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epidermic necrolysis

Eran Ellenbogen, Shmuel Epshteyn, Shir Azrielant, Mor Pavlovski, Andrea Gat, Eli Sprecher, Ilan Goldberg
BACKGROUND: Frozen section (FS) is often performed when histopathological evaluations are urgently required for implementation of therapeutic measures. In dermatology, this method is most commonly used to evaluate excision margins of tumors. FS are also routinely employed to differentiate toxic epidermal necrolysis from staphylococcal scalded skin syndrome. However, little is currently known about the performance of FS in the diagnosis of inflammatory dermatoses. OBJECTIVES: To compare histopathological diagnoses in a series of patients with a clinical diagnosis of an inflammatory dermatosis for which FS and paraffin-section (PS) specimens were obtained on the same day...
February 2019: Israel Medical Association Journal: IMAJ
Yong Wang, Fangfang Wang, Hongbin Li, Xiaoyuan Hao, Guangping Shen, Yongli Sun, Jing Xia
No abstract text is available yet for this article.
February 1, 2019: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Ikhyun Jun, John Hoon Rim, Mee Kum Kim, Kyung-Chul Yoon, Choun-Ki Joo, Shigeru Kinoshita, Kyoung Yul Seo, Mayumi Ueta
BACKGROUND/AIMS: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are a spectrum of diseases that cause an acute vesiculobullous reaction in the skin and mucous membranes. The occurrence of these diseases is associated with various drugs, a large proportion of which is comprised cold medicines (CM). We try to investigate the association between human leucocyte antigen (HLA) class I genes and CM-related SJS/TEN (CM-SJS/TEN) with severe ocular complications (SOC) in the Korean population...
January 31, 2019: British Journal of Ophthalmology
Shan Zhang, Shunli Tang, Sheng Li, Yunlei Pan, Yingguo Ding
BACKGROUND: Stevens-Johnson syndrome and toxic epidermal necrolysis(SJS-TEN) is one of severe cutaneous adverse reactions with low morbidity but high mortality. Different systemic immunomodulating treatments are proposed but still remain controversial. Tumor necrosis factor(TNF)-alpha is long thought to be a vital mediator of epithelial cell death in SJS-TEN, indicating a potential target for therapy. OBJECTIVE: The aim of this systemic review is to evaluate the efficacy and safety of biologic TNF-alpha inhibitors in the treatment of SJS-TEN...
January 31, 2019: Journal of Dermatological Treatment
Jordan A Woolum, Abby M Bailey, Regan A Baum, Elise L Metts
Stevens-Johnson syndrome and toxic epidermal necrolysis represent a spectrum of severe cutaneous adverse reactions that carry the potential for severe, long-term adverse effects, including death. Although medications are most commonly implicated in the development of these diseases, other factors, including infection and genetics, play a role. Management is generally supportive in nature and includes maintenance of the patient's airway, breathing, and circulation. Special disease considerations include the use of skin barrier management, unique infection prevention measures, and systemic immunomodulatory therapies...
January 2019: Advanced Emergency Nursing Journal
Keiko Hosohata, Ayaka Inada, Saki Oyama, Iku Niinomi, Tomohito Wakabayashi, Kazunori Iwanaga
BACKGROUND AND OBJECTIVE: Adverse cutaneous drug reactions associated with antiepileptic drugs (AEDs) are a serious problem in the clinical setting. New-generation AEDs have been reported to be better tolerated than old-generation forms; however, information about the risks of adverse cutaneous drug reactions to new-generation AEDs is limited. OBJECTIVE: The purpose of this study was to clarify the association of AEDs with adverse cutaneous drug reactions using a spontaneous reporting database...
January 28, 2019: Clinical Drug Investigation
Jéssica González-Ramos, Cristina Lamas, Teresa Bellón, Elena Ruiz-Bravo, Elena Ramírez, Victoria Lerma, Beatriz Lecumberri
We report a case of a patient with Cushing's disease with oseltamivir-induced toxic epidermal necrolysis, who was treated with cyclosporine with favorable evolution. There is only one case reported of Cushing's disease and toxic epidermal necrolysis and very few oseltamivir-induced toxic epidermal necrolysis cases in literature. This report also discusses the role that the preexisting hypercortisolism condition may have played in the development and favorable resolution of the toxic epidermal necrolysis.
January 25, 2019: Indian Journal of Dermatology, Venereology and Leprology
Min Gyu Kang, Kyung Hee Sohn, Dong Yoon Kang, Han Ki Park, Min Suk Yang, Ju Yeun Lee, Hye Ryun Kang
PURPOSE: Despite morbidities and fatalities, nationwide epidemiologic data for severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS), are not widely available. We aimed to investigate SCAR epidemiology over the last two decades in Korea. MATERIALS AND METHODS: We analyzed individual case safety reports (ICSRs) of SCARs in the Korea Adverse Event Reporting System from 1988 to 2013...
February 2019: Yonsei Medical Journal
Yvonne Wang, Rohini Rao, Deborah S Jacobs, Hajirah N Saeed
PURPOSE: To report the outcomes of Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment in pediatric patients with chronic ocular surface disease associated with Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN). DESIGN: Retrospective, interventional case series METHODS: Patients ages 18 or younger seen in consultation for PROSE treatment at a single center between January 1992 and December 2016 with a history of SJS/TEN were reviewed...
January 18, 2019: American Journal of Ophthalmology
Hea Lin Oh, Dong Yoon Kang, Hye Ryun Kang, Sujeong Kim, Young Il Koh, Sae Hoon Kim, Min Hye Kim, Dong In Suh
PURPOSE: Although severe cutaneous adverse drug reactions (SCARs) are rare, they are associated with high morbidity and mortality, and thus early diagnosis and treatment are critical for improving prognoses. However, few studies have reported the characteristics of SCARs in children. Thus, we aimed to evaluate the clinical characteristics, current management and prognosis of pediatric SCARs. METHODS: We analyzed pediatric data in the Korean SCARs registry, which was built retrospectively in 2016 with SCAR cases treated in 34 tertiary referral university hospitals during 2010-2015...
March 2019: Allergy, Asthma & Immunology Research
Suh Young Lee, Young Hee Nam, Young Il Koh, Sae Hoon Kim, Sujeong Kim, Hye Ryun Kang, Min Hye Kim, Jun Gyu Lee, Jung Won Park, Hye Kyung Park, Hyen O La, Mi Yeong Kim, Seong Ju Park, Yong Eun Kwon, Jae Woo Jung, Sang Hyon Kim, Cheol Woo Kim, Min Seok Yang, Min Gyu Kang, Jin Yong Lee, Joo Hee Kim, Sang Heon Kim, Gyu Young Hur, Young Koo Jee, Hyun Jung Jin, Chan Sun Park, Yi Yeong Jeong, Young Min Ye
PURPOSE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are common cause of severe cutaneous adverse reactions (SCARs). The present study aimed to investigate the characteristics of SCARs induced by NSAIDs in the Korean SCAR registry. METHODS: A retrospective survey of NSAID-induced SCARs recorded between 2010 and 2015 at 27 university hospitals in Korea was conducted. Clinical phenotypes of SCARs were classified into Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), SJS-TEN overlap syndrome and drug reaction with eosinophilia and systemic symptoms (DRESS)...
March 2019: Allergy, Asthma & Immunology Research
Qin Xiang, Xu Gao, Jing Fang, Lianhong Pi, Xinke Chen, Lin Chen, Qing Liu
BACKGROUND: To identity the effect of lacrimal system irrigation in the acute stage in children with Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN). METHODS: A retrospective review of 39 patients with SJS or TEN from 2012 to 2017 was analyzed. Patients were divided into two subgroups according to whether they received irrigation in the acute stage. The irrigation group included 21 inpatients and the control group included 18 inpatients. The χ2 test was used to compare clinical findings and data in both groups...
January 18, 2019: BMC Ophthalmology
Iwona Popiołek, Katarzyna Piotrowicz-Wójcik, Grzegorz Porebski
Paracetamol is a popular and easily available drug which is used world-wide as analgesic, antipyretic agent. Hypersensitivity reactions to this drug involve a wide range of symptoms of various importance for patient management. The EudraVigilance (EV) database serves as a system for monitoring adverse events (AE) due to drug intake. We retrospectively recorded AE reports for "paracetamol" reported from 1 January 2007 to 1 October 2018 which fulfilled the category of "serious" in EV. For further analysis the retrieved AE reports were selected according to the keywords corresponding to hypersensitivity symptoms...
January 17, 2019: Pharmacy (Basel, Switzerland)
Sushilkumar Satish Gupta, Nitin Sabharwal, Ravikaran Patti, Yizhak Kupfer
Allopurinol is a first line agent in treating gout, but it also carries the risk of severe side effects. Stevens-Johnson syndrome (SJS) is one of the life threatening severe cutaneous adverse reactions caused by allopurinol. The severity of the severe cutaneous adverse reactions can be categorized based upon the area of skin involvement: (1) erythema multiforme major limited to 1-2 % of the body surface area (BSA); (2) SJS involving <10% of the BSA, (3) SJS and toxic epidermal necrolysis overlap involving 10-30% of the BSA and (4) toxic epidermal necrolysis syndrome involving >30% of the BSA...
December 4, 2018: American Journal of the Medical Sciences
Alain Khoi Tran, Shireen Sidhu
BACKGROUND: Stevens Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are rare diseases with devastating consequences on morbidity and mortality. There are currently no standardized guidelines for treatment of SJS/TEN in Australia. METHOD: Retrospective chart review of all SJS/TEN cases treated at the Royal Adelaide Hospital from 2000 to 2017. RESULT: A total of 42 patients were identified (SJS =18, TEN =24). The average age of presentation for SJS was 45...
January 11, 2019: Journal of Dermatological Treatment
Radhika Shah, Steven T Chen, Daniela Kroshinsky
No abstract text is available yet for this article.
January 7, 2019: Journal of the American Academy of Dermatology
Hao Xiong, Lanting Wang, Menglin Jiang, Shengan Chen, Fanping Yang, Huizhong Zhu, Qinyuan Zhu, Chenling Tang, Shengying Qin, Qinghe Xing, Xiaoqun Luo
Stevens-Johnson syndrome (SJS) /toxic epidermal necrolysis (TEN) are life-threatening severe cutaneous adverse drug reactions characterized by widespread epidermal necrosis. Recent studies have indicated that SJS/TEN is a specific immune reaction regulated by T cells. Certain drug serves as foreign antigens that are presented by major histocompatibility complex (MHC) and recognized by T cell receptors (TCRs), inducing adaptive immune responses. However, few studies have performed detailed characterization of TCR repertoire in SJS/TEN, and it remains unclear whether the particular types of TCRs expanded clonally are drug-specific, which would provide a potential underlying mechanism of SJS/TEN...
February 2019: Molecular Immunology
D F Carr, C-W Wang, T Bellón, L Ressel, G Nwikue, V Shrivastava, W Bergfeld, A L Jorgensen, W-H Chung, M Pirmohamed
High-mobility group box 1 (HMGB1) is a damage-associated molecular-pattern protein indicative of cell/tissue injury and innate immune response. Stevens-Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN) are serious, immune-mediated skin-blistering conditions characterised by widespread keratinocyte death and epidermal detachment. The purpose of the study was to determine: a) serum and/or blister-fluid total HMGB1 levels in independent SJS/TEN cohorts: and b) HMGB1 expression in formalin-fixed, paraffin-embedded SJS/TEN skin vs...
January 5, 2019: British Journal of Dermatology
Mayuri Kulkarni, Rovin Saxena, Benjamin Diaczok, Hazem Nassif
No abstract text is available yet for this article.
December 19, 2018: American Journal of Therapeutics
Daniella Kushnir-Grinbaum, Eran Cohen-Barak, Amir Bieber, Judit Krausz, Roni Dodiuk-Gad, Reuven Mader, Michael Ziv
No abstract text is available yet for this article.
January 2019: JAAD Case Reports
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