keyword
https://read.qxmd.com/read/38543029/detection-of-adulterated-naodesheng-tablet-naodesheng-pian-via-in-depth-chemical-analysis-and-subsequent-reconstruction-of-its-pharmacopoeia-q-markers
#21
JOURNAL ARTICLE
Chunhou Li, Xican Li, Jingyuan Zeng, Rongxin Cai, Shaoman Chen, Ban Chen, Xiaojun Zhao
Naodesheng Tablet ( Naodesheng Pian ), a traditional Chinese medicine formula for stroke treatment, is made up of five herbal medicines, i.e., Sanqi , Gegen , Honghua , Shanzha , and Chuanxiong. However, the current Pharmacopoeia quality-marker (Q-marker) system cannot detect possible adulteration. Our study tried to use a new strategy, i.e., standards-library-dependent ultra-high-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry (UHPLC-Q-Orbitrap MS/MS) putative identification, to reconstruct the Q-marker system...
March 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38543016/phytochemical-profiling-by-uhplc-q-tof-ms-and-chemopreventive-effect-of-aqueous-extract-of-moringa-oleifera-leaves-and-benzyl-isothiocyanate-on-murine-mammary-carcinogenesis
#22
JOURNAL ARTICLE
Juan Pedro Rojas-Armas, Miriam Palomino-Pacheco, Jorge Luis Arroyo-Acevedo, José Manuel Ortiz-Sánchez, Hugo Jesús Justil-Guerrero, Jaime Teodocio Martínez-Heredia, Américo Castro-Luna, Crescencio Rodríguez Flores, Aldo Javier Guzmán Duxtan
Moringa oleifera Lam, commonly known as moringa, is a plant widely used both as a human food and for medicinal purposes around the world. This research aimed to evaluate the efficacy of the aqueous extract of Moringa oleifera leaves (MoAE) and benzyl isothiocyanate (BIT) in rats with induced breast cancer. Cancer was induced with 7,12-dimethylbenz[a]anthracene (DMBA) at a dose of 60 mg/kg by orogastric gavage once only. Forty-eight rats were randomly assigned to eight groups, each consisting of six individuals...
March 20, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542997/chemical-composition-of-essential-oils-from-natural-populations-of-artemisia-scoparia-collected-at-different-altitudes-antibacterial-mosquito-repellent-and-larvicidal-effects
#23
JOURNAL ARTICLE
Amna Parveen, Muhammad Ghazanfar Abbas, Ken Keefover-Ring, Muhammad Binyameen, Raimondas Mozūraitis, Muhammad Azeem
The current study aimed to evaluate the presence of chemical variations in essential oils (EOs) extracted from Artemisia scoparia growing at different altitudes and to reveal their antibacterial, mosquito larvicidal, and repellent activity. The gas chromatographic-mass spectrometric analysis of A. scoparia EOs revealed that the major compounds were capillene (9.6-31.8%), methyleugenol (0.2-26.6%), β-myrcene (1.9-21.4%), γ-terpinene (1.5-19.4%), trans -β-caryophyllene (0.8-12.4%), and eugenol (0...
March 19, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542989/in-vitro-and-ex-vivo-antifungal-activities-of-metconazole-against-the-rice-blast-fungus-pyricularia-oryzae
#24
JOURNAL ARTICLE
Liwang Fei, Lingyun Hao
Rice blast, caused by the filamentous fungus Pyricularia oryzae , has long been one of the major threats to almost all rice-growing areas worldwide. Metconazole, 5-(4-chlorobenzyl)-2, 2-dimethyl-1-(1H-1, 2, 4-triazol-1-ylmethyl) cyclopentanol, is a lipophilic, highly active triazole fungicide that has been applied in the control of various fungal pathogens of crops (cereals, barley, wheat), such as the Fusarium and Alternaria species. However, the antifungal activity of metconazole against P. oryzae is unknown...
March 19, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542979/controllable-la-deficiency-engineering-within-perovskite-oxides-for-enhanced-overall-water-splitting
#25
JOURNAL ARTICLE
Xiaohu Xu, Kaiwei Guo, Xinyue Yu
Recently, perovskite (ABO3 ) nanomaterials have been widely explored as a class of versatile electrocatalysts for oxygen evolution reactions (OER) due to their remarkable compositional flexibility and structural tunability, but their poor electrical conductivity hinders hydrogen evolution reaction (HER) activity and further limits the large-scale application of perovskite oxide in overall water splitting (OWS). In this study, hollow-nanotube-structure Lax Co0.4 Fe0.6 O3-δ (x = 1.0, 0.9, and 0.8) perovskites with superior HER/OER activity were synthesized on nickel-iron alloy foam (denoted Lax CoFe/NFF) using hydrothermal with a subsequent calcination strategy...
March 18, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542972/mass-spectrometry-based-research-of-cosmetic-ingredients
#26
REVIEW
Alina Florina Serb, Marius Georgescu, Robert Onulov, Cristina Ramona Novaconi, Eugen Sisu, Alexandru Bolocan, Raluca Elena Sandu
Cosmetic products are chemical substances or mixtures used on the skin, hair, nails, teeth, and the mucous membranes of the oral cavity, whose use is intended to clean, protect, correct body odor, perfume, keep in good condition, or change appearance. The analysis of cosmetic ingredients is often challenging because of their huge complexity and their adulteration. Among various analytical tools, mass spectrometry (MS) has been largely used for compound detection, ingredient screening, quality control, detection of product authenticity, and health risk evaluation...
March 17, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542970/purification-and-biochemical-characterization-of-polyphenol-oxidase-extracted-from-wheat-bran-wan-grano
#27
JOURNAL ARTICLE
Kun Yu, Wei He, Xiaoli Ma, Qi Zhang, Chunxu Chen, Peiyan Li, Di Wu
Currently, little is known about the characteristics of polyphenol oxidase from wheat bran, which is closely linked to the browning of wheat product. The wheat PPO was purified by ammonium sulfate precipitation, DEAE-Sepharose ion-exchange column, and Superdex G-75 chromatography column. Purified wheat PPO activity was 11.05-fold higher, its specific activity was 1365.12 U/mg, and its yield was 8.46%. SDS-PAGE showed that the molecular weight of wheat PPO was approximately 21 kDa. Its optimal pH and temperature were 6...
March 17, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542960/selective-generation-of-aldimine-and-ketimine-tautomers-of-the-schiff-base-condensates-of-amino-acids-with-imidazole-aldehydes-or-of-imidazole-methanamines-with-pyruvates-isomeric-control-with-2-vs-4-substituted-imidazoles
#28
JOURNAL ARTICLE
Greg Brewer, Cynthia Brewer, Raymond J Butcher, Peter Zavalij
The Schiff base condensation of 5-methyl-4-imidazole carboxaldehyde, 5Me4ImCHO, and the anion of an amino acid, H2 N-CH(R)CO2 - (R = -CH3 , -CH(CH3 )2 and -CH2 CH(CH3 )2 ), gives the aldimine tautomer, Im-CH=N-CH(R)CO2 - , while that of 5-methylimidazole-4-methanamine, 5MeIm-4-CH2 NH2 , with a 2-oxocarboxylate anion, R-C(O)-CO2 - , gives the isomeric ketimine tautomer, Im-CH2 -N=C(R)CO2 - . All are isolated as the neutral nickel(II) complexes, NiL2 , and are characterized by single crystal structure determination, IR, and positive ion ESI MS...
March 16, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542929/oral-delivery-of-astaxanthin-via-carboxymethyl-chitosan-modified-nanoparticles-for-ulcerative-colitis-treatment
#29
JOURNAL ARTICLE
Wen Zhang, Xinping Zhang, Xinyi Lv, Ao Qu, Wenjing Liang, Limin Wang, Pei Zhao, Zijian Wu
The oral delivery strategy of natural anti-oxidant and anti-inflammatory agents has attracted great attention to improve the effectiveness of ulcerative colitis (UC) treatment. Herein, we developed a novel orally deliverable nanoparticle, carboxymethyl chitosan (CMC)-modified astaxanthin (AXT)-loaded nanoparticles (CMC-AXT-NPs), for UC treatment. The CMC-AXT-NPs were evaluated by appearance, morphology, particle size, ζ-potential, and encapsulation efficiency (EE). The results showed that CMC-AXT-NPs were nearly spherical in shape with a particle size of 34...
March 14, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542919/physical-grinding-of-prefabricated-co-3-o-4-and-mcm-22-zeolite-for-fischer-tropsch-synthesis-impact-of-pretreatment-procedure-on-the-dispersion-and-catalytic-performance
#30
JOURNAL ARTICLE
Hua-Ping Ren, Zhi-Xia Xie, Shao-Peng Tian, Si-Yi Ding, Qiang Ma, Yu-Zhen Zhao, Zhe Zhang, Jiao-Jiao Fu, Qing-Qing Hao
To improve the mess-specific activity of Co supported on zeolite catalysts in Fischer-Tropsch (FT) synthesis, the Co-MCM-22 catalyst was prepared by simply grinding the MCM-22 with nanosized Co3 O4 prefabricated by the thermal decomposition of the Co(II)-glycine complex. It is found that this novel strategy is effective for improving the mess-specific activity of Co catalysts in FT synthesis compared to the impregnation method. Moreover, the ion exchange and calcination sequence of MCM-22 has a significant influence on the dispersion, particle size distribution, and reduction degree of Co...
March 14, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542918/design-and-synthesis-of-novel-squaraine-based-fluorescent-probe-for-far-red-detection-of-chymotrypsin-enzyme
#31
JOURNAL ARTICLE
Shekhar Gupta, Priyanka, Sai Kiran Mavileti, Shyam S Pandey, Tamaki Kato
Chymotrypsin, a crucial enzyme in human digestion, catalyzes the breakdown of milk proteins, underscoring its significance in both health diagnostics and dairy quality assurance. Addressing the critical need for rapid, cost-effective detection methods, we introduce a groundbreaking approach utilizing far-red technology and HOMO-Förster resonance energy transfer (FRET). Our novel probe, SQ-122 PC, features a unique molecular design that includes a squaraine dye (SQ), a peptide linker, and SQ moieties synthesized through solid-phase peptide synthesis...
March 14, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542910/photocatalytic-zinc-oxide-nanoparticles-in-antibacterial-ultrafiltration-membranes-for-biofouling-control
#32
JOURNAL ARTICLE
Ralfs Vevers, Akshay Kulkarni, Alissa Seifert, Kathrin Pöschel, Kornelia Schlenstedt, Jochen Meier-Haack, Linda Mezule
Global water scarcity is a threat that can be alleviated through membrane filtration technologies. However, the widespread adoption of membranes faces significant challenges, primarily due to membrane biofouling. This is the reason why membrane modifications have been under increasing investigation to address the fouling issues. Antibacterial membranes, designed to combat biofouling by eliminating microorganisms, offer a promising solution. Within this study, flat sheet ultrafiltration (UF) membranes with integrated photocatalytic zinc oxide (ZnO) nanoparticles were developed, characterized, and assessed through filtration and fouling tests...
March 13, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542893/silver-nanoparticle-embedded-hydrogels-for-electrochemical-sensing-of-sulfamethoxazole-residues-in-meat
#33
JOURNAL ARTICLE
Yuanxi Deng, Ningning Yang
A disposable electrochemical sensor based on silver nanoparticle-embedded cellulose hydrogel composites was developed for sensitive detection of sulfamethoxazole residues in meat samples. Scanning electron microscopy confirmed the porous structure of the cellulose matrix anchored with 20-50 nm silver nanoparticles (AgNPs). Fourier transform infrared spectroscopy and X-ray diffraction verified that the metallic AgNPs coordinated with the amorphous cellulose chains. At an optimum 0.5% loading, the nanocomposite sensor showed a peak-to-peak separation of 150 mV, diffusion-controlled charge transfer kinetics, and an electron transfer coefficient of 0...
March 12, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542888/efficient-recovery-of-phosphate-from-water-media-by-iron-magnesium-functionalized-lignite-adsorption-evaluation-mechanism-revelation-and-potential-application-exploration
#34
JOURNAL ARTICLE
Wenbo An, Qiqi Wang, He Chen, Yifan Liu, Xuechun Hu, Junzhen Di
Selective phosphorus removal from aquatic media has become an ideal strategy to mitigate eutrophication and meet increasingly stringent discharge requirements. To achieve phosphorus control and resource utilization of low-calorific-value lignite, iron and magnesium salts were used to functionalize lignite, and iron-magnesium functionalized lignite (called IM@BC) was prepared for phosphate recovery from water media. The adsorption properties of IM@BC were systematically evaluated, especially the influence of ambient pH and co-existing ions...
March 12, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542873/the-validation-and-determination-of-empagliflozin-concentration-in-the-presence-of-grapefruit-juice-using-hplc-for-pharmacokinetic-applications
#35
JOURNAL ARTICLE
Wael Abu Dayyih, Zainab Zakaraya, Mohammad Hailat, Nafe M Al-Tawarah, Sahem Alkharabsheh, Haya Khalid Nadher, Zeyad Hailat, Samia M Alarman, Anas Khaleel, Riad Awad
Type 2 diabetes mellitus is a multifactorial disorder whose primary manifestation usually initiates with elevated blood sugar levels. Several antidiabetic agents are used to manage type 2 diabetes mellitus, of which empagliflozin is an oral sodium-glucose co-transporter (SGLT-2) inhibitor in the kidney. This research aims to develop and validate a simple analytical method for determining empagliflozin levels in biological fluid and to further evaluate grapefruit juice's impact on empagliflozin pharmacokinetics in rats...
March 11, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542867/comparative-pharmacokinetics-research-of-13-bioactive-components-of-jieyu-pills-in-control-and-attention-deficit-hyperactivity-disorder-model-rats-based-on-uplc-orbitrap-fusion-ms
#36
JOURNAL ARTICLE
Xuefang Liu, Yan Wan, Shuding Sun, Ting Wang, Ting Li, Qi Sun, Weiwei Zhang, Di Zhao, Yange Tian, Suxiang Feng
Jieyu Pills (JYPs), a Chinese medicine consisting of 10 herbal elements, have displayed promising clinical effectiveness and low by-effects in the treatment of depression. Prior investigations mostly focused on elucidating the mechanism and therapeutic efficacy of JYPs. In our earlier study, we provided an analysis of the chemical composition, serum pharmacochemistry, and concentrations of the main bioactive chemicals found in JYPs. However, our precise understanding of the pharmacokinetics and metabolism remained vague...
March 10, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542855/research-progress-on-benzimidazole-fungicides-a-review
#37
REVIEW
Song Bai, Miaohe Zhang, Shouying Tang, Miao Li, Rong Wu, Suran Wan, Lijun Chen, Xian Wei, Feifei Li
Benzimidazole fungicides are a class of highly effective, low-toxicity, systemic broad-spectrum fungicides developed in the 1960s and 1970s, based on the fungicidal activity of the benzimidazole ring structure. They exhibit biological activities including anticancer, antibacterial, and antiparasitic effects. Due to their particularly outstanding antibacterial properties, they are widely used in agriculture to prevent and control various plant diseases caused by fungi. The main products of benzimidazole fungicides include benomyl, carbendazim, thiabendazole, albendazole, thiophanate, thiophanate-methyl, fuberidazole, methyl (1-{[(5-cyanopentyl)amino]carbonyl}-1 H -benzimidazol-2-yl) carbamate, and carbendazim salicylate...
March 8, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542851/nitroxide-mediated-controlled-radical-copolymerization-of-%C3%AE-trifluoromethylstyrenes-with-styrenes
#38
JOURNAL ARTICLE
Tadashi Kanbara, Yuriko Ito, Airi Yamaguchi, Tomoko Yajima
Fluorinated polymers are important materials in everyday life; however, most monomers of widely used fluoropolymers are gaseous, and their polymerization is difficult in an ordinary laboratory. Therefore, partially fluorinated polymers have recently been reported. As an easy-to-handle fluorine-containing monomer, α-trifluoromethylstyrene (TFMST) can be used to produce partially fluorinated polymers with trifluoromethyl groups in the main chain; however, TFMST does not homopolymerize, and there are limited reports on its copolymerization with styrene (ST)...
March 8, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542825/release-pattern-of-light-aromatic-hydrocarbons-during-the-biomass-roasting-process
#39
REVIEW
Yaying Zhao, Yuqing Yan, Yuhang Jiang, Yang Cao, Zhuozhi Wang, Jiapeng Li, Chenshuai Yan, Danya Wang, Lu Yuan, Guangbo Zhao
Roasting is an important step in the pretreatment of biomass upgrading. Roasting can improve the fuel quality of biomass, reduce the O/C and H/C ratios in the biomass, and provide the biomass with a fuel quality comparable to that of lignite. Therefore, studying the structure and component evolution laws during biomass roasting treatment is important for the rational and efficient utilization of biomass. When the roasting temperature is 200-300 °C, the cellulose and hemicellulose in the biomass undergo a depolymerization reaction, releasing many monocyclic aromatic hydrocarbons with high reactivity...
March 7, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542496/agroindustrial-by-products-as-a-source-of-biostimulants-enhancing-responses-to-abiotic-stress-of-horticultural-crops
#40
REVIEW
Javier Zuzunaga-Rosas, Monica Boscaiu, Oscar Vicente
Together with other abiotic stresses such as drought and high temperatures, salt stress is one of the most deleterious environmental factors affecting plant development and productivity, causing significant crop yield reductions. The progressive secondary salinisation of irrigated farmland is a problem as old as agriculture but is aggravated and accelerated in the current climate change scenario. Plant biostimulants, developed commercially during the last decade, are now recognised as innovative, sustainable agronomic tools for improving crop growth, yield, plant health and tolerance to abiotic stress factors such as water and soil salinity...
March 20, 2024: International Journal of Molecular Sciences
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