Riccardo De Angelis, Jacques C Jani
Fetuses at the extremes of growth abnormalities carry a risk of perinatal morbidity and mortality. Their identification is traditionally done by 2-dimensional ultrasound, the performance of which is not always optimal. Magnetic resonance imaging (MRI) superbly depicts fetal anatomy and anomalies and has largely contributed to the evaluation of high-risk pregnancies. In 1994, Baker et al. introduced MRI for estimation of fetal weight (EFW). This is done by measuring the fetal body volume (FBV) and converting it through a formula to fetal weight...
December 21, 2018: American Journal of Obstetrics and Gynecology
Elettra Berti, Monia Puglia, Silvia Perugi, Luigi Gagliardi, Cristiana Bosi, Anna Ingargiola, Letizia Magi, Elena Martelli, Simone Pratesi, Emilio Sigali, Barbara Tomasini, Franca Rusconi
Background: Great variability in enteral feeding practices for very preterm (<32 weeks gestational age-GA) and very low birth weight infants (VLBW; ≤1,500 g) have been reported. We aimed to describe data on enteral feeding in Tuscany (Italy), where a network of 6 donor milk banks is in place. Methods: A 4-years (2012-2015) observational study was performed analyzing the database "TIN Toscane online" on very preterm and VLBW infants. The database covers all 25 hospitals with a neonatal unit. Results: Data concerning the beginning of enteral nutrition were available for 1,302 newborns with a mean (standard deviation) GA of 29...
2018: Frontiers in Pediatrics
Lars Bode
Preterm infants who receive human milk instead of formula are 6- to 10-times less likely to develop necrotizing enterocolitis (NEC), one of the most common and devastating intestinal disorders that affects 5-10% of all very-low-birth-weight infants. Combined data from in vitro tissue culture models, in vivo preclinical studies in animal models, as well human mother-infant cohort studies support the hypothesis that human milk oligosaccharides (HMOs), complex sugars that are highly abundant in human milk but not in infant formula, contribute to the beneficial effects of human milk feeding in reducing NEC...
2018: Frontiers in Pediatrics
Ayesha Muneer, Attia Bari, Summaira Naveed, Agha Shabbir Ali
Objective: To find the association between breast milk feeding with retinopathy of prematurity (ROP) in preterm infants. Methods: This was a cross sectional study to examine the effects of breast milk feeding on ROP. Premature newborns below 34 weeks from neonatal unit retinopathy of prematurity program during the years 2015 to 2017 of The Lahore General Hospital were included. We recorded the gestational age, birth weight, presence of ROP and the type of feeding (breastfeeding vs...
November 2018: Pakistan Journal of Medical Sciences Quarterly
Itziar Estalella, Jaione San Millán, María José Trincado, Amaia Maquibar, Lorea Martínez-Indart, Miguel San Sebastián
BACKGROUND: Late-preterm infants show lower breastfeeding rates when compared with term infants. Current practice is to keep them in low-risk wards where clinical guidelines to support breastfeeding are well established for term infants but can be insufficient for late-preterm. OBJECTIVE: The aim of this study was to evaluate an intervention supporting breastfeeding among late-preterm infants in a maternity service in the Basque Country, Spain. METHODS: The intervention was designed to promote parents' education and involvement, provide a multidisciplinary approach and decision-making, and avoid separation of the mother-infant dyad...
December 4, 2018: Women and Birth: Journal of the Australian College of Midwives
Beatriz Salamanca-Zarzuela, María Elena Infante López, Carlos Alcalde Martín
Phenylketonuria (PKU) is an autosomal recessive inborn error of phenylalanine (phe) metabolism caused by a deficiency in the enzyme phenylalanine hydroxylase that converts phe into tyrosine. If left untreated, PKU results in increased phe concentrations in the blood and in the brain, which cause severe intellectual disability, epilepsy, and behavioral problems. These disorders can be prevented if a diet low in phe is introduced. This report focuses on a preterm newborn (gestational age 29 wk) with adequate weight (1290 g) and no family history of PKU...
March 2019: Nutrition
Vijay Gupta, Grace Rebekah, Yesudas Sudhakar, Sridhar Santhanam, Manish Kumar, Niranjan Thomas
OBJECTIVE: To optimize growth in very low birth weight (VLBW) infants, human milk fortification is standard of care in neonatal units of high income countries. However, commercial fortifiers may not be available or it may be too expensive in resource limited settings. As an alternative to using human milk fortifiers, we studied the effects of milk fortification with an infant formula on growth and biochemical parameters of very low birth weight (VLBW) infants Methods: We undertook a prospective, randomized controlled trial in the neonatal unit of a tertiary care hospital in south India...
November 28, 2018: Journal of Maternal-fetal & Neonatal Medicine
Srikanth Ravisankar, Rodney Tatum, Parvesh M Garg, Maja Herco, Prem S Shekhawat, Yan-Hua Chen
BACKGROUND: Necrotizing enterocolitis (NEC) is a leading cause of death in preterm infants. Neonates weighing <1500 grams are at the highest risk for acquiring NEC, with a prevalence of nearly 7-10%, mortality up to 30%, and several long-term complications among survivors. Despite advancements in neonatal medicine, this disease remains a challenge to treat. The aim of this study is to investigate the effect of NEC on gut epithelial tight junctions and its barrier function using a NEC mouse model...
November 27, 2018: BMC Pediatrics
Leónides Fernández, Lorena Ruiz, Josué Jara, Belén Orgaz, Juan M Rodríguez
Studies carried in the last years have revealed that human milk contains a site-specific microbiota and constitutes a source of potentially beneficial bacteria to the infant gut. Once in the infant gut, these bacteria contribute to the assembly of a physiological gut microbiota and may play several functions, contributing to infant metabolism, protection against infections, immunomodulation or neuromodulation. Many preterm neonates are fed with pasteurized donor's human milk (DHM) or formula and, therefore, are devoid of contact with human milk microbes...
2018: Frontiers in Microbiology
Jeannie Rodriguez, Olivia Affuso, Andres Azuero, Charles A Downs, Anne Turner-Henson, Marti Rice
PURPOSE: Long-term consequences of prematurity are a public health concern. A pattern of slow initial weight gain followed by a period of rapid weight gain has been associated with poor cardiometabolic health outcomes. The purpose of this study was to examine the relationships between infant feeding practices and weight gain in a sample of 18-to-24-month olds corrected age born very preterm. DESIGN AND METHODS: A cross-sectional design was used to examine the relationships between infant feeding practices and weight gain...
November 2018: Journal of Pediatric Nursing
Mehmet Buyuktiryaki, Cuneyt Tayman, Ismail Koyuncu, Ufuk Cakir, Tugba Taskin Turkmenoglu, Esra Cakir, Nilufer Okur
Necrotizing enterocolitis (NEC) is a major neonatal health problem that especially affects preterm infants and causes severe morbidity and mortality. Although its pathogenesis is not fully understood, important risk factors include prematurity, oxidative stress, inflammation, and apoptosis. Ankaferd Blood Stopper® (ABS) has antioxidant, antiinflammatory, antimicrobial, antiapoptotic, and wound healing accelerant properties. In this study, we aimed to investigate whether treatment with ABS reduced the severity of NEC in rat pups in an experimental NEC model...
November 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Marita de Waard, Yanqi Li, Yanna Zhu, Adejumoke I Ayede, Janet Berrington, Frank H Bloomfield, Olubunmi O Busari, Barbara E Cormack, Nicholas D Embleton, Johannes B van Goudoever, Gorm Greisen, Zhongqian He, Yan Huang, Xiaodong Li, Hung-Chih Lin, Jiaping Mei, Paula P Meier, Chuan Nie, Aloka L Patel, Christian Ritz, Per T Sangild, Thomas Skeath, Karen Simmer, Olukemi O Tongo, Signe S Uhlenfeldt, Sufen Ye, Xuqiang Ye, Chunyi Zhang, Ping Zhou
BACKGROUND: Transition to enteral feeding is difficult for very low-birth-weight (VLBW; ≤1500 g) infants, and optimal nutrition is important for clinical outcomes. METHOD: Data on feeding practices and short-term clinical outcomes (growth, necrotizing enterocolitis [NEC], mortality) in VLBW infants were collected from 13 neonatal intensive care units (NICUs) in 5 continents (n = 2947). Specifically, 5 NICUs in Guangdong province in China (GD), mainly using formula feeding and slow feeding advancement (n = 1366), were compared with the remaining NICUs (non-GD, n = 1581, Oceania, Europe, United States, Taiwan, Africa) using mainly human milk with faster advancement rates...
November 22, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
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