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Jim Phillips, Valerie Wright, Jim Tomlinson
Scotland's political divergence from England is a key theme in late twentieth century British history. Typically seen in terms of the post-1979 Thatcher effect, this in fact developed over a longer timeframe, rooted in industrial changes revealed by analysis of the Linwood car plant in Renfrewshire. Conservatism and Unionism was an eminent political force in Scotland in the 1940s and 1950s. But in all general elections from 1959 onwards the vote share of Conservative and Unionist candidates was lower in Scotland than in England...
March 20, 2019: Journal of Tropical Pediatrics
Ricardo Schestatsky, Camila Pauleski Zucuni, Andressa Borin Venturini, Thiago Augusto de Lima Burgo, Atais Bacchi, Luiz Felipe Valandro, Gabriel Kalil Rocha Pereira
To evaluate the fatigue failure load (FFL), number of cycles for failure (CFF) and survival probabilities of lithium-disilicate (LD) monolithic crowns manufactured by two processing techniques (pressing vs. CAD/CAM) adhesively cemented to a dentin-analogue material, considering two surface treatments (conventional vs. simplified). Surface characteristics (topography, roughness and fractal dimensions) were also assessed. Forty (40) monolithic crowns were manufactured considering two specific processing techniques for each ceramic system: LDCAD - CAD/CAM lithium-disilicate (IPS e...
March 9, 2019: Journal of the Mechanical Behavior of Biomedical Materials
Zhongqing Luo, Qile Fang, Xueyan Xu, D Vasanth Raj, Xufeng Zhou, Zhaoping Liu
Graphene oxide (GO) based membranes are widely adopted in molecular separation based on size exclusion effect by stacked GO sheets. Both high flux and efficient rejection of GO-based membranes for long-term operation are highly expected for practical applications. Here, an attapulgite (ATP) nanofibers/ GO composite (ATP/GO) membrane is assembled by filtration of mixed aqueous colloidal suspensions of ATP and GO. Due to the modification of interlayer distance and surface property of GO membrane by ATP, the ATP/GO membrane demonstrates excellent separation performance, with a high water flux of 221...
March 14, 2019: Journal of Colloid and Interface Science
Fatemeh Graily Moradi, Mir Jalil Hejazi, Hamed Hamishehkar, Ahmad Ali Enayati
A well-known strategy for managing pest resistance is application of mixture of pesticides. Conventionally formulated pesticides have several environmental incompatibilities. The use of biocompatible and biodegradable nanocarriers in formulating pesticides could improve environmental protection. In this study, a mixture of imidacloprid and lambda-cyhalothrin was co-encapsulated for the first time using liposomes as nanocarrier to simultaneously deliver these insecticides. Ethanol injection was used to produce self-assembled liposomes...
March 18, 2019: Ecotoxicology and Environmental Safety
Massimiliano Magro, Simone Bramuzzo, Davide Baratella, Juri Ugolotti, Giorgio Zoppellaro, Giulia Chemello, Ike Olivotto, Cristina Ballarin, Giuseppe Radaelli, Beatrice Arcaro, Marco De Liguoro, Olimpia Coppellotti, Laura Guidolin, Jessica de Almeida Roger, Emanuela Bonaiuto, Radek Zboril, Fabio Vianello
Aedes aegypti mosquitos are widespread vectors of several diseases and their control is of primary importance for biological and environmental reasons, and novel safe insecticides are highly desirable. An eco-friendly photosensitizing magnetic nanocarrier with larvicidal effects on Aedes aegypti was proposed. The innovative core-shell hybrid nanomaterial was synthesized by combining peculiar magnetic nanoparticles (called Surface Active Maghemite Nanoparticles - SAMNs, the core) and chlorin-e6 as photosensitizer (constituting the shell) via self-assembly in water...
March 13, 2019: Journal of Photochemistry and Photobiology. B, Biology
Zhongjie Li, Miaomiao Meng, Shasha Li, Bo Deng
Larvae of the pest Protaetia brevitarsis are used to treat infections in traditional Chinese medicine. However, genomic information about this non-model species is currently lacking. To better understand the fundamental biology of this non-model species, its transcriptome was obtained using next generation sequencing and then analyzed. A total of 7.62 Gb of clean reads were obtained, which were assembled into 169,087 transcripts corresponding to 142,000 annotated unigenes. These unigenes were functionally classified according to Gene Ontology (GO), euKaryotic Ortholog Groups of proteins (KOG), and Kyoto Encyclopedia of Genes and Genomes (KEGG) annotations...
2019: PloS One
Matías Fassolari, Guillermo D Alonso
Aurora kinases constitute a family of enzymes that play a key role during metazoan cells division, being involved in events like centrosome maturation and division, chromatin condensation, mitotic spindle assembly, control of kinetochore-microtubule attachments, and cytokinesis initiation. In this work, three Aurora kinase homologues were identified in Trypanosoma cruzi (TcAUK1, -2 and -3), a protozoan parasite of the Kinetoplastida Class. The genomic organization of these enzymes was fully analyzed, demonstrating that TcAUK1 is a single-copy gene, TcAUK2 coding sequence is present in two different forms (short and long) and TcAUK3 is a multi-copy gene...
March 21, 2019: PLoS Neglected Tropical Diseases
Lingbo Xing, Zhantao Peng, Wentao Li, Kai Wu
Molecular self-assembly (MSA) refers to spontaneous arrangement of molecular building blocks into ordered structures governed by weak interactions. Due to its high versatility and reversibility, MSA has been widely employed as a robust bottom-up approach to fabricating low-dimensional functional nanostructures, which are used in various applications in nanoscience and technology. To date, tremendous effort has been devoted to constructing various MSAs at surfaces, ranging from self-assembled monolayers and two-dimensional (2D) nanoporous networks to complex 2D quasicrystals and Sierpiński triangle fractals...
March 21, 2019: Accounts of Chemical Research
Jingjing Lu, Xia Gu, Fanglei Liu, Zhuanghua Rui, Ming Liu, Liming Zhao
Lung cancer is the most common and lethal cancer worldwide, especially in developing countries. Non‑small cell lung cancer (NSCLC) accounts for 85% of all cases of lung cancer. In aprevious study, the protein expression of ubiquitin conjugating enzyme E2 C (UBE2C/UbcH10) in NSCLC tissues and cells was found to be significantly higher than that in adjacent tissues and normal lung epithelial cells. Further study revealed that the aberrant expression of UbcH10 in NSCLC tumors or cancer cells was caused by inactivation of the post‑transcriptional regulation mechanism, and thus microRNAs (miRNAs) may play an important...
March 21, 2019: Oncology Reports
Zi-Bo Zhai, Ke-Jing Huang, Xu Wu, Han Hu, Yun Xu, Rui-Min Chai
ZnS nanoparticles wrapped in N-doped mesoporous carbon nanosheets are prepared from metal-organic frameworks through a simple co-pyrolysis process. In the composite interface, ZnS nanoparticles are directly loaded on the carbon and form a mesoporous structure, thus providing fast electron and ion dual transfer routes, and efficient electrode reaction kinetics. In addition, the heteroatom N-doping and the small-sized ZnS with embedded carbon can provide more active sites and stable electrode kinetics for electrochemical reactions...
March 21, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Han Xue, Fei Ding, Jiao Zhang, Yuanyuan Guo, Xihui Gao, Jing Feng, Xinyuan Zhu, Chuan Zhang
DNA tetrahedra are employed as building blocks to construct a novel DNA-based nanogel for intracellular siRNA delivery. With a compact architecture that embeds functional siRNA inside, the self-assembled nanogel can efficiently enter cells and knock down the target gene expression, making them potential noncationic vectors for functional nucleic acid delivery.
March 21, 2019: Chemical Communications: Chem Comm
Harnimarta Deol, Gurpreet Singh, Manoj Kumar, Vandana Bhalla
In modern organic synthesis, the utilization of metal NPs for carrying out fundamental organic transformations is an area of great interest. This frontier article describes the exploitation of supramolecular assemblies of AIEE-active materials as nanoreactors, stabilizers and shape directing agents for the preparation of various types of metal NPs without using any additives, reducing agents, stabilizing agents, etc. This article further summarizes the utilization of the as-prepared supramolecular ensembles as reusable nanocatalysts for carrying out various organic transformations under mild conditions...
March 21, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
Evgeny V Denisov, Anastasia A Schegoleva, Tatiana S Gerashchenko, Nikolay A Skryabin, Alexey A Sleptcov, Valentina D Yakushina, Liliya S Lyapunova, Sergey A Tuzikov, Olga V Pankova, Vladimir M Perelmuter
The premalignant process preceding squamous cell lung cancer is not inevitable; it can stop at any of the bronchial lesions: basal cell hyperplasia (BCH), squamous metaplasia (SM), and dysplasia and then progress or regress. At present, the mechanisms underlying the progression of the bronchial lesions remain undefined. Previously, we hypothesized that bronchial lesions that presented individually or combined with each other in the bronchi of lung cancer patients mirror the different "scenarios" of the premalignant process: individual BCH-the stoppage at the stage of hyperplasia, BCH plus SM-the progression of hyperplasia to metaplasia, and SM plus dysplasia-the progression of metaplasia to dysplasia...
March 20, 2019: Applied Immunohistochemistry & Molecular Morphology: AIMM
Patrick Federmann, Hannah K Wagner, Patrick W Antoni, Jean-Marc Mörsdorf, José Luis Pérez Lustres, Hubert Wadepohl, Marcus Motzkus, Joachim Ballmann
The previously elusive diphosphadibenzo[ a, e]pentalene core skeleton was assembled via a surprisingly straightforward cyclization pathway starting from R2 P-substituted 2,2'-diphosphinotolanes (R = Ph, i Pr). The resulting P-protected diylidic compounds 4 (R = Ph, i Pr) were converted to the corresponding P-bridged ladder stilbenes via two consecutive oxidation steps: upon selective one-electron oxidation, the persistent radical monocations 5 (R = Ph, i Pr) were obtained and further oxidized to afford the respective fluorescent and air-stable dications 6 (R = Ph, i Pr)...
March 21, 2019: Organic Letters
Zhi-Xu Zhang, Tie Zhang, Wan-Ying Zhang, Ping-Ping Shi, Qiong Ye, Da-Wei Fu
With regard to the artificial molecular motor that was recognized with the 2016 Nobel Prize, this success proves the great scientific significance of rotary motor-type motion at the molecular level, which has been expected to play an invaluable role in the development of electronic information molecular materials. However, designing electronic information-critical high-temperature molecular motors has always been a huge challenge. Since we discovered [(CH3 )3 NCH2 Cl]MnCl3 , this cation rotation pattern with a motor-type motion structure has continued to attract our attention...
March 21, 2019: Inorganic Chemistry
Mujahuddin M Siddiqui, Rupak Saha, Partha Sarathi Mukherjee
Donor-selective coordination-driven self-assembly of a bis(dipyrrin)-bridged new diruthenium acceptor (RuA) with dipyridyl and diimidazolyl donors has been reported. The self-assembly of the ruthenium(II) acceptor with imidazolyl donors resulted in the formation of either [2 + 2] self-assembled monomeric macrocycles (MMs) or a mixture of metalla[2]catenanes (MCs) and MMs depending on the solvents used. On the contrary, similar self-assembly with the pyridyl donors resulted in simple [2 + 2] macrocycles (MMs) exclusively, irrespective of the solvents used...
March 21, 2019: Inorganic Chemistry
Li Yang, Feifei Liu, Xiankun Tong, Daniel Hoffmann, Jianping Zuo, Mengji Lu
Based on the recent advance of basic research on molecular biology of hepatitis B virus (HBV) infection, novel antiviral drugs targeting various steps of HBV life cycle are developed in recent years. HBV nucleocapsid assembly is now recognized as a hot target for anti-HBV drug development. Structural and functional analysis of HBV nucleocapsid allowed rational design and improvement of small molecules with the ability to interact with the components of HBV nucleocapsid and modulate the viral nucleocapsid assembly process...
March 21, 2019: ACS Infectious Diseases
Yuewen Sheng, Tongxin Chen, Yang Lu, Ren-Jie Chang, Sapna Sinha, Jamie H Warner
The solid progress in the study of a single two-dimensional (2D) material underpins the development for creating 2D material assemblies with various electronic and optoelectronic properties. We introduce an asymmetric structure by stacking monolayer semiconducting tungsten disulfide, metallic graphene, and insulating boron nitride to fabricate numerous red channel light-emitting devices (LEDs). All the 2D crystals were grown by chemical vapor deposition (CVD), which has great potential for future industrial scale-up...
March 21, 2019: ACS Nano
Chuanjiang He, Tingting Ye, Wenqi Teng, Zhi Fang, Wei-Shuyi Ruan, Guowu Liu, Hui Chen, Jizeng Sun, Lanlan Hui, Feng Sheng, Dingyi Pan, Chunming Yang, Yi Zheng, Meng-Bo Luo, Ke Yao, Ben Wang
No abstract text is available yet for this article.
March 21, 2019: ACS Nano
Kai Le, Zhou Wang, Fenglong Wang, Qi Wang, Qian Shao, Vignesh Murugadoss, Shide Wu, Wei Liu, Jiurong Liu, Qiang Gao, Zhanhu Guo
Nanocomposites with a well-defined sandwich-like nanostructure were prepared via in situ growing NiCo-layered double hydroxide nanosheets with tunable Ni/Co ratios on reduced graphene oxide (rGO). Electrochemical impedance spectra and N2 adsorption/desorption isotherms confirmed that these sandwich nanostructures effectively promoted charge transport and enlarged the specific surface area. The nanocomposites with Ni : Co = 2 : 1 exhibited a maximum specific capacitance of 2130 F g-1 at 2 A g-1, excellent rate capability (72...
March 21, 2019: Dalton Transactions: An International Journal of Inorganic Chemistry
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