Q Leyrolle, F Decoeur, G Briere, C Amadieu, A R A A Quadros, I Voytyuk, C Lacabanne, A Benmamar-Badel, J Bourel, A Aubert, A Sere, F Chain, L Schwendimann, B Matrot, T Bourgeois, S Grégoire, J G Leblanc, A De Moreno De Leblanc, P Langella, G R Fernandes, L Bretillon, C Joffre, R Uricaru, P Thebault, P Gressens, J M Chatel, S Layé, A Nadjar
Maternal immune activation (MIA) and poor maternal nutritional habits are risk factors for the occurrence of neurodevelopmental disorders (NDD). Human studies show the deleterious impact of prenatal inflammation and low n-3 polyunsaturated fatty acid (PUFA) intake on neurodevelopment with long-lasting consequences on behavior. However, the mechanisms linking maternal nutritional status to MIA are still unclear, despite their relevance to the etiology of NDD. We demonstrate here that low maternal n-3 PUFA intake worsens MIA-induced early gut dysfunction, including modification of gut microbiota composition and higher local inflammatory reactivity...
February 2021: Neuropsychopharmacology