Marcia Ryder, Robert A Gunther, Reid A Nishikawa, Marc Stranz, Britt M Meyer, Taylor A Spangler, Albert E Parker, Charles Sylvia
PURPOSE: Infusate osmolarity, pH, and cytotoxicity were investigated as risk factors for midline catheter failure. METHODS: An experimental, randomized, controlled, blinded trial was conducted using an ovine model. Two 10-cm, 18-gauge single-lumen midline catheters were inserted into the cephalic veins of sheep. The animals were divided into 6 study arms and were administered solutions of vancomycin 4 mg/mL (a low-cytotoxicity infusate) or 10 mg/mL (a high-cytotoxicity infusate), doxycycline 1 mg/mL (an acidic infusate), or acyclovir 3...
July 24, 2020: American Journal of Health-system Pharmacy: AJHP