keyword
https://read.qxmd.com/read/38537162/advancing-bone-targeted-drug-delivery-leveraging-biological-factors-and-nanoparticle-designs-to-improve-therapeutic-efficacy
#1
JOURNAL ARTICLE
Baixue Xiao, Marian A Ackun-Farmmer, Emmanuela Adjei-Sowah, Yuxuan Liu, Indika Chandrasiri, Danielle S W Benoit
Designing targeted drug delivery systems to effectively treat bone diseases ranging from osteoporosis to nonunion bone defects remains a significant challenge. Previously, nanoparticles (NPs) self-assembled from diblock copolymers of poly(styrene- alt -maleic anhydride)- b -poly(styrene) (PSMA- b -PS) delivering a Wnt agonist were shown to effectively target bone and improve healing via the introduction of a peptide with high affinity to tartrate-resistant acid phosphatase (TRAP), an enzyme deposited by the osteoclasts during bone remodeling...
March 27, 2024: ACS Biomaterials Science & Engineering
https://read.qxmd.com/read/38537118/hierarchical-polyimide-microparticles-with-controllable-morphology
#2
JOURNAL ARTICLE
Zhichao Wang, Jianhua Hu, Haitao Wang
Hierarchical polyimides (PIs) not only show outstanding thermal stability and high mechanical strength but also have great advantages in terms of microstructure and surface area, which makes them highly valuable in various fields such as aerospace, microelectronics, adsorption, catalysis, and energy storage. However, great challenges still remain in the synthesis of hierarchical PIs with well-defined microstructure. Herein, polyamide acid salts (PAAS) with tunable ionization degree are synthesized first via the polymerization of dianhydride and diamine monomers in deionized water with 1,2-dimethylimidazole (DMIZ)...
March 27, 2024: Small
https://read.qxmd.com/read/38536949/combination-nano-delivery-systems-remodel-the-immunosuppressive-tumor-microenvironment-for-metastatic-triple-negative-breast-cancer-therapy
#3
JOURNAL ARTICLE
Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer for which effective therapies are lacking. Targeted remodeling of the immunosuppressive tumor microenvironment (TME) and activation of the body's immune system to fight tumors with well-designed nanoparticles have emerged as pivotal breakthroughs in tumor treatment. To simultaneously remodel the immunosuppressive TME and trigger immune responses, we designed two potential therapeutic nanodelivery systems to inhibit TNBC. First, the bromodomain-containing protein 4 (BRD4) inhibitor JQ1 and the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CXB) were coloaded into chondroitin sulfate (CS) to obtain CS@JQ1/CXB nanoparticles (NPs)...
March 27, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38536857/investigating-the-relationship-between-microbial-network-features-of-giant-kelp-seedbank-cultures-and-subsequent-farm-performance
#4
JOURNAL ARTICLE
Melisa G Osborne, Ariel Levi Simons, Gary Molano, Bernadeth Tolentino, Anupam Singh, Gabriel J Montecinos Arismendi, Filipe Alberto, Sergey V Nuzhdin
Microbial inoculants can increase the yield of cultivated crops and are successful in independent trials; however, efficacy drops in large-scale applications due to insufficient consideration of microbial community dynamics. The structure of microbiomes, in addition to the impact of individual taxa, is an important factor to consider when designing growth-promoting inoculants. Here, we investigate the microbial network and community assembly patterns of Macrocystis pyrifera gametophyte germplasm cultures (collectively referred to as a "seedbank") used to cultivate an offshore farm in Santa Barbara, California, and identify network features associated with increased biomass of mature sporophytes...
2024: PloS One
https://read.qxmd.com/read/38536585/the-key-role-of-tumor-budding-in-predicting-the-status-of-lymph-node-involvement-in-early-gastric-cancer-patients-a-clinical-multicenter-validation-in-china
#5
JOURNAL ARTICLE
Xiangyu Wang, Xiuding Yang, Fenglin Cai, Mingzhi Cai, Yong Liu, Li Zhang, Rupeng Zhang, Fangqin Xue, Yan Sun, Jingyu Deng
BACKGROUND: Accurate preoperative prediction of lymph node (LN) involvement is essential for the management of early gastric cancer (EGC). Our objective was to formulate a potent nomogram for predicting LN involvement in EGC by leveraging an innovative predictor of tumor budding. METHODS: We assembled a cohort of EGC patients who underwent radical surgery at two tertiary cancer centers. Tumor budding was stratified by using an optimal cutoff value and integrated with other clinicopathological variables to ascertain the risk factors associated with LN involvement...
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38536444/sec18-binds-the-tethering-sm-complex-hops-to-engage-the-qc-snare-for-membrane-fusion
#6
JOURNAL ARTICLE
Amy Orr, William Wickner
Membrane fusion is regulated by Rab GTPases, their tethering effectors such as HOPS, SNARE proteins on each fusion partner, SM proteins to catalyze SNARE assembly, Sec17 (SNAP), and Sec18 (NSF). Though concentrated HOPS can support fusion without Sec18, we now report that fusion falls off sharply at lower HOPS levels, where direct Sec18 binding to HOPS restores fusion. This Sec18-dependent fusion needs adenine nucleotide but neither ATP hydrolysis nor Sec17. Sec18 enhances HOPS recognition of the Qc-SNARE. With high levels of HOPS, Qc has a Km for fusion of a few nM...
March 27, 2024: Molecular Biology of the Cell
https://read.qxmd.com/read/38536224/cosolvent-incorporation-modulates-the-thermal-and-structural-response-of-pnipam-silyl-methacrylate-copolymers
#7
JOURNAL ARTICLE
Jason D Linn, Fabian A Rodriguez, Michelle A Calabrese
Polymers functionalized with inorganic silane groups have been used in wide-ranging applications due to the silane reactivity, which enables formation of covalently-crosslinked polymeric structures. Utilizing stimuli-responsive polymers in these hybrid systems can lead to smart and tunable behavior for sensing, drug delivery, and optical coatings. Previously, the thermoresponsive polymer poly( N -isopropyl acrylamide) (PNIPAM) functionalized with 3-(trimethoxysilyl)propyl methacrylate (TMA) demonstrated unique aqueous self-assembly and optical responses following temperature elevation...
March 27, 2024: Soft Matter
https://read.qxmd.com/read/38536171/a-revised-definition-of-left-bundle-branch-block-using-time-to-notch-in-lead-i
#8
JOURNAL ARTICLE
Jeremy S Treger, Ahmad B Allaw, Pouyan Razminia, Dipayon Roy, Amulya Gampa, Swati Rao, Andrew D Beaser, Srinath Yeshwant, Zaid Aziz, Cevher Ozcan, Gaurav A Upadhyay
IMPORTANCE: Current left bundle branch block (LBBB) criteria are based on animal experiments or mathematical models of cardiac tissue conduction and may misclassify patients. Improved criteria would impact referral decisions and device type for cardiac resynchronization therapy. OBJECTIVE: To develop a simple new criterion for LBBB based on electrophysiological studies of human patients, and then to validate this criterion in an independent population. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study, the derivation cohort was from a single-center, prospective study of patients undergoing electrophysiological study from March 2016 through November 2019...
March 27, 2024: JAMA Cardiology
https://read.qxmd.com/read/38536140/primary-care-access-for-all-a-roadmap-for-addressing-the-primary-care-crisis-in-rhode-island
#9
JOURNAL ARTICLE
Jeffrey Borkan, Denise Coppa, Patricia Flanagan, Debra Hurwitz, Andrew Saal, Yolanda Bowes, Elena Nicolella, Peter Hollmann
BACKGROUND: Primary care in Rhode Island is in crisis. The dearth of primary care providers is already affecting access to services and the situation is likely to worsen unless major steps are taken. There are inadequate numbers of trainees in primary care medical residencies, nurse practitioner (NP) and physician assistant (PA) training programs who plan to practice primary care in our state. The Care Transformation Collaborative of RI (CTC-RI) has assembled a broadly representative task force of physicians, NPs, PAs, and others to build a strong and robust primary care delivery system across the state that recruits, trains, retains, and sustains primary care providers...
April 1, 2024: Rhode Island Medical Journal
https://read.qxmd.com/read/38536070/conductive-peptide-based-mxene-hydrogel-as-a-piezoresistive-sensor
#10
JOURNAL ARTICLE
Dana Cohen-Gerassi, Or Messer, Gal Finkelstein-Zuta, Moran Aviv, Bar Favelukis, Yosi Shacham-Diamand, Maxim Sokol, Lihi Adler-Abramovich
Wearable pressure sensors have become increasingly popular for personal healthcare and motion detection applications due to recent advances in materials science and functional nanomaterials. In this study, we present a novel composite hydrogel as a sensitive piezoresistive sensor that can be utilized for various biomedical applications, such as wearable skin patches and integrated artificial skin that can measure pulse and blood pressure, as well as monitor sound as a self-powered microphone. The hydrogel is composed of self-assembled short peptides containing aromatic, positively- or negatively charged amino acids combined with 2D Ti3 C2 Tz MXene nanosheets...
March 27, 2024: Advanced Healthcare Materials
https://read.qxmd.com/read/38536035/ddx6-modulates-p-body-and-stress-granule-assembly-composition-and-docking
#11
JOURNAL ARTICLE
Nina Ripin, Luisa Macedo de Vasconcelos, Daniella A Ugay, Roy Parker
Stress granules and P-bodies are ribonucleoprotein (RNP) granules that accumulate during the stress response due to the condensation of untranslating mRNPs. Stress granules form in part by intermolecular RNA-RNA interactions and can be limited by components of the RNA chaperone network, which inhibits RNA-driven aggregation. Herein, we demonstrate that the DEAD-box helicase DDX6, a P-body component, can also limit the formation of stress granules, independent of the formation of P-bodies. In an ATPase, RNA-binding dependent manner, DDX6 limits the partitioning of itself and other RNPs into stress granules...
June 3, 2024: Journal of Cell Biology
https://read.qxmd.com/read/38535695/one-step-synthesis-of-3d-graphene-aerogel-supported-pt-nanoparticles-as-highly-active-electrocatalysts-for-methanol-oxidation-reaction
#12
JOURNAL ARTICLE
Xiaoye Wo, Rui Yan, Xiao Yu, Gang Xie, Jinlong Ma, Yanpeng Cao, Aijun Li, Jian Huang, Caixia Huo, Fenghua Li, Yu Wang, Liqiang Luo, Qixian Zhang
Nowadays, two of the biggest obstacles restricting the further development of methanol fuel cells are excessive cost and insufficient catalytic activity of platinum-based catalysts. Herein, platinum nanoparticle supported graphene aerogel (Pt/3DGA) was successfully synthesized by a one-step hydrothermal self-assembly method. The loose three-dimensional structure of the aerogel is stabilized by a simple one-step method, which not only reduces cost compared to the freeze-drying technology, but also optimizes the loading method of nanoparticles...
March 20, 2024: Nanomaterials
https://read.qxmd.com/read/38535694/a-conductive-microcavity-created-by-assembly-of-carbon-nanotube-buckypapers-for-developing-electrochemically-wired-enzyme-cascades
#13
JOURNAL ARTICLE
Itthipon Jeerapan, Yannig Nedellec, Serge Cosnier
We describe the creation of a conductive microcavity based on the assembly of two pieces of carbon nanotube buckypaper for the entrapment of two enzymes, horseradish peroxidase (HRP) and glucose oxidase (GOx), as well as a redox mediator: 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid diammonium salt (ABTS). The hollow electrode, employing GOx, HRP, and the mediator, as an electrochemical enzyme cascade model, is utilized for glucose sensing at a potential of 50 mV vs. Ag/AgCl. This bienzyme electrode demonstrates the ability to oxidize glucose by GOx and subsequently convert H2 O2 to water via the electrical wiring of HRP by ABTS...
March 20, 2024: Nanomaterials
https://read.qxmd.com/read/38535673/a-3d-printed-portable-uv-and-visible-photoreactor-for-water-purification-and-disinfection-experiments
#14
JOURNAL ARTICLE
Nelson Castro, Joana M Queirós, Dinis C Alves, Margarida M Macedo Fernandes, Senetxu Lanceros-Méndez, Pedro M Martins
Water scarcity and contamination are urgent issues to be addressed. In this context, different materials, techniques, and devices are being developed to mitigate contemporary and forthcoming water constraints. Photocatalysis-based approaches are suitable strategies to address water contamination by degrading contaminants and eliminating microbes. Photoreactors are usually designed to perform photocatalysis in a scalable and standardised way. Few or none have been developed to combine these characteristics with portability, flexibility, and cost effectiveness...
March 15, 2024: Nanomaterials
https://read.qxmd.com/read/38535667/strategic-structural-control-of-polyserotonin-nanoparticles-and-their-application-as-ph-responsive-nanomotors
#15
JOURNAL ARTICLE
Junyi Hu, Jingjing Cao, Jinwei Lin, Leilei Xu
Serotonin-based nanomaterials have been positioned as promising contenders for constructing multifunctional biomedical nanoplatforms due to notable biocompatibility, advantageous charge properties, and chemical adaptability. The elaborately designed structure and morphology are significant for their applications as functional carriers. In this study, we fabricated anisotropic bowl-like mesoporous polyserotonin (PST) nanoparticles with a diameter of approximately 170 nm through nano-emulsion polymerization, employing P123/F127 as a dual-soft template and 1,3,5-trimethylbenzene (TMB) as both pore expander and emulsion template...
March 14, 2024: Nanomaterials
https://read.qxmd.com/read/38535652/-polymerization-of-bimerons-in-quasi-two-dimensional-chiral-magnets-with-easy-plane-anisotropy
#16
JOURNAL ARTICLE
Natsuki Mukai, Andrey O Leonov
We re-examine the internal structure of bimerons, which are stabilized in easy-plane chiral magnets and represent coupled states of two merons with the same topological charge |1/2| but with opposite vorticity and the polarity. We find that, in addition to the vortices and antivortices, bimerons feature circular regions which are located behind the anti-vortices and bear the rotational sense opposite to the rotational sense chosen by the Dzyaloshinskii-Moriya interaction. In an attempt to eliminate these wrong-twist regions with an excess of positive energy density, bimerons assemble into chains, and as such exhibit an attracting interaction potential...
March 11, 2024: Nanomaterials
https://read.qxmd.com/read/38535651/energy-storage-performance-of-electrode-materials-derived-from-manganese-metal-organic-frameworks
#17
JOURNAL ARTICLE
Gyeongbeom Ryoo, Seon Kyung Kim, Do Kyung Lee, Young-Jin Kim, Yoon Soo Han, Kyung-Hye Jung
Metal-organic frameworks (MOFs) are porous materials assembled using metal and organic linkers, showing a high specific surface area and a tunable pore size. Large portions of metal open sites in MOFs can be exposed to electrolyte ions, meaning they have high potential to be used as electrode materials in energy storage devices such as supercapacitors. Also, they can be easily converted into porous metal oxides by heat treatment. In this study, we obtained high energy storage performance by preparing electrode materials through applying heat treatment to manganese MOFs (Mn-MOFs) under air...
March 11, 2024: Nanomaterials
https://read.qxmd.com/read/38535523/chiroptical-strain-sensors-from-electrospun-cadmium-sulfide-quantum-dot-fibers
#18
JOURNAL ARTICLE
Hansadi Jayamaha, Thomas J Ugras, Kirt A Page, Tobias Hanrath, Richard D Robinson, Larissa M Shepherd
Controllable synthesis of homochiral nano/micromaterials has been a constant challenge for fabricating various stimuli-responsive chiral sensors. To provide an avenue to this goal, we report electrospinning as a simple and economical strategy to form continuous homochiral microfibers with strain-sensitive chiroptical properties. First, electrospun homochiral microfibers from self-assembled cadmium sulfide (CdS) quantum dot magic-sized clusters (MSCs) are produced. Highly sensitive and reversible strain sensors are then fabricated by embedding these chiroptically active fibers into elastomeric films...
March 27, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38535519/molecular-bottlebrushes-as-emerging-nanocarriers-material-design-and-biomedical-application
#19
REVIEW
Zhen Zhang, Zheqi Li, Yi Shi, Yongming Chen
As a unique unimolecular nanoobject, molecular bottlebrushes (MBBs) have attracted great interest from researchers in nanocarriers attributed to their defined structure, size, and shape. MBBs with various architectures have been proposed and constructed with well-defined domains for loading "cargos", including core, shell, and periphery functional groups. Compared with nanomaterials based on self-assembly, MBBs have lots of advantages, including facile synthesis, flexible compositions, favorable stability, and tunable size and shape, that make them a promising nanoplatform for various applications...
March 27, 2024: Langmuir: the ACS Journal of Surfaces and Colloids
https://read.qxmd.com/read/38535487/an-annular-pulse-forming-line-based-on-coaxial-transmission-lines
#20
JOURNAL ARTICLE
Xudong Qiu, Jiancang Su, Rui Li, Jie Cheng, Bo Zeng, Binxiong Yu, Yongdong Li
The miniaturization, lightweight, and solidification of pulse forming lines (PFLs) are of prime significance during the evolution of pulsed power technology. In this paper, an all-solid-state annular pulse forming line (APFL) based on film-insulated coaxial transmission lines is developed to generate fast-rise time quasi-square pulses. First, a coiled coaxial transmission line (CCTL) comprised of multilayer polypropylene films with outstanding insulating properties is constructed. It can withstand direct current voltages up to 200 kV, with a cross section diameter of 7...
March 1, 2024: Review of Scientific Instruments
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