Sandesh Kumar Patel, Nadezda Zhdanovskaya, Ilaria Sergio, Antonella Cardinale, Marco Rosichini, Claudia Varricchio, Eleonora Pace, Carlo Capalbo, Franco Locatelli, Alberto Macone, Enrico Velardi, Rocco Palermo, Maria Pia Felli
T-cell acute lymphoblastic leukemia (T-ALL) is a hematological cancer characterized by the infiltration of immature T-cells in the bone marrow. Aberrant NOTCH signaling in T-ALL is mainly triggered by activating mutations of NOTCH1 and overexpression of NOTCH3, and rarely is it linked to NOTCH3-activating mutations. Besides the known critical role of NOTCH, the nature of intrathymic microenvironment-dependent mechanisms able to render immature thymocytes, presumably pre-leukemic cells, capable of escaping thymus retention and infiltrating the bone marrow is still unclear...
January 24, 2024: International Journal of Molecular Sciences