keyword
https://read.qxmd.com/read/35141860/the-curing-coma-campaign-international-survey-on-coma-epidemiology-evaluation-and-therapy-come-together
#21
JOURNAL ARTICLE
Raimund Helbok, Verena Rass, Ettore Beghi, Yelena G Bodien, Giuseppe Citerio, Joseph T Giacino, Daniel Kondziella, Stephan A Mayer, David Menon, Tarek Sharshar, Robert D Stevens, Hanno Ulmer, Chethan P Venkatasubba Rao, Paul Vespa, Molly McNett, Jennifer Frontera
BACKGROUND: Although coma is commonly encountered in critical care, worldwide variability exists in diagnosis and management practices. We aimed to assess variability in coma definitions, etiologies, treatment strategies, and attitudes toward prognosis. METHODS: As part of the Neurocritical Care Society Curing Coma Campaign, between September 2020 and January 2021, we conducted an anonymous, international, cross-sectional global survey of health care professionals caring for patients with coma and disorders of consciousness in the acute, subacute, or chronic setting...
August 2022: Neurocritical Care
https://read.qxmd.com/read/35086939/amantadine-treatment-is-associated-with-improved-consciousness-in-patients-with-non-traumatic-brain-injury
#22
JOURNAL ARTICLE
Lena Rühl, Joji B Kuramatsu, Jochen A Sembill, Bernd Kallmünzer, Dominik Madzar, Stefan T Gerner, Antje Giede-Jeppe, Stefanie Balk, Tamara Mueller, Jakob Jäger, Stefan Schwab, Hagen B Huttner, Maximilian I Sprügel
OBJECTIVE: This study determined the effect of amantadine treatment on consciousness in patients with non-traumatic brain injury. METHODS: We pooled individual patient data of five single-centre observational studies to determine the effect of amantadine treatment among patients with ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, community-acquired bacterial meningitis and status epilepticus, admitted between January 2012 and December 2015 and ventilated ≥7 days...
June 2022: Journal of Neurology, Neurosurgery, and Psychiatry
https://read.qxmd.com/read/35029862/comparison-of-amantadine-modafinil-and-standard-of-care-in-the-acute-treatment-of-disorders-of-consciousness-after-severe-traumatic-brain-injury
#23
JOURNAL ARTICLE
Trager D Hintze, Clay E Small, Josephine Montgomery, Kelly R Reveles, Shaheryar Hafeez, Colleen A Barthol
OBJECTIVE: Traumatic brain injury (TBI) is a major cause of death and disability worldwide. Many patients who experience severe TBI have persistent disorders of consciousness. Amantadine and modafinil are used for some neurological disorders; however, a comparison of the 2 medications in TBI has not been reported. This study compared the effectiveness of amantadine, modafinil, and standard of care (SOC) on disorders of consciousness after TBI. METHODS: All adult TBI patients admitted between January 1, 2017, and September 31, 2020 who received amantadine, modafinil, or SOC treatments were screened...
January 2022: Clinical Neuropharmacology
https://read.qxmd.com/read/34711177/early-amantadine-treatment-reduces-the-risk-of-death-in-patients-with-large-hemisphere-infarctions-a-chinese-hospital-based-study
#24
JOURNAL ARTICLE
Jie Li, Ping Zhang, Yingying Liu, Simiao Wu, Xingyang Yi, Shihong Zhang, Chun Wang, Ming Liu
BACKGROUND: Amantadine hydrochloride is one of the most frequently prescribed drugs for patients with severe traumatic brain injury in restoring consciousness and accelerating the pace of functional recovery. However, there is a paucity of studies on the effectiveness of amantadine in patients with severe stroke especially large hemisphere infarction (LHI). The present study aimed to investigate whether amantadine treatment is associated with better clinical outcomes in conservatively treated LHI patients...
October 28, 2021: BMC Neurology
https://read.qxmd.com/read/34686097/does-amantadine-maintain-function-in-long-established-brain-injury-a-single-case-experimental-design
#25
JOURNAL ARTICLE
A FitzGerald, L Main, U Duff, J Foggo, F Rowney, N Haire, R McLean
OBJECTIVE: The role of dopamine agonist (DA) in restoring consciousness and cognition in recovery phase following acquired brain injury (ABI) is established (1-5) . The role in later recovery is less well defined. We report a single case experimental design (SCED) trial of amantadine demonstrating improvement in function, six years following ABI. METHOD: A scoring system based on established abilities in personal care and interaction was used to identify tasks with component actions, 34 actions in total, each ranked in terms of quality of response to a request or prompt...
September 19, 2021: Brain Injury
https://read.qxmd.com/read/34464892/dual-neurostimulant-therapy-may-optimize-acute-neurorecovery-for-severe-traumatic-brain-injuries
#26
JOURNAL ARTICLE
Brett M Tracy, Michael E Silverman, Carlos Cordero-Caballero, Emily A Durr, Rondi B Gelbard
BACKGROUND: Neurostimulants (NS) can be used to treat patients with a traumatic brain injury (TBI) with altered levels of consciousness. We sought to determine if amantadine alone (monotherapy) versus amantadine + methylphenidate (dual therapy) would correlate with better neurorecovery (NR) among acutely hospitalized patients with a severe TBI. METHODS: We performed a retrospective review of adult patients admitted to our level I trauma center from 2016-2019 with a severe TBI...
December 2021: Journal of Surgical Research
https://read.qxmd.com/read/34320554/prescribing-patterns-of-amantadine-during-pediatric-inpatient-rehabilitation-after-traumatic-brain-injury-a-multicentered-retrospective-review-from-the-pediatric-brain-injury-consortium
#27
JOURNAL ARTICLE
Matthew J McLaughlin, Eric Caliendo, Ryan Lowder, William D Watson, Brad Kurowski, Katherine T Baum, Laura S Blackwell, Christine H Koterba, Kristen R Hoskinson, Sarah J Tlustos, Kanecia O Zimmerman, Sudhin A Shah, Stacy J Suskauer
OBJECTIVES: To describe dosing practices for amantadine hydrochloride and related adverse effects among children and young adults with traumatic brain injury (TBI) admitted to pediatric inpatient rehabilitation units. SETTING: Eight pediatric acute inpatient rehabilitation units located throughout the United States comprising the Pediatric Brain Injury Consortium. PARTICIPANTS: Two-hundred thirty-four children and young adults aged 2 months to 21 years with TBI...
July 2022: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/34236624/therapies-to-restore-consciousness-in-patients-with-severe-brain-injuries-a-gap-analysis-and-future-directions
#28
JOURNAL ARTICLE
Brian L Edlow, Leandro R D Sanz, Len Polizzotto, Nader Pouratian, John D Rolston, Samuel B Snider, Aurore Thibaut, Robert D Stevens, Olivia Gosseries
BACKGROUND/OBJECTIVE: For patients with disorders of consciousness (DoC) and their families, the search for new therapies has been a source of hope and frustration. Almost all clinical trials in patients with DoC have been limited by small sample sizes, lack of placebo groups, and use of heterogeneous outcome measures. As a result, few therapies have strong evidence to support their use; amantadine is the only therapy recommended by current clinical guidelines, specifically for patients with DoC caused by severe traumatic brain injury...
July 2021: Neurocritical Care
https://read.qxmd.com/read/34106671/successful-diagnosis-and-treatment-of-pulmonary-aspergillosis-related-malignant-catatonia-using-propofol-and-quetiapine-a-case-report
#29
JOURNAL ARTICLE
Kazuhito Nomura, Sonoko Sakawaki, Eiji Sakawaki, Ayumu Yamaoka, Wakiko Aisaka, Hiroyuki Okamoto, Yoshihiro Takeyama, Shuji Uemura, Eichi Narimatsu
INTRODUCTION: Malignant catatonia (MC) is a movement disorder syndrome characterized by immobility, rigidity, and consciousness disorders that develops in association with mental and physical diseases. It is often fatal due to hyperthermia, rhabdomyolysis, and acute kidney injury. Its clinical symptoms are similar to those of another disorder, neuroleptic malignant syndrome (NMS), and it is often difficult to distinguish between the 2 disorders. PATIENT CONCERNS: An Asian woman in her 60s with history of schizophrenia...
May 14, 2021: Medicine (Baltimore)
https://read.qxmd.com/read/33165155/safety-considerations-for-the-use-of-transcranial-magnetic-stimulation-as-treatment-for-coma-recovery-in-people-with-severe-traumatic-brain-injury
#30
JOURNAL ARTICLE
Sandra L Kletzel, Alexandra L Aaronson, Ann Guernon, Christina Carbone, Noor Chaudhry, Elyse Walsh, Mark Conneely, Vijaya Patil, Elliott Roth, Monica Steiner, Marilyn Pacheco, Joshua Rosenow, Theresa L Bender Pape
OBJECTIVE: For persons in states of disordered consciousness (DoC) after severe traumatic brain injury (sTBI), we report cumulative findings from safety examinations, including serious adverse events (AEs) of a repetitive transcranial magnetic stimulation (rTMS) parameter protocol in 2 different studies. PARTICIPANTS: Seven persons in states of DoC after sTBI with widespread neuropathology, but no large lesions in proximity to the site of rTMS. One participant had a ventriculoperitoneal shunt with programmable valve...
November 2020: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/33165151/a-pilot-trial-examining-the-merits-of-combining-amantadine-and-repetitive-transcranial-magnetic-stimulation-as-an-intervention-for-persons-with-disordered-consciousness-after-tbi
#31
JOURNAL ARTICLE
Theresa L Bender Pape, Amy A Herrold, Sherri L Livengood, Ann Guernon, Jennifer A Weaver, James P Higgins, Joshua M Rosenow, Elyse Walsh, Runa Bhaumik, Marilyn Pacheco, Vijaya K Patil, Sandra Kletzel, Mark Conneely, Dulal K Bhaumik, Trudy Mallinson, Todd Parrish
OBJECTIVE: Report pilot findings of neurobehavioral gains and network changes observed in persons with disordered consciousness (DoC) who received repetitive transcranial magnetic stimulation (rTMS) or amantadine (AMA), and then rTMS+AMA. PARTICIPANTS: Four persons with DoC 1 to 15 years after traumatic brain injury (TBI). DESIGN: Alternate treatment-order, within-subject, baseline-controlled trial. MAIN MEASURES: For group and individual neurobehavioral analyses, predetermined thresholds, based on mixed linear-effects models and conditional minimally detectable change, were used to define meaningful neurobehavioral change for the Disorders of Consciousness Scale-25 (DOCS) total and Auditory-Language measures...
November 2020: Journal of Head Trauma Rehabilitation
https://read.qxmd.com/read/32893777/-from-vegetative-state-to-participation-amantadine-as-a-trigger-of-the-rehabilitation-program
#32
JOURNAL ARTICLE
Ana Zão, Ana Filipe Almeida, Gustavo Beça, Renato Nunes
The use of amantadine in clinical practice still seems limited, despite its increasing evidence in the emergence of vegetative state after traumatic brain injury. We describe the case of an adolescent with severe traumatic brain injury after being run over by a car. After four months of hospitalization in a Central Hospital where he remained in a vegetative state, he was transferred to a Rehabilitation Center. He underwent a comprehensive rehabilitation program with physiotherapy, occupational therapy and speech therapy, including multisensory stimulation and intervention in the surrounding environment...
September 1, 2020: Acta Médica Portuguesa
https://read.qxmd.com/read/32872083/persistent-vegetative-state-after-severe-cerebral-hemorrhage-treated-with-amantadine-a-retrospective-controlled-study
#33
JOURNAL ARTICLE
Yu Gao, Yi Zhang, Zhuo Li, Linlin Ma, Jing Yang
Amantadine is currently recommended for use in patients of posttraumatic brain injury with unconsciousness. However, the application of amantadine in consciousness disturbance after cerebral hemorrhage has only been rarely reported. This allows for a further exploration of the role of amantadine in the treatment of PVS resulting from severe cerebral hemorrhage.Retrospective cohort study from 1/2015 to 7/2019 in Beijing Chaoyang hospital. We included adult patients treated with amantadine after severe cerebral hemorrhage in PVS...
August 14, 2020: Medicine (Baltimore)
https://read.qxmd.com/read/32552090/the-use-of-amantadine-in-patients-with-unresponsive-wakefulness-syndrome-after-severe-cerebral-hemorrhage
#34
JOURNAL ARTICLE
Yu Gao, Linlin Ma, Fang Liang, Yi Zhang, Lin Yang, Xuehua Liu, Jing Yang
BACKGROUND: Amantadine is currently recommended for use in patients of post-traumatic brain injury with unresponsive wakefulness syndrome (UWS). However, the application of amantadine in UWS after cerebral hemorrhage has only been rarely reported. This allows for a further exploration of the role of amantadine in the treatment of UWS resulting from a severe cerebral hemorrhage. METHODS: We observed the changes of seven patients with UWS of intracerebral hemorrhage after taking amantadine...
July 2, 2020: Brain Injury
https://read.qxmd.com/read/32057086/additive-effect-of-cerebrolysin-and-amantadine-on-disorders-of-consciousness-secondary-to-acquired-brain-injury-a-retrospective-case-control-study
#35
JOURNAL ARTICLE
Seunghwan Lee, Hyun Haeng Lee, Yejin Lee, Jongmin Lee
BACKGROUND: Acquired brain injury can cause disorders of consciousness. An additive effect of cerebrolysin and amantadine has been postulated, but not systematically studied. The present study aimed to investigate this additive effect in patients with disorders of consciousness secondary to acquired brain injury. METHODS: The medical records of patients diagnosed with disorders of consciousness after acquired brain injury were reviewed. The patients were categorized into 2 groups: single regimen (amantadine only) and dual regimen (amantadine plus cerebrolysin)...
February 27, 2020: Journal of Rehabilitation Medicine
https://read.qxmd.com/read/31505542/presynaptic-dopamine-deficit-in-minimally-conscious-state-patients-following-traumatic-brain-injury
#36
JOURNAL ARTICLE
Esteban A Fridman, Joseph R Osborne, Paul D Mozley, Jonathan D Victor, Nicholas D Schiff
Dopaminergic stimulation has been proposed as a treatment strategy for post-traumatic brain injured patients in minimally conscious state based on a clinical trial using amantadine, a weak dopamine transporter blocker. However, a specific contribution of dopaminergic neuromodulation in minimally conscious state is undemonstrated. In a phase 0 clinical trial, we evaluated 13 normal volunteers and seven post-traumatic minimally conscious state patients using 11C-raclopride PET to estimate dopamine 2-like receptors occupancy in the striatum and central thalamus before and after dopamine transporter blockade with dextroamphetamine...
July 1, 2019: Brain
https://read.qxmd.com/read/31061347/-hypothermic-action-of-oseltamivir-not-dependent-on-its-anti-influenza-virus-action
#37
JOURNAL ARTICLE
Hideki Ono
Although the anti-influenza virus drug oseltamivir ameliorates the fever of influenza, adverse events related to its hypothermic effect have been reported. We found that oseltamivir causes dose-dependent hypothermia in normal mice, and have been studying the pharmacological mechanisms responsible for 12 years. Oseltamivir blocks nicotinic cholinergic transmission at sympathetic ganglia and reduces sympathetic modulation of brown adipose tissue (BAT), a heat generator. Oseltamivir was found to target the ion channels of nicotinic acetylcholine receptors, as demonstrated by patch clamp experiments with cells expressing the human α3β4 nicotinic receptor...
2019: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://read.qxmd.com/read/31003899/therapeutic-interventions-in-patients-with-prolonged-disorders-of-consciousness
#38
REVIEW
Aurore Thibaut, Nicholas Schiff, Joseph Giacino, Steven Laureys, Olivia Gosseries
The management of patients with severe brain injuries and prolonged disorders of consciousness raises important issues particularly with respect to their therapeutic options. The scarcity of treatment options is challenged by new clinical and neuroimaging data indicating that some patients with prolonged disorders of consciousness might benefit from therapeutic interventions, even years after the injury. Most studies of interventions aimed at improving patients' level of consciousness and functional recovery were behavioural and brain imaging open-label trials and case reports, but several randomised controlled trials have been done, particularly focused on the effects of drugs or use of non-invasive brain stimulation...
June 2019: Lancet Neurology
https://read.qxmd.com/read/30966863/stimulant-therapy-in-acute-traumatic-brain-injury-prescribing-patterns-and-adverse-event-rates-at-2-level-1-trauma-centers
#39
JOURNAL ARTICLE
Megan E Barra, Saef Izzy, Aliyah Sarro-Schwartz, Ronald E Hirschberg, Nicole Mazwi, Brian L Edlow
BACKGROUND/OBJECTIVE: Pharmacological stimulant therapies are routinely administered to promote recovery in patients with subacute and chronic disorders of consciousness (DoC). However, utilization rates and adverse drug event (ADE) rates of stimulant therapies in patients with acute DoC are unknown. We aimed to determine the frequency of stimulant use and associated ADEs in intensive care unit (ICU) patients with acute DoC caused by traumatic brain injury (TBI). METHODS: We retrospectively identified patients with TBI admitted to the ICU at 2 level 1 trauma centers between 2015 and 2018...
November 2020: Journal of Intensive Care Medicine
https://read.qxmd.com/read/30098792/comprehensive-systematic-review-update-summary-disorders-of-consciousness-report-of-the-guideline-development-dissemination-and-implementation-subcommittee-of-the-american-academy-of-neurology-the-american-congress-of-rehabilitation-medicine-and-the-national
#40
JOURNAL ARTICLE
Joseph T Giacino, Douglas I Katz, Nicholas D Schiff, John Whyte, Eric J Ashman, Stephen Ashwal, Richard Barbano, Flora M Hammond, Steven Laureys, Geoffrey S F Ling, Risa Nakase-Richardson, Ronald T Seel, Stuart Yablon, Thomas S D Getchius, Gary S Gronseth, Melissa J Armstrong
OBJECTIVE: To update the 1995 American Academy of Neurology (AAN) practice parameter on persistent vegetative state and the 2002 case definition for the minimally conscious state (MCS) by reviewing the literature on the diagnosis, natural history, prognosis, and treatment of disorders of consciousness lasting at least 28 days. METHODS: Articles were classified per the AAN evidence-based classification system. Evidence synthesis occurred through a modified Grading of Recommendations Assessment, Development and Evaluation process...
September 2018: Archives of Physical Medicine and Rehabilitation
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